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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MCF2L2
Full Name:
Probable guanine nucleotide exchange factor MCF2L2
Alias:
Dbs-related Rho family guanine nucleotide exchange factor; DRG; KIAA0861; MCF.2 cell line derived transforming sequence-like 2; Rho family guanine-nucleotide exchange factor
Type:
Unknown function
Mass (Da):
117510
Number AA:
1031
UniProt ID:
Q86YR7
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
E
M
P
P
Q
E
L
T
R
R
L
A
T
V
I
Site 2
T20
E
L
T
R
R
L
A
T
V
I
T
H
V
D
E
Site 3
S53
H
R
Q
F
A
I
L
S
G
G
R
G
E
D
G
Site 4
S112
D
R
R
R
D
K
W
S
S
V
K
A
S
L
T
Site 5
S113
R
R
R
D
K
W
S
S
V
K
A
S
L
T
R
Site 6
T144
P
S
R
F
I
Q
R
T
F
T
D
I
G
I
K
Site 7
T146
R
F
I
Q
R
T
F
T
D
I
G
I
K
Y
Y
Site 8
Y152
F
T
D
I
G
I
K
Y
Y
R
N
E
F
K
T
Site 9
Y175
S
V
S
D
L
H
G
Y
I
D
K
S
Q
L
T
Site 10
S179
L
H
G
Y
I
D
K
S
Q
L
T
R
E
L
G
Site 11
T188
L
T
R
E
L
G
G
T
L
E
Y
R
H
G
Q
Site 12
S232
A
T
A
E
L
P
R
S
M
L
S
T
E
D
L
Site 13
S235
E
L
P
R
S
M
L
S
T
E
D
L
L
M
S
Site 14
T236
L
P
R
S
M
L
S
T
E
D
L
L
M
S
H
Site 15
S266
K
Q
G
T
T
L
L
S
C
I
Q
E
P
A
T
Site 16
T273
S
C
I
Q
E
P
A
T
K
C
P
N
S
K
L
Site 17
S278
P
A
T
K
C
P
N
S
K
L
N
L
N
Q
L
Site 18
T290
N
Q
L
E
N
V
T
T
M
E
R
L
L
V
Q
Site 19
T301
L
L
V
Q
L
D
E
T
E
K
A
F
S
H
F
Site 20
S370
H
K
K
L
E
E
K
S
Q
E
P
L
E
K
A
Site 21
S426
K
W
D
I
L
G
K
S
L
E
F
H
R
Q
L
Site 22
Y478
F
L
G
T
V
K
E
Y
P
L
L
S
P
K
E
Site 23
S482
V
K
E
Y
P
L
L
S
P
K
E
F
Y
N
E
Site 24
S522
I
F
H
K
R
Q
V
S
L
M
K
L
A
A
K
Site 25
T531
M
K
L
A
A
K
Q
T
R
P
V
Q
P
V
A
Site 26
S543
P
V
A
P
H
P
E
S
S
P
K
W
V
S
S
Site 27
S544
V
A
P
H
P
E
S
S
P
K
W
V
S
S
K
Site 28
S549
E
S
S
P
K
W
V
S
S
K
T
S
Q
P
S
Site 29
S550
S
S
P
K
W
V
S
S
K
T
S
Q
P
S
T
Site 30
T552
P
K
W
V
S
S
K
T
S
Q
P
S
T
S
V
Site 31
S553
K
W
V
S
S
K
T
S
Q
P
S
T
S
V
P
Site 32
S556
S
S
K
T
S
Q
P
S
T
S
V
P
L
A
R
Site 33
T557
S
K
T
S
Q
P
S
T
S
V
P
L
A
R
P
Site 34
S558
K
T
S
Q
P
S
T
S
V
P
L
A
R
P
L
Site 35
S568
L
A
R
P
L
R
T
S
E
E
P
Y
T
E
T
Site 36
Y572
L
R
T
S
E
E
P
Y
T
E
T
E
L
N
S
Site 37
T573
R
T
S
E
E
P
Y
T
E
T
E
L
N
S
R
Site 38
T587
R
G
K
E
D
D
E
T
K
F
E
V
K
S
E
Site 39
S593
E
T
K
F
E
V
K
S
E
E
I
F
E
S
H
Site 40
S599
K
S
E
E
I
F
E
S
H
H
E
R
G
N
P
Site 41
S618
Q
A
R
L
G
D
L
S
P
R
R
R
I
I
R
Site 42
T630
I
I
R
D
L
L
E
T
E
E
I
Y
I
K
E
Site 43
Y677
F
G
N
I
R
E
L
Y
E
F
H
N
R
T
F
Site 44
T683
L
Y
E
F
H
N
R
T
F
L
K
E
L
E
K
Site 45
Y712
R
K
E
D
L
Q
I
Y
F
K
Y
H
K
N
L
Site 46
Y715
D
L
Q
I
Y
F
K
Y
H
K
N
L
P
R
A
Site 47
Y751
H
N
L
P
L
F
K
Y
L
K
G
P
S
Q
R
Site 48
S756
F
K
Y
L
K
G
P
S
Q
R
L
I
K
Y
Q
Site 49
Y762
P
S
Q
R
L
I
K
Y
Q
M
L
L
K
G
L
Site 50
S774
K
G
L
L
D
F
E
S
P
E
D
M
E
I
D
Site 51
S788
D
P
G
E
L
G
G
S
A
K
D
G
P
K
R
Site 52
S799
G
P
K
R
T
K
D
S
A
F
S
T
E
L
Q
Site 53
S802
R
T
K
D
S
A
F
S
T
E
L
Q
Q
A
L
Site 54
T803
T
K
D
S
A
F
S
T
E
L
Q
Q
A
L
A
Site 55
T829
A
V
D
L
A
A
V
T
E
C
P
D
D
I
G
Site 56
Y857
W
T
I
H
K
D
R
Y
K
M
K
D
L
I
R
Site 57
S868
D
L
I
R
F
K
P
S
Q
R
Q
I
Y
L
F
Site 58
Y873
K
P
S
Q
R
Q
I
Y
L
F
E
R
G
I
V
Site 59
S894
E
P
G
D
Q
G
L
S
P
H
Y
S
F
K
K
Site 60
Y897
D
Q
G
L
S
P
H
Y
S
F
K
K
A
M
K
Site 61
S898
Q
G
L
S
P
H
Y
S
F
K
K
A
M
K
L
Site 62
T907
K
K
A
M
K
L
M
T
L
S
I
R
Q
L
G
Site 63
S917
I
R
Q
L
G
R
G
S
H
R
K
F
E
I
A
Site 64
Y932
S
R
N
G
L
E
K
Y
I
L
Q
A
A
S
K
Site 65
S971
G
N
P
Q
F
E
M
S
T
S
K
G
S
G
A
Site 66
S973
P
Q
F
E
M
S
T
S
K
G
S
G
A
G
S
Site 67
S976
E
M
S
T
S
K
G
S
G
A
G
S
G
P
W
Site 68
S980
S
K
G
S
G
A
G
S
G
P
W
I
K
N
M
Site 69
T991
I
K
N
M
E
R
A
T
T
S
K
E
D
P
A
Site 70
T992
K
N
M
E
R
A
T
T
S
K
E
D
P
A
S
Site 71
S993
N
M
E
R
A
T
T
S
K
E
D
P
A
S
S
Site 72
S999
T
S
K
E
D
P
A
S
S
T
G
G
I
K
G
Site 73
T1001
K
E
D
P
A
S
S
T
G
G
I
K
G
C
S
Site 74
S1008
T
G
G
I
K
G
C
S
S
R
E
F
S
S
M
Site 75
S1009
G
G
I
K
G
C
S
S
R
E
F
S
S
M
D
Site 76
S1013
G
C
S
S
R
E
F
S
S
M
D
T
F
E
D
Site 77
S1014
C
S
S
R
E
F
S
S
M
D
T
F
E
D
C
Site 78
T1017
R
E
F
S
S
M
D
T
F
E
D
C
E
G
A
Site 79
S1031
A
E
D
M
E
K
E
S
S
A
L
S
L
A
G
Site 80
S1032
E
D
M
E
K
E
S
S
A
L
S
L
A
G
L
Site 81
S1035
E
K
E
S
S
A
L
S
L
A
G
L
F
Q
S
Site 82
S1042
S
L
A
G
L
F
Q
S
D
D
S
H
E
T
C
Site 83
S1045
G
L
F
Q
S
D
D
S
H
E
T
C
S
S
K
Site 84
T1048
Q
S
D
D
S
H
E
T
C
S
S
K
S
A
F
Site 85
S1051
D
S
H
E
T
C
S
S
K
S
A
F
L
E
R
Site 86
S1061
A
F
L
E
R
G
E
S
S
Q
G
E
K
E
E
Site 87
T1074
E
E
R
D
E
E
E
T
A
T
R
S
T
E
E
Site 88
T1076
R
D
E
E
E
T
A
T
R
S
T
E
E
E
R
Site 89
T1079
E
E
T
A
T
R
S
T
E
E
E
R
A
G
A
Site 90
T1088
E
E
R
A
G
A
S
T
G
R
L
A
P
A
G
Site 91
T1109
A
R
A
L
R
P
R
T
S
A
Q
E
S
_
_
Site 92
S1110
R
A
L
R
P
R
T
S
A
Q
E
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation