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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TICAM1
Full Name:
TIR domain-containing adapter molecule 1
Alias:
MGC35334; PRVTIRB; TCAM1; TICAM-1; TIR domain containing adaptor inducing interferon-beta; toll-like receptor adaptor 1; toll-like receptor adaptor molecule 1; TRIF
Type:
Mass (Da):
76420
Number AA:
UniProt ID:
Q8IUC6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007249
GO:0006915
GO:0006954
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y25
A
G
Q
D
K
L
L
Y
L
K
H
K
L
K
T
Site 2
T32
Y
L
K
H
K
L
K
T
P
R
P
G
C
Q
G
Site 3
S60
Q
E
T
E
A
R
I
S
L
E
A
L
K
A
D
Site 4
S82
R
Q
W
A
G
V
D
S
T
E
D
P
E
E
P
Site 5
T83
Q
W
A
G
V
D
S
T
E
D
P
E
E
P
P
Site 6
S93
P
E
E
P
P
D
V
S
W
A
V
A
R
L
Y
Site 7
Y100
S
W
A
V
A
R
L
Y
H
L
L
A
E
E
K
Site 8
S112
E
E
K
L
C
P
A
S
L
R
D
V
A
Y
Q
Site 9
Y118
A
S
L
R
D
V
A
Y
Q
E
A
V
R
T
L
Site 10
T124
A
Y
Q
E
A
V
R
T
L
S
S
R
D
D
H
Site 11
S126
Q
E
A
V
R
T
L
S
S
R
D
D
H
R
L
Site 12
S154
D
I
A
G
D
P
G
S
I
R
T
L
Q
S
N
Site 13
T157
G
D
P
G
S
I
R
T
L
Q
S
N
L
G
C
Site 14
S160
G
S
I
R
T
L
Q
S
N
L
G
C
L
P
P
Site 15
S169
L
G
C
L
P
P
S
S
A
L
P
S
G
T
R
Site 16
S173
P
P
S
S
A
L
P
S
G
T
R
S
L
P
R
Site 17
S177
A
L
P
S
G
T
R
S
L
P
R
P
I
D
G
Site 18
S186
P
R
P
I
D
G
V
S
D
W
S
Q
G
C
S
Site 19
S189
I
D
G
V
S
D
W
S
Q
G
C
S
L
R
S
Site 20
S193
S
D
W
S
Q
G
C
S
L
R
S
T
G
S
P
Site 21
S196
S
Q
G
C
S
L
R
S
T
G
S
P
A
S
L
Site 22
T197
Q
G
C
S
L
R
S
T
G
S
P
A
S
L
A
Site 23
S199
C
S
L
R
S
T
G
S
P
A
S
L
A
S
N
Site 24
S202
R
S
T
G
S
P
A
S
L
A
S
N
L
E
I
Site 25
S205
G
S
P
A
S
L
A
S
N
L
E
I
S
Q
S
Site 26
S210
L
A
S
N
L
E
I
S
Q
S
P
T
M
P
F
Site 27
S212
S
N
L
E
I
S
Q
S
P
T
M
P
F
L
S
Site 28
S219
S
P
T
M
P
F
L
S
L
H
R
S
P
H
G
Site 29
S223
P
F
L
S
L
H
R
S
P
H
G
P
S
K
L
Site 30
S237
L
C
D
D
P
Q
A
S
L
V
P
E
P
V
P
Site 31
S254
C
Q
E
P
E
E
M
S
W
P
P
S
G
E
I
Site 32
S258
E
E
M
S
W
P
P
S
G
E
I
A
S
P
P
Site 33
S263
P
P
S
G
E
I
A
S
P
P
E
L
P
S
S
Site 34
S269
A
S
P
P
E
L
P
S
S
P
P
P
G
L
P
Site 35
S270
S
P
P
E
L
P
S
S
P
P
P
G
L
P
E
Site 36
T290
T
S
T
G
L
P
D
T
P
A
A
P
E
T
S
Site 37
Y300
A
P
E
T
S
T
N
Y
P
V
E
C
T
E
G
Site 38
S308
P
V
E
C
T
E
G
S
A
G
P
Q
S
L
P
Site 39
S313
E
G
S
A
G
P
Q
S
L
P
L
P
I
L
E
Site 40
S327
E
P
V
K
N
P
C
S
V
K
D
Q
T
P
L
Site 41
T332
P
C
S
V
K
D
Q
T
P
L
Q
L
S
V
E
Site 42
S337
D
Q
T
P
L
Q
L
S
V
E
D
T
T
S
P
Site 43
T341
L
Q
L
S
V
E
D
T
T
S
P
N
T
K
P
Site 44
S343
L
S
V
E
D
T
T
S
P
N
T
K
P
C
P
Site 45
T352
N
T
K
P
C
P
P
T
P
T
T
P
E
T
S
Site 46
T355
P
C
P
P
T
P
T
T
P
E
T
S
P
P
P
Site 47
T358
P
T
P
T
T
P
E
T
S
P
P
P
P
P
P
Site 48
S359
T
P
T
T
P
E
T
S
P
P
P
P
P
P
P
Site 49
S368
P
P
P
P
P
P
P
S
S
T
P
C
S
A
H
Site 50
S369
P
P
P
P
P
P
S
S
T
P
C
S
A
H
L
Site 51
T370
P
P
P
P
P
S
S
T
P
C
S
A
H
L
T
Site 52
S373
P
P
S
S
T
P
C
S
A
H
L
T
P
S
S
Site 53
T377
T
P
C
S
A
H
L
T
P
S
S
L
F
P
S
Site 54
S380
S
A
H
L
T
P
S
S
L
F
P
S
S
L
E
Site 55
S384
T
P
S
S
L
F
P
S
S
L
E
S
S
S
E
Site 56
S385
P
S
S
L
F
P
S
S
L
E
S
S
S
E
Q
Site 57
S388
L
F
P
S
S
L
E
S
S
S
E
Q
K
F
Y
Site 58
S389
F
P
S
S
L
E
S
S
S
E
Q
K
F
Y
N
Site 59
S390
P
S
S
L
E
S
S
S
E
Q
K
F
Y
N
F
Site 60
Y395
S
S
S
E
Q
K
F
Y
N
F
V
I
L
H
A
Site 61
S465
S
N
F
D
C
R
L
S
L
H
Q
V
N
Q
A
Site 62
T478
Q
A
M
M
S
N
L
T
R
Q
G
S
P
D
C
Site 63
S482
S
N
L
T
R
Q
G
S
P
D
C
V
I
P
F
Site 64
S495
P
F
L
P
L
E
S
S
P
A
Q
L
S
S
D
Site 65
S500
E
S
S
P
A
Q
L
S
S
D
T
A
S
L
L
Site 66
S501
S
S
P
A
Q
L
S
S
D
T
A
S
L
L
S
Site 67
S517
L
V
R
L
D
E
H
S
Q
I
F
A
R
K
V
Site 68
T527
F
A
R
K
V
A
N
T
F
K
P
H
R
L
Q
Site 69
T546
M
W
R
K
E
Q
D
T
R
A
L
R
E
Q
S
Site 70
S553
T
R
A
L
R
E
Q
S
Q
H
L
D
G
E
R
Site 71
Y570
A
A
A
L
N
A
A
Y
S
A
Y
L
Q
S
Y
Site 72
Y573
L
N
A
A
Y
S
A
Y
L
Q
S
Y
L
S
Y
Site 73
Y577
Y
S
A
Y
L
Q
S
Y
L
S
Y
Q
A
Q
M
Site 74
S579
A
Y
L
Q
S
Y
L
S
Y
Q
A
Q
M
E
Q
Site 75
Y580
Y
L
Q
S
Y
L
S
Y
Q
A
Q
M
E
Q
L
Site 76
T599
G
S
H
M
S
F
G
T
G
A
P
Y
G
A
R
Site 77
Y603
S
F
G
T
G
A
P
Y
G
A
R
M
P
F
G
Site 78
T623
G
A
P
P
P
F
P
T
W
P
G
C
P
Q
P
Site 79
T640
L
H
A
W
Q
A
G
T
P
P
P
P
S
P
Q
Site 80
S645
A
G
T
P
P
P
P
S
P
Q
P
A
A
F
P
Site 81
S654
Q
P
A
A
F
P
Q
S
L
P
F
P
Q
S
P
Site 82
S660
Q
S
L
P
F
P
Q
S
P
A
F
P
T
A
S
Site 83
T665
P
Q
S
P
A
F
P
T
A
S
P
A
P
P
Q
Site 84
S667
S
P
A
F
P
T
A
S
P
A
P
P
Q
S
P
Site 85
S673
A
S
P
A
P
P
Q
S
P
G
L
Q
P
L
I
Site 86
S701
H
M
W
N
Q
R
G
S
Q
A
P
E
D
K
T
Site 87
T708
S
Q
A
P
E
D
K
T
Q
E
A
E
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation