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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RALGAPB
Full Name:
Ral GTPase-activating protein subunit beta
Alias:
DKFZp781M2411; K1219; KC19; KIAA1219; Ral GTPase activating protein, beta subunit (non-catalytic); RalGAPbeta
Type:
GTPase activating protein, Ras
Mass (Da):
166799
Number AA:
1494
UniProt ID:
Q86X10
International Prot ID:
IPI00409601
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0044464
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0008047
GO:0030234
PhosphoSite+
KinaseNET
Biological Process:
GO:0009966
GO:0050789
GO:0050794
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
Q
N
D
Q
G
H
T
S
V
L
H
S
Y
P
E
Site 2
S24
G
H
T
S
V
L
H
S
Y
P
E
S
V
G
R
Site 3
Y25
H
T
S
V
L
H
S
Y
P
E
S
V
G
R
E
Site 4
S28
V
L
H
S
Y
P
E
S
V
G
R
E
V
A
N
Site 5
S53
G
T
P
S
V
A
G
S
E
N
L
L
K
T
D
Site 6
Y85
L
D
G
E
T
V
K
Y
C
V
D
V
Y
T
D
Site 7
Y115
V
I
K
E
P
N
Q
Y
V
Q
T
I
L
K
H
Site 8
S135
V
P
R
Q
E
Q
G
S
S
Q
I
R
L
C
L
Site 9
S136
P
R
Q
E
Q
G
S
S
Q
I
R
L
C
L
Q
Site 10
S155
I
Q
K
L
A
R
E
S
S
L
M
A
R
E
T
Site 11
S156
Q
K
L
A
R
E
S
S
L
M
A
R
E
T
W
Site 12
Y216
R
C
F
P
T
P
P
Y
W
K
T
A
K
E
M
Site 13
S246
K
V
I
C
A
L
T
S
R
L
L
R
F
T
Y
Site 14
T252
T
S
R
L
L
R
F
T
Y
G
P
S
F
P
A
Site 15
Y253
S
R
L
L
R
F
T
Y
G
P
S
F
P
A
F
Site 16
S268
K
V
P
D
E
D
A
S
L
I
P
P
E
M
D
Site 17
S291
F
R
F
L
H
M
L
S
N
P
V
D
L
S
N
Site 18
S303
L
S
N
P
A
I
I
S
S
T
P
K
F
Q
E
Site 19
S304
S
N
P
A
I
I
S
S
T
P
K
F
Q
E
Q
Site 20
T305
N
P
A
I
I
S
S
T
P
K
F
Q
E
Q
F
Site 21
Y325
M
P
Q
E
L
N
Q
Y
P
C
L
K
H
L
P
Site 22
S353
V
D
A
F
L
G
I
S
R
P
R
S
D
S
A
Site 23
S357
L
G
I
S
R
P
R
S
D
S
A
P
P
T
P
Site 24
S359
I
S
R
P
R
S
D
S
A
P
P
T
P
V
N
Site 25
T363
R
S
D
S
A
P
P
T
P
V
N
R
L
S
M
Site 26
S369
P
T
P
V
N
R
L
S
M
P
Q
S
A
A
V
Site 27
S373
N
R
L
S
M
P
Q
S
A
A
V
S
T
T
P
Site 28
S377
M
P
Q
S
A
A
V
S
T
T
P
P
H
N
R
Site 29
T378
P
Q
S
A
A
V
S
T
T
P
P
H
N
R
R
Site 30
T379
Q
S
A
A
V
S
T
T
P
P
H
N
R
R
H
Site 31
T390
N
R
R
H
R
A
V
T
V
N
K
A
T
M
K
Site 32
T395
A
V
T
V
N
K
A
T
M
K
T
S
T
V
S
Site 33
T398
V
N
K
A
T
M
K
T
S
T
V
S
T
A
H
Site 34
S399
N
K
A
T
M
K
T
S
T
V
S
T
A
H
A
Site 35
T400
K
A
T
M
K
T
S
T
V
S
T
A
H
A
S
Site 36
T403
M
K
T
S
T
V
S
T
A
H
A
S
K
V
Q
Site 37
T413
A
S
K
V
Q
H
Q
T
S
S
T
S
P
L
S
Site 38
S414
S
K
V
Q
H
Q
T
S
S
T
S
P
L
S
S
Site 39
S415
K
V
Q
H
Q
T
S
S
T
S
P
L
S
S
P
Site 40
T416
V
Q
H
Q
T
S
S
T
S
P
L
S
S
P
N
Site 41
S417
Q
H
Q
T
S
S
T
S
P
L
S
S
P
N
Q
Site 42
S420
T
S
S
T
S
P
L
S
S
P
N
Q
T
S
S
Site 43
S421
S
S
T
S
P
L
S
S
P
N
Q
T
S
S
E
Site 44
T425
P
L
S
S
P
N
Q
T
S
S
E
P
R
P
L
Site 45
S426
L
S
S
P
N
Q
T
S
S
E
P
R
P
L
P
Site 46
S427
S
S
P
N
Q
T
S
S
E
P
R
P
L
P
A
Site 47
S442
P
R
R
P
K
V
N
S
I
L
N
L
F
G
S
Site 48
S469
H
N
G
I
N
R
D
S
S
M
T
A
I
T
T
Site 49
S470
N
G
I
N
R
D
S
S
M
T
A
I
T
T
Q
Site 50
T472
I
N
R
D
S
S
M
T
A
I
T
T
Q
A
S
Site 51
S487
M
E
F
R
R
K
G
S
Q
M
S
T
D
T
M
Site 52
S490
R
R
K
G
S
Q
M
S
T
D
T
M
V
S
N
Site 53
T491
R
K
G
S
Q
M
S
T
D
T
M
V
S
N
P
Site 54
T493
G
S
Q
M
S
T
D
T
M
V
S
N
P
M
F
Site 55
S496
M
S
T
D
T
M
V
S
N
P
M
F
D
A
S
Site 56
S503
S
N
P
M
F
D
A
S
E
F
P
D
N
Y
E
Site 57
Y509
A
S
E
F
P
D
N
Y
E
A
G
R
A
E
A
Site 58
Y537
G
E
E
I
L
P
A
Y
L
S
R
F
Y
M
L
Site 59
S599
I
L
P
D
R
E
L
S
K
F
K
S
Y
V
N
Site 60
S603
R
E
L
S
K
F
K
S
Y
V
N
P
T
E
L
Site 61
Y604
E
L
S
K
F
K
S
Y
V
N
P
T
E
L
R
Site 62
T608
F
K
S
Y
V
N
P
T
E
L
R
R
S
S
I
Site 63
S613
N
P
T
E
L
R
R
S
S
I
N
I
L
L
S
Site 64
S633
H
H
F
G
T
V
K
S
E
V
V
L
E
G
K
Site 65
S642
V
V
L
E
G
K
F
S
N
D
D
S
S
S
Y
Site 66
S646
G
K
F
S
N
D
D
S
S
S
Y
D
K
P
I
Site 67
S647
K
F
S
N
D
D
S
S
S
Y
D
K
P
I
T
Site 68
S648
F
S
N
D
D
S
S
S
Y
D
K
P
I
T
F
Site 69
Y649
S
N
D
D
S
S
S
Y
D
K
P
I
T
F
L
Site 70
T654
S
S
Y
D
K
P
I
T
F
L
S
L
K
L
R
Site 71
S714
G
G
E
N
N
L
K
S
H
S
R
T
N
S
G
Site 72
S716
E
N
N
L
K
S
H
S
R
T
N
S
G
I
S
Site 73
T718
N
L
K
S
H
S
R
T
N
S
G
I
S
S
A
Site 74
S720
K
S
H
S
R
T
N
S
G
I
S
S
A
S
G
Site 75
S723
S
R
T
N
S
G
I
S
S
A
S
G
G
S
T
Site 76
S724
R
T
N
S
G
I
S
S
A
S
G
G
S
T
E
Site 77
S729
I
S
S
A
S
G
G
S
T
E
P
T
T
P
D
Site 78
T730
S
S
A
S
G
G
S
T
E
P
T
T
P
D
S
Site 79
T733
S
G
G
S
T
E
P
T
T
P
D
S
E
R
P
Site 80
T734
G
G
S
T
E
P
T
T
P
D
S
E
R
P
A
Site 81
S737
T
E
P
T
T
P
D
S
E
R
P
A
Q
A
L
Site 82
Y748
A
Q
A
L
L
R
D
Y
A
L
N
T
D
S
A
Site 83
T767
I
R
S
I
H
L
V
T
Q
R
L
N
S
Q
W
Site 84
S772
L
V
T
Q
R
L
N
S
Q
W
R
Q
D
M
S
Site 85
S789
L
A
A
L
E
L
L
S
G
L
A
K
V
K
V
Site 86
S808
G
D
R
K
R
A
I
S
S
V
C
T
Y
I
V
Site 87
S809
D
R
K
R
A
I
S
S
V
C
T
Y
I
V
Y
Site 88
S819
T
Y
I
V
Y
Q
C
S
R
P
A
P
L
H
S
Site 89
S826
S
R
P
A
P
L
H
S
R
D
L
H
S
M
I
Site 90
S869
E
I
V
E
L
G
I
S
G
S
K
S
K
N
N
Site 91
S871
V
E
L
G
I
S
G
S
K
S
K
N
N
E
Q
Site 92
S873
L
G
I
S
G
S
K
S
K
N
N
E
Q
E
V
Site 93
S892
D
K
E
P
N
P
A
S
M
R
V
K
D
A
A
Site 94
S915
Q
L
L
G
A
F
P
S
P
S
G
P
A
S
P
Site 95
S917
L
G
A
F
P
S
P
S
G
P
A
S
P
C
S
Site 96
S921
P
S
P
S
G
P
A
S
P
C
S
L
V
N
E
Site 97
S924
S
G
P
A
S
P
C
S
L
V
N
E
T
T
L
Site 98
Y934
N
E
T
T
L
I
K
Y
S
R
L
P
T
I
N
Site 99
S935
E
T
T
L
I
K
Y
S
R
L
P
T
I
N
K
Site 100
T939
I
K
Y
S
R
L
P
T
I
N
K
H
S
F
R
Site 101
Y947
I
N
K
H
S
F
R
Y
F
V
L
D
N
S
V
Site 102
S973
E
Q
N
D
F
F
P
S
V
T
V
L
V
R
G
Site 103
Y1021
K
N
D
V
G
F
K
Y
S
V
K
H
R
P
F
Site 104
S1022
N
D
V
G
F
K
Y
S
V
K
H
R
P
F
P
Site 105
S1080
E
I
H
L
E
Q
Q
S
E
E
E
L
Q
K
R
Site 106
S1088
E
E
E
L
Q
K
R
S
F
P
D
P
V
T
D
Site 107
T1094
R
S
F
P
D
P
V
T
D
C
K
P
P
P
P
Site 108
T1107
P
P
A
Q
E
F
Q
T
A
R
L
F
L
S
H
Site 109
S1129
A
L
K
E
P
A
N
S
R
L
P
P
H
L
I
Site 110
Y1167
F
D
T
V
F
I
F
Y
M
K
P
G
Q
K
T
Site 111
S1184
E
I
L
K
N
V
E
S
S
R
T
V
Q
P
H
Site 112
T1187
K
N
V
E
S
S
R
T
V
Q
P
H
F
L
E
Site 113
S1230
C
C
D
D
G
E
G
S
Q
Q
E
V
I
S
S
Site 114
S1237
S
Q
Q
E
V
I
S
S
E
D
I
G
A
S
I
Site 115
Y1253
N
G
Q
K
K
V
L
Y
Y
A
D
A
L
T
E
Site 116
S1271
V
V
P
S
P
V
E
S
L
T
D
S
L
E
S
Site 117
T1273
P
S
P
V
E
S
L
T
D
S
L
E
S
N
I
Site 118
S1275
P
V
E
S
L
T
D
S
L
E
S
N
I
S
D
Site 119
S1281
D
S
L
E
S
N
I
S
D
Q
D
S
D
S
N
Site 120
S1285
S
N
I
S
D
Q
D
S
D
S
N
M
D
L
M
Site 121
S1287
I
S
D
Q
D
S
D
S
N
M
D
L
M
P
G
Site 122
T1302
I
L
K
Q
P
S
L
T
L
E
L
F
P
N
H
Site 123
T1310
L
E
L
F
P
N
H
T
D
N
L
N
S
S
Q
Site 124
S1315
N
H
T
D
N
L
N
S
S
Q
R
L
S
P
S
Site 125
S1316
H
T
D
N
L
N
S
S
Q
R
L
S
P
S
S
Site 126
S1320
L
N
S
S
Q
R
L
S
P
S
S
R
M
R
K
Site 127
S1322
S
S
Q
R
L
S
P
S
S
R
M
R
K
L
P
Site 128
S1323
S
Q
R
L
S
P
S
S
R
M
R
K
L
P
Q
Site 129
S1344
L
G
P
E
T
R
V
S
V
V
W
V
E
R
Y
Site 130
Y1351
S
V
V
W
V
E
R
Y
D
D
I
E
N
F
P
Site 131
S1360
D
I
E
N
F
P
L
S
E
L
M
T
E
I
S
Site 132
T1372
E
I
S
T
G
V
E
T
T
A
N
S
S
T
S
Site 133
T1373
I
S
T
G
V
E
T
T
A
N
S
S
T
S
L
Site 134
T1378
E
T
T
A
N
S
S
T
S
L
R
S
T
T
L
Site 135
S1379
T
T
A
N
S
S
T
S
L
R
S
T
T
L
E
Site 136
T1383
S
S
T
S
L
R
S
T
T
L
E
K
E
V
P
Site 137
T1384
S
T
S
L
R
S
T
T
L
E
K
E
V
P
V
Site 138
S1449
C
R
R
K
R
L
E
S
D
S
Y
S
P
P
H
Site 139
S1451
R
K
R
L
E
S
D
S
Y
S
P
P
H
V
R
Site 140
Y1452
K
R
L
E
S
D
S
Y
S
P
P
H
V
R
R
Site 141
S1453
R
L
E
S
D
S
Y
S
P
P
H
V
R
R
K
Site 142
T1464
V
R
R
K
Q
K
I
T
D
I
V
N
K
Y
R
Site 143
Y1470
I
T
D
I
V
N
K
Y
R
N
K
Q
L
E
P
Site 144
Y1480
K
Q
L
E
P
E
F
Y
T
S
L
F
Q
E
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation