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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMTC1
Full Name:
Transmembrane and TPR repeat-containing protein 1
Alias:
ARG99; OLF
Type:
Uncharacterized
Mass (Da):
87352
Number AA:
774
UniProt ID:
Q8IUR5
International Prot ID:
IPI00043430
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T28
L
M
Y
T
C
D
K
T
V
F
K
N
R
G
L
Site 2
S78
A
F
L
S
Y
N
R
S
L
D
Q
G
C
V
G
Site 3
S87
D
Q
G
C
V
G
G
S
F
P
S
T
V
S
P
Site 4
S128
C
L
V
Y
D
L
F
S
L
S
N
K
Q
D
K
Site 5
S130
V
Y
D
L
F
S
L
S
N
K
Q
D
K
S
S
Site 6
S136
L
S
N
K
Q
D
K
S
S
N
G
A
L
C
P
Site 7
S137
S
N
K
Q
D
K
S
S
N
G
A
L
C
P
R
Site 8
S145
N
G
A
L
C
P
R
S
P
Q
Q
P
G
S
P
Site 9
S151
R
S
P
Q
Q
P
G
S
P
Q
P
S
S
L
P
Site 10
S155
Q
P
G
S
P
Q
P
S
S
L
P
G
H
P
H
Site 11
S156
P
G
S
P
Q
P
S
S
L
P
G
H
P
H
R
Site 12
S182
G
A
W
G
G
C
H
S
P
L
P
P
E
P
K
Site 13
S190
P
L
P
P
E
P
K
S
S
G
F
P
V
S
P
Site 14
S191
L
P
P
E
P
K
S
S
G
F
P
V
S
P
R
Site 15
S196
K
S
S
G
F
P
V
S
P
R
A
V
W
S
M
Site 16
Y306
V
V
A
E
R
V
L
Y
M
P
S
M
G
Y
C
Site 17
Y312
L
Y
M
P
S
M
G
Y
C
I
L
F
V
H
G
Site 18
S359
K
Q
N
E
I
W
L
S
R
E
S
L
F
R
S
Site 19
S362
E
I
W
L
S
R
E
S
L
F
R
S
G
V
Q
Site 20
S366
S
R
E
S
L
F
R
S
G
V
Q
T
L
P
H
Site 21
T370
L
F
R
S
G
V
Q
T
L
P
H
N
A
K
V
Site 22
Y396
G
R
N
K
E
A
I
Y
H
Y
R
T
A
L
K
Site 23
Y405
Y
R
T
A
L
K
L
Y
P
R
H
A
S
A
L
Site 24
S410
K
L
Y
P
R
H
A
S
A
L
N
N
L
G
T
Site 25
T417
S
A
L
N
N
L
G
T
L
T
R
D
T
A
E
Site 26
T422
L
G
T
L
T
R
D
T
A
E
A
K
M
Y
Y
Site 27
Y428
D
T
A
E
A
K
M
Y
Y
Q
R
A
L
Q
L
Site 28
Y429
T
A
E
A
K
M
Y
Y
Q
R
A
L
Q
L
H
Site 29
S452
N
L
G
N
L
L
K
S
Q
E
K
K
E
E
A
Site 30
T461
E
K
K
E
E
A
I
T
L
L
K
D
S
I
K
Site 31
S482
D
A
Y
S
S
L
A
S
L
L
A
E
Q
E
R
Site 32
T499
E
A
E
E
I
Y
Q
T
G
I
K
N
C
P
D
Site 33
Y514
S
S
D
L
H
N
N
Y
G
V
F
L
V
D
T
Site 34
S538
Y
Q
Q
A
I
K
L
S
P
S
H
H
V
A
M
Site 35
Y552
M
V
N
L
G
R
L
Y
R
S
L
G
E
N
S
Site 36
S554
N
L
G
R
L
Y
R
S
L
G
E
N
S
M
A
Site 37
S559
Y
R
S
L
G
E
N
S
M
A
E
E
W
Y
K
Site 38
Y585
L
S
P
L
G
A
L
Y
Y
N
T
G
R
Y
E
Site 39
Y586
S
P
L
G
A
L
Y
Y
N
T
G
R
Y
E
E
Site 40
T588
L
G
A
L
Y
Y
N
T
G
R
Y
E
E
A
L
Site 41
Y591
L
Y
Y
N
T
G
R
Y
E
E
A
L
Q
I
Y
Site 42
S607
E
A
A
A
L
Q
P
S
Q
R
E
L
R
L
A
Site 43
S650
L
E
C
Y
R
L
L
S
A
I
Y
S
K
Q
E
Site 44
S654
R
L
L
S
A
I
Y
S
K
Q
E
N
H
D
K
Site 45
S681
P
K
D
P
K
V
I
S
E
L
F
F
T
K
G
Site 46
T686
V
I
S
E
L
F
F
T
K
G
N
Q
L
R
E
Site 47
Y731
I
Q
H
I
K
G
K
Y
V
S
A
R
A
Y
Y
Site 48
S733
H
I
K
G
K
Y
V
S
A
R
A
Y
Y
E
R
Site 49
Y737
K
Y
V
S
A
R
A
Y
Y
E
R
A
L
Q
L
Site 50
Y738
Y
V
S
A
R
A
Y
Y
E
R
A
L
Q
L
V
Site 51
S748
A
L
Q
L
V
P
D
S
K
L
L
K
E
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation