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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
K6IRS3
Full Name:
Keratin, type II cytoskeletal 73
Alias:
K2C73; Keratin 6 irs3; Keratin 73; KRT6IRS3
Type:
Cytoskeletal protein
Mass (Da):
58923
Number AA:
540
UniProt ID:
Q86Y46
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0045095
Uniprot
OncoNet
Molecular Function:
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
S
R
Q
F
T
Y
K
S
G
A
A
A
Site 2
S9
S
R
Q
F
T
Y
K
S
G
A
A
A
K
G
G
Site 3
S25
S
G
C
S
A
V
L
S
G
G
S
S
S
S
Y
Site 4
S29
A
V
L
S
G
G
S
S
S
S
Y
R
A
G
G
Site 5
S30
V
L
S
G
G
S
S
S
S
Y
R
A
G
G
K
Site 6
S31
L
S
G
G
S
S
S
S
Y
R
A
G
G
K
G
Site 7
Y32
S
G
G
S
S
S
S
Y
R
A
G
G
K
G
L
Site 8
S40
R
A
G
G
K
G
L
S
G
G
F
S
S
R
S
Site 9
S44
K
G
L
S
G
G
F
S
S
R
S
L
Y
S
L
Site 10
S45
G
L
S
G
G
F
S
S
R
S
L
Y
S
L
G
Site 11
S47
S
G
G
F
S
S
R
S
L
Y
S
L
G
G
A
Site 12
Y49
G
F
S
S
R
S
L
Y
S
L
G
G
A
R
S
Site 13
S50
F
S
S
R
S
L
Y
S
L
G
G
A
R
S
I
Site 14
S65
S
F
N
V
A
S
G
S
G
W
A
G
G
Y
G
Site 15
Y71
G
S
G
W
A
G
G
Y
G
F
G
R
G
R
A
Site 16
S79
G
F
G
R
G
R
A
S
G
F
A
G
S
M
F
Site 17
S145
V
L
N
N
K
F
A
S
F
I
D
K
V
R
F
Site 18
S188
P
I
L
E
G
Y
I
S
N
L
R
K
Q
L
E
Site 19
T196
N
L
R
K
Q
L
E
T
L
S
G
D
R
V
R
Site 20
S198
R
K
Q
L
E
T
L
S
G
D
R
V
R
L
D
Site 21
S206
G
D
R
V
R
L
D
S
E
L
R
S
V
R
E
Site 22
S210
R
L
D
S
E
L
R
S
V
R
E
V
V
E
D
Site 23
Y218
V
R
E
V
V
E
D
Y
K
K
R
Y
E
E
E
Site 24
T231
E
E
I
N
K
R
T
T
A
E
N
E
F
V
V
Site 25
Y247
K
K
D
V
D
A
A
Y
T
S
K
V
E
L
Q
Site 26
S249
D
V
D
A
A
Y
T
S
K
V
E
L
Q
A
K
Site 27
S280
G
E
T
A
Q
I
Q
S
H
I
S
D
T
S
I
Site 28
S286
Q
S
H
I
S
D
T
S
I
I
L
S
M
D
N
Site 29
S290
S
D
T
S
I
I
L
S
M
D
N
N
R
N
L
Site 30
S301
N
R
N
L
D
L
D
S
I
I
A
E
V
R
A
Site 31
Y310
I
A
E
V
R
A
Q
Y
E
E
I
A
R
K
S
Site 32
S317
Y
E
E
I
A
R
K
S
K
A
E
A
E
A
L
Site 33
Y325
K
A
E
A
E
A
L
Y
Q
T
K
F
Q
E
L
Site 34
T327
E
A
E
A
L
Y
Q
T
K
F
Q
E
L
Q
L
Site 35
S351
K
H
T
K
N
E
I
S
E
L
T
R
L
I
Q
Site 36
S362
R
L
I
Q
R
L
R
S
E
I
E
S
V
K
K
Site 37
S366
R
L
R
S
E
I
E
S
V
K
K
Q
C
A
N
Site 38
Y417
L
A
R
M
L
R
E
Y
Q
E
L
L
S
V
K
Site 39
S422
R
E
Y
Q
E
L
L
S
V
K
L
S
L
D
I
Site 40
Y434
L
D
I
E
I
A
T
Y
R
K
L
L
E
G
E
Site 41
S446
E
G
E
E
C
R
M
S
G
E
Y
T
N
S
V
Site 42
Y449
E
C
R
M
S
G
E
Y
T
N
S
V
S
I
S
Site 43
T450
C
R
M
S
G
E
Y
T
N
S
V
S
I
S
V
Site 44
S452
M
S
G
E
Y
T
N
S
V
S
I
S
V
I
N
Site 45
S454
G
E
Y
T
N
S
V
S
I
S
V
I
N
S
S
Site 46
S475
T
G
A
G
F
G
F
S
N
A
G
T
Y
G
Y
Site 47
T479
F
G
F
S
N
A
G
T
Y
G
Y
W
P
S
S
Site 48
Y482
S
N
A
G
T
Y
G
Y
W
P
S
S
V
S
G
Site 49
S485
G
T
Y
G
Y
W
P
S
S
V
S
G
G
Y
S
Site 50
S486
T
Y
G
Y
W
P
S
S
V
S
G
G
Y
S
M
Site 51
S488
G
Y
W
P
S
S
V
S
G
G
Y
S
M
L
P
Site 52
S502
P
G
G
C
V
T
G
S
G
N
C
S
P
R
G
Site 53
S506
V
T
G
S
G
N
C
S
P
R
G
E
A
R
T
Site 54
T513
S
P
R
G
E
A
R
T
R
L
G
S
A
S
E
Site 55
S517
E
A
R
T
R
L
G
S
A
S
E
F
R
D
S
Site 56
S519
R
T
R
L
G
S
A
S
E
F
R
D
S
Q
G
Site 57
S524
S
A
S
E
F
R
D
S
Q
G
K
T
L
A
L
Site 58
T528
F
R
D
S
Q
G
K
T
L
A
L
S
S
P
T
Site 59
S532
Q
G
K
T
L
A
L
S
S
P
T
K
K
T
M
Site 60
S533
G
K
T
L
A
L
S
S
P
T
K
K
T
M
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation