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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MGC48595
Full Name:
HEAT repeat-containing protein 4
Alias:
HEAT repeat containing 4; HEAT4; LOC399671
Type:
Unknown function
Mass (Da):
111877
Number AA:
979
UniProt ID:
Q86WZ0
International Prot ID:
IPI00384508
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
Q
Y
R
L
H
R
K
S
Q
Y
L
K
M
A
A
Site 2
Y16
R
L
H
R
K
S
Q
Y
L
K
M
A
A
A
N
Site 3
S27
A
A
A
N
L
T
F
S
Q
E
V
V
W
Q
R
Site 4
S38
V
W
Q
R
G
L
P
S
I
P
Y
S
Q
Y
S
Site 5
Y41
R
G
L
P
S
I
P
Y
S
Q
Y
S
F
D
H
Site 6
S42
G
L
P
S
I
P
Y
S
Q
Y
S
F
D
H
L
Site 7
S45
S
I
P
Y
S
Q
Y
S
F
D
H
L
Y
N
T
Site 8
Y50
Q
Y
S
F
D
H
L
Y
N
T
N
D
I
I
H
Site 9
T58
N
T
N
D
I
I
H
T
P
Q
I
R
K
A
R
Site 10
S71
A
R
P
Q
K
P
V
S
F
K
F
L
G
S
S
Site 11
S77
V
S
F
K
F
L
G
S
S
S
P
L
T
G
D
Site 12
S78
S
F
K
F
L
G
S
S
S
P
L
T
G
D
T
Site 13
S79
F
K
F
L
G
S
S
S
P
L
T
G
D
T
S
Site 14
S86
S
P
L
T
G
D
T
S
L
A
V
K
T
E
S
Site 15
S104
P
E
K
K
L
K
K
S
K
P
A
S
T
V
R
Site 16
S108
L
K
K
S
K
P
A
S
T
V
R
E
A
P
R
Site 17
T109
K
K
S
K
P
A
S
T
V
R
E
A
P
R
P
Site 18
S133
D
M
L
G
R
P
P
S
L
D
V
N
L
E
E
Site 19
T158
E
A
R
A
W
E
A
T
V
L
E
K
L
N
E
Site 20
S173
R
T
A
R
W
I
Q
S
K
R
P
R
R
P
G
Site 21
S182
R
P
R
R
P
G
A
S
P
N
K
W
Q
S
F
Site 22
S188
A
S
P
N
K
W
Q
S
F
L
R
Q
Q
Y
D
Site 23
Y194
Q
S
F
L
R
Q
Q
Y
D
W
S
H
I
R
D
Site 24
T204
S
H
I
R
D
E
L
T
S
A
S
D
L
E
L
Site 25
S205
H
I
R
D
E
L
T
S
A
S
D
L
E
L
L
Site 26
S207
R
D
E
L
T
S
A
S
D
L
E
L
L
K
Q
Site 27
T220
K
Q
L
E
A
E
E
T
A
E
F
E
D
Q
S
Site 28
S227
T
A
E
F
E
D
Q
S
V
I
L
P
P
Q
E
Site 29
S250
P
V
Y
Y
R
L
P
S
Y
F
Q
Q
A
E
T
Site 30
Y251
V
Y
Y
R
L
P
S
Y
F
Q
Q
A
E
T
V
Site 31
T257
S
Y
F
Q
Q
A
E
T
V
E
I
M
P
G
N
Site 32
S266
E
I
M
P
G
N
K
S
T
E
D
I
H
E
K
Site 33
S277
I
H
E
K
T
S
L
S
Q
P
Q
T
Q
S
Y
Site 34
T281
T
S
L
S
Q
P
Q
T
Q
S
Y
F
R
Q
V
Site 35
Y284
S
Q
P
Q
T
Q
S
Y
F
R
Q
V
T
P
R
Site 36
T289
Q
S
Y
F
R
Q
V
T
P
R
A
G
K
F
A
Site 37
S298
R
A
G
K
F
A
Y
S
T
D
N
T
F
E
Q
Site 38
T299
A
G
K
F
A
Y
S
T
D
N
T
F
E
Q
E
Site 39
T302
F
A
Y
S
T
D
N
T
F
E
Q
E
I
Y
F
Site 40
Y308
N
T
F
E
Q
E
I
Y
F
D
E
V
Q
I
I
Site 41
S338
N
R
Y
N
K
Q
L
S
K
V
F
P
E
T
P
Site 42
T344
L
S
K
V
F
P
E
T
P
E
K
W
S
A
Q
Site 43
S357
A
Q
A
I
P
E
A
S
Y
R
P
V
Q
G
A
Site 44
T368
V
Q
G
A
L
R
W
T
A
L
P
T
P
A
K
Site 45
T390
E
K
D
V
P
I
K
T
R
R
L
K
K
Q
A
Site 46
S399
R
L
K
K
Q
A
K
S
L
Q
E
D
V
T
W
Site 47
T405
K
S
L
Q
E
D
V
T
W
E
L
V
V
L
R
Site 48
T432
I
I
E
W
H
H
E
T
V
E
N
L
L
Q
S
Site 49
S439
T
V
E
N
L
L
Q
S
L
G
D
L
H
D
D
Site 50
T467
L
E
R
P
R
I
A
T
S
Q
R
D
S
D
K
Site 51
S468
E
R
P
R
I
A
T
S
Q
R
D
S
D
K
T
Site 52
S472
I
A
T
S
Q
R
D
S
D
K
T
I
Q
D
L
Site 53
T475
S
Q
R
D
S
D
K
T
I
Q
D
L
P
E
V
Site 54
T522
L
A
R
N
I
M
Q
T
A
L
L
K
G
N
S
Site 55
T565
F
T
K
K
N
E
D
T
E
E
Q
S
Y
I
L
Site 56
Y570
E
D
T
E
E
Q
S
Y
I
L
L
S
Y
L
S
Site 57
S574
E
Q
S
Y
I
L
L
S
Y
L
S
E
K
T
T
Site 58
Y575
Q
S
Y
I
L
L
S
Y
L
S
E
K
T
T
L
Site 59
S645
A
Q
A
L
G
Q
M
S
L
G
K
E
V
H
D
Site 60
S663
V
K
L
G
Q
G
N
S
Q
E
R
V
E
A
L
Site 61
S692
P
S
F
L
H
C
F
S
D
D
F
T
A
V
R
Site 62
T696
H
C
F
S
D
D
F
T
A
V
R
R
A
A
C
Site 63
Y729
N
L
M
Q
R
D
P
Y
W
K
I
K
A
F
A
Site 64
S763
W
A
I
H
Y
E
E
S
P
G
V
R
L
E
A
Site 65
T831
E
I
K
N
R
I
K
T
L
S
Q
K
D
L
L
Site 66
S833
K
N
R
I
K
T
L
S
Q
K
D
L
L
T
H
Site 67
T839
L
S
Q
K
D
L
L
T
H
K
I
L
K
L
E
Site 68
Y860
R
E
E
A
K
R
V
Y
L
K
P
K
G
E
Q
Site 69
T871
K
G
E
Q
G
P
L
T
L
Q
T
L
L
Q
E
Site 70
T874
Q
G
P
L
T
L
Q
T
L
L
Q
E
T
F
Q
Site 71
S891
M
V
L
P
R
R
P
S
E
V
C
D
T
E
A
Site 72
T896
R
P
S
E
V
C
D
T
E
A
V
I
K
P
V
Site 73
S914
A
P
N
P
W
L
Q
S
S
V
P
G
L
T
T
Site 74
S915
P
N
P
W
L
Q
S
S
V
P
G
L
T
T
R
Site 75
T920
Q
S
S
V
P
G
L
T
T
R
S
K
V
R
S
Site 76
T921
S
S
V
P
G
L
T
T
R
S
K
V
R
S
S
Site 77
S923
V
P
G
L
T
T
R
S
K
V
R
S
S
L
V
Site 78
S927
T
T
R
S
K
V
R
S
S
L
V
K
D
L
R
Site 79
S928
T
R
S
K
V
R
S
S
L
V
K
D
L
R
T
Site 80
S936
L
V
K
D
L
R
T
S
P
E
K
R
I
A
V
Site 81
Y950
V
G
P
F
R
S
D
Y
P
A
L
Y
L
G
K
Site 82
Y954
R
S
D
Y
P
A
L
Y
L
G
K
F
S
E
R
Site 83
S959
A
L
Y
L
G
K
F
S
E
R
T
F
F
S
P
Site 84
T962
L
G
K
F
S
E
R
T
F
F
S
P
I
M
S
Site 85
S965
F
S
E
R
T
F
F
S
P
I
M
S
S
P
S
Site 86
S969
T
F
F
S
P
I
M
S
S
P
S
G
K
K
G
Site 87
S970
F
F
S
P
I
M
S
S
P
S
G
K
K
G
A
Site 88
S972
S
P
I
M
S
S
P
S
G
K
K
G
A
H
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation