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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CILP2
Full Name:
Cartilage intermediate layer protein 2
Alias:
cartilage intermediate layer 2; cartilage intermediate layer protein 2; CILP-2; CLIP-2; MGC45771
Type:
Unknown function
Mass (Da):
126290
Number AA:
UniProt ID:
Q8IUL8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
L
A
G
A
R
D
A
T
P
T
E
E
P
M
A
Site 2
T26
G
A
R
D
A
T
P
T
E
E
P
M
A
T
A
Site 3
T32
P
T
E
E
P
M
A
T
A
L
G
L
E
R
R
Site 4
S40
A
L
G
L
E
R
R
S
V
Y
T
G
Q
P
S
Site 5
Y42
G
L
E
R
R
S
V
Y
T
G
Q
P
S
P
A
Site 6
T43
L
E
R
R
S
V
Y
T
G
Q
P
S
P
A
L
Site 7
S47
S
V
Y
T
G
Q
P
S
P
A
L
E
D
W
E
Site 8
S76
G
G
D
G
D
F
E
S
L
A
A
I
R
F
Y
Site 9
S107
T
T
D
W
A
L
P
S
A
V
G
E
R
V
H
Site 10
S135
Q
P
R
G
R
R
C
S
N
Y
H
V
R
F
R
Site 11
Y137
R
G
R
R
C
S
N
Y
H
V
R
F
R
C
P
Site 12
S161
P
W
G
P
C
S
G
S
C
G
P
G
R
R
L
Site 13
S175
L
R
R
R
H
C
P
S
P
A
G
D
A
C
P
Site 14
S229
P
L
L
G
A
R
V
S
L
R
D
Q
P
G
T
Site 15
T236
S
L
R
D
Q
P
G
T
V
A
T
S
D
A
H
Site 16
S240
Q
P
G
T
V
A
T
S
D
A
H
G
T
F
R
Site 17
S255
V
P
G
V
C
A
D
S
R
A
N
I
R
A
Q
Site 18
Y293
L
D
K
L
E
K
P
Y
L
V
K
H
P
E
S
Site 19
S300
Y
L
V
K
H
P
E
S
R
V
R
E
A
G
Q
Site 20
T310
R
E
A
G
Q
N
V
T
F
C
C
K
A
S
G
Site 21
T318
F
C
C
K
A
S
G
T
P
M
P
K
K
Y
S
Site 22
Y324
G
T
P
M
P
K
K
Y
S
W
F
H
N
G
T
Site 23
Y340
L
D
R
R
A
H
G
Y
G
A
H
L
E
L
R
Site 24
Y357
R
P
D
Q
A
G
I
Y
H
C
K
A
W
N
E
Site 25
T376
R
S
G
T
A
R
L
T
V
L
A
P
G
Q
P
Site 26
Y392
C
D
P
R
P
R
E
Y
L
I
K
L
P
E
D
Site 27
S405
E
D
C
G
Q
P
G
S
G
P
A
Y
L
D
V
Site 28
Y409
Q
P
G
S
G
P
A
Y
L
D
V
G
L
C
P
Site 29
S422
C
P
D
T
R
C
P
S
L
A
G
S
S
P
R
Site 30
S426
R
C
P
S
L
A
G
S
S
P
R
C
G
D
A
Site 31
S427
C
P
S
L
A
G
S
S
P
R
C
G
D
A
S
Site 32
S434
S
P
R
C
G
D
A
S
S
R
C
C
S
V
R
Site 33
S435
P
R
C
G
D
A
S
S
R
C
C
S
V
R
R
Site 34
S439
D
A
S
S
R
C
C
S
V
R
R
L
E
R
R
Site 35
S484
G
R
V
V
A
A
D
S
G
E
P
L
R
F
A
Site 36
Y505
E
P
I
G
F
T
A
Y
Q
G
D
F
T
I
E
Site 37
T510
T
A
Y
Q
G
D
F
T
I
E
V
P
P
S
T
Site 38
T523
S
T
Q
R
L
V
V
T
F
V
D
P
S
G
E
Site 39
Y548
D
P
R
G
A
G
V
Y
H
E
V
K
A
M
R
Site 40
S567
V
I
L
H
T
S
Q
S
N
T
I
P
L
G
E
Site 41
T569
L
H
T
S
Q
S
N
T
I
P
L
G
E
L
E
Site 42
Y599
R
R
A
D
G
K
P
Y
S
G
P
V
E
A
R
Site 43
S600
R
A
D
G
K
P
Y
S
G
P
V
E
A
R
V
Site 44
T608
G
P
V
E
A
R
V
T
F
V
D
P
R
D
L
Site 45
T616
F
V
D
P
R
D
L
T
S
A
A
S
A
P
S
Site 46
S617
V
D
P
R
D
L
T
S
A
A
S
A
P
S
D
Site 47
S620
R
D
L
T
S
A
A
S
A
P
S
D
L
R
F
Site 48
S623
T
S
A
A
S
A
P
S
D
L
R
F
V
D
S
Site 49
S630
S
D
L
R
F
V
D
S
D
G
E
L
A
P
L
Site 50
S652
V
D
L
R
A
P
G
S
A
E
Q
L
Q
V
G
Site 51
S695
T
G
L
W
E
E
E
S
G
F
R
R
E
G
S
Site 52
S702
S
G
F
R
R
E
G
S
S
G
P
R
V
R
R
Site 53
S703
G
F
R
R
E
G
S
S
G
P
R
V
R
R
E
Site 54
Y744
C
F
V
K
V
R
A
Y
A
N
D
K
F
T
P
Site 55
T750
A
Y
A
N
D
K
F
T
P
S
E
Q
V
E
G
Site 56
S772
L
E
P
A
P
G
F
S
A
N
P
R
A
W
G
Site 57
S783
R
A
W
G
R
F
D
S
A
V
T
G
P
N
G
Site 58
Y805
D
A
D
R
P
D
A
Y
T
A
L
V
T
A
T
Site 59
S823
E
E
L
E
P
A
P
S
L
P
R
P
L
P
A
Site 60
T831
L
P
R
P
L
P
A
T
V
G
V
T
Q
P
Y
Site 61
Y838
T
V
G
V
T
Q
P
Y
L
D
R
L
G
Y
R
Site 62
Y844
P
Y
L
D
R
L
G
Y
R
R
T
D
H
D
D
Site 63
T847
D
R
L
G
Y
R
R
T
D
H
D
D
P
A
F
Site 64
Y879
A
E
A
N
G
P
V
Y
P
W
R
S
L
R
E
Site 65
S883
G
P
V
Y
P
W
R
S
L
R
E
C
Q
G
A
Site 66
T893
E
C
Q
G
A
P
V
T
A
S
H
F
R
F
A
Site 67
S895
Q
G
A
P
V
T
A
S
H
F
R
F
A
R
V
Site 68
Y907
A
R
V
E
A
D
K
Y
E
Y
N
V
V
P
F
Site 69
T918
V
V
P
F
R
E
G
T
P
A
S
W
T
G
D
Site 70
S921
F
R
E
G
T
P
A
S
W
T
G
D
L
L
A
Site 71
Y951
K
I
Q
G
P
Q
E
Y
M
V
R
S
H
N
A
Site 72
S955
P
Q
E
Y
M
V
R
S
H
N
A
G
G
S
H
Site 73
S961
R
S
H
N
A
G
G
S
H
P
R
T
R
G
Q
Site 74
T965
A
G
G
S
H
P
R
T
R
G
Q
L
Y
G
L
Site 75
Y970
P
R
T
R
G
Q
L
Y
G
L
R
D
A
R
S
Site 76
S977
Y
G
L
R
D
A
R
S
V
R
D
P
E
R
P
Site 77
T986
R
D
P
E
R
P
G
T
S
A
A
C
V
E
F
Site 78
T1008
D
Q
R
Q
V
D
R
T
L
V
T
I
M
P
Q
Site 79
Y1030
V
N
G
L
L
R
D
Y
L
T
R
H
P
P
P
Site 80
T1032
G
L
L
R
D
Y
L
T
R
H
P
P
P
V
P
Site 81
Y1062
L
G
H
N
Y
G
V
Y
T
V
T
D
Q
S
P
Site 82
T1063
G
H
N
Y
G
V
Y
T
V
T
D
Q
S
P
R
Site 83
S1068
V
Y
T
V
T
D
Q
S
P
R
L
A
K
E
I
Site 84
S1084
I
G
R
C
F
D
G
S
S
D
G
F
S
R
E
Site 85
S1085
G
R
C
F
D
G
S
S
D
G
F
S
R
E
M
Site 86
S1089
D
G
S
S
D
G
F
S
R
E
M
K
A
D
A
Site 87
T1098
E
M
K
A
D
A
G
T
A
V
T
F
Q
C
R
Site 88
S1113
E
P
P
A
G
R
P
S
L
F
Q
R
L
L
E
Site 89
T1124
R
L
L
E
S
P
A
T
A
L
G
D
I
R
R
Site 90
S1134
G
D
I
R
R
E
M
S
E
A
A
Q
A
Q
A
Site 91
S1144
A
Q
A
Q
A
R
A
S
G
P
L
R
T
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation