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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DGKH
Full Name:
Diacylglycerol kinase eta
Alias:
DAG kinase eta; DGKeta; DGK-eta; Diacylglycerol kinase, eta; Diglyceride kinase eta; EC 2.7.1.107
Type:
Kinase (non-protein); EC 2.7.1.107; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - glycerolipid
Mass (Da):
134866
Number AA:
1220
UniProt ID:
Q86XP1
International Prot ID:
IPI00329264
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005768
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004143
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007205
GO:0007242
GO:0051259
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
A
V
T
S
A
A
A
S
A
G
P
G
E
D
S
Site 2
S38
S
A
G
P
G
E
D
S
S
D
S
E
A
E
Q
Site 3
S39
A
G
P
G
E
D
S
S
D
S
E
A
E
Q
E
Site 4
S41
P
G
E
D
S
S
D
S
E
A
E
Q
E
G
P
Site 5
S56
Q
K
L
I
R
K
V
S
T
S
G
Q
I
R
T
Site 6
T57
K
L
I
R
K
V
S
T
S
G
Q
I
R
T
K
Site 7
S58
L
I
R
K
V
S
T
S
G
Q
I
R
T
K
T
Site 8
T65
S
G
Q
I
R
T
K
T
S
I
K
E
G
Q
L
Site 9
S77
G
Q
L
L
K
Q
T
S
S
F
Q
R
W
K
K
Site 10
S78
Q
L
L
K
Q
T
S
S
F
Q
R
W
K
K
R
Site 11
Y86
F
Q
R
W
K
K
R
Y
F
K
L
R
G
R
T
Site 12
T93
Y
F
K
L
R
G
R
T
L
Y
Y
A
K
D
S
Site 13
Y95
K
L
R
G
R
T
L
Y
Y
A
K
D
S
K
S
Site 14
Y96
L
R
G
R
T
L
Y
Y
A
K
D
S
K
S
L
Site 15
S100
T
L
Y
Y
A
K
D
S
K
S
L
I
F
D
E
Site 16
S102
Y
Y
A
K
D
S
K
S
L
I
F
D
E
V
D
Site 17
S114
E
V
D
L
S
D
A
S
V
A
E
A
S
T
K
Site 18
S126
S
T
K
N
A
N
N
S
F
T
I
I
T
P
F
Site 19
S151
K
E
M
E
D
W
I
S
S
L
K
S
V
Q
T
Site 20
S152
E
M
E
D
W
I
S
S
L
K
S
V
Q
T
R
Site 21
S155
D
W
I
S
S
L
K
S
V
Q
T
R
E
P
Y
Site 22
Y162
S
V
Q
T
R
E
P
Y
E
V
A
Q
F
N
V
Site 23
S195
F
C
N
V
C
R
E
S
L
S
G
V
T
S
H
Site 24
S197
N
V
C
R
E
S
L
S
G
V
T
S
H
G
L
Site 25
S201
E
S
L
S
G
V
T
S
H
G
L
S
C
E
V
Site 26
Y294
H
T
A
C
K
D
L
Y
H
P
I
C
P
L
G
Site 27
T316
P
P
I
A
L
N
S
T
D
S
D
G
F
C
R
Site 28
S318
I
A
L
N
S
T
D
S
D
G
F
C
R
A
T
Site 29
S339
P
L
L
V
F
V
N
S
K
S
G
D
N
Q
G
Site 30
S341
L
V
F
V
N
S
K
S
G
D
N
Q
G
V
K
Site 31
S432
R
V
L
G
W
G
G
S
Y
D
D
D
T
Q
L
Site 32
T437
G
G
S
Y
D
D
D
T
Q
L
P
Q
I
L
E
Site 33
S450
L
E
K
L
E
R
A
S
T
K
M
L
D
R
W
Site 34
T451
E
K
L
E
R
A
S
T
K
M
L
D
R
W
S
Site 35
T461
L
D
R
W
S
I
M
T
Y
E
L
K
L
P
P
Site 36
Y462
D
R
W
S
I
M
T
Y
E
L
K
L
P
P
K
Site 37
S471
L
K
L
P
P
K
A
S
L
L
P
G
P
P
E
Site 38
Y484
P
E
A
S
E
E
F
Y
M
T
I
Y
E
D
S
Site 39
T486
A
S
E
E
F
Y
M
T
I
Y
E
D
S
V
A
Site 40
Y488
E
E
F
Y
M
T
I
Y
E
D
S
V
A
T
H
Site 41
T518
S
A
K
T
L
C
E
T
V
K
D
F
V
A
K
Site 42
T529
F
V
A
K
V
E
K
T
Y
D
K
T
L
E
N
Site 43
T533
V
E
K
T
Y
D
K
T
L
E
N
A
V
V
A
Site 44
S545
V
V
A
D
A
V
A
S
K
C
S
V
L
N
E
Site 45
S587
E
E
D
A
V
E
S
S
S
E
E
S
L
G
E
Site 46
S588
E
D
A
V
E
S
S
S
E
E
S
L
G
E
S
Site 47
S591
V
E
S
S
S
E
E
S
L
G
E
S
K
E
Q
Site 48
S595
S
E
E
S
L
G
E
S
K
E
Q
L
G
D
D
Site 49
T604
E
Q
L
G
D
D
V
T
K
P
S
S
Q
K
A
Site 50
S608
D
D
V
T
K
P
S
S
Q
K
A
V
K
P
R
Site 51
S623
E
I
M
L
R
A
N
S
L
K
K
A
V
R
Q
Site 52
T643
G
K
V
M
D
D
P
T
V
H
P
C
E
P
A
Site 53
S654
C
E
P
A
N
Q
S
S
D
Y
D
S
T
E
T
Site 54
Y656
P
A
N
Q
S
S
D
Y
D
S
T
E
T
D
E
Site 55
S658
N
Q
S
S
D
Y
D
S
T
E
T
D
E
S
K
Site 56
T659
Q
S
S
D
Y
D
S
T
E
T
D
E
S
K
E
Site 57
T661
S
D
Y
D
S
T
E
T
D
E
S
K
E
E
A
Site 58
S664
D
S
T
E
T
D
E
S
K
E
E
A
K
D
D
Site 59
S676
K
D
D
G
A
K
E
S
I
T
V
K
T
A
P
Site 60
T678
D
G
A
K
E
S
I
T
V
K
T
A
P
R
S
Site 61
T681
K
E
S
I
T
V
K
T
A
P
R
S
P
D
A
Site 62
S685
T
V
K
T
A
P
R
S
P
D
A
R
A
S
Y
Site 63
S691
R
S
P
D
A
R
A
S
Y
G
H
S
Q
T
D
Site 64
Y692
S
P
D
A
R
A
S
Y
G
H
S
Q
T
D
S
Site 65
S695
A
R
A
S
Y
G
H
S
Q
T
D
S
V
P
G
Site 66
T697
A
S
Y
G
H
S
Q
T
D
S
V
P
G
P
A
Site 67
S699
Y
G
H
S
Q
T
D
S
V
P
G
P
A
V
A
Site 68
T717
E
N
L
P
V
L
N
T
R
I
I
C
P
G
L
Site 69
T752
N
I
D
P
F
G
A
T
P
F
I
D
P
D
L
Site 70
S761
F
I
D
P
D
L
D
S
V
D
G
Y
S
E
K
Site 71
Y765
D
L
D
S
V
D
G
Y
S
E
K
C
V
M
N
Site 72
S784
I
G
L
D
A
K
I
S
L
E
F
N
N
K
R
Site 73
T802
P
E
K
C
R
S
R
T
K
N
L
M
W
Y
G
Site 74
Y808
R
T
K
N
L
M
W
Y
G
V
L
G
T
R
E
Site 75
Y821
R
E
L
L
Q
R
S
Y
K
N
L
E
Q
R
V
Site 76
Y836
Q
L
E
C
D
G
Q
Y
I
P
L
P
S
L
Q
Site 77
S873
D
D
I
F
A
A
P
S
F
D
D
K
I
L
E
Site 78
T947
K
N
R
A
Q
M
L
T
R
D
R
A
F
E
S
Site 79
S954
T
R
D
R
A
F
E
S
T
L
K
S
W
E
D
Site 80
T955
R
D
R
A
F
E
S
T
L
K
S
W
E
D
K
Site 81
S958
A
F
E
S
T
L
K
S
W
E
D
K
Q
K
C
Site 82
S967
E
D
K
Q
K
C
D
S
G
K
P
V
L
R
T
Site 83
T974
S
G
K
P
V
L
R
T
H
L
Y
I
H
H
A
Site 84
T986
H
H
A
I
D
L
A
T
E
E
V
S
Q
M
Q
Site 85
S1041
A
N
P
R
C
P
E
S
L
T
R
D
T
A
T
Site 86
T1046
P
E
S
L
T
R
D
T
A
T
E
I
A
I
N
Site 87
S1075
R
V
P
L
Q
L
E
S
P
H
E
E
R
V
S
Site 88
S1082
S
P
H
E
E
R
V
S
N
A
L
H
S
V
E
Site 89
T1096
E
V
E
L
Q
K
L
T
E
I
P
W
L
Y
Y
Site 90
Y1102
L
T
E
I
P
W
L
Y
Y
I
L
H
P
N
E
Site 91
T1118
E
E
P
P
M
D
C
T
K
R
N
N
R
S
T
Site 92
T1125
T
K
R
N
N
R
S
T
V
F
R
I
V
P
K
Site 93
S1145
V
Q
K
Q
K
T
S
S
Q
P
V
Q
K
W
G
Site 94
Y1168
D
L
L
N
L
G
E
Y
K
D
I
F
I
R
H
Site 95
S1214
G
I
K
E
L
G
R
S
T
P
Q
S
E
V
_
Site 96
T1215
I
K
E
L
G
R
S
T
P
Q
S
E
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation