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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CAND1
Full Name:
Cullin-associated NEDD8-dissociated protein 1
Alias:
Cullin-associated and neddylation-dissociated protein 1; KIAA0829, TIP120, TIP120A; TBP-interacting protein of 120 kDa A
Type:
Regulator of ubiquitination
Mass (Da):
136376
Number AA:
1230
UniProt ID:
Q86VP6
International Prot ID:
IPI00100160
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000151
GO:0005634
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
S
A
S
Y
H
I
S
N
L
L
E
K
M
T
Site 2
S17
N
L
L
E
K
M
T
S
S
D
K
D
F
R
F
Site 3
S18
L
L
E
K
M
T
S
S
D
K
D
F
R
F
M
Site 4
S45
S
I
K
L
D
D
D
S
E
R
K
V
V
K
M
Site 5
S77
K
C
L
G
P
L
V
S
K
V
K
E
Y
Q
V
Site 6
Y82
L
V
S
K
V
K
E
Y
Q
V
E
T
I
V
D
Site 7
T86
V
K
E
Y
Q
V
E
T
I
V
D
T
L
C
T
Site 8
S97
T
L
C
T
N
M
L
S
D
K
E
Q
L
R
D
Site 9
S106
K
E
Q
L
R
D
I
S
S
I
G
L
K
T
V
Site 10
S107
E
Q
L
R
D
I
S
S
I
G
L
K
T
V
I
Site 11
S122
G
E
L
P
P
A
S
S
G
S
A
L
A
A
N
Site 12
T139
K
K
I
T
G
R
L
T
S
A
I
A
K
Q
E
Site 13
S140
K
I
T
G
R
L
T
S
A
I
A
K
Q
E
D
Site 14
S149
I
A
K
Q
E
D
V
S
V
Q
L
E
A
L
D
Site 15
S220
D
L
I
E
H
L
L
S
E
L
S
K
N
D
S
Site 16
S223
E
H
L
L
S
E
L
S
K
N
D
S
M
S
T
Site 17
S227
S
E
L
S
K
N
D
S
M
S
T
T
R
T
Y
Site 18
S229
L
S
K
N
D
S
M
S
T
T
R
T
Y
I
Q
Site 19
T230
S
K
N
D
S
M
S
T
T
R
T
Y
I
Q
C
Site 20
T233
D
S
M
S
T
T
R
T
Y
I
Q
C
I
A
A
Site 21
Y274
D
D
D
E
L
R
E
Y
C
I
Q
A
F
E
S
Site 22
S281
Y
C
I
Q
A
F
E
S
F
V
R
R
C
P
K
Site 23
Y291
R
R
C
P
K
E
V
Y
P
H
V
S
T
I
I
Site 24
S295
K
E
V
Y
P
H
V
S
T
I
I
N
I
C
L
Site 25
T296
E
V
Y
P
H
V
S
T
I
I
N
I
C
L
K
Site 26
Y304
I
I
N
I
C
L
K
Y
L
T
Y
D
P
N
Y
Site 27
T306
N
I
C
L
K
Y
L
T
Y
D
P
N
Y
N
Y
Site 28
Y307
I
C
L
K
Y
L
T
Y
D
P
N
Y
N
Y
D
Site 29
Y311
Y
L
T
Y
D
P
N
Y
N
Y
D
D
E
D
E
Site 30
S335
G
D
D
D
D
Q
G
S
D
D
E
Y
S
D
D
Site 31
Y339
D
Q
G
S
D
D
E
Y
S
D
D
D
D
M
S
Site 32
S340
Q
G
S
D
D
E
Y
S
D
D
D
D
M
S
W
Site 33
S346
Y
S
D
D
D
D
M
S
W
K
V
R
R
A
A
Site 34
S362
K
C
L
D
A
V
V
S
T
R
H
E
M
L
P
Site 35
Y372
H
E
M
L
P
E
F
Y
K
T
V
S
P
A
L
Site 36
S376
P
E
F
Y
K
T
V
S
P
A
L
I
S
R
F
Site 37
S381
T
V
S
P
A
L
I
S
R
F
K
E
R
E
E
Site 38
Y398
K
A
D
V
F
H
A
Y
L
S
L
L
K
Q
T
Site 39
S400
D
V
F
H
A
Y
L
S
L
L
K
Q
T
R
P
Site 40
T423
D
A
M
E
Q
G
E
T
P
L
T
M
L
Q
S
Site 41
T426
E
Q
G
E
T
P
L
T
M
L
Q
S
Q
V
P
Site 42
S488
I
F
S
L
N
D
K
S
S
S
S
N
L
K
I
Site 43
S489
F
S
L
N
D
K
S
S
S
S
N
L
K
I
D
Site 44
S557
I
R
P
L
D
Q
P
S
S
F
D
A
T
P
Y
Site 45
S558
R
P
L
D
Q
P
S
S
F
D
A
T
P
Y
I
Site 46
T562
Q
P
S
S
F
D
A
T
P
Y
I
K
D
L
F
Site 47
Y564
S
S
F
D
A
T
P
Y
I
K
D
L
F
T
C
Site 48
T570
P
Y
I
K
D
L
F
T
C
T
I
K
R
L
K
Site 49
T611
L
G
S
D
L
P
N
T
L
Q
I
F
L
E
R
Site 50
T624
E
R
L
K
N
E
I
T
R
L
T
T
V
K
A
Site 51
T627
K
N
E
I
T
R
L
T
T
V
K
A
L
T
L
Site 52
S657
E
G
V
P
I
L
A
S
F
L
R
K
N
Q
R
Site 53
T670
Q
R
A
L
K
L
G
T
L
S
A
L
D
I
L
Site 54
S672
A
L
K
L
G
T
L
S
A
L
D
I
L
I
K
Site 55
T686
K
N
Y
S
D
S
L
T
A
A
M
I
D
A
V
Site 56
S702
D
E
L
P
P
L
I
S
E
S
D
M
H
V
S
Site 57
S704
L
P
P
L
I
S
E
S
D
M
H
V
S
Q
M
Site 58
S725
T
L
A
K
V
Y
P
S
S
L
S
K
I
S
G
Site 59
S726
L
A
K
V
Y
P
S
S
L
S
K
I
S
G
S
Site 60
S728
K
V
Y
P
S
S
L
S
K
I
S
G
S
I
L
Site 61
S731
P
S
S
L
S
K
I
S
G
S
I
L
N
E
L
Site 62
Y772
T
G
T
N
N
L
G
Y
M
D
L
L
R
M
L
Site 63
Y784
R
M
L
T
G
P
V
Y
S
Q
S
T
A
L
T
Site 64
S785
M
L
T
G
P
V
Y
S
Q
S
T
A
L
T
H
Site 65
S787
T
G
P
V
Y
S
Q
S
T
A
L
T
H
K
Q
Site 66
T791
Y
S
Q
S
T
A
L
T
H
K
Q
S
Y
Y
S
Site 67
T831
D
V
K
N
S
R
S
T
D
S
I
R
L
L
A
Site 68
S833
K
N
S
R
S
T
D
S
I
R
L
L
A
L
L
Site 69
S852
V
G
H
H
I
D
L
S
G
Q
L
E
L
K
S
Site 70
S867
V
I
L
E
A
F
S
S
P
S
E
E
V
K
S
Site 71
S869
L
E
A
F
S
S
P
S
E
E
V
K
S
A
A
Site 72
S874
S
P
S
E
E
V
K
S
A
A
S
Y
A
L
G
Site 73
S877
E
E
V
K
S
A
A
S
Y
A
L
G
S
I
S
Site 74
T900
P
F
V
L
Q
E
I
T
S
Q
P
K
R
Q
Y
Site 75
S901
F
V
L
Q
E
I
T
S
Q
P
K
R
Q
Y
L
Site 76
Y907
T
S
Q
P
K
R
Q
Y
L
L
L
H
S
L
K
Site 77
S912
R
Q
Y
L
L
L
H
S
L
K
E
I
I
S
S
Site 78
S918
H
S
L
K
E
I
I
S
S
A
S
V
V
G
L
Site 79
S919
S
L
K
E
I
I
S
S
A
S
V
V
G
L
K
Site 80
Y928
S
V
V
G
L
K
P
Y
V
E
N
I
W
A
L
Site 81
Y973
L
L
P
R
L
K
G
Y
L
I
S
G
S
S
Y
Site 82
S976
R
L
K
G
Y
L
I
S
G
S
S
Y
A
R
S
Site 83
S978
K
G
Y
L
I
S
G
S
S
Y
A
R
S
S
V
Site 84
Y980
Y
L
I
S
G
S
S
Y
A
R
S
S
V
V
T
Site 85
S983
S
G
S
S
Y
A
R
S
S
V
V
T
A
V
K
Site 86
S994
T
A
V
K
F
T
I
S
D
H
P
Q
P
I
D
Site 87
T1014
C
I
G
D
F
L
K
T
L
E
D
P
D
L
N
Site 88
S1039
S
A
A
H
N
K
P
S
L
I
R
D
L
L
D
Site 89
Y1053
D
T
V
L
P
H
L
Y
N
E
T
K
V
R
K
Site 90
T1074
E
M
G
P
F
K
H
T
V
D
D
G
L
D
I
Site 91
Y1117
E
D
G
L
K
D
H
Y
D
I
K
M
L
T
F
Site 92
T1154
E
P
L
R
A
T
C
T
T
K
V
K
A
N
S
Site 93
T1155
P
L
R
A
T
C
T
T
K
V
K
A
N
S
V
Site 94
S1175
K
Q
D
E
L
K
R
S
A
M
R
A
V
A
A
Site 95
S1192
T
I
P
E
A
E
K
S
P
L
M
S
E
F
Q
Site 96
S1196
A
E
K
S
P
L
M
S
E
F
Q
S
Q
I
S
Site 97
S1200
P
L
M
S
E
F
Q
S
Q
I
S
S
N
P
E
Site 98
S1203
S
E
F
Q
S
Q
I
S
S
N
P
E
L
A
A
Site 99
S1204
E
F
Q
S
Q
I
S
S
N
P
E
L
A
A
I
Site 100
S1219
F
E
S
I
Q
K
D
S
S
S
T
N
L
E
S
Site 101
S1220
E
S
I
Q
K
D
S
S
S
T
N
L
E
S
M
Site 102
S1221
S
I
Q
K
D
S
S
S
T
N
L
E
S
M
D
Site 103
S1226
S
S
S
T
N
L
E
S
M
D
T
S
_
_
_
Site 104
T1229
T
N
L
E
S
M
D
T
S
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation