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Updated November 2019
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Protein Info
Short Name:
MTMR13
Full Name:
Myotubularin-related protein 13
Alias:
CMT4B2; KIAA1766; MTMRD; SBF2; SET-binding factor 2
Type:
Protein phosphatase, Myotubularin related
Mass (Da):
208464
Number AA:
1849
UniProt ID:
Q86WG5
International Prot ID:
IPI00654703
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005774
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0016791
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016311
GO:0042552
GO:0006796
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
D
Y
F
I
V
V
G
Y
D
H
E
K
P
G
S
Site 2
S20
Y
D
H
E
K
P
G
S
G
E
G
L
G
K
I
Site 3
T39
P
Q
K
D
W
D
D
T
P
F
P
Q
G
I
E
Site 4
S57
Q
P
G
G
W
Q
L
S
R
E
R
K
Q
P
T
Site 5
T64
S
R
E
R
K
Q
P
T
F
F
V
V
V
L
T
Site 6
Y79
D
I
D
S
D
R
H
Y
C
S
C
L
T
F
Y
Site 7
S107
I
E
G
E
A
K
V
S
G
L
I
Q
P
A
E
Site 8
S175
G
G
S
Q
K
L
F
S
L
G
A
G
D
R
Q
Site 9
T186
G
D
R
Q
L
I
Q
T
P
L
H
D
S
L
P
Site 10
S191
I
Q
T
P
L
H
D
S
L
P
I
T
G
T
S
Site 11
S228
E
N
K
V
L
F
H
S
A
S
F
Q
R
L
S
Site 12
S230
K
V
L
F
H
S
A
S
F
Q
R
L
S
D
A
Site 13
S235
S
A
S
F
Q
R
L
S
D
A
C
R
A
L
E
Site 14
Y254
P
L
K
Y
S
Y
P
Y
I
P
I
L
P
A
Q
Site 15
T282
G
V
H
S
V
F
K
T
D
V
H
E
L
L
D
Site 16
T343
H
A
F
P
P
P
R
T
A
L
S
H
S
K
M
Site 17
S346
P
P
P
R
T
A
L
S
H
S
K
M
L
D
K
Site 18
T390
P
V
I
H
F
H
K
T
A
F
L
G
Q
R
G
Site 19
S418
M
A
F
A
G
F
V
S
E
R
G
P
P
Y
R
Site 20
Y424
V
S
E
R
G
P
P
Y
R
S
C
D
L
F
D
Site 21
T481
F
Q
K
V
P
R
P
T
E
G
S
H
L
R
V
Site 22
S484
V
P
R
P
T
E
G
S
H
L
R
V
H
I
L
Site 23
T542
S
I
M
D
K
V
T
T
V
F
N
S
A
Q
R
Site 24
T568
F
E
N
K
I
L
E
T
E
K
T
L
P
A
A
Site 25
T571
K
I
L
E
T
E
K
T
L
P
A
A
L
R
A
Site 26
T589
K
A
A
R
Q
C
L
T
D
E
L
G
L
H
V
Site 27
S624
C
T
L
Q
D
C
S
S
L
E
E
Y
N
I
A
Site 28
Y654
P
G
V
S
Q
F
A
Y
T
C
V
Q
D
H
P
Site 29
Y674
Q
F
W
E
T
T
F
Y
N
A
V
Q
E
Q
V
Site 30
S683
A
V
Q
E
Q
V
R
S
L
Y
L
S
A
K
E
Site 31
Y685
Q
E
Q
V
R
S
L
Y
L
S
A
K
E
D
N
Site 32
S687
Q
V
R
S
L
Y
L
S
A
K
E
D
N
H
A
Site 33
Y708
D
K
L
P
D
D
H
Y
Q
E
K
T
A
M
D
Site 34
T726
E
Q
L
R
L
W
P
T
L
S
K
S
T
Q
Q
Site 35
S728
L
R
L
W
P
T
L
S
K
S
T
Q
Q
E
L
Site 36
S730
L
W
P
T
L
S
K
S
T
Q
Q
E
L
V
Q
Site 37
S741
E
L
V
Q
H
E
E
S
T
V
F
S
Q
A
I
Site 38
S745
H
E
E
S
T
V
F
S
Q
A
I
H
F
A
N
Site 39
T763
N
L
L
V
P
L
D
T
S
K
N
K
L
L
R
Site 40
S764
L
L
V
P
L
D
T
S
K
N
K
L
L
R
T
Site 41
T771
S
K
N
K
L
L
R
T
S
A
P
G
D
W
E
Site 42
S772
K
N
K
L
L
R
T
S
A
P
G
D
W
E
S
Site 43
S779
S
A
P
G
D
W
E
S
G
S
N
S
I
V
T
Site 44
S781
P
G
D
W
E
S
G
S
N
S
I
V
T
N
S
Site 45
S783
D
W
E
S
G
S
N
S
I
V
T
N
S
I
A
Site 46
S792
V
T
N
S
I
A
G
S
V
A
E
S
Y
D
T
Site 47
S796
I
A
G
S
V
A
E
S
Y
D
T
E
S
G
F
Site 48
Y797
A
G
S
V
A
E
S
Y
D
T
E
S
G
F
E
Site 49
T799
S
V
A
E
S
Y
D
T
E
S
G
F
E
D
S
Site 50
S801
A
E
S
Y
D
T
E
S
G
F
E
D
S
E
N
Site 51
S806
T
E
S
G
F
E
D
S
E
N
T
D
I
A
N
Site 52
S814
E
N
T
D
I
A
N
S
V
V
R
F
I
T
R
Site 53
T828
R
F
I
D
K
V
C
T
E
S
G
V
T
Q
D
Site 54
T833
V
C
T
E
S
G
V
T
Q
D
H
I
K
S
L
Site 55
S862
L
E
A
V
H
R
E
S
R
R
L
P
P
I
Q
Site 56
T930
Y
R
I
L
F
R
G
T
P
H
D
Q
L
V
G
Site 57
S949
V
R
S
F
P
I
A
S
I
T
K
E
K
K
I
Site 58
T951
S
F
P
I
A
S
I
T
K
E
K
K
I
T
M
Site 59
T957
I
T
K
E
K
K
I
T
M
Q
N
Q
L
Q
Q
Site 60
Y1005
K
Q
L
M
K
F
R
Y
P
Q
S
I
F
S
T
Site 61
S1035
K
Q
K
E
K
N
T
S
F
R
T
F
S
K
T
Site 62
T1038
E
K
N
T
S
F
R
T
F
S
K
T
I
V
K
Site 63
S1040
N
T
S
F
R
T
F
S
K
T
I
V
K
G
A
Site 64
T1042
S
F
R
T
F
S
K
T
I
V
K
G
A
K
R
Site 65
T1054
A
K
R
A
G
K
M
T
I
G
R
Q
Y
L
L
Site 66
Y1059
K
M
T
I
G
R
Q
Y
L
L
K
K
K
T
G
Site 67
S1085
W
N
E
D
D
D
V
S
V
S
D
E
S
E
L
Site 68
S1087
E
D
D
D
V
S
V
S
D
E
S
E
L
P
T
Site 69
S1090
D
V
S
V
S
D
E
S
E
L
P
T
S
T
T
Site 70
T1094
S
D
E
S
E
L
P
T
S
T
T
L
K
A
S
Site 71
S1095
D
E
S
E
L
P
T
S
T
T
L
K
A
S
E
Site 72
T1097
S
E
L
P
T
S
T
T
L
K
A
S
E
K
S
Site 73
T1105
L
K
A
S
E
K
S
T
M
E
Q
L
V
E
K
Site 74
Y1118
E
K
A
C
F
R
D
Y
Q
R
L
G
L
G
T
Site 75
T1125
Y
Q
R
L
G
L
G
T
I
S
G
S
S
S
R
Site 76
S1127
R
L
G
L
G
T
I
S
G
S
S
S
R
S
R
Site 77
S1129
G
L
G
T
I
S
G
S
S
S
R
S
R
P
E
Site 78
S1130
L
G
T
I
S
G
S
S
S
R
S
R
P
E
Y
Site 79
S1131
G
T
I
S
G
S
S
S
R
S
R
P
E
Y
F
Site 80
S1133
I
S
G
S
S
S
R
S
R
P
E
Y
F
R
I
Site 81
Y1137
S
S
R
S
R
P
E
Y
F
R
I
T
A
S
N
Site 82
T1141
R
P
E
Y
F
R
I
T
A
S
N
R
M
Y
S
Site 83
Y1147
I
T
A
S
N
R
M
Y
S
L
C
R
S
Y
P
Site 84
S1148
T
A
S
N
R
M
Y
S
L
C
R
S
Y
P
G
Site 85
S1166
V
P
Q
A
V
Q
D
S
S
L
P
R
V
A
R
Site 86
S1167
P
Q
A
V
Q
D
S
S
L
P
R
V
A
R
C
Site 87
Y1175
L
P
R
V
A
R
C
Y
R
H
N
R
L
P
V
Site 88
T1192
W
K
N
S
R
S
G
T
L
L
L
R
S
G
G
Site 89
S1197
S
G
T
L
L
L
R
S
G
G
F
H
G
K
G
Site 90
S1211
G
V
V
G
L
F
K
S
Q
N
S
P
Q
A
A
Site 91
S1214
G
L
F
K
S
Q
N
S
P
Q
A
A
P
T
S
Site 92
T1220
N
S
P
Q
A
A
P
T
S
S
L
E
S
S
S
Site 93
S1221
S
P
Q
A
A
P
T
S
S
L
E
S
S
S
S
Site 94
S1222
P
Q
A
A
P
T
S
S
L
E
S
S
S
S
I
Site 95
S1225
A
P
T
S
S
L
E
S
S
S
S
I
E
Q
E
Site 96
S1226
P
T
S
S
L
E
S
S
S
S
I
E
Q
E
K
Site 97
S1228
S
S
L
E
S
S
S
S
I
E
Q
E
K
Y
L
Site 98
Y1234
S
S
I
E
Q
E
K
Y
L
Q
A
L
L
N
A
Site 99
S1243
Q
A
L
L
N
A
V
S
V
H
Q
K
L
R
G
Site 100
S1252
H
Q
K
L
R
G
N
S
T
L
T
V
R
P
A
Site 101
T1253
Q
K
L
R
G
N
S
T
L
T
V
R
P
A
F
Site 102
S1263
V
R
P
A
F
A
L
S
P
G
V
W
A
S
L
Site 103
S1269
L
S
P
G
V
W
A
S
L
R
S
S
T
R
L
Site 104
S1272
G
V
W
A
S
L
R
S
S
T
R
L
I
S
S
Site 105
S1273
V
W
A
S
L
R
S
S
T
R
L
I
S
S
P
Site 106
T1274
W
A
S
L
R
S
S
T
R
L
I
S
S
P
T
Site 107
S1278
R
S
S
T
R
L
I
S
S
P
T
S
F
I
D
Site 108
S1296
R
L
A
G
K
D
H
S
A
S
F
S
N
S
S
Site 109
S1298
A
G
K
D
H
S
A
S
F
S
N
S
S
Y
L
Site 110
S1300
K
D
H
S
A
S
F
S
N
S
S
Y
L
Q
N
Site 111
S1302
H
S
A
S
F
S
N
S
S
Y
L
Q
N
Q
L
Site 112
Y1304
A
S
F
S
N
S
S
Y
L
Q
N
Q
L
L
K
Site 113
Y1317
L
K
R
Q
A
A
L
Y
I
F
G
E
K
S
Q
Site 114
S1323
L
Y
I
F
G
E
K
S
Q
L
R
N
F
K
V
Site 115
S1352
E
I
R
Q
V
K
A
S
F
K
K
L
M
R
A
Site 116
S1363
L
M
R
A
C
I
P
S
T
I
P
T
D
S
E
Site 117
T1364
M
R
A
C
I
P
S
T
I
P
T
D
S
E
V
Site 118
S1369
P
S
T
I
P
T
D
S
E
V
T
F
L
K
A
Site 119
Y1432
Q
L
L
S
D
P
F
Y
R
T
L
E
G
F
Q
Site 120
T1434
L
S
D
P
F
Y
R
T
L
E
G
F
Q
M
L
Site 121
S1448
L
V
E
K
E
W
L
S
F
G
H
K
F
S
Q
Site 122
S1454
L
S
F
G
H
K
F
S
Q
R
S
S
L
T
L
Site 123
S1458
H
K
F
S
Q
R
S
S
L
T
L
N
C
Q
G
Site 124
T1460
F
S
Q
R
S
S
L
T
L
N
C
Q
G
S
G
Site 125
Y1486
V
H
Q
V
H
N
Q
Y
P
T
E
F
E
F
N
Site 126
Y1504
L
K
F
L
A
F
H
Y
V
S
N
R
F
K
T
Site 127
T1511
Y
V
S
N
R
F
K
T
F
L
L
D
S
D
Y
Site 128
S1516
F
K
T
F
L
L
D
S
D
Y
E
R
L
E
H
Site 129
Y1518
T
F
L
L
D
S
D
Y
E
R
L
E
H
G
T
Site 130
T1525
Y
E
R
L
E
H
G
T
L
F
D
D
K
G
E
Site 131
Y1582
S
S
L
K
K
W
D
Y
Y
I
E
E
T
L
S
Site 132
Y1583
S
L
K
K
W
D
Y
Y
I
E
E
T
L
S
T
Site 133
T1587
W
D
Y
Y
I
E
E
T
L
S
T
G
P
S
Y
Site 134
S1589
Y
Y
I
E
E
T
L
S
T
G
P
S
Y
D
W
Site 135
T1590
Y
I
E
E
T
L
S
T
G
P
S
Y
D
W
M
Site 136
S1593
E
T
L
S
T
G
P
S
Y
D
W
M
M
L
T
Site 137
Y1594
T
L
S
T
G
P
S
Y
D
W
M
M
L
T
P
Site 138
S1606
L
T
P
K
H
F
P
S
E
D
S
D
L
A
G
Site 139
S1609
K
H
F
P
S
E
D
S
D
L
A
G
E
A
G
Site 140
S1619
A
G
E
A
G
P
R
S
Q
R
R
T
V
W
P
Site 141
T1623
G
P
R
S
Q
R
R
T
V
W
P
C
Y
D
D
Site 142
Y1628
R
R
T
V
W
P
C
Y
D
D
V
S
C
T
Q
Site 143
T1640
C
T
Q
P
D
A
L
T
S
L
F
S
E
I
E
Site 144
S1641
T
Q
P
D
A
L
T
S
L
F
S
E
I
E
K
Site 145
S1644
D
A
L
T
S
L
F
S
E
I
E
K
L
E
H
Site 146
T1668
Q
Q
L
W
E
R
V
T
V
D
L
K
E
E
P
Site 147
T1677
D
L
K
E
E
P
R
T
D
R
S
Q
R
H
L
Site 148
S1680
E
E
P
R
T
D
R
S
Q
R
H
L
S
R
S
Site 149
S1685
D
R
S
Q
R
H
L
S
R
S
P
G
I
V
S
Site 150
S1687
S
Q
R
H
L
S
R
S
P
G
I
V
S
T
N
Site 151
S1692
S
R
S
P
G
I
V
S
T
N
L
P
S
Y
Q
Site 152
T1693
R
S
P
G
I
V
S
T
N
L
P
S
Y
Q
K
Site 153
S1697
I
V
S
T
N
L
P
S
Y
Q
K
R
S
L
L
Site 154
Y1698
V
S
T
N
L
P
S
Y
Q
K
R
S
L
L
H
Site 155
S1702
L
P
S
Y
Q
K
R
S
L
L
H
L
P
D
S
Site 156
S1709
S
L
L
H
L
P
D
S
S
M
G
E
E
Q
N
Site 157
S1710
L
L
H
L
P
D
S
S
M
G
E
E
Q
N
S
Site 158
S1717
S
M
G
E
E
Q
N
S
S
I
S
P
S
N
G
Site 159
S1718
M
G
E
E
Q
N
S
S
I
S
P
S
N
G
V
Site 160
S1720
E
E
Q
N
S
S
I
S
P
S
N
G
V
E
R
Site 161
S1722
Q
N
S
S
I
S
P
S
N
G
V
E
R
R
A
Site 162
T1731
G
V
E
R
R
A
A
T
L
Y
S
Q
Y
T
S
Site 163
Y1733
E
R
R
A
A
T
L
Y
S
Q
Y
T
S
K
N
Site 164
S1734
R
R
A
A
T
L
Y
S
Q
Y
T
S
K
N
D
Site 165
Y1736
A
A
T
L
Y
S
Q
Y
T
S
K
N
D
E
N
Site 166
S1738
T
L
Y
S
Q
Y
T
S
K
N
D
E
N
R
S
Site 167
S1745
S
K
N
D
E
N
R
S
F
E
G
T
L
Y
K
Site 168
T1749
E
N
R
S
F
E
G
T
L
Y
K
R
G
A
L
Site 169
Y1751
R
S
F
E
G
T
L
Y
K
R
G
A
L
L
K
Site 170
Y1777
T
K
H
Q
L
R
Y
Y
D
S
G
E
D
T
S
Site 171
S1779
H
Q
L
R
Y
Y
D
S
G
E
D
T
S
C
K
Site 172
T1783
Y
Y
D
S
G
E
D
T
S
C
K
G
H
I
D
Site 173
S1784
Y
D
S
G
E
D
T
S
C
K
G
H
I
D
L
Site 174
T1820
K
A
F
F
D
L
K
T
S
K
R
V
Y
N
F
Site 175
Y1825
L
K
T
S
K
R
V
Y
N
F
C
A
Q
D
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation