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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TLK2
Full Name:
Serine/threonine-protein kinase tousled-like 2
Alias:
EC 2.7.11.1; MGC44450; PKU-alpha; Tousled-like kinase 2
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Other group; TLK family
Mass (Da):
87661
Number AA:
772
UniProt ID:
Q86UE8
International Prot ID:
IPI00385652
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0016568
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
M
E
E
L
H
S
L
D
P
R
R
Q
E
Site 2
S26
R
F
T
G
V
G
V
S
K
G
P
L
N
S
E
Site 3
S32
V
S
K
G
P
L
N
S
E
S
S
N
Q
S
L
Site 4
S34
K
G
P
L
N
S
E
S
S
N
Q
S
L
C
S
Site 5
S35
G
P
L
N
S
E
S
S
N
Q
S
L
C
S
V
Site 6
S38
N
S
E
S
S
N
Q
S
L
C
S
V
G
S
L
Site 7
S41
S
S
N
Q
S
L
C
S
V
G
S
L
S
D
K
Site 8
S44
Q
S
L
C
S
V
G
S
L
S
D
K
E
V
E
Site 9
S46
L
C
S
V
G
S
L
S
D
K
E
V
E
T
P
Site 10
T52
L
S
D
K
E
V
E
T
P
E
K
K
Q
N
D
Site 11
Y70
R
K
R
K
A
E
P
Y
E
T
S
Q
G
K
G
Site 12
T72
R
K
A
E
P
Y
E
T
S
Q
G
K
G
T
P
Site 13
S73
K
A
E
P
Y
E
T
S
Q
G
K
G
T
P
R
Site 14
T78
E
T
S
Q
G
K
G
T
P
R
G
H
K
I
S
Site 15
S85
T
P
R
G
H
K
I
S
D
Y
F
E
F
A
G
Site 16
Y87
R
G
H
K
I
S
D
Y
F
E
F
A
G
G
S
Site 17
S94
Y
F
E
F
A
G
G
S
A
P
G
T
S
P
G
Site 18
T98
A
G
G
S
A
P
G
T
S
P
G
R
S
V
P
Site 19
S99
G
G
S
A
P
G
T
S
P
G
R
S
V
P
P
Site 20
S103
P
G
T
S
P
G
R
S
V
P
P
V
A
R
S
Site 21
S110
S
V
P
P
V
A
R
S
S
P
Q
H
S
L
S
Site 22
S111
V
P
P
V
A
R
S
S
P
Q
H
S
L
S
N
Site 23
S115
A
R
S
S
P
Q
H
S
L
S
N
P
L
P
R
Site 24
S117
S
S
P
Q
H
S
L
S
N
P
L
P
R
R
V
Site 25
Y129
R
R
V
E
Q
P
L
Y
G
L
D
G
S
A
A
Site 26
S134
P
L
Y
G
L
D
G
S
A
A
K
E
A
T
E
Site 27
T161
L
A
K
P
R
L
D
T
E
Q
L
A
Q
R
G
Site 28
S177
G
L
C
F
T
F
V
S
A
Q
Q
N
S
P
S
Site 29
S182
F
V
S
A
Q
Q
N
S
P
S
S
T
G
S
G
Site 30
S184
S
A
Q
Q
N
S
P
S
S
T
G
S
G
N
T
Site 31
S185
A
Q
Q
N
S
P
S
S
T
G
S
G
N
T
E
Site 32
T186
Q
Q
N
S
P
S
S
T
G
S
G
N
T
E
H
Site 33
S188
N
S
P
S
S
T
G
S
G
N
T
E
H
S
C
Site 34
S194
G
S
G
N
T
E
H
S
C
S
S
Q
K
Q
I
Site 35
S196
G
N
T
E
H
S
C
S
S
Q
K
Q
I
S
I
Site 36
S197
N
T
E
H
S
C
S
S
Q
K
Q
I
S
I
Q
Site 37
T208
I
S
I
Q
H
R
Q
T
Q
S
D
L
T
I
E
Site 38
T213
R
Q
T
Q
S
D
L
T
I
E
K
I
S
A
L
Site 39
Y259
Q
Q
K
M
L
E
K
Y
K
E
R
L
N
R
C
Site 40
T268
E
R
L
N
R
C
V
T
M
S
K
K
L
L
I
Site 41
S270
L
N
R
C
V
T
M
S
K
K
L
L
I
E
K
Site 42
S278
K
K
L
L
I
E
K
S
K
Q
E
K
M
A
C
Site 43
S289
K
M
A
C
R
D
K
S
M
Q
D
R
L
R
L
Site 44
T300
R
L
R
L
G
H
F
T
T
V
R
H
G
A
S
Site 45
T301
L
R
L
G
H
F
T
T
V
R
H
G
A
S
F
Site 46
S307
T
T
V
R
H
G
A
S
F
T
E
Q
W
T
D
Site 47
Y316
T
E
Q
W
T
D
G
Y
A
F
Q
N
L
I
K
Site 48
S330
K
Q
Q
E
R
I
N
S
Q
R
E
E
I
E
R
Site 49
T357
M
G
Q
A
P
P
A
T
N
E
Q
K
Q
R
K
Site 50
S365
N
E
Q
K
Q
R
K
S
K
T
N
G
A
E
N
Site 51
T374
T
N
G
A
E
N
E
T
P
S
S
G
N
T
E
Site 52
S377
A
E
N
E
T
P
S
S
G
N
T
E
L
K
D
Site 53
T380
E
T
P
S
S
G
N
T
E
L
K
D
T
A
P
Site 54
T385
G
N
T
E
L
K
D
T
A
P
A
L
G
A
H
Site 55
T398
A
H
S
L
L
R
L
T
L
A
E
Y
H
E
Q
Site 56
Y402
L
R
L
T
L
A
E
Y
H
E
Q
E
E
I
F
Site 57
S450
R
I
H
N
E
D
N
S
Q
F
K
D
H
P
T
Site 58
T457
S
Q
F
K
D
H
P
T
L
N
D
R
Y
L
L
Site 59
Y477
R
G
G
F
S
E
V
Y
K
A
F
D
L
T
E
Site 60
Y487
F
D
L
T
E
Q
R
Y
V
A
V
K
I
H
Q
Site 61
Y515
H
K
H
A
C
R
E
Y
R
I
H
K
E
L
D
Site 62
Y530
H
P
R
I
V
K
L
Y
D
Y
F
S
L
D
T
Site 63
Y532
R
I
V
K
L
Y
D
Y
F
S
L
D
T
D
S
Site 64
S534
V
K
L
Y
D
Y
F
S
L
D
T
D
S
F
C
Site 65
Y546
S
F
C
T
V
L
E
Y
C
E
G
N
D
L
D
Site 66
Y555
E
G
N
D
L
D
F
Y
L
K
Q
H
K
L
M
Site 67
Y580
Q
I
V
N
A
L
K
Y
L
N
E
I
K
P
P
Site 68
Y591
I
K
P
P
I
I
H
Y
D
L
K
P
G
N
I
Site 69
S624
S
K
I
M
D
D
D
S
Y
N
S
V
D
G
M
Site 70
Y625
K
I
M
D
D
D
S
Y
N
S
V
D
G
M
E
Site 71
T634
S
V
D
G
M
E
L
T
S
Q
G
A
G
T
Y
Site 72
S635
V
D
G
M
E
L
T
S
Q
G
A
G
T
Y
W
Site 73
Y643
Q
G
A
G
T
Y
W
Y
L
P
P
E
C
F
V
Site 74
S659
G
K
E
P
P
K
I
S
N
K
V
D
V
W
S
Site 75
Y672
W
S
V
G
V
I
F
Y
Q
C
L
Y
G
R
K
Site 76
Y676
V
I
F
Y
Q
C
L
Y
G
R
K
P
F
G
H
Site 77
S686
K
P
F
G
H
N
Q
S
Q
Q
D
I
L
Q
E
Site 78
Y724
F
I
R
R
C
L
A
Y
R
K
E
D
R
I
D
Site 79
Y740
Q
Q
L
A
C
D
P
Y
L
L
P
H
I
R
K
Site 80
S748
L
L
P
H
I
R
K
S
V
S
T
S
S
P
A
Site 81
S750
P
H
I
R
K
S
V
S
T
S
S
P
A
G
A
Site 82
T751
H
I
R
K
S
V
S
T
S
S
P
A
G
A
A
Site 83
S752
I
R
K
S
V
S
T
S
S
P
A
G
A
A
I
Site 84
S753
R
K
S
V
S
T
S
S
P
A
G
A
A
I
A
Site 85
S761
P
A
G
A
A
I
A
S
T
S
G
A
S
N
N
Site 86
S763
G
A
A
I
A
S
T
S
G
A
S
N
N
S
S
Site 87
S766
I
A
S
T
S
G
A
S
N
N
S
S
S
N
_
Site 88
S769
T
S
G
A
S
N
N
S
S
S
N
_
_
_
_
Site 89
S770
S
G
A
S
N
N
S
S
S
N
_
_
_
_
_
Site 90
S771
G
A
S
N
N
S
S
S
N
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation