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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RTTN
Full Name:
Rotatin
Alias:
DKFZP434G145
Type:
Mass (Da):
248552
Number AA:
2226
UniProt ID:
Q86VV8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
I
R
E
R
A
L
K
S
I
L
C
K
I
E
H
Site 2
S69
E
E
V
L
N
L
L
S
R
L
V
K
Y
P
P
Site 3
S95
E
F
L
S
K
L
R
S
N
V
E
P
N
L
Q
Site 4
S123
P
S
E
V
P
A
L
S
S
A
S
Y
Q
T
N
Site 5
S124
S
E
V
P
A
L
S
S
A
S
Y
Q
T
N
Q
Site 6
Y127
P
A
L
S
S
A
S
Y
Q
T
N
Q
T
E
L
Site 7
Y144
N
P
E
I
L
T
G
Y
F
P
Q
D
K
S
N
Site 8
T181
T
F
P
W
L
P
L
T
T
T
D
R
H
V
L
Site 9
T183
P
W
L
P
L
T
T
T
D
R
H
V
L
S
S
Site 10
S189
T
T
D
R
H
V
L
S
S
N
E
S
S
L
R
Site 11
S190
T
D
R
H
V
L
S
S
N
E
S
S
L
R
S
Site 12
S193
H
V
L
S
S
N
E
S
S
L
R
S
S
N
H
Site 13
S194
V
L
S
S
N
E
S
S
L
R
S
S
N
H
T
Site 14
S197
S
N
E
S
S
L
R
S
S
N
H
T
L
I
W
Site 15
S198
N
E
S
S
L
R
S
S
N
H
T
L
I
W
N
Site 16
T201
S
L
R
S
S
N
H
T
L
I
W
N
T
C
E
Site 17
S252
K
H
R
L
A
L
Q
S
V
S
C
L
Q
Q
L
Site 18
S277
H
R
D
P
G
F
F
S
N
K
H
D
T
V
S
Site 19
T282
F
F
S
N
K
H
D
T
V
S
Q
N
S
S
L
Site 20
S284
S
N
K
H
D
T
V
S
Q
N
S
S
L
S
Y
Site 21
S288
D
T
V
S
Q
N
S
S
L
S
Y
C
H
E
A
Site 22
S290
V
S
Q
N
S
S
L
S
Y
C
H
E
A
R
G
Site 23
Y291
S
Q
N
S
S
L
S
Y
C
H
E
A
R
G
T
Site 24
T298
Y
C
H
E
A
R
G
T
H
H
S
Q
N
P
S
Site 25
S301
E
A
R
G
T
H
H
S
Q
N
P
S
P
G
S
Site 26
S305
T
H
H
S
Q
N
P
S
P
G
S
S
S
P
R
Site 27
S308
S
Q
N
P
S
P
G
S
S
S
P
R
P
S
V
Site 28
S309
Q
N
P
S
P
G
S
S
S
P
R
P
S
V
V
Site 29
S310
N
P
S
P
G
S
S
S
P
R
P
S
V
V
G
Site 30
S314
G
S
S
S
P
R
P
S
V
V
G
R
T
G
Q
Site 31
S334
G
Q
D
W
D
A
A
S
S
S
G
S
S
S
H
Site 32
S335
Q
D
W
D
A
A
S
S
S
G
S
S
S
H
A
Site 33
S336
D
W
D
A
A
S
S
S
G
S
S
S
H
A
H
Site 34
S338
D
A
A
S
S
S
G
S
S
S
H
A
H
V
N
Site 35
S339
A
A
S
S
S
G
S
S
S
H
A
H
V
N
S
Site 36
S340
A
S
S
S
G
S
S
S
H
A
H
V
N
S
R
Site 37
S346
S
S
H
A
H
V
N
S
R
I
S
V
H
S
P
Site 38
S349
A
H
V
N
S
R
I
S
V
H
S
P
L
D
M
Site 39
S352
N
S
R
I
S
V
H
S
P
L
D
M
G
H
I
Site 40
T369
P
E
L
E
T
E
D
T
L
E
L
Q
F
Q
Q
Site 41
T422
L
I
G
E
A
I
S
T
D
I
W
D
D
S
S
Site 42
Y452
A
L
G
E
T
M
C
Y
H
K
S
S
I
S
L
Site 43
S455
E
T
M
C
Y
H
K
S
S
I
S
L
E
Q
P
Site 44
S458
C
Y
H
K
S
S
I
S
L
E
Q
P
E
V
M
Site 45
S498
E
K
A
S
E
F
L
S
E
P
M
S
T
A
L
Site 46
Y518
D
M
P
I
S
L
E
Y
P
N
I
H
E
A
V
Site 47
S534
A
Y
L
E
Q
L
N
S
E
N
Y
S
I
Y
K
Site 48
S538
Q
L
N
S
E
N
Y
S
I
Y
K
R
T
A
E
Site 49
Y540
N
S
E
N
Y
S
I
Y
K
R
T
A
E
A
V
Site 50
S558
E
C
T
C
N
F
L
S
D
I
G
K
E
G
E
Site 51
S581
L
A
D
Q
A
L
R
S
F
S
Y
H
Q
H
F
Site 52
S583
D
Q
A
L
R
S
F
S
Y
H
Q
H
F
P
L
Site 53
Y584
Q
A
L
R
S
F
S
Y
H
Q
H
F
P
L
I
Site 54
S608
I
W
K
S
A
Q
A
S
P
L
L
Q
G
E
S
Site 55
S615
S
P
L
L
Q
G
E
S
Q
K
V
L
L
H
M
Site 56
Y635
P
R
V
K
A
E
T
Y
H
C
C
L
E
I
T
Site 57
S684
F
G
I
Q
E
P
E
S
E
V
N
T
A
A
K
Site 58
T688
E
P
E
S
E
V
N
T
A
A
K
A
I
L
L
Site 59
T729
I
L
Q
G
Y
A
D
T
E
D
P
L
G
N
C
Site 60
S741
G
N
C
I
L
L
L
S
K
A
S
S
D
T
E
Site 61
S745
L
L
L
S
K
A
S
S
D
T
E
E
M
L
P
Site 62
T747
L
S
K
A
S
S
D
T
E
E
M
L
P
C
T
Site 63
T754
T
E
E
M
L
P
C
T
T
R
L
K
S
M
L
Site 64
T755
E
E
M
L
P
C
T
T
R
L
K
S
M
L
R
Site 65
S759
P
C
T
T
R
L
K
S
M
L
R
L
L
L
V
Site 66
T791
T
S
E
E
G
A
D
T
K
R
P
L
I
D
A
Site 67
T830
E
L
V
I
K
L
E
T
V
E
K
V
Y
E
I
Site 68
S886
E
Y
L
N
E
C
V
S
Q
D
G
K
V
V
E
Site 69
S916
G
D
P
V
M
R
V
S
L
S
Q
Q
S
S
L
Site 70
S963
V
S
R
M
D
M
W
S
V
N
P
S
N
K
P
Site 71
S967
D
M
W
S
V
N
P
S
N
K
P
S
L
P
S
Site 72
S971
V
N
P
S
N
K
P
S
L
P
S
V
F
S
L
Site 73
S974
S
N
K
P
S
L
P
S
V
F
S
L
P
V
S
Site 74
S1042
N
L
L
K
Q
M
N
S
E
T
K
T
Q
E
I
Site 75
T1046
Q
M
N
S
E
T
K
T
Q
E
I
L
D
A
L
Site 76
S1096
R
A
A
V
T
R
M
S
F
Y
L
L
N
D
R
Site 77
S1105
Y
L
L
N
D
R
L
S
L
K
G
C
P
G
P
Site 78
S1161
I
K
E
Q
R
K
N
S
S
L
E
L
L
N
W
Site 79
S1162
K
E
Q
R
K
N
S
S
L
E
L
L
N
W
I
Site 80
S1190
D
L
L
V
L
T
E
S
Q
A
R
E
E
T
D
Site 81
T1196
E
S
Q
A
R
E
E
T
D
D
I
R
T
A
V
Site 82
T1226
L
L
N
F
M
E
V
T
D
R
K
C
S
E
L
Site 83
S1231
E
V
T
D
R
K
C
S
E
L
L
Y
V
F
Q
Site 84
Y1235
R
K
C
S
E
L
L
Y
V
F
Q
T
Q
L
A
Site 85
Y1258
V
T
D
A
P
H
F
Y
G
L
P
S
L
E
R
Site 86
S1262
P
H
F
Y
G
L
P
S
L
E
R
T
L
R
G
Site 87
T1266
G
L
P
S
L
E
R
T
L
R
G
M
A
N
L
Site 88
S1280
L
T
A
F
P
G
W
S
S
H
S
P
L
T
K
Site 89
S1281
T
A
F
P
G
W
S
S
H
S
P
L
T
K
P
Site 90
S1283
F
P
G
W
S
S
H
S
P
L
T
K
P
L
D
Site 91
Y1307
L
E
V
I
T
S
F
Y
V
E
R
G
G
N
A
Site 92
S1316
E
R
G
G
N
A
M
S
F
M
G
K
G
V
T
Site 93
S1356
L
W
F
L
P
L
G
S
H
S
E
E
H
I
P
Site 94
S1358
F
L
P
L
G
S
H
S
E
E
H
I
P
T
Q
Site 95
T1364
H
S
E
E
H
I
P
T
Q
Q
G
L
A
W
L
Site 96
T1385
R
D
P
E
V
R
F
T
S
L
G
L
G
S
A
Site 97
S1426
V
N
I
L
L
D
Q
S
E
C
S
M
V
R
R
Site 98
Y1455
P
T
E
I
I
K
D
Y
T
W
Q
G
P
C
V
Site 99
S1467
P
C
V
H
D
E
D
S
G
L
S
L
I
G
K
Site 100
S1470
H
D
E
D
S
G
L
S
L
I
G
K
P
A
L
Site 101
Y1482
P
A
L
Q
A
L
L
Y
H
C
H
F
Y
E
H
Site 102
S1515
F
S
A
F
D
R
N
S
E
S
N
D
L
N
G
Site 103
S1517
A
F
D
R
N
S
E
S
N
D
L
N
G
L
D
Site 104
S1526
D
L
N
G
L
D
D
S
F
K
F
W
R
A
P
Site 105
S1534
F
K
F
W
R
A
P
S
R
T
S
Q
D
R
D
Site 106
T1536
F
W
R
A
P
S
R
T
S
Q
D
R
D
P
S
Site 107
S1537
W
R
A
P
S
R
T
S
Q
D
R
D
P
S
S
Site 108
S1543
T
S
Q
D
R
D
P
S
S
L
S
T
S
E
T
Site 109
S1544
S
Q
D
R
D
P
S
S
L
S
T
S
E
T
T
Site 110
S1546
D
R
D
P
S
S
L
S
T
S
E
T
T
V
A
Site 111
T1547
R
D
P
S
S
L
S
T
S
E
T
T
V
A
P
Site 112
S1548
D
P
S
S
L
S
T
S
E
T
T
V
A
P
S
Site 113
T1550
S
S
L
S
T
S
E
T
T
V
A
P
S
L
G
Site 114
T1551
S
L
S
T
S
E
T
T
V
A
P
S
L
G
S
Site 115
S1555
S
E
T
T
V
A
P
S
L
G
S
T
E
F
Q
Site 116
S1567
E
F
Q
P
L
V
Q
S
T
T
L
L
P
E
A
Site 117
T1569
Q
P
L
V
Q
S
T
T
L
L
P
E
A
S
H
Site 118
S1575
T
T
L
L
P
E
A
S
H
D
Q
F
V
A
Q
Site 119
S1587
V
A
Q
G
H
Q
E
S
T
S
P
R
P
P
H
Site 120
T1588
A
Q
G
H
Q
E
S
T
S
P
R
P
P
H
D
Site 121
S1589
Q
G
H
Q
E
S
T
S
P
R
P
P
H
D
S
Site 122
S1596
S
P
R
P
P
H
D
S
S
L
S
A
P
L
P
Site 123
S1597
P
R
P
P
H
D
S
S
L
S
A
P
L
P
K
Site 124
S1599
P
P
H
D
S
S
L
S
A
P
L
P
K
L
C
Site 125
T1632
L
T
I
A
P
R
D
T
A
K
A
F
R
Q
A
Site 126
S1667
E
L
R
A
L
L
P
S
S
P
P
A
E
H
T
Site 127
S1668
L
R
A
L
L
P
S
S
P
P
A
E
H
T
Q
Site 128
T1674
S
S
P
P
A
E
H
T
Q
A
Q
V
S
F
L
Site 129
S1679
E
H
T
Q
A
Q
V
S
F
L
L
E
Y
L
S
Site 130
Y1737
K
E
L
I
S
A
F
Y
H
T
W
T
H
L
F
Site 131
S1814
K
G
H
L
Q
A
K
S
K
T
H
L
C
C
S
Site 132
S1831
V
A
S
L
L
D
D
S
Q
E
N
Q
K
S
L
Site 133
S1837
D
S
Q
E
N
Q
K
S
L
E
Q
L
S
D
V
Site 134
S1842
Q
K
S
L
E
Q
L
S
D
V
I
L
Q
C
Y
Site 135
Y1849
S
D
V
I
L
Q
C
Y
E
G
K
S
S
K
D
Site 136
S1853
L
Q
C
Y
E
G
K
S
S
K
D
I
L
K
R
Site 137
S1873
L
M
S
L
L
A
V
S
R
R
A
Q
K
H
A
Site 138
S1904
N
A
Q
L
N
L
D
S
L
R
P
G
K
A
A
Site 139
Y1935
Q
L
L
R
N
C
L
Y
Q
N
E
E
C
K
E
Site 140
T2001
G
Q
H
P
V
Q
A
T
H
R
G
A
V
S
N
Site 141
S2072
K
G
G
N
K
H
L
S
N
L
T
I
L
W
L
Site 142
S2086
L
K
L
L
L
N
I
S
S
G
E
D
G
Q
Q
Site 143
S2087
K
L
L
L
N
I
S
S
G
E
D
G
Q
Q
M
Site 144
T2106
D
G
C
L
D
L
L
T
E
M
S
K
Y
K
H
Site 145
S2109
L
D
L
L
T
E
M
S
K
Y
K
H
K
S
S
Site 146
Y2111
L
L
T
E
M
S
K
Y
K
H
K
S
S
P
L
Site 147
S2115
M
S
K
Y
K
H
K
S
S
P
L
L
P
L
L
Site 148
S2116
S
K
Y
K
H
K
S
S
P
L
L
P
L
L
I
Site 149
Y2171
A
A
L
W
A
L
I
Y
N
Y
Q
K
A
K
T
Site 150
T2178
Y
N
Y
Q
K
A
K
T
A
L
K
S
P
S
V
Site 151
S2182
K
A
K
T
A
L
K
S
P
S
V
K
R
R
V
Site 152
S2184
K
T
A
L
K
S
P
S
V
K
R
R
V
D
E
Site 153
Y2193
K
R
R
V
D
E
A
Y
S
L
A
K
K
T
F
Site 154
S2194
R
R
V
D
E
A
Y
S
L
A
K
K
T
F
P
Site 155
T2199
A
Y
S
L
A
K
K
T
F
P
N
S
E
A
N
Site 156
S2203
A
K
K
T
F
P
N
S
E
A
N
P
L
N
A
Site 157
Y2212
A
N
P
L
N
A
Y
Y
L
K
C
L
E
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation