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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HPS6
Full Name:
Hermansky-Pudlak syndrome 6 protein
Alias:
Ruby-eye protein homolog
Type:
Uncharacterized
Mass (Da):
82975
Number AA:
775
UniProt ID:
Q86YV9
International Prot ID:
IPI00015505
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
K
R
S
G
T
L
R
L
L
S
D
L
Site 2
S14
L
R
L
L
S
D
L
S
A
F
G
G
A
A
R
Site 3
S30
R
E
L
V
A
G
D
S
A
V
R
V
R
G
S
Site 4
S37
S
A
V
R
V
R
G
S
P
D
G
R
H
L
L
Site 5
S117
P
G
W
R
P
L
Q
S
T
E
L
C
P
G
G
Site 6
T118
G
W
R
P
L
Q
S
T
E
L
C
P
G
G
G
Site 7
S152
Q
A
R
A
E
G
P
S
G
S
P
A
A
A
F
Site 8
S154
R
A
E
G
P
S
G
S
P
A
A
A
F
S
H
Site 9
T167
S
H
C
V
C
V
R
T
L
E
P
S
G
E
A
Site 10
S171
C
V
R
T
L
E
P
S
G
E
A
S
T
S
L
Site 11
S175
L
E
P
S
G
E
A
S
T
S
L
G
R
T
H
Site 12
S177
P
S
G
E
A
S
T
S
L
G
R
T
H
V
L
Site 13
S236
A
A
P
R
L
G
L
S
Y
S
K
S
L
N
P
Site 14
S238
P
R
L
G
L
S
Y
S
K
S
L
N
P
G
R
Site 15
S240
L
G
L
S
Y
S
K
S
L
N
P
G
R
G
D
Site 16
T248
L
N
P
G
R
G
D
T
W
D
F
R
T
L
L
Site 17
T253
G
D
T
W
D
F
R
T
L
L
R
G
L
P
G
Site 18
T272
R
E
P
L
A
V
H
T
W
A
P
T
P
Q
G
Site 19
T298
L
L
Q
S
H
G
G
T
R
A
V
G
T
L
Q
Site 20
T303
G
G
T
R
A
V
G
T
L
Q
E
A
P
V
G
Site 21
S339
L
E
L
L
D
M
G
S
G
Q
L
L
E
R
K
Site 22
T350
L
E
R
K
V
L
S
T
D
R
V
H
L
L
E
Site 23
Y410
V
F
E
E
A
C
G
Y
Y
Q
R
R
S
L
R
Site 24
Y411
F
E
E
A
C
G
Y
Y
Q
R
R
S
L
R
G
Site 25
S415
C
G
Y
Y
Q
R
R
S
L
R
G
A
Q
L
T
Site 26
T422
S
L
R
G
A
Q
L
T
P
E
E
L
R
H
S
Site 27
S429
T
P
E
E
L
R
H
S
S
T
F
R
A
P
Q
Site 28
S430
P
E
E
L
R
H
S
S
T
F
R
A
P
Q
A
Site 29
T431
E
E
L
R
H
S
S
T
F
R
A
P
Q
A
L
Site 30
Y462
L
R
T
E
L
R
D
Y
R
G
L
E
Q
L
K
Site 31
T483
D
D
E
E
A
G
W
T
E
L
A
E
Q
E
V
Site 32
S537
D
G
N
G
K
L
R
S
Q
A
P
P
D
V
W
Site 33
S662
A
G
L
A
L
G
P
S
S
P
L
L
R
S
E
Site 34
T720
P
D
E
V
G
P
P
T
P
F
P
E
P
G
A
Site 35
S750
T
G
A
Q
G
W
L
S
G
P
V
L
S
P
Y
Site 36
Y757
S
G
P
V
L
S
P
Y
E
D
I
L
W
D
P
Site 37
S765
E
D
I
L
W
D
P
S
T
P
P
P
T
P
P
Site 38
T766
D
I
L
W
D
P
S
T
P
P
P
T
P
P
R
Site 39
T770
D
P
S
T
P
P
P
T
P
P
R
D
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation