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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CHSY1
Full Name:
Chondroitin sulfate synthase 1
Alias:
Carbohydrate (chondroitin) synthase 1; Chondroitin glucuronyltransferase II; Chondroitin synthase; CHSS1; EC 2.4.1.175; EC 2.4.1.226; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1; N-acetylgalactosaminyltransferase II
Type:
Enzyme -Transferase. Glycan Biosynthesis and Metabolism group, Chondroitin sulfate biosynthesis family, Glycan structures - biosynthesis 1 family.
Mass (Da):
91784
Number AA:
802
UniProt ID:
Q86X52
International Prot ID:
IPI00329141
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032580
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0050510
GO:0047238
GO:0046872
PhosphoSite+
KinaseNET
Biological Process:
GO:0030206
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
R
L
V
L
P
R
A
S
E
L
K
R
A
G
P
Site 2
S44
A
G
P
R
R
R
A
S
P
E
G
C
R
S
G
Site 3
S50
A
S
P
E
G
C
R
S
G
Q
A
A
A
S
Q
Site 4
S56
R
S
G
Q
A
A
A
S
Q
A
G
G
A
R
G
Site 5
S75
A
Q
L
W
P
P
G
S
D
P
D
G
G
P
R
Site 6
Y106
Q
T
R
A
V
A
A
Y
R
T
W
S
K
T
I
Site 7
S110
V
A
A
Y
R
T
W
S
K
T
I
P
G
K
V
Site 8
T112
A
Y
R
T
W
S
K
T
I
P
G
K
V
Q
F
Site 9
S121
P
G
K
V
Q
F
F
S
S
E
G
S
D
T
S
Site 10
S122
G
K
V
Q
F
F
S
S
E
G
S
D
T
S
V
Site 11
S125
Q
F
F
S
S
E
G
S
D
T
S
V
P
I
P
Site 12
S128
S
S
E
G
S
D
T
S
V
P
I
P
V
V
P
Site 13
S142
P
L
R
G
V
D
D
S
Y
P
P
Q
K
K
S
Site 14
Y143
L
R
G
V
D
D
S
Y
P
P
Q
K
K
S
F
Site 15
Y175
M
R
A
D
D
D
V
Y
I
K
G
D
R
L
E
Site 16
S187
R
L
E
N
F
L
R
S
L
N
S
S
E
P
L
Site 17
S190
N
F
L
R
S
L
N
S
S
E
P
L
F
L
G
Site 18
S191
F
L
R
S
L
N
S
S
E
P
L
F
L
G
Q
Site 19
S228
G
G
P
G
V
I
M
S
R
E
V
L
R
R
M
Site 20
Y247
G
K
C
L
R
E
M
Y
T
T
H
E
D
V
E
Site 21
T249
C
L
R
E
M
Y
T
T
H
E
D
V
E
V
G
Site 22
Y278
Y
E
M
Q
Q
L
F
Y
E
N
Y
E
Q
N
K
Site 23
Y281
Q
Q
L
F
Y
E
N
Y
E
Q
N
K
K
G
Y
Site 24
Y288
Y
E
Q
N
K
K
G
Y
I
R
D
L
H
N
S
Site 25
Y311
H
P
N
K
N
P
P
Y
Q
Y
R
L
H
S
Y
Site 26
S317
P
Y
Q
Y
R
L
H
S
Y
M
L
S
R
K
I
Site 27
S321
R
L
H
S
Y
M
L
S
R
K
I
S
E
L
R
Site 28
S325
Y
M
L
S
R
K
I
S
E
L
R
H
R
T
I
Site 29
T331
I
S
E
L
R
H
R
T
I
Q
L
H
R
E
I
Site 30
S342
H
R
E
I
V
L
M
S
K
Y
S
N
T
E
I
Site 31
Y344
E
I
V
L
M
S
K
Y
S
N
T
E
I
H
K
Site 32
S361
L
Q
L
G
I
P
P
S
F
M
R
F
Q
P
R
Site 33
Y385
F
L
T
G
K
Y
L
Y
S
A
V
D
G
Q
P
Site 34
S399
P
P
R
R
G
M
D
S
A
Q
R
E
A
L
D
Site 35
T422
M
I
N
A
N
A
K
T
R
G
R
I
I
D
F
Site 36
Y436
F
K
E
I
Q
Y
G
Y
R
R
V
N
P
M
Y
Site 37
Y443
Y
R
R
V
N
P
M
Y
G
A
E
Y
I
L
D
Site 38
Y455
I
L
D
L
L
L
L
Y
K
K
H
K
G
K
K
Site 39
T464
K
H
K
G
K
K
M
T
V
P
V
R
R
H
A
Site 40
Y472
V
P
V
R
R
H
A
Y
L
Q
Q
T
F
S
K
Site 41
T476
R
H
A
Y
L
Q
Q
T
F
S
K
I
Q
F
V
Site 42
S478
A
Y
L
Q
Q
T
F
S
K
I
Q
F
V
E
H
Site 43
S501
A
K
R
I
N
Q
E
S
G
S
L
S
F
L
S
Site 44
S503
R
I
N
Q
E
S
G
S
L
S
F
L
S
N
S
Site 45
S505
N
Q
E
S
G
S
L
S
F
L
S
N
S
L
K
Site 46
S522
V
P
F
Q
L
P
G
S
K
S
E
H
K
E
P
Site 47
S524
F
Q
L
P
G
S
K
S
E
H
K
E
P
K
D
Site 48
S576
V
L
L
F
N
S
D
S
N
P
D
K
A
K
Q
Site 49
Y590
Q
V
E
L
M
R
D
Y
R
I
K
Y
P
K
A
Site 50
Y594
M
R
D
Y
R
I
K
Y
P
K
A
D
M
Q
I
Site 51
S619
L
A
L
E
V
G
S
S
Q
F
N
N
E
S
L
Site 52
S625
S
S
Q
F
N
N
E
S
L
L
F
F
C
D
V
Site 53
T648
L
Q
R
C
R
A
N
T
V
L
G
Q
Q
I
Y
Site 54
Y669
Q
Y
D
P
K
I
V
Y
S
G
K
V
P
S
D
Site 55
S675
V
Y
S
G
K
V
P
S
D
N
H
F
A
F
T
Site 56
Y691
K
T
G
F
W
R
N
Y
G
F
G
I
T
C
I
Site 57
Y699
G
F
G
I
T
C
I
Y
K
G
D
L
V
R
V
Site 58
S712
R
V
G
G
F
D
V
S
I
Q
G
W
G
L
E
Site 59
T734
V
V
Q
A
G
L
K
T
F
R
S
Q
E
V
G
Site 60
S737
A
G
L
K
T
F
R
S
Q
E
V
G
V
V
H
Site 61
Y760
P
N
L
D
P
K
Q
Y
K
M
C
L
G
S
K
Site 62
S769
M
C
L
G
S
K
A
S
T
Y
G
S
T
Q
Q
Site 63
T770
C
L
G
S
K
A
S
T
Y
G
S
T
Q
Q
L
Site 64
Y771
L
G
S
K
A
S
T
Y
G
S
T
Q
Q
L
A
Site 65
S773
S
K
A
S
T
Y
G
S
T
Q
Q
L
A
E
M
Site 66
S788
W
L
E
K
N
D
P
S
Y
S
K
S
S
N
N
Site 67
Y789
L
E
K
N
D
P
S
Y
S
K
S
S
N
N
N
Site 68
S790
E
K
N
D
P
S
Y
S
K
S
S
N
N
N
G
Site 69
S792
N
D
P
S
Y
S
K
S
S
N
N
N
G
S
V
Site 70
S798
K
S
S
N
N
N
G
S
V
R
T
A
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation