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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPFIBP1
Full Name:
Liprin-beta-1
Alias:
HSGT2; KIAA1230; L2; LIPB1; Liprin beta 1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein binding protein 1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1; PTPRF interacting protein, binding protein 1; PTPRF-interacting protein binding protein 1; PTPRF-interacting protein-binding protein 1; SGT2
Type:
Adapter/scaffold protein
Mass (Da):
114024
Number AA:
1011
UniProt ID:
Q86W92
International Prot ID:
IPI00397366
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y28
A
G
S
K
A
L
E
Y
S
N
G
I
F
D
C
Site 2
S29
G
S
K
A
L
E
Y
S
N
G
I
F
D
C
Q
Site 3
S37
N
G
I
F
D
C
Q
S
P
T
S
P
F
M
G
Site 4
T39
I
F
D
C
Q
S
P
T
S
P
F
M
G
S
L
Site 5
S40
F
D
C
Q
S
P
T
S
P
F
M
G
S
L
R
Site 6
T64
G
L
L
E
M
M
E
T
D
E
K
E
G
L
R
Site 7
S77
L
R
C
Q
I
P
D
S
T
A
E
T
L
V
E
Site 8
T78
R
C
Q
I
P
D
S
T
A
E
T
L
V
E
W
Site 9
T81
I
P
D
S
T
A
E
T
L
V
E
W
L
Q
S
Site 10
Y102
L
P
G
N
G
D
V
Y
Q
E
R
L
A
R
L
Site 11
S115
R
L
E
N
D
K
E
S
L
V
L
Q
V
S
V
Site 12
S161
M
L
Q
Q
E
L
L
S
R
T
S
L
E
T
Q
Site 13
T163
Q
Q
E
L
L
S
R
T
S
L
E
T
Q
K
L
Site 14
S164
Q
E
L
L
S
R
T
S
L
E
T
Q
K
L
D
Site 15
T167
L
S
R
T
S
L
E
T
Q
K
L
D
L
M
A
Site 16
T184
S
N
L
K
L
K
L
T
A
V
E
K
D
R
L
Site 17
Y193
V
E
K
D
R
L
D
Y
E
D
K
F
R
D
T
Site 18
T200
Y
E
D
K
F
R
D
T
E
G
L
I
Q
E
I
Site 19
S215
N
D
L
R
L
K
V
S
E
M
D
S
E
R
L
Site 20
S219
L
K
V
S
E
M
D
S
E
R
L
Q
Y
E
K
Site 21
Y224
M
D
S
E
R
L
Q
Y
E
K
K
L
K
S
T
Site 22
S230
Q
Y
E
K
K
L
K
S
T
K
S
L
M
A
K
Site 23
S233
K
K
L
K
S
T
K
S
L
M
A
K
L
S
S
Site 24
Y250
I
K
V
G
Q
M
Q
Y
E
K
Q
R
M
E
Q
Site 25
S261
R
M
E
Q
K
W
E
S
L
K
D
E
L
A
S
Site 26
S268
S
L
K
D
E
L
A
S
L
K
E
Q
L
E
E
Site 27
S278
E
Q
L
E
E
K
E
S
E
V
K
R
L
Q
E
Site 28
T342
R
Y
K
K
M
Q
D
T
V
V
L
A
Q
G
K
Site 29
Y353
A
Q
G
K
D
G
E
Y
E
E
L
L
N
S
S
Site 30
S359
E
Y
E
E
L
L
N
S
S
S
I
S
S
L
L
Site 31
S360
Y
E
E
L
L
N
S
S
S
I
S
S
L
L
D
Site 32
S361
E
E
L
L
N
S
S
S
I
S
S
L
L
D
A
Site 33
S372
L
L
D
A
Q
G
F
S
D
L
E
K
S
P
S
Site 34
S377
G
F
S
D
L
E
K
S
P
S
P
T
P
V
M
Site 35
S379
S
D
L
E
K
S
P
S
P
T
P
V
M
G
S
Site 36
T381
L
E
K
S
P
S
P
T
P
V
M
G
S
P
S
Site 37
S386
S
P
T
P
V
M
G
S
P
S
C
D
P
F
N
Site 38
S388
T
P
V
M
G
S
P
S
C
D
P
F
N
T
S
Site 39
T394
P
S
C
D
P
F
N
T
S
V
P
E
E
F
H
Site 40
S395
S
C
D
P
F
N
T
S
V
P
E
E
F
H
T
Site 41
S418
S
L
L
P
A
T
V
S
M
E
T
S
E
K
S
Site 42
S422
A
T
V
S
M
E
T
S
E
K
S
K
L
T
P
Site 43
T428
T
S
E
K
S
K
L
T
P
K
P
E
T
S
F
Site 44
T433
K
L
T
P
K
P
E
T
S
F
E
E
N
D
G
Site 45
S434
L
T
P
K
P
E
T
S
F
E
E
N
D
G
N
Site 46
S459
L
C
D
K
L
L
T
S
S
L
Q
K
S
S
S
Site 47
S460
C
D
K
L
L
T
S
S
L
Q
K
S
S
S
L
Site 48
S464
L
T
S
S
L
Q
K
S
S
S
L
G
N
L
K
Site 49
S465
T
S
S
L
Q
K
S
S
S
L
G
N
L
K
K
Site 50
S466
S
S
L
Q
K
S
S
S
L
G
N
L
K
K
E
Site 51
S475
G
N
L
K
K
E
T
S
D
G
E
K
E
T
I
Site 52
S494
E
D
R
A
P
A
E
S
R
P
F
G
T
L
P
Site 53
T499
A
E
S
R
P
F
G
T
L
P
P
R
P
P
G
Site 54
T509
P
R
P
P
G
Q
D
T
S
M
D
D
N
P
F
Site 55
S510
R
P
P
G
Q
D
T
S
M
D
D
N
P
F
G
Site 56
T518
M
D
D
N
P
F
G
T
R
K
V
R
S
S
F
Site 57
S523
F
G
T
R
K
V
R
S
S
F
G
R
G
F
F
Site 58
S524
G
T
R
K
V
R
S
S
F
G
R
G
F
F
K
Site 59
S534
R
G
F
F
K
I
K
S
N
K
R
T
A
S
A
Site 60
T538
K
I
K
S
N
K
R
T
A
S
A
P
N
L
A
Site 61
S540
K
S
N
K
R
T
A
S
A
P
N
L
A
E
T
Site 62
S561
H
L
D
L
A
G
A
S
S
R
P
K
D
S
Q
Site 63
S562
L
D
L
A
G
A
S
S
R
P
K
D
S
Q
R
Site 64
S567
A
S
S
R
P
K
D
S
Q
R
N
S
P
F
Q
Site 65
S571
P
K
D
S
Q
R
N
S
P
F
Q
I
P
P
P
Site 66
S579
P
F
Q
I
P
P
P
S
P
D
S
K
K
K
S
Site 67
S582
I
P
P
P
S
P
D
S
K
K
K
S
R
G
I
Site 68
S586
S
P
D
S
K
K
K
S
R
G
I
M
K
L
F
Site 69
S599
L
F
G
K
L
R
R
S
Q
S
T
T
F
N
P
Site 70
S601
G
K
L
R
R
S
Q
S
T
T
F
N
P
D
D
Site 71
T602
K
L
R
R
S
Q
S
T
T
F
N
P
D
D
M
Site 72
T603
L
R
R
S
Q
S
T
T
F
N
P
D
D
M
S
Site 73
S610
T
F
N
P
D
D
M
S
E
P
E
F
K
R
G
Site 74
T619
P
E
F
K
R
G
G
T
R
A
T
A
G
P
R
Site 75
T622
K
R
G
G
T
R
A
T
A
G
P
R
L
G
W
Site 76
S630
A
G
P
R
L
G
W
S
R
D
L
G
Q
S
N
Site 77
S636
W
S
R
D
L
G
Q
S
N
S
D
L
D
M
P
Site 78
S638
R
D
L
G
Q
S
N
S
D
L
D
M
P
F
A
Site 79
S663
L
M
E
Q
G
L
G
S
Y
L
N
S
G
K
H
Site 80
Y664
M
E
Q
G
L
G
S
Y
L
N
S
G
K
H
W
Site 81
S667
G
L
G
S
Y
L
N
S
G
K
H
W
I
A
S
Site 82
S695
K
E
L
G
I
K
H
S
L
H
R
K
K
L
Q
Site 83
S710
L
A
L
Q
A
L
G
S
E
E
E
T
N
H
G
Site 84
T714
A
L
G
S
E
E
E
T
N
H
G
K
L
D
F
Site 85
Y736
D
D
I
G
L
P
Q
Y
K
T
Q
F
D
E
G
Site 86
T738
I
G
L
P
Q
Y
K
T
Q
F
D
E
G
R
V
Site 87
Y752
V
D
G
R
M
L
H
Y
M
T
V
D
D
L
L
Site 88
T754
G
R
M
L
H
Y
M
T
V
D
D
L
L
S
L
Site 89
S760
M
T
V
D
D
L
L
S
L
K
V
V
S
V
L
Site 90
S794
N
C
L
R
R
R
P
S
D
E
N
T
I
A
P
Site 91
T798
R
R
P
S
D
E
N
T
I
A
P
S
E
V
Q
Site 92
S818
R
V
M
E
W
L
R
S
V
D
L
A
E
Y
A
Site 93
Y824
R
S
V
D
L
A
E
Y
A
P
N
L
R
G
S
Site 94
S831
Y
A
P
N
L
R
G
S
G
V
H
G
G
L
M
Site 95
T848
E
P
R
F
N
V
E
T
M
A
Q
L
L
N
I
Site 96
T860
L
N
I
P
P
N
K
T
L
L
R
R
H
L
A
Site 97
Y891
D
A
M
E
L
P
D
Y
V
L
L
T
A
T
A
Site 98
T895
L
P
D
Y
V
L
L
T
A
T
A
K
V
K
P
Site 99
S908
K
P
K
K
L
A
F
S
N
F
G
N
L
R
K
Site 100
Y924
K
Q
E
D
G
E
E
Y
V
C
P
M
E
L
G
Site 101
S934
P
M
E
L
G
Q
A
S
G
S
A
S
K
K
G
Site 102
S936
E
L
G
Q
A
S
G
S
A
S
K
K
G
F
K
Site 103
S938
G
Q
A
S
G
S
A
S
K
K
G
F
K
P
G
Site 104
Y951
P
G
L
D
M
R
L
Y
E
E
D
D
L
D
R
Site 105
S965
R
L
E
Q
M
E
D
S
E
G
T
V
R
Q
I
Site 106
T968
Q
M
E
D
S
E
G
T
V
R
Q
I
G
A
F
Site 107
T983
S
E
G
I
N
N
L
T
H
M
L
K
E
D
D
Site 108
S999
F
K
D
F
A
A
R
S
P
S
A
S
I
T
D
Site 109
S1001
D
F
A
A
R
S
P
S
A
S
I
T
D
E
D
Site 110
S1003
A
A
R
S
P
S
A
S
I
T
D
E
D
S
N
Site 111
T1005
R
S
P
S
A
S
I
T
D
E
D
S
N
V
_
Site 112
S1009
A
S
I
T
D
E
D
S
N
V
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation