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Updated November 2019
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Protein Info
Short Name:
PALB2
Full Name:
Partner and localizer of BRCA2
Alias:
Type:
Mass (Da):
131295
Number AA:
1186
UniProt ID:
Q86YC2
International Prot ID:
IPI00783507
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
E
P
P
G
K
P
L
S
C
E
E
K
E
K
L
Site 2
Y28
L
A
F
L
K
R
E
Y
S
K
T
L
A
R
L
Site 3
S29
A
F
L
K
R
E
Y
S
K
T
L
A
R
L
Q
Site 4
T31
L
K
R
E
Y
S
K
T
L
A
R
L
Q
R
A
Site 5
T51
I
K
H
S
I
K
K
T
V
E
E
Q
D
C
L
Site 6
S59
V
E
E
Q
D
C
L
S
Q
Q
D
L
S
P
Q
Site 7
S64
C
L
S
Q
Q
D
L
S
P
Q
L
K
H
S
E
Site 8
S70
L
S
P
Q
L
K
H
S
E
P
K
N
K
I
C
Site 9
Y79
P
K
N
K
I
C
V
Y
D
K
L
H
I
K
T
Site 10
T92
K
T
H
L
D
E
E
T
G
E
K
T
S
I
T
Site 11
T99
T
G
E
K
T
S
I
T
L
D
V
G
P
E
S
Site 12
S106
T
L
D
V
G
P
E
S
F
N
P
G
D
G
P
Site 13
T121
G
G
L
P
I
Q
R
T
D
D
T
Q
E
H
F
Site 14
T124
P
I
Q
R
T
D
D
T
Q
E
H
F
P
H
R
Site 15
S133
E
H
F
P
H
R
V
S
D
P
S
G
E
Q
K
Site 16
S136
P
H
R
V
S
D
P
S
G
E
Q
K
Q
K
L
Site 17
S145
E
Q
K
Q
K
L
P
S
R
R
K
K
Q
Q
K
Site 18
T154
R
K
K
Q
Q
K
R
T
F
I
S
Q
E
R
D
Site 19
S157
Q
Q
K
R
T
F
I
S
Q
E
R
D
C
V
F
Site 20
T166
E
R
D
C
V
F
G
T
D
S
L
R
L
S
G
Site 21
S168
D
C
V
F
G
T
D
S
L
R
L
S
G
K
R
Site 22
S172
G
T
D
S
L
R
L
S
G
K
R
L
K
E
Q
Site 23
S184
K
E
Q
E
E
I
S
S
K
N
P
A
R
S
P
Site 24
S190
S
S
K
N
P
A
R
S
P
V
T
E
I
R
T
Site 25
T197
S
P
V
T
E
I
R
T
H
L
L
S
L
K
S
Site 26
S201
E
I
R
T
H
L
L
S
L
K
S
E
L
P
D
Site 27
S204
T
H
L
L
S
L
K
S
E
L
P
D
S
P
E
Site 28
S209
L
K
S
E
L
P
D
S
P
E
P
V
T
E
I
Site 29
T214
P
D
S
P
E
P
V
T
E
I
N
E
D
S
V
Site 30
T226
D
S
V
L
I
P
P
T
A
Q
P
E
K
G
V
Site 31
T235
Q
P
E
K
G
V
D
T
F
L
R
R
P
N
F
Site 32
T246
R
P
N
F
T
R
A
T
T
V
P
L
Q
T
L
Site 33
T247
P
N
F
T
R
A
T
T
V
P
L
Q
T
L
S
Site 34
T252
A
T
T
V
P
L
Q
T
L
S
D
S
G
S
S
Site 35
S254
T
V
P
L
Q
T
L
S
D
S
G
S
S
Q
H
Site 36
S256
P
L
Q
T
L
S
D
S
G
S
S
Q
H
L
E
Site 37
S258
Q
T
L
S
D
S
G
S
S
Q
H
L
E
H
I
Site 38
T274
P
K
G
S
S
E
L
T
T
H
D
L
K
N
I
Site 39
T275
K
G
S
S
E
L
T
T
H
D
L
K
N
I
R
Site 40
T284
D
L
K
N
I
R
F
T
S
P
V
S
L
E
A
Site 41
S285
L
K
N
I
R
F
T
S
P
V
S
L
E
A
Q
Site 42
S288
I
R
F
T
S
P
V
S
L
E
A
Q
G
K
K
Site 43
T297
E
A
Q
G
K
K
M
T
V
S
T
D
N
L
L
Site 44
S299
Q
G
K
K
M
T
V
S
T
D
N
L
L
V
N
Site 45
S312
V
N
K
A
I
S
K
S
G
Q
L
P
T
S
S
Site 46
S318
K
S
G
Q
L
P
T
S
S
N
L
E
A
N
I
Site 47
S319
S
G
Q
L
P
T
S
S
N
L
E
A
N
I
S
Site 48
S326
S
N
L
E
A
N
I
S
C
S
L
N
E
L
T
Site 49
S328
L
E
A
N
I
S
C
S
L
N
E
L
T
Y
N
Site 50
T333
S
C
S
L
N
E
L
T
Y
N
N
L
P
A
N
Site 51
T351
N
L
K
E
Q
N
Q
T
E
K
S
L
K
S
P
Site 52
S354
E
Q
N
Q
T
E
K
S
L
K
S
P
S
D
T
Site 53
S357
Q
T
E
K
S
L
K
S
P
S
D
T
L
D
G
Site 54
S359
E
K
S
L
K
S
P
S
D
T
L
D
G
R
N
Site 55
T361
S
L
K
S
P
S
D
T
L
D
G
R
N
E
N
Site 56
S376
L
Q
E
S
E
I
L
S
Q
P
K
S
L
S
L
Site 57
S380
E
I
L
S
Q
P
K
S
L
S
L
E
A
T
S
Site 58
S382
L
S
Q
P
K
S
L
S
L
E
A
T
S
P
L
Site 59
T386
K
S
L
S
L
E
A
T
S
P
L
S
A
E
K
Site 60
S387
S
L
S
L
E
A
T
S
P
L
S
A
E
K
H
Site 61
S390
L
E
A
T
S
P
L
S
A
E
K
H
S
C
T
Site 62
T397
S
A
E
K
H
S
C
T
V
P
E
G
L
L
F
Site 63
Y408
G
L
L
F
P
A
E
Y
Y
V
R
T
T
R
S
Site 64
Y409
L
L
F
P
A
E
Y
Y
V
R
T
T
R
S
M
Site 65
S417
V
R
T
T
R
S
M
S
N
C
Q
R
K
V
A
Site 66
S454
A
S
K
N
L
N
L
S
N
E
E
T
D
Q
S
Site 67
T458
L
N
L
S
N
E
E
T
D
Q
S
E
I
R
M
Site 68
S461
S
N
E
E
T
D
Q
S
E
I
R
M
S
G
T
Site 69
S466
D
Q
S
E
I
R
M
S
G
T
C
T
G
Q
P
Site 70
T468
S
E
I
R
M
S
G
T
C
T
G
Q
P
S
S
Site 71
T470
I
R
M
S
G
T
C
T
G
Q
P
S
S
R
T
Site 72
S474
G
T
C
T
G
Q
P
S
S
R
T
S
Q
K
L
Site 73
S475
T
C
T
G
Q
P
S
S
R
T
S
Q
K
L
L
Site 74
S478
G
Q
P
S
S
R
T
S
Q
K
L
L
S
L
T
Site 75
S483
R
T
S
Q
K
L
L
S
L
T
K
V
S
S
P
Site 76
T485
S
Q
K
L
L
S
L
T
K
V
S
S
P
A
G
Site 77
S489
L
S
L
T
K
V
S
S
P
A
G
P
T
E
D
Site 78
Y512
A
Q
A
P
G
R
R
Y
T
G
K
R
K
S
A
Site 79
T513
Q
A
P
G
R
R
Y
T
G
K
R
K
S
A
C
Site 80
S518
R
Y
T
G
K
R
K
S
A
C
T
P
A
S
D
Site 81
T521
G
K
R
K
S
A
C
T
P
A
S
D
H
C
E
Site 82
S524
K
S
A
C
T
P
A
S
D
H
C
E
P
L
L
Site 83
S535
E
P
L
L
P
T
S
S
L
S
I
V
N
R
S
Site 84
S537
L
L
P
T
S
S
L
S
I
V
N
R
S
K
E
Site 85
S542
S
L
S
I
V
N
R
S
K
E
E
V
T
S
H
Site 86
Y551
E
E
V
T
S
H
K
Y
Q
H
E
K
L
F
I
Site 87
S565
I
Q
V
K
G
K
K
S
R
H
Q
K
E
D
S
Site 88
S572
S
R
H
Q
K
E
D
S
L
S
W
S
N
S
A
Site 89
S574
H
Q
K
E
D
S
L
S
W
S
N
S
A
Y
L
Site 90
S576
K
E
D
S
L
S
W
S
N
S
A
Y
L
S
L
Site 91
S578
D
S
L
S
W
S
N
S
A
Y
L
S
L
D
D
Site 92
Y580
L
S
W
S
N
S
A
Y
L
S
L
D
D
D
A
Site 93
S582
W
S
N
S
A
Y
L
S
L
D
D
D
A
F
T
Site 94
T589
S
L
D
D
D
A
F
T
A
P
F
H
R
D
G
Site 95
S599
F
H
R
D
G
M
L
S
L
K
Q
L
L
S
F
Site 96
S629
L
K
L
E
K
V
K
S
C
S
E
K
P
V
E
Site 97
S631
L
E
K
V
K
S
C
S
E
K
P
V
E
P
F
Site 98
S640
K
P
V
E
P
F
E
S
K
M
F
G
E
R
H
Site 99
S652
E
R
H
L
K
E
G
S
C
I
F
P
E
E
L
Site 100
S660
C
I
F
P
E
E
L
S
P
K
R
M
D
T
E
Site 101
T666
L
S
P
K
R
M
D
T
E
M
E
D
L
E
E
Site 102
S682
L
I
V
L
P
G
K
S
H
P
K
R
P
N
S
Site 103
S689
S
H
P
K
R
P
N
S
Q
S
Q
H
T
K
T
Site 104
S691
P
K
R
P
N
S
Q
S
Q
H
T
K
T
G
L
Site 105
T696
S
Q
S
Q
H
T
K
T
G
L
S
S
S
I
L
Site 106
S699
Q
H
T
K
T
G
L
S
S
S
I
L
L
Y
T
Site 107
T710
L
L
Y
T
P
L
N
T
V
A
P
D
D
N
D
Site 108
T720
P
D
D
N
D
R
P
T
T
D
M
C
S
P
A
Site 109
T721
D
D
N
D
R
P
T
T
D
M
C
S
P
A
F
Site 110
S742
P
A
F
G
P
Q
G
S
Y
E
K
A
S
T
E
Site 111
Y743
A
F
G
P
Q
G
S
Y
E
K
A
S
T
E
V
Site 112
S747
Q
G
S
Y
E
K
A
S
T
E
V
A
G
R
T
Site 113
T748
G
S
Y
E
K
A
S
T
E
V
A
G
R
T
C
Site 114
S766
Q
L
A
H
L
K
D
S
V
C
L
A
S
D
T
Site 115
S771
K
D
S
V
C
L
A
S
D
T
K
Q
F
D
S
Site 116
T773
S
V
C
L
A
S
D
T
K
Q
F
D
S
S
G
Site 117
S778
S
D
T
K
Q
F
D
S
S
G
S
P
A
K
P
Site 118
S779
D
T
K
Q
F
D
S
S
G
S
P
A
K
P
H
Site 119
S781
K
Q
F
D
S
S
G
S
P
A
K
P
H
T
T
Site 120
T787
G
S
P
A
K
P
H
T
T
L
Q
V
S
G
R
Site 121
T788
S
P
A
K
P
H
T
T
L
Q
V
S
G
R
Q
Site 122
S792
P
H
T
T
L
Q
V
S
G
R
Q
G
Q
P
T
Site 123
T799
S
G
R
Q
G
Q
P
T
C
D
C
D
S
V
P
Site 124
S804
Q
P
T
C
D
C
D
S
V
P
P
G
T
P
P
Site 125
T809
C
D
S
V
P
P
G
T
P
P
P
I
E
S
F
Site 126
S815
G
T
P
P
P
I
E
S
F
T
F
K
E
N
Q
Site 127
T817
P
P
P
I
E
S
F
T
F
K
E
N
Q
L
C
Site 128
T839
H
K
H
S
V
E
Q
T
E
T
A
E
L
P
A
Site 129
T841
H
S
V
E
Q
T
E
T
A
E
L
P
A
S
D
Site 130
S847
E
T
A
E
L
P
A
S
D
S
I
N
P
G
N
Site 131
S849
A
E
L
P
A
S
D
S
I
N
P
G
N
L
Q
Site 132
S859
P
G
N
L
Q
L
V
S
E
L
K
N
P
S
G
Site 133
S865
V
S
E
L
K
N
P
S
G
S
C
S
V
D
V
Site 134
S867
E
L
K
N
P
S
G
S
C
S
V
D
V
S
A
Site 135
S869
K
N
P
S
G
S
C
S
V
D
V
S
A
M
F
Site 136
S950
E
I
R
A
L
F
C
S
S
D
D
E
S
E
K
Site 137
S951
I
R
A
L
F
C
S
S
D
D
E
S
E
K
Q
Site 138
S955
F
C
S
S
D
D
E
S
E
K
Q
V
L
L
K
Site 139
S963
E
K
Q
V
L
L
K
S
G
N
I
K
A
V
L
Site 140
S979
L
T
K
R
R
L
V
S
S
S
G
T
L
S
D
Site 141
S980
T
K
R
R
L
V
S
S
S
G
T
L
S
D
Q
Site 142
S981
K
R
R
L
V
S
S
S
G
T
L
S
D
Q
Q
Site 143
T983
R
L
V
S
S
S
G
T
L
S
D
Q
Q
V
E
Site 144
S985
V
S
S
S
G
T
L
S
D
Q
Q
V
E
V
M
Site 145
T993
D
Q
Q
V
E
V
M
T
F
A
E
D
G
G
G
Site 146
T1015
P
P
E
E
T
I
L
T
F
A
E
V
Q
G
M
Site 147
Y1055
K
M
H
I
D
D
S
Y
Q
A
S
V
C
H
K
Site 148
S1082
S
H
P
C
A
K
E
S
E
S
L
R
S
P
V
Site 149
S1084
P
C
A
K
E
S
E
S
L
R
S
P
V
F
Q
Site 150
S1087
K
E
S
E
S
L
R
S
P
V
F
Q
L
I
V
Site 151
T1167
S
F
V
K
W
S
G
T
D
S
H
L
L
A
G
Site 152
S1169
V
K
W
S
G
T
D
S
H
L
L
A
G
Q
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation