KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SMG6
Full Name:
Telomerase-binding protein EST1A
Alias:
C17orf31; EST1 telomerase component A; EST1A; EST1-like protein A; Est1p-like protein A; Ever shorter telomeres 1A; KIAA0732; SMG-6; Smg-6, nonsense mediated mRNA decay factor; Telomerase subunit EST1A
Type:
DNA binding protein; Hydrolase; EC 3.1.-.-
Mass (Da):
160462
Number AA:
1419
UniProt ID:
Q86US8
International Prot ID:
IPI00015793
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000781
GO:0005737
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0004519
GO:0030145
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006406
GO:0000184
GO:0035303
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
G
L
E
R
V
R
I
S
A
S
E
L
R
G
I
Site 2
S13
E
R
V
R
I
S
A
S
E
L
R
G
I
L
A
Site 3
Y52
R
R
P
D
L
E
I
Y
K
P
G
L
S
R
L
Site 4
S57
E
I
Y
K
P
G
L
S
R
L
R
N
K
P
K
Site 5
S71
K
I
K
E
P
P
G
S
E
E
F
K
D
E
I
Site 6
S85
I
V
N
D
R
D
C
S
A
V
E
N
G
T
Q
Site 7
S120
E
N
N
R
G
Q
E
S
F
P
R
T
A
G
Q
Site 8
T124
G
Q
E
S
F
P
R
T
A
G
Q
E
D
R
S
Site 9
S131
T
A
G
Q
E
D
R
S
L
K
I
I
K
R
T
Site 10
T138
S
L
K
I
I
K
R
T
K
K
P
D
L
Q
I
Site 11
Y146
K
K
P
D
L
Q
I
Y
Q
P
G
R
R
L
Q
Site 12
T154
Q
P
G
R
R
L
Q
T
V
S
K
E
S
A
S
Site 13
S156
G
R
R
L
Q
T
V
S
K
E
S
A
S
R
V
Site 14
S203
D
R
A
E
I
E
K
S
P
G
G
G
R
V
G
Site 15
T229
K
G
E
G
V
R
E
T
H
D
D
P
A
R
G
Site 16
S240
P
A
R
G
R
P
G
S
A
K
R
Y
S
R
S
Site 17
Y244
R
P
G
S
A
K
R
Y
S
R
S
D
K
R
R
Site 18
S245
P
G
S
A
K
R
Y
S
R
S
D
K
R
R
N
Site 19
S247
S
A
K
R
Y
S
R
S
D
K
R
R
N
R
Y
Site 20
Y254
S
D
K
R
R
N
R
Y
R
T
R
S
T
S
S
Site 21
T256
K
R
R
N
R
Y
R
T
R
S
T
S
S
A
G
Site 22
S258
R
N
R
Y
R
T
R
S
T
S
S
A
G
S
N
Site 23
T259
N
R
Y
R
T
R
S
T
S
S
A
G
S
N
N
Site 24
S260
R
Y
R
T
R
S
T
S
S
A
G
S
N
N
S
Site 25
S264
R
S
T
S
S
A
G
S
N
N
S
A
E
G
A
Site 26
S267
S
S
A
G
S
N
N
S
A
E
G
A
G
L
T
Site 27
T286
R
R
R
R
Q
D
R
T
K
E
R
P
R
L
K
Site 28
S297
P
R
L
K
K
Q
V
S
V
S
S
T
D
S
L
Site 29
S299
L
K
K
Q
V
S
V
S
S
T
D
S
L
D
E
Site 30
T301
K
Q
V
S
V
S
S
T
D
S
L
D
E
D
R
Site 31
S303
V
S
V
S
S
T
D
S
L
D
E
D
R
I
D
Site 32
S320
D
G
L
G
P
R
R
S
S
E
R
K
R
H
L
Site 33
S321
G
L
G
P
R
R
S
S
E
R
K
R
H
L
E
Site 34
S332
R
H
L
E
R
N
W
S
G
R
G
E
G
E
Q
Site 35
S342
G
E
G
E
Q
K
N
S
A
K
E
Y
R
G
T
Site 36
T349
S
A
K
E
Y
R
G
T
L
R
V
T
F
D
A
Site 37
T353
Y
R
G
T
L
R
V
T
F
D
A
E
A
M
N
Site 38
S363
A
E
A
M
N
K
E
S
P
M
V
R
S
A
R
Site 39
S368
K
E
S
P
M
V
R
S
A
R
D
D
M
D
R
Site 40
S383
G
K
P
D
K
G
L
S
S
G
G
K
G
S
E
Site 41
S384
K
P
D
K
G
L
S
S
G
G
K
G
S
E
K
Site 42
S389
L
S
S
G
G
K
G
S
E
K
Q
E
S
K
N
Site 43
S394
K
G
S
E
K
Q
E
S
K
N
P
K
Q
E
L
Site 44
S418
L
P
A
H
T
T
L
S
V
N
S
A
G
S
P
Site 45
S424
L
S
V
N
S
A
G
S
P
E
S
A
P
L
G
Site 46
S427
N
S
A
G
S
P
E
S
A
P
L
G
P
R
L
Site 47
S438
G
P
R
L
L
F
G
S
G
S
K
G
S
R
S
Site 48
S440
R
L
L
F
G
S
G
S
K
G
S
R
S
W
G
Site 49
S443
F
G
S
G
S
K
G
S
R
S
W
G
R
G
G
Site 50
S445
S
G
S
K
G
S
R
S
W
G
R
G
G
T
T
Site 51
T451
R
S
W
G
R
G
G
T
T
R
R
L
W
D
P
Site 52
T469
D
Q
K
P
A
L
K
T
Q
T
P
Q
L
H
F
Site 53
T471
K
P
A
L
K
T
Q
T
P
Q
L
H
F
L
D
Site 54
T479
P
Q
L
H
F
L
D
T
D
D
E
V
S
P
T
Site 55
S484
L
D
T
D
D
E
V
S
P
T
S
W
G
D
S
Site 56
T486
T
D
D
E
V
S
P
T
S
W
G
D
S
R
Q
Site 57
S487
D
D
E
V
S
P
T
S
W
G
D
S
R
Q
A
Site 58
S491
S
P
T
S
W
G
D
S
R
Q
A
Q
A
S
Y
Site 59
S497
D
S
R
Q
A
Q
A
S
Y
Y
K
F
Q
N
S
Site 60
Y498
S
R
Q
A
Q
A
S
Y
Y
K
F
Q
N
S
D
Site 61
Y508
F
Q
N
S
D
N
P
Y
Y
Y
P
R
T
P
G
Site 62
Y509
Q
N
S
D
N
P
Y
Y
Y
P
R
T
P
G
P
Site 63
Y510
N
S
D
N
P
Y
Y
Y
P
R
T
P
G
P
A
Site 64
T513
N
P
Y
Y
Y
P
R
T
P
G
P
A
S
Q
Y
Site 65
S518
P
R
T
P
G
P
A
S
Q
Y
P
Y
T
G
Y
Site 66
Y520
T
P
G
P
A
S
Q
Y
P
Y
T
G
Y
N
P
Site 67
Y522
G
P
A
S
Q
Y
P
Y
T
G
Y
N
P
L
Q
Site 68
T523
P
A
S
Q
Y
P
Y
T
G
Y
N
P
L
Q
Y
Site 69
Y525
S
Q
Y
P
Y
T
G
Y
N
P
L
Q
Y
P
V
Site 70
Y530
T
G
Y
N
P
L
Q
Y
P
V
G
P
T
N
G
Site 71
Y539
V
G
P
T
N
G
V
Y
P
G
P
Y
Y
P
G
Site 72
Y543
N
G
V
Y
P
G
P
Y
Y
P
G
Y
P
T
P
Site 73
Y544
G
V
Y
P
G
P
Y
Y
P
G
Y
P
T
P
S
Site 74
Y547
P
G
P
Y
Y
P
G
Y
P
T
P
S
G
Q
Y
Site 75
T549
P
Y
Y
P
G
Y
P
T
P
S
G
Q
Y
V
C
Site 76
S551
Y
P
G
Y
P
T
P
S
G
Q
Y
V
C
S
P
Site 77
Y554
Y
P
T
P
S
G
Q
Y
V
C
S
P
L
P
T
Site 78
S557
P
S
G
Q
Y
V
C
S
P
L
P
T
S
T
M
Site 79
T561
Y
V
C
S
P
L
P
T
S
T
M
S
P
E
E
Site 80
S562
V
C
S
P
L
P
T
S
T
M
S
P
E
E
V
Site 81
T563
C
S
P
L
P
T
S
T
M
S
P
E
E
V
E
Site 82
S565
P
L
P
T
S
T
M
S
P
E
E
V
E
Q
H
Site 83
S596
D
N
Q
E
L
Q
L
S
N
L
L
S
R
D
R
Site 84
S600
L
Q
L
S
N
L
L
S
R
D
R
I
S
P
E
Site 85
S605
L
L
S
R
D
R
I
S
P
E
G
L
E
K
M
Site 86
S634
I
L
L
D
I
E
F
S
D
N
Q
N
V
D
Q
Site 87
Y649
I
L
W
K
N
A
F
Y
Q
V
I
E
K
F
R
Site 88
S687
E
G
S
D
F
F
D
S
L
L
Q
K
L
Q
V
Site 89
Y703
Y
K
F
K
L
E
D
Y
M
D
G
L
A
I
R
Site 90
T717
R
S
K
P
L
R
K
T
V
K
Y
A
L
I
S
Site 91
Y720
P
L
R
K
T
V
K
Y
A
L
I
S
A
Q
R
Site 92
S743
A
R
Y
R
E
Q
A
S
D
T
A
N
Y
G
K
Site 93
T745
Y
R
E
Q
A
S
D
T
A
N
Y
G
K
A
R
Site 94
Y755
Y
G
K
A
R
S
W
Y
L
K
A
Q
H
I
A
Site 95
Y769
A
P
K
N
G
R
P
Y
N
Q
L
A
L
L
A
Site 96
Y778
Q
L
A
L
L
A
V
Y
T
R
R
K
L
D
A
Site 97
Y787
R
R
K
L
D
A
V
Y
Y
Y
M
R
S
L
A
Site 98
Y788
R
K
L
D
A
V
Y
Y
Y
M
R
S
L
A
A
Site 99
Y789
K
L
D
A
V
Y
Y
Y
M
R
S
L
A
A
S
Site 100
S808
T
A
K
E
S
L
M
S
L
F
E
E
T
K
R
Site 101
S831
Q
H
E
E
F
D
L
S
P
D
Q
W
R
K
G
Site 102
S841
Q
W
R
K
G
K
K
S
T
F
R
H
V
G
D
Site 103
T842
W
R
K
G
K
K
S
T
F
R
H
V
G
D
D
Site 104
T850
F
R
H
V
G
D
D
T
T
R
L
E
I
W
I
Site 105
S860
L
E
I
W
I
H
P
S
H
P
R
S
S
Q
G
Site 106
S864
I
H
P
S
H
P
R
S
S
Q
G
T
E
S
G
Site 107
S865
H
P
S
H
P
R
S
S
Q
G
T
E
S
G
K
Site 108
T868
H
P
R
S
S
Q
G
T
E
S
G
K
D
S
E
Site 109
S870
R
S
S
Q
G
T
E
S
G
K
D
S
E
Q
E
Site 110
S874
G
T
E
S
G
K
D
S
E
Q
E
N
G
L
G
Site 111
S882
E
Q
E
N
G
L
G
S
L
S
P
S
D
L
N
Site 112
S884
E
N
G
L
G
S
L
S
P
S
D
L
N
K
R
Site 113
S886
G
L
G
S
L
S
P
S
D
L
N
K
R
F
I
Site 114
S895
L
N
K
R
F
I
L
S
F
L
H
A
H
G
K
Site 115
S930
F
Q
V
L
L
Q
H
S
P
S
P
I
G
S
T
Site 116
S932
V
L
L
Q
H
S
P
S
P
I
G
S
T
R
M
Site 117
S936
H
S
P
S
P
I
G
S
T
R
M
L
Q
L
M
Site 118
S960
S
Q
L
K
D
C
F
S
E
E
C
R
S
V
I
Site 119
S965
C
F
S
E
E
C
R
S
V
I
Q
E
Q
A
A
Site 120
S1000
S
A
K
A
Q
L
S
S
P
E
D
Q
D
D
Q
Site 121
S1014
Q
D
D
I
K
V
S
S
F
V
P
D
L
K
E
Site 122
S1025
D
L
K
E
L
L
P
S
V
K
V
W
S
D
W
Site 123
T1045
D
T
W
N
P
P
P
T
S
L
D
L
P
S
H
Site 124
S1046
T
W
N
P
P
P
T
S
L
D
L
P
S
H
V
Site 125
Y1079
N
Q
S
E
V
P
L
Y
K
D
P
D
D
D
L
Site 126
T1087
K
D
P
D
D
D
L
T
L
L
I
L
E
E
D
Site 127
Y1112
A
A
P
Q
D
P
C
Y
V
E
K
T
S
D
K
Site 128
S1155
F
K
G
G
K
Y
V
S
V
A
P
V
P
D
T
Site 129
T1162
S
V
A
P
V
P
D
T
M
G
K
E
M
G
S
Site 130
S1169
T
M
G
K
E
M
G
S
Q
E
G
T
R
L
E
Site 131
S1191
I
E
D
F
E
E
D
S
E
A
E
G
S
G
G
Site 132
S1196
E
D
S
E
A
E
G
S
G
G
E
D
D
I
R
Site 133
S1234
Q
A
V
L
E
D
H
S
Q
M
R
Q
M
E
L
Site 134
Y1299
T
D
H
R
A
G
G
Y
A
R
V
V
Q
E
K
Site 135
S1310
V
Q
E
K
A
R
K
S
I
E
F
L
E
Q
R
Site 136
S1320
F
L
E
Q
R
F
E
S
R
D
S
C
L
R
A
Site 137
S1323
Q
R
F
E
S
R
D
S
C
L
R
A
L
T
S
Site 138
T1329
D
S
C
L
R
A
L
T
S
R
G
N
E
L
E
Site 139
S1330
S
C
L
R
A
L
T
S
R
G
N
E
L
E
S
Site 140
S1337
S
R
G
N
E
L
E
S
I
A
F
R
S
E
D
Site 141
T1346
A
F
R
S
E
D
I
T
G
Q
L
G
N
N
D
Site 142
S1375
A
K
D
F
M
P
A
S
K
E
E
P
I
R
L
Site 143
T1390
L
R
E
V
V
L
L
T
D
D
R
N
L
R
V
Site 144
T1401
N
L
R
V
K
A
L
T
R
N
V
P
V
R
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation