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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANKLE2
Full Name:
Ankyrin repeat and LEM domain-containing protein 2
Alias:
Ankyrin repeat and LEM domain-containing protein 2: cDNA FLJ77829; cDNA FLJ77829; KIAA0692
Type:
Mass (Da):
104114
Number AA:
938
UniProt ID:
Q86XL3
International Prot ID:
IPI00829741
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005635
GO:0005737
GO:0016020
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S45
R
P
G
G
L
G
R
S
G
T
P
V
P
P
P
Site 2
T47
G
G
L
G
R
S
G
T
P
V
P
P
P
S
A
Site 3
T97
K
C
G
P
I
T
S
T
T
R
F
I
F
E
K
Site 4
S118
L
E
Q
G
G
R
L
S
S
F
Y
Y
H
E
A
Site 5
S119
E
Q
G
G
R
L
S
S
F
Y
Y
H
E
A
G
Site 6
Y121
G
G
R
L
S
S
F
Y
Y
H
E
A
G
V
T
Site 7
Y122
G
R
L
S
S
F
Y
Y
H
E
A
G
V
T
A
Site 8
S131
E
A
G
V
T
A
L
S
Q
D
P
Q
R
I
L
Site 9
T146
K
P
A
E
G
N
P
T
D
Q
A
G
F
S
E
Site 10
Y159
S
E
D
R
D
F
G
Y
S
V
G
L
N
P
P
Site 11
S160
E
D
R
D
F
G
Y
S
V
G
L
N
P
P
E
Site 12
T172
P
P
E
E
E
A
V
T
S
K
T
C
S
V
P
Site 13
S173
P
E
E
E
A
V
T
S
K
T
C
S
V
P
P
Site 14
T175
E
E
A
V
T
S
K
T
C
S
V
P
P
S
D
Site 15
S177
A
V
T
S
K
T
C
S
V
P
P
S
D
T
D
Site 16
S181
K
T
C
S
V
P
P
S
D
T
D
T
Y
R
A
Site 17
T185
V
P
P
S
D
T
D
T
Y
R
A
G
A
T
A
Site 18
Y186
P
P
S
D
T
D
T
Y
R
A
G
A
T
A
S
Site 19
T191
D
T
Y
R
A
G
A
T
A
S
K
E
P
P
L
Site 20
S193
Y
R
A
G
A
T
A
S
K
E
P
P
L
Y
Y
Site 21
Y199
A
S
K
E
P
P
L
Y
Y
G
V
C
P
V
Y
Site 22
Y200
S
K
E
P
P
L
Y
Y
G
V
C
P
V
Y
E
Site 23
Y206
Y
Y
G
V
C
P
V
Y
E
D
V
P
A
R
N
Site 24
Y217
P
A
R
N
E
R
I
Y
V
Y
E
N
K
K
E
Site 25
Y219
R
N
E
R
I
Y
V
Y
E
N
K
K
E
A
L
Site 26
S235
A
V
K
M
I
K
G
S
R
F
K
A
F
S
T
Site 27
S241
G
S
R
F
K
A
F
S
T
R
E
D
A
E
K
Site 28
Y256
F
A
R
G
I
C
D
Y
F
P
S
P
S
K
T
Site 29
S259
G
I
C
D
Y
F
P
S
P
S
K
T
S
L
P
Site 30
S261
C
D
Y
F
P
S
P
S
K
T
S
L
P
L
S
Site 31
T263
Y
F
P
S
P
S
K
T
S
L
P
L
S
P
V
Site 32
S264
F
P
S
P
S
K
T
S
L
P
L
S
P
V
K
Site 33
S268
S
K
T
S
L
P
L
S
P
V
K
T
A
P
L
Site 34
T272
L
P
L
S
P
V
K
T
A
P
L
F
S
N
D
Site 35
S277
V
K
T
A
P
L
F
S
N
D
R
L
K
D
G
Site 36
S288
L
K
D
G
L
C
L
S
E
S
E
T
V
N
K
Site 37
S290
D
G
L
C
L
S
E
S
E
T
V
N
K
E
R
Site 38
T292
L
C
L
S
E
S
E
T
V
N
K
E
R
A
N
Site 39
S300
V
N
K
E
R
A
N
S
Y
K
N
P
R
T
Q
Site 40
Y301
N
K
E
R
A
N
S
Y
K
N
P
R
T
Q
D
Site 41
T310
N
P
R
T
Q
D
L
T
A
K
L
R
K
A
V
Site 42
T324
V
E
K
G
E
E
D
T
F
S
D
L
I
W
S
Site 43
S326
K
G
E
E
D
T
F
S
D
L
I
W
S
N
P
Site 44
Y335
L
I
W
S
N
P
R
Y
L
I
G
S
G
D
N
Site 45
S339
N
P
R
Y
L
I
G
S
G
D
N
P
T
I
V
Site 46
T344
I
G
S
G
D
N
P
T
I
V
Q
E
G
C
R
Site 47
S365
A
A
K
E
N
Q
A
S
I
C
Q
L
T
L
D
Site 48
Y384
P
D
F
M
R
L
M
Y
P
D
D
D
E
A
M
Site 49
Y398
M
L
Q
K
R
I
R
Y
V
V
D
L
Y
L
N
Site 50
Y403
I
R
Y
V
V
D
L
Y
L
N
T
P
D
K
M
Site 51
T406
V
V
D
L
Y
L
N
T
P
D
K
M
G
Y
D
Site 52
Y412
N
T
P
D
K
M
G
Y
D
T
P
L
H
F
A
Site 53
T414
P
D
K
M
G
Y
D
T
P
L
H
F
A
C
K
Site 54
Y445
V
K
N
S
R
N
K
Y
D
K
T
P
E
D
V
Site 55
T448
S
R
N
K
Y
D
K
T
P
E
D
V
I
C
E
Site 56
S457
E
D
V
I
C
E
R
S
K
N
K
S
V
E
L
Site 57
S461
C
E
R
S
K
N
K
S
V
E
L
K
E
R
I
Site 58
Y471
L
K
E
R
I
R
E
Y
L
K
G
H
Y
Y
V
Site 59
Y476
R
E
Y
L
K
G
H
Y
Y
V
P
L
L
R
A
Site 60
Y477
E
Y
L
K
G
H
Y
Y
V
P
L
L
R
A
E
Site 61
T486
P
L
L
R
A
E
E
T
S
S
P
V
I
G
E
Site 62
S487
L
L
R
A
E
E
T
S
S
P
V
I
G
E
L
Site 63
S488
L
R
A
E
E
T
S
S
P
V
I
G
E
L
W
Site 64
S496
P
V
I
G
E
L
W
S
P
D
Q
T
A
E
A
Site 65
T500
E
L
W
S
P
D
Q
T
A
E
A
S
H
V
S
Site 66
S504
P
D
Q
T
A
E
A
S
H
V
S
R
Y
G
G
Site 67
Y509
E
A
S
H
V
S
R
Y
G
G
S
P
R
D
P
Site 68
S512
H
V
S
R
Y
G
G
S
P
R
D
P
V
L
T
Site 69
T519
S
P
R
D
P
V
L
T
L
R
A
F
A
G
P
Site 70
S528
R
A
F
A
G
P
L
S
P
A
K
A
E
D
F
Site 71
T541
D
F
R
K
L
W
K
T
P
P
R
E
K
A
G
Site 72
S556
F
L
H
H
V
K
K
S
D
P
E
R
G
F
E
Site 73
Y575
E
L
A
H
E
L
G
Y
P
W
V
E
Y
W
E
Site 74
S591
L
G
C
F
V
D
L
S
S
Q
E
G
L
Q
R
Site 75
S592
G
C
F
V
D
L
S
S
Q
E
G
L
Q
R
L
Site 76
Y602
G
L
Q
R
L
E
E
Y
L
T
Q
Q
E
I
G
Site 77
T604
Q
R
L
E
E
Y
L
T
Q
Q
E
I
G
K
K
Site 78
S622
E
T
G
E
R
E
A
S
C
R
D
K
A
T
T
Site 79
T628
A
S
C
R
D
K
A
T
T
S
G
S
N
S
I
Site 80
T629
S
C
R
D
K
A
T
T
S
G
S
N
S
I
S
Site 81
S630
C
R
D
K
A
T
T
S
G
S
N
S
I
S
V
Site 82
S632
D
K
A
T
T
S
G
S
N
S
I
S
V
R
A
Site 83
S636
T
S
G
S
N
S
I
S
V
R
A
F
L
D
E
Site 84
S647
F
L
D
E
D
D
M
S
L
E
E
I
K
N
R
Site 85
S662
Q
N
A
A
R
N
N
S
P
P
T
V
G
A
F
Site 86
T665
A
R
N
N
S
P
P
T
V
G
A
F
G
H
T
Site 87
S675
A
F
G
H
T
R
C
S
A
F
P
L
E
Q
E
Site 88
S696
A
E
P
G
G
P
H
S
S
R
N
G
L
C
H
Site 89
S697
E
P
G
G
P
H
S
S
R
N
G
L
C
H
P
Site 90
T710
H
P
L
N
H
S
R
T
L
A
G
K
R
P
K
Site 91
S730
E
A
H
L
P
P
V
S
D
L
T
V
E
F
D
Site 92
T733
L
P
P
V
S
D
L
T
V
E
F
D
K
L
N
Site 93
S747
N
L
Q
N
I
G
R
S
V
S
K
T
P
D
E
Site 94
S749
Q
N
I
G
R
S
V
S
K
T
P
D
E
S
T
Site 95
T751
I
G
R
S
V
S
K
T
P
D
E
S
T
K
T
Site 96
T758
T
P
D
E
S
T
K
T
K
D
Q
I
L
T
S
Site 97
S778
E
R
D
L
L
E
P
S
P
A
D
Q
L
G
N
Site 98
T790
L
G
N
G
H
R
R
T
E
S
E
M
S
A
R
Site 99
S792
N
G
H
R
R
T
E
S
E
M
S
A
R
I
A
Site 100
S795
R
R
T
E
S
E
M
S
A
R
I
A
K
M
S
Site 101
S802
S
A
R
I
A
K
M
S
L
S
P
S
S
P
R
Site 102
S804
R
I
A
K
M
S
L
S
P
S
S
P
R
H
E
Site 103
S806
A
K
M
S
L
S
P
S
S
P
R
H
E
D
Q
Site 104
S807
K
M
S
L
S
P
S
S
P
R
H
E
D
Q
L
Site 105
S832
F
L
F
G
E
E
P
S
K
L
D
Q
D
V
L
Site 106
S860
P
A
V
H
R
W
K
S
A
V
L
C
Y
S
P
Site 107
S866
K
S
A
V
L
C
Y
S
P
S
D
R
Q
S
W
Site 108
S868
A
V
L
C
Y
S
P
S
D
R
Q
S
W
P
S
Site 109
S872
Y
S
P
S
D
R
Q
S
W
P
S
P
A
V
K
Site 110
S875
S
D
R
Q
S
W
P
S
P
A
V
K
G
R
F
Site 111
S884
A
V
K
G
R
F
K
S
Q
L
P
D
L
S
G
Site 112
S890
K
S
Q
L
P
D
L
S
G
P
H
S
Y
S
P
Site 113
S894
P
D
L
S
G
P
H
S
Y
S
P
G
R
N
S
Site 114
S896
L
S
G
P
H
S
Y
S
P
G
R
N
S
V
A
Site 115
S901
S
Y
S
P
G
R
N
S
V
A
G
S
N
P
A
Site 116
S905
G
R
N
S
V
A
G
S
N
P
A
K
P
G
L
Site 117
S914
P
A
K
P
G
L
G
S
P
G
R
Y
S
P
V
Site 118
Y918
G
L
G
S
P
G
R
Y
S
P
V
H
G
S
Q
Site 119
S919
L
G
S
P
G
R
Y
S
P
V
H
G
S
Q
L
Site 120
S924
R
Y
S
P
V
H
G
S
Q
L
R
R
M
A
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation