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Updated November 2019
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Protein Info
Short Name:
HEATR5A
Full Name:
HEAT repeat-containing protein 5A
Alias:
Type:
Mass (Da):
222004
Number AA:
2040
UniProt ID:
Q86XA9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
L
L
L
N
E
E
A
Y
N
Q
L
G
E
V
Q
Site 2
Y32
F
I
F
E
W
L
R
Y
L
E
K
L
L
L
A
Site 3
S41
E
K
L
L
L
A
T
S
R
N
D
V
R
E
K
Site 4
T51
D
V
R
E
K
Q
K
T
L
V
E
Q
L
L
S
Site 5
S62
Q
L
L
S
L
L
N
S
S
P
G
P
P
T
R
Site 6
S63
L
L
S
L
L
N
S
S
P
G
P
P
T
R
K
Site 7
S87
Y
S
I
G
D
T
F
S
V
H
E
A
I
D
K
Site 8
S101
K
C
N
D
L
I
R
S
K
D
D
S
P
S
Y
Site 9
S105
L
I
R
S
K
D
D
S
P
S
Y
L
P
T
K
Site 10
S107
R
S
K
D
D
S
P
S
Y
L
P
T
K
L
A
Site 11
Y108
S
K
D
D
S
P
S
Y
L
P
T
K
L
A
A
Site 12
S147
N
I
L
K
A
M
K
S
A
E
S
Q
G
R
Y
Site 13
S150
K
A
M
K
S
A
E
S
Q
G
R
Y
E
I
M
Site 14
Y154
S
A
E
S
Q
G
R
Y
E
I
M
L
S
L
Q
Site 15
S159
G
R
Y
E
I
M
L
S
L
Q
N
I
L
N
G
Site 16
Y179
A
P
C
H
R
D
V
Y
K
A
A
R
S
C
L
Site 17
T187
K
A
A
R
S
C
L
T
D
R
S
M
A
V
R
Site 18
S190
R
S
C
L
T
D
R
S
M
A
V
R
C
A
A
Site 19
S220
V
A
T
L
C
F
K
S
F
E
G
S
N
Y
D
Site 20
S224
C
F
K
S
F
E
G
S
N
Y
D
V
R
I
S
Site 21
Y226
K
S
F
E
G
S
N
Y
D
V
R
I
S
V
S
Site 22
T251
V
I
S
K
H
P
G
T
A
A
S
R
Q
S
I
Site 23
S257
G
T
A
A
S
R
Q
S
I
R
R
V
S
L
E
Site 24
S262
R
Q
S
I
R
R
V
S
L
E
E
V
L
E
L
Site 25
T272
E
V
L
E
L
L
G
T
G
F
L
R
G
S
S
Site 26
S278
G
T
G
F
L
R
G
S
S
G
F
L
R
A
S
Site 27
S279
T
G
F
L
R
G
S
S
G
F
L
R
A
S
G
Site 28
S285
S
S
G
F
L
R
A
S
G
D
M
L
K
G
T
Site 29
T292
S
G
D
M
L
K
G
T
S
S
V
S
R
D
V
Site 30
S294
D
M
L
K
G
T
S
S
V
S
R
D
V
R
V
Site 31
S296
L
K
G
T
S
S
V
S
R
D
V
R
V
G
V
Site 32
T313
A
Y
V
V
F
V
S
T
L
G
G
A
W
L
E
Site 33
S335
S
H
I
L
S
L
A
S
P
S
H
P
K
A
T
Site 34
S337
I
L
S
L
A
S
P
S
H
P
K
A
T
Q
T
Site 35
T344
S
H
P
K
A
T
Q
T
Q
I
D
A
V
C
C
Site 36
S395
K
V
M
D
A
V
M
S
D
G
N
L
E
T
R
Site 37
S405
N
L
E
T
R
L
G
S
T
D
V
A
A
S
Q
Site 38
T490
D
R
C
L
E
R
L
T
G
H
K
S
S
P
E
Site 39
S494
E
R
L
T
G
H
K
S
S
P
E
A
V
T
G
Site 40
S495
R
L
T
G
H
K
S
S
P
E
A
V
T
G
F
Site 41
S546
A
A
Q
N
S
R
L
S
A
Q
R
T
Q
A
G
Site 42
T550
S
R
L
S
A
Q
R
T
Q
A
G
W
L
L
I
Site 43
S586
W
K
C
V
F
P
A
S
P
K
D
L
E
T
E
Site 44
T592
A
S
P
K
D
L
E
T
E
K
S
R
G
D
S
Site 45
S595
K
D
L
E
T
E
K
S
R
G
D
S
F
T
W
Site 46
S599
T
E
K
S
R
G
D
S
F
T
W
Q
V
T
L
Site 47
T601
K
S
R
G
D
S
F
T
W
Q
V
T
L
E
G
Site 48
T628
S
H
C
G
D
L
L
T
E
E
V
T
Q
R
L
Site 49
T632
D
L
L
T
E
E
V
T
Q
R
L
L
P
P
L
Site 50
Y656
L
S
S
I
L
K
M
Y
G
S
P
L
K
T
P
Site 51
S658
S
I
L
K
M
Y
G
S
P
L
K
T
P
S
V
Site 52
T662
M
Y
G
S
P
L
K
T
P
S
V
V
Y
R
Q
Site 53
S664
G
S
P
L
K
T
P
S
V
V
Y
R
Q
R
L
Site 54
S725
Q
D
D
L
L
I
L
S
P
F
L
Q
E
T
D
Site 55
T731
L
S
P
F
L
Q
E
T
D
H
R
F
I
E
E
Site 56
S750
G
N
G
V
A
C
G
S
L
E
Y
D
P
Y
S
Site 57
Y753
V
A
C
G
S
L
E
Y
D
P
Y
S
I
Y
E
Site 58
Y756
G
S
L
E
Y
D
P
Y
S
I
Y
E
K
D
V
Site 59
S757
S
L
E
Y
D
P
Y
S
I
Y
E
K
D
V
E
Site 60
Y759
E
Y
D
P
Y
S
I
Y
E
K
D
V
E
G
D
Site 61
S767
E
K
D
V
E
G
D
S
V
P
K
P
L
P
P
Site 62
S777
K
P
L
P
P
A
L
S
V
I
S
S
A
S
K
Site 63
S780
P
P
A
L
S
V
I
S
S
A
S
K
L
F
G
Site 64
S783
L
S
V
I
S
S
A
S
K
L
F
G
V
V
C
Site 65
S808
I
L
E
Q
L
L
D
S
I
K
H
T
K
G
A
Site 66
T812
L
L
D
S
I
K
H
T
K
G
A
R
Q
Q
V
Site 67
S838
F
L
K
Y
V
A
G
S
K
G
C
L
G
P
E
Site 68
S900
V
S
F
D
K
L
K
S
A
R
D
V
V
T
R
Site 69
S916
G
H
S
L
A
L
G
S
L
H
R
Y
L
G
G
Site 70
S925
H
R
Y
L
G
G
I
S
S
S
Q
H
L
N
S
Site 71
S926
R
Y
L
G
G
I
S
S
S
Q
H
L
N
S
C
Site 72
S927
Y
L
G
G
I
S
S
S
Q
H
L
N
S
C
I
Site 73
S932
S
S
S
Q
H
L
N
S
C
I
G
I
L
Y
T
Site 74
S944
L
Y
T
L
A
Q
D
S
T
S
P
D
V
Q
T
Site 75
S946
T
L
A
Q
D
S
T
S
P
D
V
Q
T
W
A
Site 76
T951
S
T
S
P
D
V
Q
T
W
A
L
H
S
L
S
Site 77
Y968
I
D
S
A
G
P
L
Y
Y
V
H
V
E
P
T
Site 78
Y969
D
S
A
G
P
L
Y
Y
V
H
V
E
P
T
L
Site 79
T989
L
L
L
N
V
P
P
T
H
A
E
V
H
Q
S
Site 80
S996
T
H
A
E
V
H
Q
S
L
G
R
C
L
N
A
Site 81
S1016
G
P
E
L
Q
G
N
S
T
S
I
S
T
L
R
Site 82
T1017
P
E
L
Q
G
N
S
T
S
I
S
T
L
R
T
Site 83
S1018
E
L
Q
G
N
S
T
S
I
S
T
L
R
T
S
Site 84
S1020
Q
G
N
S
T
S
I
S
T
L
R
T
S
C
L
Site 85
T1021
G
N
S
T
S
I
S
T
L
R
T
S
C
L
L
Site 86
S1110
A
V
M
L
A
K
D
S
R
E
E
L
T
P
D
Site 87
T1115
K
D
S
R
E
E
L
T
P
D
A
N
I
R
E
Site 88
T1137
L
I
L
L
D
K
E
T
D
E
R
L
C
H
D
Site 89
T1148
L
C
H
D
I
K
E
T
L
N
Y
M
L
T
S
Site 90
S1199
G
D
K
G
D
D
A
S
V
L
T
T
R
R
D
Site 91
T1202
G
D
D
A
S
V
L
T
T
R
R
D
E
K
S
Site 92
T1203
D
D
A
S
V
L
T
T
R
R
D
E
K
S
H
Site 93
S1209
T
T
R
R
D
E
K
S
H
P
F
T
N
P
R
Site 94
T1213
D
E
K
S
H
P
F
T
N
P
R
W
A
T
R
Site 95
T1219
F
T
N
P
R
W
A
T
R
V
F
A
A
E
C
Site 96
S1255
Q
E
M
K
K
R
D
S
R
N
D
F
L
V
L
Site 97
S1279
F
M
A
A
T
D
H
S
D
Q
L
R
L
S
G
Site 98
S1328
A
L
R
P
A
F
T
S
E
T
P
P
D
V
T
Site 99
T1330
R
P
A
F
T
S
E
T
P
P
D
V
T
A
K
Site 100
S1352
W
I
A
S
G
V
V
S
D
L
N
D
L
R
R
Site 101
Y1382
K
E
A
L
S
H
L
Y
N
E
S
A
S
T
M
Site 102
T1418
N
H
R
Q
P
L
K
T
T
T
C
L
E
D
G
Site 103
S1430
E
D
G
I
R
N
G
S
C
S
S
D
G
L
L
Site 104
S1432
G
I
R
N
G
S
C
S
S
D
G
L
L
D
L
Site 105
S1469
T
L
P
S
E
F
A
S
Q
L
P
A
E
G
G
Site 106
S1484
A
F
Y
T
A
E
T
S
E
N
A
K
L
H
Y
Site 107
Y1492
E
N
A
K
L
H
Y
Y
N
S
W
A
L
I
L
Site 108
S1524
D
E
G
A
S
N
L
S
R
P
V
T
P
T
S
Site 109
T1528
S
N
L
S
R
P
V
T
P
T
S
M
C
Q
G
Site 110
T1530
L
S
R
P
V
T
P
T
S
M
C
Q
G
S
S
Site 111
S1531
S
R
P
V
T
P
T
S
M
C
Q
G
S
S
S
Site 112
S1536
P
T
S
M
C
Q
G
S
S
S
G
A
T
I
K
Site 113
S1538
S
M
C
Q
G
S
S
S
G
A
T
I
K
S
P
Site 114
T1541
Q
G
S
S
S
G
A
T
I
K
S
P
E
D
V
Site 115
S1544
S
S
G
A
T
I
K
S
P
E
D
V
Y
T
D
Site 116
Y1549
I
K
S
P
E
D
V
Y
T
D
R
F
H
L
I
Site 117
T1550
K
S
P
E
D
V
Y
T
D
R
F
H
L
I
L
Site 118
S1575
R
S
D
A
T
M
E
S
I
T
A
C
L
H
A
Site 119
S1594
L
D
V
P
W
P
R
S
K
I
G
S
D
Q
D
Site 120
S1598
W
P
R
S
K
I
G
S
D
Q
D
L
G
I
E
Site 121
S1619
R
V
I
L
T
R
E
S
P
S
I
Q
L
A
S
Site 122
S1647
H
V
K
E
K
R
R
S
A
E
V
D
D
G
A
Site 123
T1659
D
G
A
A
E
K
E
T
L
P
E
F
G
E
G
Site 124
T1669
E
F
G
E
G
K
D
T
G
G
L
V
P
G
K
Site 125
T1702
P
E
L
N
P
K
L
T
G
S
P
G
V
K
A
Site 126
S1704
L
N
P
K
L
T
G
S
P
G
V
K
A
T
K
Site 127
S1785
Q
A
L
K
G
I
L
S
S
P
M
A
R
A
E
Site 128
S1786
A
L
K
G
I
L
S
S
P
M
A
R
A
E
K
Site 129
S1794
P
M
A
R
A
E
K
S
R
T
A
W
T
D
L
Site 130
T1796
A
R
A
E
K
S
R
T
A
W
T
D
L
L
R
Site 131
T1844
L
S
T
S
P
E
V
T
T
I
P
C
L
Q
K
Site 132
S1888
Q
Y
P
N
P
A
V
S
Y
P
Y
I
Y
S
L
Site 133
Y1889
Y
P
N
P
A
V
S
Y
P
Y
I
Y
S
L
A
Site 134
T1914
D
K
R
K
P
E
N
T
A
E
L
E
I
F
Q
Site 135
T1932
K
V
L
E
T
L
V
T
V
A
E
E
H
H
R
Site 136
S1965
N
S
L
G
S
A
T
S
I
M
R
N
L
H
D
Site 137
S1991
Q
Y
S
S
V
F
K
S
L
V
A
S
S
P
A
Site 138
S1996
F
K
S
L
V
A
S
S
P
A
L
K
A
R
L
Site 139
S2013
A
I
K
G
N
Q
E
S
V
K
V
K
I
P
T
Site 140
S2021
V
K
V
K
I
P
T
S
K
Y
T
K
S
P
G
Site 141
Y2023
V
K
I
P
T
S
K
Y
T
K
S
P
G
K
N
Site 142
S2026
P
T
S
K
Y
T
K
S
P
G
K
N
S
S
I
Site 143
S2032
K
S
P
G
K
N
S
S
I
Q
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Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation