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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ERC1
Full Name:
ELKS/Rab6-interacting/CAST family member 1
Alias:
Cast2; Elks; Erc 1; Erc1; RAB6 interacting protein 2; RAB6-interacting protein 2; Rb6I2
Type:
Protein type: Adaptor/scaffold
Mass (Da):
128086
Number AA:
1116
UniProt ID:
Q8IUD2
International Prot ID:
IPI00171230
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0008385
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0043522
PhosphoSite+
KinaseNET
Biological Process:
GO:0007252
GO:0007275
GO:0051092
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
Y
G
S
A
R
S
V
G
K
V
E
P
S
Site 2
S14
S
V
G
K
V
E
P
S
S
Q
S
P
G
R
S
Site 3
S15
V
G
K
V
E
P
S
S
Q
S
P
G
R
S
P
Site 4
S17
K
V
E
P
S
S
Q
S
P
G
R
S
P
R
L
Site 5
S21
S
S
Q
S
P
G
R
S
P
R
L
P
R
S
P
Site 6
S27
R
S
P
R
L
P
R
S
P
R
L
G
H
R
R
Site 7
T35
P
R
L
G
H
R
R
T
N
S
T
G
G
S
S
Site 8
S37
L
G
H
R
R
T
N
S
T
G
G
S
S
G
S
Site 9
T38
G
H
R
R
T
N
S
T
G
G
S
S
G
S
S
Site 10
S41
R
T
N
S
T
G
G
S
S
G
S
S
V
G
G
Site 11
S42
T
N
S
T
G
G
S
S
G
S
S
V
G
G
G
Site 12
S44
S
T
G
G
S
S
G
S
S
V
G
G
G
S
G
Site 13
S45
T
G
G
S
S
G
S
S
V
G
G
G
S
G
K
Site 14
S50
G
S
S
V
G
G
G
S
G
K
T
L
S
M
E
Site 15
T53
V
G
G
G
S
G
K
T
L
S
M
E
N
I
Q
Site 16
S55
G
G
S
G
K
T
L
S
M
E
N
I
Q
S
L
Site 17
S61
L
S
M
E
N
I
Q
S
L
N
A
A
Y
A
T
Site 18
Y66
I
Q
S
L
N
A
A
Y
A
T
S
G
P
M
Y
Site 19
S69
L
N
A
A
Y
A
T
S
G
P
M
Y
L
S
D
Site 20
Y73
Y
A
T
S
G
P
M
Y
L
S
D
H
E
N
V
Site 21
S75
T
S
G
P
M
Y
L
S
D
H
E
N
V
G
S
Site 22
S82
S
D
H
E
N
V
G
S
E
T
P
K
S
T
M
Site 23
T84
H
E
N
V
G
S
E
T
P
K
S
T
M
T
L
Site 24
S87
V
G
S
E
T
P
K
S
T
M
T
L
G
R
S
Site 25
T88
G
S
E
T
P
K
S
T
M
T
L
G
R
S
G
Site 26
T90
E
T
P
K
S
T
M
T
L
G
R
S
G
G
R
Site 27
S94
S
T
M
T
L
G
R
S
G
G
R
L
P
Y
G
Site 28
Y100
R
S
G
G
R
L
P
Y
G
V
R
M
T
A
M
Site 29
T105
L
P
Y
G
V
R
M
T
A
M
G
S
S
P
N
Site 30
S109
V
R
M
T
A
M
G
S
S
P
N
I
A
S
S
Site 31
S110
R
M
T
A
M
G
S
S
P
N
I
A
S
S
G
Site 32
S115
G
S
S
P
N
I
A
S
S
G
V
A
S
D
T
Site 33
S116
S
S
P
N
I
A
S
S
G
V
A
S
D
T
I
Site 34
T122
S
S
G
V
A
S
D
T
I
A
F
G
E
H
H
Site 35
S134
E
H
H
L
P
P
V
S
M
A
S
T
V
P
H
Site 36
T138
P
P
V
S
M
A
S
T
V
P
H
S
L
R
Q
Site 37
S142
M
A
S
T
V
P
H
S
L
R
Q
A
R
D
N
Site 38
T150
L
R
Q
A
R
D
N
T
I
M
D
L
Q
T
Q
Site 39
S177
K
D
V
E
V
K
E
S
K
L
S
S
S
M
N
Site 40
S180
E
V
K
E
S
K
L
S
S
S
M
N
S
I
K
Site 41
S181
V
K
E
S
K
L
S
S
S
M
N
S
I
K
T
Site 42
S182
K
E
S
K
L
S
S
S
M
N
S
I
K
T
F
Site 43
S185
K
L
S
S
S
M
N
S
I
K
T
F
W
S
P
Site 44
T188
S
S
M
N
S
I
K
T
F
W
S
P
E
L
K
Site 45
S191
N
S
I
K
T
F
W
S
P
E
L
K
K
E
R
Site 46
S206
A
L
R
K
D
E
A
S
K
I
T
I
W
K
E
Site 47
S250
N
Q
L
F
Q
Q
D
S
S
S
R
T
G
E
P
Site 48
S251
Q
L
F
Q
Q
D
S
S
S
R
T
G
E
P
C
Site 49
S252
L
F
Q
Q
D
S
S
S
R
T
G
E
P
C
V
Site 50
T254
Q
Q
D
S
S
S
R
T
G
E
P
C
V
A
E
Site 51
T263
E
P
C
V
A
E
L
T
E
E
N
F
Q
R
L
Site 52
T287
E
L
F
L
L
R
K
T
L
E
E
M
E
L
R
Site 53
T297
E
M
E
L
R
I
E
T
Q
K
Q
T
L
N
A
Site 54
S308
T
L
N
A
R
D
E
S
I
K
K
L
L
E
M
Site 55
S318
K
L
L
E
M
L
Q
S
K
G
L
S
A
K
A
Site 56
S322
M
L
Q
S
K
G
L
S
A
K
A
T
E
E
D
Site 57
T326
K
G
L
S
A
K
A
T
E
E
D
H
E
R
T
Site 58
S358
E
Q
K
E
K
E
N
S
M
L
R
E
E
M
H
Site 59
S374
R
F
E
N
A
P
D
S
A
K
T
K
A
L
Q
Site 60
S389
T
V
I
E
M
K
D
S
K
I
S
S
M
E
R
Site 61
S393
M
K
D
S
K
I
S
S
M
E
R
G
L
R
D
Site 62
S410
E
E
I
Q
M
L
K
S
N
G
A
L
S
T
E
Site 63
S415
L
K
S
N
G
A
L
S
T
E
E
R
E
E
E
Site 64
Y429
E
M
K
Q
M
E
V
Y
R
S
H
S
K
F
M
Site 65
S448
E
Q
L
K
E
E
L
S
S
K
E
A
Q
W
E
Site 66
S449
Q
L
K
E
E
L
S
S
K
E
A
Q
W
E
E
Site 67
T480
Q
E
L
S
R
K
D
T
E
L
L
A
L
Q
T
Site 68
T493
Q
T
K
L
E
T
L
T
N
Q
F
S
D
S
K
Site 69
S497
E
T
L
T
N
Q
F
S
D
S
K
Q
H
I
E
Site 70
S509
H
I
E
V
L
K
E
S
L
T
A
K
E
Q
R
Site 71
T536
L
R
L
E
E
K
E
T
M
L
N
K
K
T
K
Site 72
T554
D
M
A
E
E
K
G
T
Q
A
G
E
I
H
D
Site 73
S595
R
D
K
E
K
Q
M
S
S
L
K
E
R
V
K
Site 74
S596
D
K
E
K
Q
M
S
S
L
K
E
R
V
K
S
Site 75
S603
S
L
K
E
R
V
K
S
L
Q
A
D
T
T
N
Site 76
T628
A
L
A
E
K
E
R
T
I
E
R
L
K
E
Q
Site 77
Y650
K
Q
E
E
I
D
N
Y
K
K
D
L
K
D
L
Site 78
S662
K
D
L
K
E
K
V
S
L
L
Q
G
D
L
S
Site 79
S669
S
L
L
Q
G
D
L
S
E
K
E
A
S
L
L
Site 80
S674
D
L
S
E
K
E
A
S
L
L
D
L
K
E
H
Site 81
S683
L
D
L
K
E
H
A
S
S
L
A
S
S
G
L
Site 82
S684
D
L
K
E
H
A
S
S
L
A
S
S
G
L
K
Site 83
S687
E
H
A
S
S
L
A
S
S
G
L
K
K
D
S
Site 84
S688
H
A
S
S
L
A
S
S
G
L
K
K
D
S
R
Site 85
S694
S
S
G
L
K
K
D
S
R
L
K
T
L
E
I
Site 86
T698
K
K
D
S
R
L
K
T
L
E
I
A
L
E
Q
Site 87
S715
E
E
C
L
K
M
E
S
Q
L
K
K
A
H
E
Site 88
S730
A
A
L
E
A
R
A
S
P
E
M
S
D
R
I
Site 89
S734
A
R
A
S
P
E
M
S
D
R
I
Q
H
L
E
Site 90
T745
Q
H
L
E
R
E
I
T
R
Y
K
D
E
S
S
Site 91
Y747
L
E
R
E
I
T
R
Y
K
D
E
S
S
K
A
Site 92
S751
I
T
R
Y
K
D
E
S
S
K
A
Q
A
E
V
Site 93
S807
E
Q
V
E
K
K
K
S
A
Q
M
L
E
E
A
Site 94
S824
R
E
D
N
L
N
D
S
S
Q
Q
L
Q
D
S
Site 95
S825
E
D
N
L
N
D
S
S
Q
Q
L
Q
D
S
L
Site 96
S831
S
S
Q
Q
L
Q
D
S
L
R
K
K
D
D
R
Site 97
S849
L
E
E
A
L
R
E
S
V
Q
I
T
A
E
R
Site 98
T853
L
R
E
S
V
Q
I
T
A
E
R
E
M
V
L
Site 99
S865
M
V
L
A
Q
E
E
S
A
R
T
N
A
E
K
Site 100
T868
A
Q
E
E
S
A
R
T
N
A
E
K
Q
V
E
Site 101
S890
K
V
K
Q
E
L
E
S
M
K
A
K
L
S
S
Site 102
S896
E
S
M
K
A
K
L
S
S
T
Q
Q
S
L
A
Site 103
S897
S
M
K
A
K
L
S
S
T
Q
Q
S
L
A
E
Site 104
S901
K
L
S
S
T
Q
Q
S
L
A
E
K
E
T
H
Site 105
T910
A
E
K
E
T
H
L
T
N
L
R
A
E
R
R
Site 106
S948
N
I
A
L
L
E
L
S
S
S
K
K
K
T
Q
Site 107
S949
I
A
L
L
E
L
S
S
S
K
K
K
T
Q
E
Site 108
S950
A
L
L
E
L
S
S
S
K
K
K
T
Q
E
E
Site 109
T954
L
S
S
S
K
K
K
T
Q
E
E
V
A
A
L
Site 110
Y987
M
K
L
M
A
D
N
Y
E
D
D
H
F
K
S
Site 111
S994
Y
E
D
D
H
F
K
S
S
H
S
N
Q
T
N
Site 112
S995
E
D
D
H
F
K
S
S
H
S
N
Q
T
N
H
Site 113
S1005
N
Q
T
N
H
K
P
S
P
D
Q
I
I
Q
P
Site 114
S1021
L
E
L
D
Q
N
R
S
K
L
K
L
Y
I
G
Site 115
Y1026
N
R
S
K
L
K
L
Y
I
G
H
L
T
T
L
Site 116
T1046
P
L
I
L
R
G
L
T
P
P
A
S
Y
N
L
Site 117
S1050
R
G
L
T
P
P
A
S
Y
N
L
D
D
D
Q
Site 118
Y1051
G
L
T
P
P
A
S
Y
N
L
D
D
D
Q
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation