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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HEATR2
Full Name:
HEAT repeat-containing protein 2
Alias:
Type:
Mass (Da):
93515
Number AA:
855
UniProt ID:
Q86Y56
International Prot ID:
IPI00242630
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
H
P
A
E
G
A
E
T
A
E
A
V
E
L
S
Site 2
S42
L
P
G
L
E
A
D
S
K
P
G
R
R
R
A
Site 3
T67
P
G
P
A
A
D
P
T
A
F
Q
G
P
W
A
Site 4
S86
P
R
L
L
R
C
L
S
D
P
A
E
G
C
R
Site 5
T197
A
A
A
L
A
Q
A
T
P
D
H
F
H
M
Q
Site 6
S205
P
D
H
F
H
M
Q
S
E
S
L
I
G
P
L
Site 7
S242
I
H
F
G
N
G
K
S
V
D
D
V
L
S
H
Site 8
S248
K
S
V
D
D
V
L
S
H
F
A
Q
R
L
F
Site 9
S281
L
C
L
R
D
R
Y
S
F
F
H
K
L
I
P
Site 10
T334
K
L
D
F
A
P
P
T
P
P
H
Y
P
P
H
Site 11
Y338
A
P
P
T
P
P
H
Y
P
P
H
E
R
R
P
Site 12
T395
L
H
A
E
D
H
A
T
Q
H
L
E
V
V
L
Site 13
S419
E
E
A
A
V
V
Q
S
C
T
R
S
A
E
L
Site 14
S451
L
K
K
T
P
S
A
S
G
L
L
V
L
A
S
Site 15
Y493
Q
A
S
E
N
D
L
Y
L
E
R
L
L
L
C
Site 16
S545
K
A
Q
E
T
M
D
S
L
A
M
V
E
G
V
Site 17
S554
A
M
V
E
G
V
S
S
C
Q
D
L
Y
R
K
Site 18
Y559
V
S
S
C
Q
D
L
Y
R
K
H
I
G
P
L
Site 19
T571
G
P
L
L
E
R
V
T
A
S
H
L
D
W
T
Site 20
S573
L
L
E
R
V
T
A
S
H
L
D
W
T
A
H
Site 21
T578
T
A
S
H
L
D
W
T
A
H
S
P
E
L
L
Site 22
S581
H
L
D
W
T
A
H
S
P
E
L
L
Q
F
S
Site 23
S616
L
R
A
C
L
Q
P
S
Q
D
P
Q
M
R
L
Site 24
T637
S
T
V
L
L
R
A
T
D
T
I
N
S
Q
G
Site 25
S642
R
A
T
D
T
I
N
S
Q
G
Q
F
P
S
Y
Site 26
S648
N
S
Q
G
Q
F
P
S
Y
L
E
T
V
T
K
Site 27
Y649
S
Q
G
Q
F
P
S
Y
L
E
T
V
T
K
D
Site 28
S691
L
T
S
S
E
V
L
S
A
E
Q
I
R
D
V
Site 29
T701
Q
I
R
D
V
Q
E
T
L
M
P
Q
V
L
T
Site 30
S714
L
T
T
L
E
E
D
S
K
M
T
R
L
I
S
Site 31
S721
S
K
M
T
R
L
I
S
C
R
I
I
N
T
F
Site 32
T727
I
S
C
R
I
I
N
T
F
L
K
T
S
G
G
Site 33
T731
I
I
N
T
F
L
K
T
S
G
G
M
T
D
P
Site 34
S732
I
N
T
F
L
K
T
S
G
G
M
T
D
P
E
Site 35
T736
L
K
T
S
G
G
M
T
D
P
E
K
L
I
K
Site 36
Y745
P
E
K
L
I
K
I
Y
P
E
L
L
K
R
L
Site 37
S756
L
K
R
L
D
D
V
S
N
D
V
R
M
A
A
Site 38
S781
V
K
G
A
N
A
K
S
Y
Y
Q
S
S
V
Q
Site 39
Y782
K
G
A
N
A
K
S
Y
Y
Q
S
S
V
Q
Y
Site 40
Y783
G
A
N
A
K
S
Y
Y
Q
S
S
V
Q
Y
L
Site 41
S785
N
A
K
S
Y
Y
Q
S
S
V
Q
Y
L
Y
R
Site 42
S786
A
K
S
Y
Y
Q
S
S
V
Q
Y
L
Y
R
E
Site 43
Y789
Y
Y
Q
S
S
V
Q
Y
L
Y
R
E
L
L
V
Site 44
Y791
Q
S
S
V
Q
Y
L
Y
R
E
L
L
V
H
L
Site 45
T828
P
D
L
L
V
R
E
T
E
A
V
I
H
K
H
Site 46
T839
I
H
K
H
R
S
A
T
Y
C
E
Q
L
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation