PhosphoNET

           
Protein Info 
   
Short Name:  THOC4
Full Name:  THO complex subunit 4
Alias:  Ally of AML-1 and LEF-1; ALY; BEF; BZIP enhancing factor; BZIP-enhancing factor BEF; THO complex 4; Tho4; Transcriptional coactivator; Transcriptional coactivator Aly/REF
Type:  Chaperone; RNA binding protein; Transcription, coactivator/corepressor
Mass (Da):  26888
Number AA:  257
UniProt ID:  Q86V81
International Prot ID:  IPI00328840
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0016607  GO:0005681 Uniprot OncoNet
Molecular Function:  GO:0003723  GO:0000166  GO:0005515 PhosphoSite+ KinaseNET
Biological Process:  GO:0046784  GO:0000398   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S8MADKMDMSLDDIIKL
Site 2S18DIIKLNRSQRGGRGG
Site 3S34RGRGRAGSQGGRGGG
Site 4Y77GRNRPAPYSRPKQLP
Site 5S78RNRPAPYSRPKQLPD
Site 6S94WQHDLFDSGFGGGAG
Site 7S118SNLDFGVSDADIQEL
Site 8Y139LKKAAVHYDRSGRSL
Site 9S142AAVHYDRSGRSLGTA
Site 10S183MNIQLVTSQIDAQRR
Site 11S194AQRRPAQSVNRGGMT
Site 12T215GFGGGGGTRRGTRGG
Site 13T219GGGTRRGTRGGARGR
Site 14S234GRGAGRNSKQQLSAE
Site 15S239RNSKQQLSAEELDAQ
Site 16Y250LDAQLDAYNARMDTS
Site 17T256AYNARMDTS______
Site 18S257YNARMDTS_______
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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