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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NLRC5
Full Name:
Protein NLRC5
Alias:
Caterpiller protein 16.1;Nucleotide-binding oligomerization domain protein 27;Nucleotide-binding oligomerization domain protein 4
Type:
Mass (Da):
204595
Number AA:
1866
UniProt ID:
Q86WI3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
S
C
L
V
R
L
L
T
K
D
P
E
W
L
N
Site 2
T39
M
K
F
F
L
P
N
T
D
L
D
S
R
N
E
Site 3
S43
L
P
N
T
D
L
D
S
R
N
E
T
L
D
P
Site 4
T47
D
L
D
S
R
N
E
T
L
D
P
E
Q
R
V
Site 5
Y96
L
L
L
S
T
F
G
Y
D
D
G
F
T
S
Q
Site 6
T101
F
G
Y
D
D
G
F
T
S
Q
L
G
A
E
G
Site 7
S102
G
Y
D
D
G
F
T
S
Q
L
G
A
E
G
K
Site 8
S110
Q
L
G
A
E
G
K
S
Q
P
E
S
Q
L
H
Site 9
S114
E
G
K
S
Q
P
E
S
Q
L
H
H
G
L
K
Site 10
S126
G
L
K
R
P
H
Q
S
C
G
S
S
P
R
R
Site 11
S129
R
P
H
Q
S
C
G
S
S
P
R
R
K
Q
C
Site 12
S130
P
H
Q
S
C
G
S
S
P
R
R
K
Q
C
K
Site 13
S154
Y
L
Q
L
L
R
T
S
A
Q
Q
R
Y
R
S
Site 14
Y159
R
T
S
A
Q
Q
R
Y
R
S
Q
I
P
G
S
Site 15
S161
S
A
Q
Q
R
Y
R
S
Q
I
P
G
S
G
Q
Site 16
S166
Y
R
S
Q
I
P
G
S
G
Q
P
H
A
F
H
Site 17
Y176
P
H
A
F
H
Q
V
Y
V
P
P
I
L
R
R
Site 18
T185
P
P
I
L
R
R
A
T
A
S
L
D
T
P
E
Site 19
S187
I
L
R
R
A
T
A
S
L
D
T
P
E
G
A
Site 20
T190
R
A
T
A
S
L
D
T
P
E
G
A
I
M
G
Site 21
S208
V
E
D
G
A
D
V
S
I
S
D
L
F
N
T
Site 22
S210
D
G
A
D
V
S
I
S
D
L
F
N
T
R
V
Site 23
T215
S
I
S
D
L
F
N
T
R
V
N
K
G
P
R
Site 24
T236
K
A
G
M
G
K
T
T
L
A
H
R
L
C
Q
Site 25
Y281
S
E
L
L
F
D
L
Y
L
S
P
E
S
D
H
Site 26
S283
L
L
F
D
L
Y
L
S
P
E
S
D
H
D
T
Site 27
S286
D
L
Y
L
S
P
E
S
D
H
D
T
V
F
Q
Site 28
T290
S
P
E
S
D
H
D
T
V
F
Q
Y
L
E
K
Site 29
Y294
D
H
D
T
V
F
Q
Y
L
E
K
N
A
D
Q
Site 30
T345
P
G
C
R
V
M
A
T
S
R
P
G
K
L
P
Site 31
S346
G
C
R
V
M
A
T
S
R
P
G
K
L
P
A
Site 32
Y375
D
G
P
R
V
E
E
Y
V
N
H
F
F
S
A
Site 33
S381
E
Y
V
N
H
F
F
S
A
Q
P
S
R
E
G
Site 34
S385
H
F
F
S
A
Q
P
S
R
E
G
A
L
V
E
Site 35
T395
G
A
L
V
E
L
Q
T
N
G
R
L
R
S
L
Site 36
S455
P
P
G
H
L
P
T
S
S
L
L
D
L
G
E
Site 37
T508
T
G
P
G
H
Q
Q
T
G
Y
A
F
T
H
L
Site 38
Y510
P
G
H
Q
Q
T
G
Y
A
F
T
H
L
S
L
Site 39
S529
A
A
L
H
L
M
A
S
P
K
V
N
K
D
T
Site 40
T536
S
P
K
V
N
K
D
T
L
T
Q
Y
V
T
L
Site 41
T538
K
V
N
K
D
T
L
T
Q
Y
V
T
L
H
S
Site 42
Y540
N
K
D
T
L
T
Q
Y
V
T
L
H
S
R
W
Site 43
T542
D
T
L
T
Q
Y
V
T
L
H
S
R
W
V
Q
Site 44
T551
H
S
R
W
V
Q
R
T
K
A
R
L
G
L
S
Site 45
S558
T
K
A
R
L
G
L
S
D
H
L
P
T
F
L
Site 46
T608
K
L
A
T
R
K
L
T
G
P
K
V
V
E
L
Site 47
T622
L
C
H
C
V
D
E
T
Q
E
P
E
L
A
S
Site 48
S629
T
Q
E
P
E
L
A
S
L
T
A
Q
S
L
P
Site 49
T631
E
P
E
L
A
S
L
T
A
Q
S
L
P
Y
Q
Site 50
Y637
L
T
A
Q
S
L
P
Y
Q
L
P
F
H
N
F
Site 51
S692
C
G
Q
I
E
N
L
S
F
K
S
R
K
C
G
Site 52
S707
D
A
F
A
E
A
L
S
R
S
L
P
T
M
G
Site 53
S748
C
P
Q
L
K
E
V
S
F
R
D
N
Q
L
S
Site 54
S755
S
F
R
D
N
Q
L
S
D
Q
V
V
L
N
I
Site 55
S778
R
L
R
K
L
D
L
S
S
N
S
I
C
V
S
Site 56
S779
L
R
K
L
D
L
S
S
N
S
I
C
V
S
T
Site 57
S833
R
A
P
D
L
Q
E
S
D
G
Q
R
K
G
A
Site 58
S842
G
Q
R
K
G
A
Q
S
R
S
L
T
L
R
L
Site 59
S844
R
K
G
A
Q
S
R
S
L
T
L
R
L
Q
K
Site 60
T846
G
A
Q
S
R
S
L
T
L
R
L
Q
K
C
Q
Site 61
S878
H
L
E
E
V
D
L
S
G
N
Q
L
E
D
E
Site 62
S923
H
C
V
L
R
A
V
S
A
C
W
T
L
A
E
Site 63
S970
S
L
M
L
Q
M
P
S
E
L
P
L
S
S
R
Site 64
S975
M
P
S
E
L
P
L
S
S
R
R
M
R
L
T
Site 65
S976
P
S
E
L
P
L
S
S
R
R
M
R
L
T
H
Site 66
T982
S
S
R
R
M
R
L
T
H
C
G
L
Q
E
K
Site 67
S1012
G
H
L
H
L
D
F
S
G
N
A
L
G
D
E
Site 68
S1036
P
G
L
G
A
L
Q
S
L
N
L
S
E
N
G
Site 69
S1040
A
L
Q
S
L
N
L
S
E
N
G
L
S
L
D
Site 70
S1071
R
L
D
I
S
F
E
S
Q
H
I
L
L
R
G
Site 71
T1081
I
L
L
R
G
D
K
T
S
R
D
M
W
A
T
Site 72
S1082
L
L
R
G
D
K
T
S
R
D
M
W
A
T
G
Site 73
T1088
T
S
R
D
M
W
A
T
G
S
L
P
D
F
P
Site 74
S1090
R
D
M
W
A
T
G
S
L
P
D
F
P
A
A
Site 75
S1111
R
Q
R
C
I
P
R
S
L
C
L
S
E
C
P
Site 76
S1115
I
P
R
S
L
C
L
S
E
C
P
L
E
P
P
Site 77
S1123
E
C
P
L
E
P
P
S
L
T
R
L
C
A
T
Site 78
T1130
S
L
T
R
L
C
A
T
L
K
D
C
P
G
P
Site 79
S1143
G
P
L
E
L
Q
L
S
C
E
F
L
S
D
Q
Site 80
S1148
Q
L
S
C
E
F
L
S
D
Q
S
L
E
T
L
Site 81
S1171
Q
L
S
L
L
Q
L
S
Q
T
G
L
S
P
K
Site 82
T1173
S
L
L
Q
L
S
Q
T
G
L
S
P
K
S
P
Site 83
S1176
Q
L
S
Q
T
G
L
S
P
K
S
P
F
L
L
Site 84
S1179
Q
T
G
L
S
P
K
S
P
F
L
L
A
N
T
Site 85
S1200
V
K
K
V
D
L
R
S
L
H
H
A
T
L
H
Site 86
S1226
C
G
R
F
T
G
C
S
L
S
Q
E
H
V
E
Site 87
S1228
R
F
T
G
C
S
L
S
Q
E
H
V
E
S
L
Site 88
S1234
L
S
Q
E
H
V
E
S
L
C
W
L
L
S
K
Site 89
S1240
E
S
L
C
W
L
L
S
K
C
K
D
L
S
Q
Site 90
S1246
L
S
K
C
K
D
L
S
Q
V
D
L
S
A
N
Site 91
S1251
D
L
S
Q
V
D
L
S
A
N
L
L
G
D
S
Site 92
S1279
I
S
G
L
L
D
L
S
H
N
S
I
S
Q
E
Site 93
S1282
L
L
D
L
S
H
N
S
I
S
Q
E
S
A
L
Site 94
S1284
D
L
S
H
N
S
I
S
Q
E
S
A
L
Y
L
Site 95
S1297
Y
L
L
E
T
L
P
S
C
P
R
V
R
E
A
Site 96
S1305
C
P
R
V
R
E
A
S
V
N
L
G
S
E
Q
Site 97
S1310
E
A
S
V
N
L
G
S
E
Q
S
F
R
I
H
Site 98
S1313
V
N
L
G
S
E
Q
S
F
R
I
H
F
S
R
Site 99
T1327
R
E
D
Q
A
G
K
T
L
R
L
S
E
C
S
Site 100
S1331
A
G
K
T
L
R
L
S
E
C
S
F
R
P
E
Site 101
S1334
T
L
R
L
S
E
C
S
F
R
P
E
H
V
S
Site 102
S1341
S
F
R
P
E
H
V
S
R
L
A
T
G
L
S
Site 103
T1345
E
H
V
S
R
L
A
T
G
L
S
K
S
L
Q
Site 104
S1348
S
R
L
A
T
G
L
S
K
S
L
Q
L
T
E
Site 105
T1359
Q
L
T
E
L
T
L
T
Q
C
C
L
G
Q
K
Site 106
S1383
G
R
P
A
G
L
F
S
L
R
V
Q
E
P
W
Site 107
T1411
A
Q
A
S
G
S
V
T
E
I
S
I
S
E
T
Site 108
S1414
S
G
S
V
T
E
I
S
I
S
E
T
Q
Q
Q
Site 109
S1416
S
V
T
E
I
S
I
S
E
T
Q
Q
Q
L
C
Site 110
T1418
T
E
I
S
I
S
E
T
Q
Q
Q
L
C
V
Q
Site 111
S1471
R
L
Q
Q
L
S
L
S
Q
V
N
L
C
E
D
Site 112
T1502
E
L
K
T
F
R
L
T
S
S
C
V
S
T
E
Site 113
S1503
L
K
T
F
R
L
T
S
S
C
V
S
T
E
G
Site 114
S1504
K
T
F
R
L
T
S
S
C
V
S
T
E
G
L
Site 115
S1516
E
G
L
A
H
L
A
S
G
L
G
H
C
H
H
Site 116
S1530
H
L
E
E
L
D
L
S
N
N
Q
F
D
E
E
Site 117
T1578
T
H
R
L
S
Q
M
T
C
L
Q
S
L
R
L
Site 118
S1582
S
Q
M
T
C
L
Q
S
L
R
L
N
R
N
S
Site 119
S1589
S
L
R
L
N
R
N
S
I
G
D
V
G
C
C
Site 120
T1606
S
E
A
L
R
A
A
T
S
L
E
E
L
D
L
Site 121
S1607
E
A
L
R
A
A
T
S
L
E
E
L
D
L
S
Site 122
S1614
S
L
E
E
L
D
L
S
H
N
Q
I
G
D
A
Site 123
S1642
E
L
R
K
I
D
L
S
G
N
S
I
S
S
A
Site 124
S1645
K
I
D
L
S
G
N
S
I
S
S
A
G
G
V
Site 125
S1647
D
L
S
G
N
S
I
S
S
A
G
G
V
Q
L
Site 126
S1715
L
A
Q
A
L
D
G
S
P
H
L
E
E
I
S
Site 127
S1722
S
P
H
L
E
E
I
S
L
A
E
N
N
L
A
Site 128
T1756
S
C
K
I
D
N
Q
T
A
K
L
L
T
S
S
Site 129
S1846
D
M
A
Q
H
L
K
S
Q
E
P
R
L
D
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation