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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TXNDC2
Full Name:
Thioredoxin domain-containing protein 2
Alias:
Spermatid-specific thioredoxin-1
Type:
Mass (Da):
60462
Number AA:
553
UniProt ID:
Q86VQ3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
D
K
E
L
G
M
E
S
V
K
A
G
A
S
G
Site 2
T26
K
P
E
M
R
L
G
T
Q
E
E
T
S
E
G
Site 3
S38
S
E
G
D
A
N
E
S
S
L
L
V
L
S
S
Site 4
S39
E
G
D
A
N
E
S
S
L
L
V
L
S
S
N
Site 5
T72
F
L
P
M
V
S
H
T
F
H
M
R
T
E
E
Site 6
S80
F
H
M
R
T
E
E
S
D
A
S
Q
E
G
D
Site 7
S83
R
T
E
E
S
D
A
S
Q
E
G
D
D
L
P
Site 8
S92
E
G
D
D
L
P
K
S
S
A
N
T
S
H
P
Site 9
S93
G
D
D
L
P
K
S
S
A
N
T
S
H
P
K
Site 10
S97
P
K
S
S
A
N
T
S
H
P
K
Q
D
D
S
Site 11
S104
S
H
P
K
Q
D
D
S
P
K
S
S
E
E
T
Site 12
S107
K
Q
D
D
S
P
K
S
S
E
E
T
I
Q
P
Site 13
S108
Q
D
D
S
P
K
S
S
E
E
T
I
Q
P
K
Site 14
T111
S
P
K
S
S
E
E
T
I
Q
P
K
E
G
D
Site 15
S129
A
P
E
E
T
I
Q
S
K
K
E
D
L
P
K
Site 16
S137
K
K
E
D
L
P
K
S
S
E
K
A
I
Q
P
Site 17
S147
K
A
I
Q
P
K
E
S
N
I
P
K
S
S
A
Site 18
S152
K
E
S
N
I
P
K
S
S
A
K
P
I
Q
P
Site 19
S153
E
S
N
I
P
K
S
S
A
K
P
I
Q
P
K
Site 20
S168
L
G
N
I
P
K
A
S
V
K
P
S
Q
P
K
Site 21
S172
P
K
A
S
V
K
P
S
Q
P
K
E
G
D
I
Site 22
S197
K
K
E
D
L
P
K
S
S
E
E
A
I
Q
P
Site 23
S212
K
E
G
D
I
P
K
S
S
A
K
P
I
Q
P
Site 24
S213
E
G
D
I
P
K
S
S
A
K
P
I
Q
P
K
Site 25
T227
K
L
G
N
I
A
K
T
S
V
K
P
S
Q
P
Site 26
S228
L
G
N
I
A
K
T
S
V
K
P
S
Q
P
K
Site 27
S232
A
K
T
S
V
K
P
S
Q
P
K
E
S
D
I
Site 28
S237
K
P
S
Q
P
K
E
S
D
I
P
K
S
P
E
Site 29
S242
K
E
S
D
I
P
K
S
P
E
E
T
I
Q
P
Site 30
T246
I
P
K
S
P
E
E
T
I
Q
P
K
E
G
D
Site 31
S285
Q
P
K
E
G
D
I
S
K
S
P
E
E
A
I
Site 32
S287
K
E
G
D
I
S
K
S
P
E
E
A
I
Q
P
Site 33
S302
K
E
G
D
L
P
K
S
L
E
E
A
I
Q
P
Site 34
S317
K
E
G
D
I
P
K
S
P
E
E
A
I
Q
P
Site 35
S332
K
E
G
D
I
P
K
S
L
E
E
A
I
Q
P
Site 36
S347
K
K
G
D
I
P
K
S
P
E
E
T
I
Q
P
Site 37
T351
I
P
K
S
P
E
E
T
I
Q
P
K
K
D
D
Site 38
S362
K
K
D
D
I
P
K
S
P
E
E
A
I
Q
P
Site 39
S377
K
E
G
D
I
P
K
S
P
K
Q
A
I
Q
P
Site 40
S392
K
E
G
D
I
P
K
S
L
E
E
A
I
P
P
Site 41
S407
K
E
I
D
I
P
K
S
P
E
E
T
I
Q
P
Site 42
T411
I
P
K
S
P
E
E
T
I
Q
P
K
E
D
D
Site 43
S419
I
Q
P
K
E
D
D
S
P
K
S
L
E
E
A
Site 44
S422
K
E
D
D
S
P
K
S
L
E
E
A
T
P
S
Site 45
T427
P
K
S
L
E
E
A
T
P
S
K
E
G
D
I
Site 46
S429
S
L
E
E
A
T
P
S
K
E
G
D
I
L
K
Site 47
S455
D
K
V
K
V
I
L
S
K
E
D
F
E
A
S
Site 48
S494
R
P
F
F
H
A
L
S
V
K
H
E
D
V
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation