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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FAM35A
Full Name:
Protein FAM35A
Alias:
FA35A; Family with sequence similarity 35, member A; MGC5560
Type:
Mass (Da):
93705
Number AA:
835
UniProt ID:
Q86V20
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
T
V
S
E
D
T
A
S
L
M
S
V
A
D
P
Site 2
Y43
W
K
K
I
Q
L
L
Y
S
Q
H
S
L
Y
L
Site 3
S44
K
K
I
Q
L
L
Y
S
Q
H
S
L
Y
L
K
Site 4
S47
Q
L
L
Y
S
Q
H
S
L
Y
L
K
D
E
K
Site 5
Y49
L
Y
S
Q
H
S
L
Y
L
K
D
E
K
Q
H
Site 6
Y62
Q
H
K
N
L
E
N
Y
K
V
P
E
S
I
G
Site 7
S67
E
N
Y
K
V
P
E
S
I
G
S
P
D
L
S
Site 8
S70
K
V
P
E
S
I
G
S
P
D
L
S
G
H
F
Site 9
S95
V
K
D
D
F
V
R
S
V
S
E
T
Q
N
I
Site 10
S97
D
D
F
V
R
S
V
S
E
T
Q
N
I
E
S
Site 11
T99
F
V
R
S
V
S
E
T
Q
N
I
E
S
Q
K
Site 12
S104
S
E
T
Q
N
I
E
S
Q
K
I
H
S
S
R
Site 13
S109
I
E
S
Q
K
I
H
S
S
R
L
S
D
I
T
Site 14
S110
E
S
Q
K
I
H
S
S
R
L
S
D
I
T
S
Site 15
S113
K
I
H
S
S
R
L
S
D
I
T
S
S
N
M
Site 16
T116
S
S
R
L
S
D
I
T
S
S
N
M
Q
I
C
Site 17
S117
S
R
L
S
D
I
T
S
S
N
M
Q
I
C
G
Site 18
T128
Q
I
C
G
F
K
S
T
V
P
H
F
T
E
E
Site 19
Y138
H
F
T
E
E
E
K
Y
Q
K
L
L
S
E
N
Site 20
Y203
R
E
C
V
P
T
E
Y
H
E
I
Q
N
Q
C
Site 21
S216
Q
C
L
G
L
F
S
S
N
A
V
D
K
S
R
Site 22
S222
S
S
N
A
V
D
K
S
R
S
E
A
A
V
R
Site 23
S232
E
A
A
V
R
K
V
S
D
L
K
I
S
T
D
Site 24
S263
Q
K
K
D
K
R
R
S
P
V
N
K
G
N
V
Site 25
T274
K
G
N
V
N
M
E
T
E
P
K
A
S
Y
G
Site 26
S279
M
E
T
E
P
K
A
S
Y
G
E
I
R
I
P
Site 27
T297
S
I
Q
L
D
G
F
T
E
A
Y
E
S
G
Q
Site 28
Y300
L
D
G
F
T
E
A
Y
E
S
G
Q
N
Q
A
Site 29
S309
S
G
Q
N
Q
A
Y
S
L
E
L
F
S
P
V
Site 30
S314
A
Y
S
L
E
L
F
S
P
V
C
P
K
T
E
Site 31
T320
F
S
P
V
C
P
K
T
E
N
S
R
I
H
I
Site 32
S329
N
S
R
I
H
I
N
S
D
K
G
L
E
E
H
Site 33
S339
G
L
E
E
H
T
G
S
Q
E
L
F
S
S
E
Site 34
S344
T
G
S
Q
E
L
F
S
S
E
D
E
L
P
P
Site 35
S345
G
S
Q
E
L
F
S
S
E
D
E
L
P
P
N
Site 36
S366
C
S
S
G
I
L
C
S
Q
L
N
T
F
H
K
Site 37
S379
H
K
S
A
I
K
R
S
C
T
S
E
D
K
V
Site 38
T381
S
A
I
K
R
S
C
T
S
E
D
K
V
G
Q
Site 39
S382
A
I
K
R
S
C
T
S
E
D
K
V
G
Q
S
Site 40
S389
S
E
D
K
V
G
Q
S
E
A
L
S
R
V
L
Site 41
S406
A
K
K
M
K
L
I
S
N
G
G
D
S
A
V
Site 42
S421
E
M
D
R
R
N
V
S
E
F
K
S
I
K
K
Site 43
S425
R
N
V
S
E
F
K
S
I
K
K
T
S
L
I
Site 44
T429
E
F
K
S
I
K
K
T
S
L
I
K
N
C
D
Site 45
S430
F
K
S
I
K
K
T
S
L
I
K
N
C
D
S
Site 46
Y442
C
D
S
K
S
Q
K
Y
N
C
L
V
M
V
L
Site 47
S465
N
I
K
F
G
P
N
S
G
S
K
V
P
L
A
Site 48
S467
K
F
G
P
N
S
G
S
K
V
P
L
A
T
V
Site 49
T473
G
S
K
V
P
L
A
T
V
T
V
I
D
Q
S
Site 50
S480
T
V
T
V
I
D
Q
S
E
T
K
K
K
V
F
Site 51
T521
E
D
Q
W
I
G
E
T
V
L
Q
S
T
F
S
Site 52
T526
G
E
T
V
L
Q
S
T
F
S
S
Q
L
L
N
Site 53
S536
S
Q
L
L
N
L
G
S
Y
S
S
I
Q
P
E
Site 54
S539
L
N
L
G
S
Y
S
S
I
Q
P
E
E
Y
S
Site 55
Y545
S
S
I
Q
P
E
E
Y
S
S
V
V
S
E
V
Site 56
S546
S
I
Q
P
E
E
Y
S
S
V
V
S
E
V
V
Site 57
Y560
V
L
Q
D
L
L
A
Y
V
S
S
K
H
S
Y
Site 58
S562
Q
D
L
L
A
Y
V
S
S
K
H
S
Y
L
R
Site 59
S563
D
L
L
A
Y
V
S
S
K
H
S
Y
L
R
D
Site 60
S566
A
Y
V
S
S
K
H
S
Y
L
R
D
L
P
P
Site 61
Y567
Y
V
S
S
K
H
S
Y
L
R
D
L
P
P
R
Site 62
S581
R
Q
P
Q
R
V
N
S
I
D
F
V
E
L
E
Site 63
Y613
T
I
L
T
E
A
V
Y
S
Y
R
G
Q
K
Q
Site 64
S614
I
L
T
E
A
V
Y
S
Y
R
G
Q
K
Q
K
Site 65
T626
K
Q
K
K
V
M
L
T
V
E
Q
A
Q
D
Q
Site 66
Y635
E
Q
A
Q
D
Q
H
Y
A
L
V
L
W
G
P
Site 67
Y647
W
G
P
G
A
A
W
Y
P
Q
L
Q
R
K
K
Site 68
S686
N
A
H
S
S
L
K
S
I
F
S
S
L
P
N
Site 69
Y714
E
T
D
E
N
R
I
Y
K
Q
C
F
S
C
L
Site 70
Y729
P
F
T
M
K
K
I
Y
Y
R
P
A
L
M
T
Site 71
T736
Y
Y
R
P
A
L
M
T
A
I
D
G
R
H
D
Site 72
S810
L
F
V
L
D
E
N
S
Y
P
L
Q
Q
D
F
Site 73
Y811
F
V
L
D
E
N
S
Y
P
L
Q
Q
D
F
S
Site 74
S818
Y
P
L
Q
Q
D
F
S
L
L
D
F
Y
P
D
Site 75
Y823
D
F
S
L
L
D
F
Y
P
D
I
V
K
H
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation