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Updated November 2019
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Protein Info
Short Name:
MED12L
Full Name:
Mediator of RNA polymerase II transcription subunit 12-like protein
Alias:
KIAA1635; MD12L; mediator complex subunit 12-like; mediator of RNA polymerase II transcription, subunit 12; no opposite paired repeat; NOPAR; TNRC11L; TRALP; TRALPUSH
Type:
Mass (Da):
240080
Number AA:
UniProt ID:
Q86YW9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016592
Uniprot
OncoNet
Molecular Function:
GO:0016455
PhosphoSite+
KinaseNET
Biological Process:
GO:0006357
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
A
F
G
L
L
S
Y
E
Q
R
P
L
K
Site 2
Y25
R
L
G
P
P
D
V
Y
P
Q
D
P
K
Q
K
Site 3
T37
K
Q
K
E
D
E
L
T
A
V
N
V
K
Q
G
Site 4
S58
F
T
G
D
E
H
G
S
A
R
N
I
V
I
N
Site 5
Y72
N
P
S
K
I
G
A
Y
F
S
S
I
L
A
E
Site 6
T85
A
E
K
L
K
L
N
T
F
Q
D
T
G
K
K
Site 7
T89
K
L
N
T
F
Q
D
T
G
K
K
K
P
Q
V
Site 8
Y102
Q
V
N
A
K
D
N
Y
W
L
V
T
A
R
S
Site 9
T106
K
D
N
Y
W
L
V
T
A
R
S
Q
S
A
I
Site 10
S111
L
V
T
A
R
S
Q
S
A
I
H
S
W
F
S
Site 11
S115
R
S
Q
S
A
I
H
S
W
F
S
D
L
A
G
Site 12
S137
A
K
K
V
P
I
L
S
K
K
E
D
V
F
A
Site 13
Y145
K
K
E
D
V
F
A
Y
L
A
K
Y
S
V
P
Site 14
Y149
V
F
A
Y
L
A
K
Y
S
V
P
M
V
R
A
Site 15
Y167
I
K
M
T
C
A
Y
Y
S
A
I
S
E
A
K
Site 16
T188
P
D
P
N
L
E
W
T
Q
I
S
T
R
Y
L
Site 17
S191
N
L
E
W
T
Q
I
S
T
R
Y
L
R
E
Q
Site 18
Y194
W
T
Q
I
S
T
R
Y
L
R
E
Q
L
A
K
Site 19
S203
R
E
Q
L
A
K
I
S
D
F
Y
H
M
A
S
Site 20
Y206
L
A
K
I
S
D
F
Y
H
M
A
S
S
T
G
Site 21
S210
S
D
F
Y
H
M
A
S
S
T
G
D
G
P
V
Site 22
S211
D
F
Y
H
M
A
S
S
T
G
D
G
P
V
P
Site 23
S287
Y
S
D
E
F
V
Q
S
A
Y
L
S
R
R
L
Site 24
Y289
D
E
F
V
Q
S
A
Y
L
S
R
R
L
A
Y
Site 25
Y296
Y
L
S
R
R
L
A
Y
F
C
A
R
R
L
S
Site 26
S327
M
M
I
G
P
N
N
S
S
I
G
A
P
S
P
Site 27
S328
M
I
G
P
N
N
S
S
I
G
A
P
S
P
G
Site 28
S333
N
S
S
I
G
A
P
S
P
G
P
P
G
P
G
Site 29
S342
G
P
P
G
P
G
M
S
P
V
Q
L
A
F
S
Site 30
S384
S
A
L
V
W
N
Y
S
T
N
E
N
K
S
A
Site 31
S390
Y
S
T
N
E
N
K
S
A
N
P
G
S
P
L
Site 32
S395
N
K
S
A
N
P
G
S
P
L
D
L
L
Q
V
Site 33
Y425
Q
Q
V
R
A
R
I
Y
E
V
E
Q
Q
I
K
Site 34
S443
R
A
V
E
V
R
W
S
F
D
K
C
Q
E
S
Site 35
S450
S
F
D
K
C
Q
E
S
T
A
G
V
T
I
S
Site 36
T462
T
I
S
R
V
L
H
T
L
E
V
L
D
R
H
Site 37
T474
D
R
H
C
F
D
R
T
D
S
S
N
S
M
E
Site 38
S476
H
C
F
D
R
T
D
S
S
N
S
M
E
T
L
Site 39
S477
C
F
D
R
T
D
S
S
N
S
M
E
T
L
Y
Site 40
Y484
S
N
S
M
E
T
L
Y
H
K
I
F
W
A
N
Site 41
S555
E
V
L
D
E
K
E
S
I
S
S
S
S
L
A
Site 42
S557
L
D
E
K
E
S
I
S
S
S
S
L
A
G
S
Site 43
S558
D
E
K
E
S
I
S
S
S
S
L
A
G
S
S
Site 44
S559
E
K
E
S
I
S
S
S
S
L
A
G
S
S
L
Site 45
S560
K
E
S
I
S
S
S
S
L
A
G
S
S
L
P
Site 46
S564
S
S
S
S
L
A
G
S
S
L
P
V
F
Q
N
Site 47
S583
F
L
D
T
Q
A
P
S
L
S
D
P
N
S
E
Site 48
S585
D
T
Q
A
P
S
L
S
D
P
N
S
E
C
E
Site 49
S589
P
S
L
S
D
P
N
S
E
C
E
K
V
E
F
Site 50
T620
S
H
D
A
Y
M
C
T
L
I
S
R
G
D
L
Site 51
S628
L
I
S
R
G
D
L
S
V
T
A
S
T
R
P
Site 52
T630
S
R
G
D
L
S
V
T
A
S
T
R
P
R
S
Site 53
S632
G
D
L
S
V
T
A
S
T
R
P
R
S
P
V
Site 54
T633
D
L
S
V
T
A
S
T
R
P
R
S
P
V
G
Site 55
S637
T
A
S
T
R
P
R
S
P
V
G
E
N
A
D
Site 56
Y647
G
E
N
A
D
E
H
Y
S
K
D
H
D
V
K
Site 57
S659
D
V
K
M
E
I
F
S
P
M
P
G
E
S
C
Site 58
S665
F
S
P
M
P
G
E
S
C
E
N
A
N
T
S
Site 59
T671
E
S
C
E
N
A
N
T
S
L
G
R
R
M
S
Site 60
S672
S
C
E
N
A
N
T
S
L
G
R
R
M
S
V
Site 61
S678
T
S
L
G
R
R
M
S
V
N
C
E
K
L
V
Site 62
S697
P
R
E
L
I
F
P
S
N
Y
D
L
L
R
H
Site 63
Y707
D
L
L
R
H
L
Q
Y
A
T
H
F
P
I
P
Site 64
T709
L
R
H
L
Q
Y
A
T
H
F
P
I
P
L
D
Site 65
S720
I
P
L
D
E
S
S
S
H
E
C
N
Q
R
T
Site 66
Y731
N
Q
R
T
I
L
L
Y
G
V
G
K
E
R
D
Site 67
S759
L
K
I
L
N
K
K
S
T
T
E
T
G
V
G
Site 68
T763
N
K
K
S
T
T
E
T
G
V
G
D
E
G
Q
Site 69
T782
N
K
Q
E
T
F
P
T
L
E
T
V
F
T
K
Site 70
S794
F
T
K
L
Q
L
L
S
Y
F
D
Q
H
Q
V
Site 71
Y795
T
K
L
Q
L
L
S
Y
F
D
Q
H
Q
V
T
Site 72
S815
N
V
L
E
Q
I
T
S
F
A
S
G
T
S
Y
Site 73
Y822
S
F
A
S
G
T
S
Y
H
L
P
L
A
H
H
Site 74
S868
E
A
E
L
L
L
K
S
S
S
L
A
G
S
Y
Site 75
S870
E
L
L
L
K
S
S
S
L
A
G
S
Y
T
T
Site 76
S919
V
K
H
V
V
N
P
S
E
C
S
S
P
E
R
Site 77
S922
V
V
N
P
S
E
C
S
S
P
E
R
C
I
L
Site 78
S923
V
N
P
S
E
C
S
S
P
E
R
C
I
L
A
Site 79
S940
Y
D
L
Y
V
S
C
S
H
L
R
S
K
F
G
Site 80
S944
V
S
C
S
H
L
R
S
K
F
G
D
L
F
S
Site 81
S951
S
K
F
G
D
L
F
S
S
A
C
S
K
V
K
Site 82
S952
K
F
G
D
L
F
S
S
A
C
S
K
V
K
Q
Site 83
S955
D
L
F
S
S
A
C
S
K
V
K
Q
T
I
Y
Site 84
Y962
S
K
V
K
Q
T
I
Y
N
N
V
M
P
A
N
Site 85
S987
M
D
F
I
E
N
P
S
A
R
S
I
N
Y
S
Site 86
S990
I
E
N
P
S
A
R
S
I
N
Y
S
M
L
G
Site 87
S994
S
A
R
S
I
N
Y
S
M
L
G
K
I
L
S
Site 88
S1001
S
M
L
G
K
I
L
S
D
N
A
A
N
R
Y
Site 89
S1157
K
P
F
P
G
I
R
S
S
C
D
R
H
L
L
Site 90
S1158
P
F
P
G
I
R
S
S
C
D
R
H
L
L
A
Site 91
S1195
D
A
K
I
G
N
N
S
V
S
S
L
K
N
D
Site 92
T1205
S
L
K
N
D
D
F
T
M
R
G
L
R
C
D
Site 93
T1220
G
N
A
D
D
I
W
T
A
S
Q
N
P
K
S
Site 94
S1222
A
D
D
I
W
T
A
S
Q
N
P
K
S
C
G
Site 95
S1227
T
A
S
Q
N
P
K
S
C
G
K
S
I
S
I
Site 96
S1231
N
P
K
S
C
G
K
S
I
S
I
E
T
A
N
Site 97
S1233
K
S
C
G
K
S
I
S
I
E
T
A
N
L
R
Site 98
Y1242
E
T
A
N
L
R
E
Y
A
R
Y
V
L
R
T
Site 99
Y1245
N
L
R
E
Y
A
R
Y
V
L
R
T
I
C
Q
Site 100
T1269
K
E
P
E
R
L
C
T
D
K
E
L
I
L
D
Site 101
T1322
L
Q
N
L
E
Q
W
T
L
R
Q
S
W
L
E
Site 102
S1343
Q
C
L
K
D
P
G
S
G
S
V
A
E
M
N
Site 103
S1345
L
K
D
P
G
S
G
S
V
A
E
M
N
N
L
Site 104
S1373
Q
S
A
D
L
N
N
S
S
N
S
G
M
S
L
Site 105
S1374
S
A
D
L
N
N
S
S
N
S
G
M
S
L
F
Site 106
S1376
D
L
N
N
S
S
N
S
G
M
S
L
F
N
P
Site 107
S1379
N
S
S
N
S
G
M
S
L
F
N
P
N
S
I
Site 108
S1385
M
S
L
F
N
P
N
S
I
G
S
A
D
T
S
Site 109
S1388
F
N
P
N
S
I
G
S
A
D
T
S
S
T
R
Site 110
S1392
S
I
G
S
A
D
T
S
S
T
R
Q
N
G
I
Site 111
S1393
I
G
S
A
D
T
S
S
T
R
Q
N
G
I
K
Site 112
T1401
T
R
Q
N
G
I
K
T
F
L
S
S
S
E
R
Site 113
S1404
N
G
I
K
T
F
L
S
S
S
E
R
R
G
V
Site 114
S1405
G
I
K
T
F
L
S
S
S
E
R
R
G
V
W
Site 115
S1406
I
K
T
F
L
S
S
S
E
R
R
G
V
W
L
Site 116
S1445
E
K
G
Q
H
L
G
S
S
S
K
K
E
R
D
Site 117
S1458
R
D
R
Q
K
Q
K
S
M
S
L
L
S
Q
Q
Site 118
S1460
R
Q
K
Q
K
S
M
S
L
L
S
Q
Q
P
F
Site 119
S1463
Q
K
S
M
S
L
L
S
Q
Q
P
F
L
S
L
Site 120
T1487
E
Q
R
E
G
L
L
T
S
L
Q
N
Q
V
N
Site 121
S1488
Q
R
E
G
L
L
T
S
L
Q
N
Q
V
N
Q
Site 122
Y1505
S
N
W
R
E
E
R
Y
Q
D
D
I
K
A
R
Site 123
T1532
L
V
G
G
M
F
D
T
V
Q
R
S
T
Q
W
Site 124
T1540
V
Q
R
S
T
Q
W
T
T
D
W
A
L
L
L
Site 125
T1560
S
G
T
V
D
M
H
T
N
N
E
L
F
T
T
Site 126
S1585
G
T
L
A
S
D
L
S
N
A
S
P
G
G
S
Site 127
S1588
A
S
D
L
S
N
A
S
P
G
G
S
E
E
N
Site 128
S1592
S
N
A
S
P
G
G
S
E
E
N
K
R
A
Y
Site 129
Y1599
S
E
E
N
K
R
A
Y
M
N
L
V
K
K
L
Site 130
S1615
K
E
L
G
D
K
R
S
E
S
I
D
K
V
R
Site 131
S1617
L
G
D
K
R
S
E
S
I
D
K
V
R
Q
L
Site 132
T1636
K
Q
T
C
D
V
I
T
C
E
P
M
G
S
L
Site 133
S1642
I
T
C
E
P
M
G
S
L
I
D
T
K
G
N
Site 134
T1646
P
M
G
S
L
I
D
T
K
G
N
K
I
A
G
Site 135
S1656
N
K
I
A
G
F
D
S
I
D
K
K
Q
G
L
Site 136
S1666
K
K
Q
G
L
Q
V
S
T
K
Q
K
V
S
P
Site 137
S1672
V
S
T
K
Q
K
V
S
P
W
D
L
F
E
G
Site 138
Y1703
V
D
R
R
V
I
K
Y
E
E
Q
H
H
L
L
Site 139
Y1712
E
Q
H
H
L
L
L
Y
H
T
H
P
M
P
K
Site 140
S1722
H
P
M
P
K
P
R
S
Y
Y
L
Q
P
L
P
Site 141
Y1723
P
M
P
K
P
R
S
Y
Y
L
Q
P
L
P
L
Site 142
Y1724
M
P
K
P
R
S
Y
Y
L
Q
P
L
P
L
P
Site 143
T1740
E
E
E
E
E
E
P
T
S
P
V
S
Q
E
P
Site 144
S1741
E
E
E
E
E
P
T
S
P
V
S
Q
E
P
E
Site 145
S1744
E
E
P
T
S
P
V
S
Q
E
P
E
R
K
S
Site 146
S1751
S
Q
E
P
E
R
K
S
A
E
L
S
D
Q
G
Site 147
S1755
E
R
K
S
A
E
L
S
D
Q
G
K
T
T
T
Site 148
T1768
T
T
D
E
E
K
K
T
K
G
R
K
R
K
T
Site 149
T1775
T
K
G
R
K
R
K
T
K
S
S
S
R
V
D
Site 150
S1777
G
R
K
R
K
T
K
S
S
S
R
V
D
E
Y
Site 151
S1778
R
K
R
K
T
K
S
S
S
R
V
D
E
Y
P
Site 152
S1779
K
R
K
T
K
S
S
S
R
V
D
E
Y
P
Q
Site 153
Y1784
S
S
S
R
V
D
E
Y
P
Q
S
N
I
Y
R
Site 154
S1787
R
V
D
E
Y
P
Q
S
N
I
Y
R
V
P
P
Site 155
Y1790
E
Y
P
Q
S
N
I
Y
R
V
P
P
N
Y
S
Site 156
Y1796
I
Y
R
V
P
P
N
Y
S
P
I
S
S
Q
M
Site 157
S1797
Y
R
V
P
P
N
Y
S
P
I
S
S
Q
M
M
Site 158
Y1814
P
Q
S
T
L
W
G
Y
N
L
V
G
Q
P
Q
Site 159
S1831
G
F
F
L
Q
N
Q
S
L
T
P
G
G
S
R
Site 160
T1833
F
L
Q
N
Q
S
L
T
P
G
G
S
R
L
D
Site 161
S1844
S
R
L
D
P
A
G
S
F
V
P
T
N
T
K
Site 162
T1848
P
A
G
S
F
V
P
T
N
T
K
Q
A
L
S
Site 163
S1855
T
N
T
K
Q
A
L
S
N
M
L
Q
R
R
S
Site 164
S1862
S
N
M
L
Q
R
R
S
G
A
M
M
Q
P
P
Site 165
S1870
G
A
M
M
Q
P
P
S
L
H
A
I
T
S
Q
Site 166
S1876
P
S
L
H
A
I
T
S
Q
Q
Q
L
I
Q
M
Site 167
S1922
F
A
A
Q
A
R
P
S
P
Q
L
P
Q
Y
P
Site 168
Y1928
P
S
P
Q
L
P
Q
Y
P
G
L
Q
Q
A
Q
Site 169
T1936
P
G
L
Q
Q
A
Q
T
M
P
Q
G
Y
T
M
Site 170
Y1944
M
P
Q
G
Y
T
M
Y
G
T
Q
M
P
L
Q
Site 171
S1954
Q
M
P
L
Q
Q
T
S
Q
Q
Q
A
G
S
V
Site 172
S1960
T
S
Q
Q
Q
A
G
S
V
V
L
S
P
S
Y
Site 173
S1964
Q
A
G
S
V
V
L
S
P
S
Y
N
S
R
A
Site 174
S1966
G
S
V
V
L
S
P
S
Y
N
S
R
A
Y
P
Site 175
Y1967
S
V
V
L
S
P
S
Y
N
S
R
A
Y
P
A
Site 176
Y1972
P
S
Y
N
S
R
A
Y
P
A
A
H
S
N
P
Site 177
S1993
R
Q
I
Q
Q
Q
P
S
G
Y
V
Q
Q
Q
A
Site 178
Y1995
I
Q
Q
Q
P
S
G
Y
V
Q
Q
Q
A
S
P
Site 179
S2001
G
Y
V
Q
Q
Q
A
S
P
Y
L
Q
P
L
T
Site 180
Y2003
V
Q
Q
Q
A
S
P
Y
L
Q
P
L
T
G
S
Site 181
T2008
S
P
Y
L
Q
P
L
T
G
S
Q
R
L
N
H
Site 182
S2010
Y
L
Q
P
L
T
G
S
Q
R
L
N
H
Q
A
Site 183
S2021
N
H
Q
A
L
Q
Q
S
P
L
V
G
G
G
I
Site 184
S2041
S
A
H
P
N
L
P
S
V
P
L
P
Q
D
P
Site 185
S2082
Q
P
P
Q
P
Q
Q
S
S
Q
S
Q
S
Q
T
Site 186
S2083
P
P
Q
P
Q
Q
S
S
Q
S
Q
S
Q
T
L
Site 187
S2085
Q
P
Q
Q
S
S
Q
S
Q
S
Q
T
L
G
L
Site 188
S2087
Q
Q
S
S
Q
S
Q
S
Q
T
L
G
L
Q
A
Site 189
T2089
S
S
Q
S
Q
S
Q
T
L
G
L
Q
A
M
Q
Site 190
T2116
Q
T
Q
Q
Q
Q
Q
T
A
A
L
V
R
Q
L
Site 191
S2128
R
Q
L
Q
K
Q
L
S
S
N
Q
P
Q
Q
G
Site 192
T2137
N
Q
P
Q
Q
G
V
T
P
Y
G
H
P
S
H
Site 193
Y2139
P
Q
Q
G
V
T
P
Y
G
H
P
S
H
F
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation