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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NPAS4
Full Name:
Neuronal PAS domain-containing protein 4
Alias:
BHLHe79; HLH-PAS transcription factor NXF; Le-PAS; Neuronal PAS domain protein 4; Neuronal PAS4; NXF; PASD10
Type:
Mass (Da):
87120
Number AA:
UniProt ID:
Q8IUM7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Neuronal PAS domain-containing protein 4 pan-specific antibody AB-NN299-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN299-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y39
A
D
K
V
R
L
S
Y
L
H
I
M
S
L
A
Site 2
Y49
I
M
S
L
A
C
I
Y
T
R
K
G
V
F
F
Site 3
Y96
T
A
E
G
K
L
L
Y
L
S
E
S
V
S
E
Site 4
S98
E
G
K
L
L
Y
L
S
E
S
V
S
E
H
L
Site 5
S100
K
L
L
Y
L
S
E
S
V
S
E
H
L
G
H
Site 6
S102
L
Y
L
S
E
S
V
S
E
H
L
G
H
S
M
Site 7
Y120
V
A
Q
G
D
S
I
Y
D
I
I
D
P
A
D
Site 8
T130
I
D
P
A
D
H
L
T
V
R
Q
Q
L
T
L
Site 9
T143
T
L
P
S
A
L
D
T
D
R
L
F
R
C
R
Site 10
T153
L
F
R
C
R
F
N
T
S
K
S
L
R
R
Q
Site 11
S154
F
R
C
R
F
N
T
S
K
S
L
R
R
Q
S
Site 12
S156
C
R
F
N
T
S
K
S
L
R
R
Q
S
A
G
Site 13
S161
S
K
S
L
R
R
Q
S
A
G
N
K
L
V
L
Site 14
S243
I
Y
L
G
F
E
R
S
E
L
L
C
K
S
W
Site 15
S249
R
S
E
L
L
C
K
S
W
Y
G
L
L
H
P
Site 16
Y251
E
L
L
C
K
S
W
Y
G
L
L
H
P
E
D
Site 17
Y267
A
H
A
S
A
Q
H
Y
R
L
L
A
E
S
G
Site 18
S273
H
Y
R
L
L
A
E
S
G
D
I
Q
A
E
M
Site 19
Y299
A
W
I
Y
C
L
L
Y
S
E
G
P
E
G
P
Site 20
T308
E
G
P
E
G
P
I
T
A
N
N
Y
P
I
S
Site 21
Y312
G
P
I
T
A
N
N
Y
P
I
S
D
M
E
A
Site 22
S315
T
A
N
N
Y
P
I
S
D
M
E
A
W
S
L
Site 23
S321
I
S
D
M
E
A
W
S
L
R
Q
Q
L
N
S
Site 24
S328
S
L
R
Q
Q
L
N
S
E
D
T
Q
A
A
Y
Site 25
Y335
S
E
D
T
Q
A
A
Y
V
L
G
T
P
T
M
Site 26
S345
G
T
P
T
M
L
P
S
F
P
E
N
I
L
S
Site 27
S352
S
F
P
E
N
I
L
S
Q
E
E
C
S
S
T
Site 28
S358
L
S
Q
E
E
C
S
S
T
N
P
L
F
T
A
Site 29
T359
S
Q
E
E
C
S
S
T
N
P
L
F
T
A
A
Site 30
S372
A
A
L
G
A
P
R
S
T
S
F
P
S
A
P
Site 31
T373
A
L
G
A
P
R
S
T
S
F
P
S
A
P
E
Site 32
S374
L
G
A
P
R
S
T
S
F
P
S
A
P
E
L
Site 33
S377
P
R
S
T
S
F
P
S
A
P
E
L
S
V
V
Site 34
S382
F
P
S
A
P
E
L
S
V
V
S
A
S
E
E
Site 35
S385
A
P
E
L
S
V
V
S
A
S
E
E
L
P
R
Site 36
S394
S
E
E
L
P
R
P
S
K
E
L
D
F
S
Y
Site 37
S400
P
S
K
E
L
D
F
S
Y
L
T
F
P
S
G
Site 38
Y401
S
K
E
L
D
F
S
Y
L
T
F
P
S
G
P
Site 39
T403
E
L
D
F
S
Y
L
T
F
P
S
G
P
E
P
Site 40
S406
F
S
Y
L
T
F
P
S
G
P
E
P
S
L
Q
Site 41
S411
F
P
S
G
P
E
P
S
L
Q
A
E
L
S
K
Site 42
S417
P
S
L
Q
A
E
L
S
K
D
L
V
C
T
P
Site 43
T423
L
S
K
D
L
V
C
T
P
P
Y
T
P
H
Q
Site 44
Y426
D
L
V
C
T
P
P
Y
T
P
H
Q
P
G
G
Site 45
T427
L
V
C
T
P
P
Y
T
P
H
Q
P
G
G
C
Site 46
T446
S
L
H
E
P
F
Q
T
H
L
P
T
P
S
S
Site 47
T450
P
F
Q
T
H
L
P
T
P
S
S
T
L
Q
E
Site 48
S453
T
H
L
P
T
P
S
S
T
L
Q
E
Q
L
T
Site 49
T460
S
T
L
Q
E
Q
L
T
P
S
T
A
T
F
S
Site 50
S462
L
Q
E
Q
L
T
P
S
T
A
T
F
S
D
Q
Site 51
T463
Q
E
Q
L
T
P
S
T
A
T
F
S
D
Q
L
Site 52
T465
Q
L
T
P
S
T
A
T
F
S
D
Q
L
T
P
Site 53
S467
T
P
S
T
A
T
F
S
D
Q
L
T
P
S
S
Site 54
T471
A
T
F
S
D
Q
L
T
P
S
S
A
T
F
P
Site 55
S473
F
S
D
Q
L
T
P
S
S
A
T
F
P
D
P
Site 56
S474
S
D
Q
L
T
P
S
S
A
T
F
P
D
P
L
Site 57
T476
Q
L
T
P
S
S
A
T
F
P
D
P
L
T
S
Site 58
T482
A
T
F
P
D
P
L
T
S
P
L
Q
G
Q
L
Site 59
S483
T
F
P
D
P
L
T
S
P
L
Q
G
Q
L
T
Site 60
T490
S
P
L
Q
G
Q
L
T
E
T
S
V
R
S
Y
Site 61
T492
L
Q
G
Q
L
T
E
T
S
V
R
S
Y
E
D
Site 62
S493
Q
G
Q
L
T
E
T
S
V
R
S
Y
E
D
Q
Site 63
Y497
T
E
T
S
V
R
S
Y
E
D
Q
L
T
P
C
Site 64
T502
R
S
Y
E
D
Q
L
T
P
C
T
S
T
F
P
Site 65
S506
D
Q
L
T
P
C
T
S
T
F
P
D
Q
L
L
Site 66
T507
Q
L
T
P
C
T
S
T
F
P
D
Q
L
L
P
Site 67
S515
F
P
D
Q
L
L
P
S
T
A
T
F
P
E
P
Site 68
T518
Q
L
L
P
S
T
A
T
F
P
E
P
L
G
S
Site 69
S525
T
F
P
E
P
L
G
S
P
A
H
E
Q
L
T
Site 70
T532
S
P
A
H
E
Q
L
T
P
P
S
T
A
F
Q
Site 71
S535
H
E
Q
L
T
P
P
S
T
A
F
Q
A
H
L
Site 72
T536
E
Q
L
T
P
P
S
T
A
F
Q
A
H
L
D
Site 73
S544
A
F
Q
A
H
L
D
S
P
S
Q
T
F
P
E
Site 74
S546
Q
A
H
L
D
S
P
S
Q
T
F
P
E
Q
L
Site 75
T548
H
L
D
S
P
S
Q
T
F
P
E
Q
L
S
P
Site 76
S554
Q
T
F
P
E
Q
L
S
P
N
P
T
K
T
Y
Site 77
T558
E
Q
L
S
P
N
P
T
K
T
Y
F
A
Q
E
Site 78
T560
L
S
P
N
P
T
K
T
Y
F
A
Q
E
G
C
Site 79
Y561
S
P
N
P
T
K
T
Y
F
A
Q
E
G
C
S
Site 80
S568
Y
F
A
Q
E
G
C
S
F
L
Y
E
K
L
P
Site 81
Y571
Q
E
G
C
S
F
L
Y
E
K
L
P
P
S
P
Site 82
S577
L
Y
E
K
L
P
P
S
P
S
S
P
G
N
G
Site 83
S579
E
K
L
P
P
S
P
S
S
P
G
N
G
D
C
Site 84
S580
K
L
P
P
S
P
S
S
P
G
N
G
D
C
T
Site 85
S620
E
A
S
P
V
K
Q
S
F
F
H
Y
S
E
K
Site 86
Y624
V
K
Q
S
F
F
H
Y
S
E
K
E
Q
N
E
Site 87
S640
D
R
L
I
Q
Q
I
S
Q
L
A
Q
G
M
D
Site 88
S651
Q
G
M
D
R
P
F
S
A
E
A
G
T
G
G
Site 89
S670
G
G
L
E
P
L
D
S
N
L
S
L
S
G
A
Site 90
S673
E
P
L
D
S
N
L
S
L
S
G
A
G
P
P
Site 91
S683
G
A
G
P
P
V
L
S
L
D
L
K
P
W
K
Site 92
T708
D
N
M
F
L
E
E
T
P
V
E
D
I
F
M
Site 93
S718
E
D
I
F
M
D
L
S
T
P
D
P
S
E
E
Site 94
T719
D
I
F
M
D
L
S
T
P
D
P
S
E
E
W
Site 95
S723
D
L
S
T
P
D
P
S
E
E
W
G
S
G
D
Site 96
S728
D
P
S
E
E
W
G
S
G
D
P
E
A
E
G
Site 97
S741
E
G
P
G
G
A
P
S
P
C
N
N
L
S
P
Site 98
S747
P
S
P
C
N
N
L
S
P
E
D
H
S
F
L
Site 99
S752
N
L
S
P
E
D
H
S
F
L
E
D
L
A
T
Site 100
T759
S
F
L
E
D
L
A
T
Y
E
T
A
F
E
T
Site 101
Y760
F
L
E
D
L
A
T
Y
E
T
A
F
E
T
G
Site 102
Y773
T
G
V
S
A
F
P
Y
D
G
F
T
D
E
L
Site 103
T777
A
F
P
Y
D
G
F
T
D
E
L
H
Q
L
Q
Site 104
S785
D
E
L
H
Q
L
Q
S
Q
V
Q
D
S
F
H
Site 105
S790
L
Q
S
Q
V
Q
D
S
F
H
E
D
G
S
G
Site 106
S796
D
S
F
H
E
D
G
S
G
G
E
P
T
F
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation