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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NLRP10
Full Name:
NACHT, LRR and PYD domains-containing protein 10
Alias:
CLR11.1; NA10; NACHT-, LRR- and PYD-containing protein 10; NAL10; NALP10; NLR family, pyrin domain containing 10; NOD8; Nucleotide-binding oligomerization domain protein 8; Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10; PAN5; Pynod
Type:
Unknown function
Mass (Da):
75032
Number AA:
655
UniProt ID:
Q86W26
International Prot ID:
IPI00328970
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
E
A
L
L
W
A
L
S
D
L
E
E
N
D
F
Site 2
Y31
D
F
K
K
L
K
F
Y
L
R
D
M
T
L
S
Site 3
T36
K
F
Y
L
R
D
M
T
L
S
E
G
Q
P
P
Site 4
S38
Y
L
R
D
M
T
L
S
E
G
Q
P
P
L
A
Site 5
S63
D
L
A
E
L
L
I
S
K
Y
G
E
K
E
A
Site 6
Y65
A
E
L
L
I
S
K
Y
G
E
K
E
A
V
K
Site 7
Y98
S
H
I
C
L
H
D
Y
R
E
V
Y
R
E
H
Site 8
Y102
L
H
D
Y
R
E
V
Y
R
E
H
V
R
C
L
Site 9
S132
L
L
V
A
K
P
S
S
E
S
P
E
S
L
A
Site 10
S134
V
A
K
P
S
S
E
S
P
E
S
L
A
C
P
Site 11
S137
P
S
S
E
S
P
E
S
L
A
C
P
F
P
E
Site 12
T181
S
A
G
T
G
K
T
T
L
A
R
K
M
V
L
Site 13
T192
K
M
V
L
D
W
A
T
G
T
L
Y
P
G
R
Site 14
T194
V
L
D
W
A
T
G
T
L
Y
P
G
R
F
D
Site 15
Y196
D
W
A
T
G
T
L
Y
P
G
R
F
D
Y
V
Site 16
Y202
L
Y
P
G
R
F
D
Y
V
F
Y
V
S
C
K
Site 17
S268
K
L
K
K
R
G
L
S
P
K
E
S
L
L
H
Site 18
S272
R
G
L
S
P
K
E
S
L
L
H
L
L
I
R
Site 19
S287
R
H
T
L
P
T
C
S
L
L
I
T
T
R
P
Site 20
S316
H
V
H
I
L
G
F
S
E
E
E
R
A
R
Y
Site 21
Y323
S
E
E
E
R
A
R
Y
F
S
S
Y
F
T
D
Site 22
S325
E
E
R
A
R
Y
F
S
S
Y
F
T
D
E
K
Site 23
Y327
R
A
R
Y
F
S
S
Y
F
T
D
E
K
Q
A
Site 24
T329
R
Y
F
S
S
Y
F
T
D
E
K
Q
A
D
R
Site 25
Y348
V
Q
K
N
D
I
L
Y
K
A
C
Q
V
P
G
Site 26
T377
R
G
K
V
V
L
E
T
P
R
N
S
T
D
I
Site 27
S381
V
L
E
T
P
R
N
S
T
D
I
F
M
A
Y
Site 28
T382
L
E
T
P
R
N
S
T
D
I
F
M
A
Y
V
Site 29
S405
D
G
G
C
S
E
L
S
R
H
R
V
L
R
S
Site 30
S412
S
R
H
R
V
L
R
S
L
C
S
L
A
A
E
Site 31
S448
P
R
L
A
A
F
L
S
S
N
D
Y
Q
L
G
Site 32
Y478
D
F
F
H
A
M
S
Y
L
V
K
E
D
Q
S
Site 33
S485
Y
L
V
K
E
D
Q
S
R
L
G
K
E
S
R
Site 34
S491
Q
S
R
L
G
K
E
S
R
R
E
V
Q
R
L
Site 35
T511
Q
E
G
N
D
E
M
T
L
T
M
Q
F
L
L
Site 36
S521
M
Q
F
L
L
D
I
S
K
K
D
S
F
S
N
Site 37
S525
L
D
I
S
K
K
D
S
F
S
N
L
E
L
K
Site 38
S527
I
S
K
K
D
S
F
S
N
L
E
L
K
F
C
Site 39
S566
R
T
W
D
L
E
F
S
L
Y
E
A
K
I
K
Site 40
Y568
W
D
L
E
F
S
L
Y
E
A
K
I
K
N
L
Site 41
S591
V
S
F
K
I
K
H
S
N
E
K
K
S
Q
S
Site 42
S596
K
H
S
N
E
K
K
S
Q
S
Q
N
L
F
S
Site 43
S598
S
N
E
K
K
S
Q
S
Q
N
L
F
S
V
K
Site 44
S603
S
Q
S
Q
N
L
F
S
V
K
S
S
L
S
H
Site 45
S606
Q
N
L
F
S
V
K
S
S
L
S
H
G
P
K
Site 46
S607
N
L
F
S
V
K
S
S
L
S
H
G
P
K
E
Site 47
S609
F
S
V
K
S
S
L
S
H
G
P
K
E
E
Q
Site 48
S639
A
G
T
Q
K
E
A
S
T
G
K
G
R
G
T
Site 49
T640
G
T
Q
K
E
A
S
T
G
K
G
R
G
T
E
Site 50
T646
S
T
G
K
G
R
G
T
E
E
T
P
K
N
T
Site 51
T649
K
G
R
G
T
E
E
T
P
K
N
T
Y
I
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation