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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SUV420H2
Full Name:
Histone-lysine N-methyltransferase SUV420H2
Alias:
Suppressor of variegation 4-20 homologue 2
Type:
Mass (Da):
52095
Number AA:
462
UniProt ID:
Q86Y97
International Prot ID:
IPI00013441
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005694
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0008168
GO:0008170
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006325
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
G
P
D
R
V
T
A
R
E
L
C
E
N
Site 2
S20
E
N
D
D
L
A
T
S
L
V
L
D
P
Y
L
Site 3
Y26
T
S
L
V
L
D
P
Y
L
G
F
R
T
H
K
Site 4
S37
R
T
H
K
M
N
V
S
P
V
P
P
L
R
R
Site 5
S50
R
R
Q
Q
H
L
R
S
A
L
E
T
F
L
R
Site 6
T54
H
L
R
S
A
L
E
T
F
L
R
Q
R
D
L
Site 7
T69
E
A
A
Y
R
A
L
T
L
G
G
W
T
A
R
Site 8
T74
A
L
T
L
G
G
W
T
A
R
Y
F
Q
S
R
Site 9
Y77
L
G
G
W
T
A
R
Y
F
Q
S
R
G
P
R
Site 10
T91
R
Q
E
A
A
L
K
T
H
V
Y
R
Y
L
R
Site 11
Y96
L
K
T
H
V
Y
R
Y
L
R
A
F
L
P
E
Site 12
Y114
T
I
L
P
C
T
R
Y
S
M
E
T
N
G
A
Site 13
S115
I
L
P
C
T
R
Y
S
M
E
T
N
G
A
K
Site 14
S125
T
N
G
A
K
I
V
S
T
R
A
W
K
K
N
Site 15
S161
R
A
G
E
N
D
F
S
I
M
Y
S
T
R
K
Site 16
S165
N
D
F
S
I
M
Y
S
T
R
K
R
S
A
Q
Site 17
T166
D
F
S
I
M
Y
S
T
R
K
R
S
A
Q
L
Site 18
S170
M
Y
S
T
R
K
R
S
A
Q
L
W
L
G
P
Site 19
T214
I
E
P
G
D
E
V
T
C
F
Y
G
E
G
F
Site 20
Y217
G
D
E
V
T
C
F
Y
G
E
G
F
F
G
E
Site 21
T244
K
G
E
G
A
F
R
T
R
P
R
E
P
A
L
Site 22
Y259
P
P
R
P
L
D
K
Y
Q
L
R
E
T
K
R
Site 23
T264
D
K
Y
Q
L
R
E
T
K
R
R
L
Q
Q
G
Site 24
S274
R
L
Q
Q
G
L
D
S
G
S
R
Q
G
L
L
Site 25
S276
Q
Q
G
L
D
S
G
S
R
Q
G
L
L
G
P
Site 26
S290
P
R
A
C
V
H
P
S
P
L
R
R
D
P
F
Site 27
S310
P
L
R
L
P
A
C
S
A
R
P
D
T
S
P
Site 28
T315
A
C
S
A
R
P
D
T
S
P
L
W
L
Q
W
Site 29
S316
C
S
A
R
P
D
T
S
P
L
W
L
Q
W
L
Site 30
S347
P
R
R
A
P
V
L
S
T
H
H
A
A
R
V
Site 31
Y400
A
R
R
Y
G
L
P
Y
V
V
R
V
D
L
R
Site 32
T416
L
A
P
A
P
P
A
T
P
A
P
A
G
T
P
Site 33
T422
A
T
P
A
P
A
G
T
P
G
P
I
L
I
P
Site 34
S449
K
R
L
R
L
V
V
S
H
G
S
I
D
L
D
Site 35
S452
R
L
V
V
S
H
G
S
I
D
L
D
V
G
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation