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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMEM173
Full Name:
Transmembrane protein 173
Alias:
Endoplasmic reticulum interferon stimulator;Mediator of IRF3 activation;Stimulator of interferon genes protein
Type:
Mass (Da):
42193
Number AA:
379
UniProt ID:
Q86WV6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
P
H
S
S
L
H
P
S
I
P
C
P
R
G
H
Site 2
T43
L
G
E
P
P
E
H
T
L
R
Y
L
V
L
H
Site 3
Y46
P
P
E
H
T
L
R
Y
L
V
L
H
L
A
S
Site 4
Y81
H
S
R
Y
R
G
S
Y
W
R
T
V
R
A
C
Site 5
T181
E
L
Q
A
R
I
R
T
Y
N
Q
H
Y
N
N
Site 6
Y182
L
Q
A
R
I
R
T
Y
N
Q
H
Y
N
N
L
Site 7
S213
C
G
V
P
D
N
L
S
M
A
D
P
N
I
R
Site 8
Y240
A
G
I
K
D
R
V
Y
S
N
S
I
Y
E
L
Site 9
S241
G
I
K
D
R
V
Y
S
N
S
I
Y
E
L
L
Site 10
S243
K
D
R
V
Y
S
N
S
I
Y
E
L
L
E
N
Site 11
Y245
R
V
Y
S
N
S
I
Y
E
L
L
E
N
G
Q
Site 12
T256
E
N
G
Q
R
A
G
T
C
V
L
E
Y
A
T
Site 13
T267
E
Y
A
T
P
L
Q
T
L
F
A
M
S
Q
Y
Site 14
S275
L
F
A
M
S
Q
Y
S
Q
A
G
F
S
R
E
Site 15
S305
I
L
A
D
A
P
E
S
Q
N
N
C
R
L
I
Site 16
Y314
N
N
C
R
L
I
A
Y
Q
E
P
A
D
D
S
Site 17
S321
Y
Q
E
P
A
D
D
S
S
F
S
L
S
Q
E
Site 18
S322
Q
E
P
A
D
D
S
S
F
S
L
S
Q
E
V
Site 19
S324
P
A
D
D
S
S
F
S
L
S
Q
E
V
L
R
Site 20
S326
D
D
S
S
F
S
L
S
Q
E
V
L
R
H
L
Site 21
S345
K
E
E
V
T
V
G
S
L
K
T
S
A
V
P
Site 22
S349
T
V
G
S
L
K
T
S
A
V
P
S
T
S
T
Site 23
S353
L
K
T
S
A
V
P
S
T
S
T
M
S
Q
E
Site 24
T354
K
T
S
A
V
P
S
T
S
T
M
S
Q
E
P
Site 25
T356
S
A
V
P
S
T
S
T
M
S
Q
E
P
E
L
Site 26
S358
V
P
S
T
S
T
M
S
Q
E
P
E
L
L
I
Site 27
S366
Q
E
P
E
L
L
I
S
G
M
E
K
P
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation