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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF546
Full Name:
Zinc finger protein 546
Alias:
MGC43537; ZN546; ZNF49
Type:
Unknown function
Mass (Da):
98405
Number AA:
836
UniProt ID:
Q86UE3
International Prot ID:
IPI00328713
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T42
L
C
F
S
M
E
E
T
Q
G
E
L
T
S
S
Site 2
S48
E
T
Q
G
E
L
T
S
S
C
G
S
K
T
M
Site 3
S49
T
Q
G
E
L
T
S
S
C
G
S
K
T
M
A
Site 4
S52
E
L
T
S
S
C
G
S
K
T
M
A
N
V
S
Site 5
T54
T
S
S
C
G
S
K
T
M
A
N
V
S
L
A
Site 6
S59
S
K
T
M
A
N
V
S
L
A
F
R
D
V
S
Site 7
S66
S
L
A
F
R
D
V
S
I
D
L
S
Q
E
E
Site 8
S70
R
D
V
S
I
D
L
S
Q
E
E
W
E
C
L
Site 9
Y85
D
A
V
Q
R
D
L
Y
K
D
V
M
L
E
N
Site 10
Y93
K
D
V
M
L
E
N
Y
S
N
L
V
S
L
G
Site 11
S98
E
N
Y
S
N
L
V
S
L
G
Y
T
I
P
K
Site 12
Y135
N
W
F
T
D
L
E
Y
K
Y
I
T
K
N
L
Site 13
Y137
F
T
D
L
E
Y
K
Y
I
T
K
N
L
L
S
Site 14
Y152
E
K
N
V
C
K
I
Y
L
S
Q
L
Q
T
G
Site 15
S154
N
V
C
K
I
Y
L
S
Q
L
Q
T
G
E
K
Site 16
T158
I
Y
L
S
Q
L
Q
T
G
E
K
S
K
N
T
Site 17
S162
Q
L
Q
T
G
E
K
S
K
N
T
I
H
E
D
Site 18
S216
K
I
H
A
R
E
K
S
Y
E
C
K
E
C
R
Site 19
S230
R
K
A
F
R
Q
Q
S
Y
L
I
Q
H
L
R
Site 20
Y231
K
A
F
R
Q
Q
S
Y
L
I
Q
H
L
R
I
Site 21
T240
I
Q
H
L
R
I
H
T
G
E
R
P
Y
K
C
Site 22
Y245
I
H
T
G
E
R
P
Y
K
C
M
E
C
G
K
Site 23
Y273
I
H
A
G
E
R
P
Y
E
C
K
E
C
G
K
Site 24
Y286
G
K
A
F
R
L
H
Y
H
L
T
E
H
Q
R
Site 25
S296
T
E
H
Q
R
I
H
S
G
V
K
P
Y
E
C
Site 26
Y301
I
H
S
G
V
K
P
Y
E
C
K
E
C
G
K
Site 27
S311
K
E
C
G
K
A
F
S
R
V
R
D
L
R
V
Site 28
Y342
G
K
A
F
R
L
H
Y
Q
L
T
E
H
Q
R
Site 29
T352
T
E
H
Q
R
I
H
T
G
E
R
P
Y
E
C
Site 30
Y357
I
H
T
G
E
R
P
Y
E
C
K
V
C
G
K
Site 31
S395
N
E
C
G
K
A
F
S
H
G
S
Y
L
V
Q
Site 32
S398
G
K
A
F
S
H
G
S
Y
L
V
Q
H
Q
K
Site 33
Y399
K
A
F
S
H
G
S
Y
L
V
Q
H
Q
K
I
Site 34
T408
V
Q
H
Q
K
I
H
T
G
E
K
P
Y
E
C
Site 35
Y413
I
H
T
G
E
K
P
Y
E
C
K
E
C
G
K
Site 36
S421
E
C
K
E
C
G
K
S
F
S
F
H
A
E
L
Site 37
S423
K
E
C
G
K
S
F
S
F
H
A
E
L
A
R
Site 38
T436
A
R
H
R
R
I
H
T
G
E
K
P
Y
E
C
Site 39
Y441
I
H
T
G
E
K
P
Y
E
C
R
E
C
G
K
Site 40
T454
G
K
A
F
R
L
Q
T
E
L
T
R
H
H
R
Site 41
T457
F
R
L
Q
T
E
L
T
R
H
H
R
T
H
T
Site 42
T462
E
L
T
R
H
H
R
T
H
T
G
E
K
P
Y
Site 43
T464
T
R
H
H
R
T
H
T
G
E
K
P
Y
E
C
Site 44
Y469
T
H
T
G
E
K
P
Y
E
C
K
E
C
G
K
Site 45
T492
T
L
H
L
R
T
H
T
G
E
I
P
Y
E
C
Site 46
Y497
T
H
T
G
E
I
P
Y
E
C
K
E
C
G
K
Site 47
T505
E
C
K
E
C
G
K
T
F
S
S
R
Y
H
L
Site 48
S507
K
E
C
G
K
T
F
S
S
R
Y
H
L
T
Q
Site 49
Y516
R
Y
H
L
T
Q
H
Y
R
I
H
T
G
E
K
Site 50
T520
T
Q
H
Y
R
I
H
T
G
E
K
P
Y
I
C
Site 51
Y525
I
H
T
G
E
K
P
Y
I
C
N
E
C
G
K
Site 52
T541
F
R
L
Q
G
E
L
T
R
H
H
R
I
H
T
Site 53
T548
T
R
H
H
R
I
H
T
C
E
K
P
Y
E
C
Site 54
Y553
I
H
T
C
E
K
P
Y
E
C
K
E
C
G
K
Site 55
T576
I
S
H
Q
R
I
H
T
S
E
S
T
Y
I
C
Site 56
Y581
I
H
T
S
E
S
T
Y
I
C
K
E
C
G
K
Site 57
S591
K
E
C
G
K
I
F
S
R
R
Y
N
L
T
Q
Site 58
Y594
G
K
I
F
S
R
R
Y
N
L
T
Q
H
F
K
Site 59
T604
T
Q
H
F
K
I
H
T
G
E
K
P
Y
I
C
Site 60
T622
G
K
A
F
R
F
Q
T
E
L
T
Q
H
H
R
Site 61
T632
T
Q
H
H
R
I
H
T
G
E
K
P
Y
K
C
Site 62
T650
G
K
A
F
I
R
S
T
H
L
T
Q
H
H
R
Site 63
T660
T
Q
H
H
R
I
H
T
G
E
K
P
Y
E
C
Site 64
Y665
I
H
T
G
E
K
P
Y
E
C
T
E
C
G
K
Site 65
Y678
G
K
T
F
S
R
H
Y
H
L
T
Q
H
H
R
Site 66
T688
T
Q
H
H
R
G
H
T
G
E
K
P
Y
I
C
Site 67
Y693
G
H
T
G
E
K
P
Y
I
C
N
E
C
G
N
Site 68
T716
T
L
H
Q
R
I
H
T
G
E
L
P
Y
E
C
Site 69
Y721
I
H
T
G
E
L
P
Y
E
C
K
E
C
G
K
Site 70
T729
E
C
K
E
C
G
K
T
F
S
R
R
Y
H
L
Site 71
S731
K
E
C
G
K
T
F
S
R
R
Y
H
L
T
Q
Site 72
Y734
G
K
T
F
S
R
R
Y
H
L
T
Q
H
F
R
Site 73
T744
T
Q
H
F
R
L
H
T
G
E
K
P
Y
S
C
Site 74
T765
F
R
L
Q
A
E
L
T
R
H
H
I
V
H
T
Site 75
T772
T
R
H
H
I
V
H
T
G
E
K
P
Y
K
C
Site 76
Y777
V
H
T
G
E
K
P
Y
K
C
K
E
C
G
K
Site 77
S787
K
E
C
G
K
A
F
S
V
N
S
E
L
T
R
Site 78
S790
G
K
A
F
S
V
N
S
E
L
T
R
H
H
R
Site 79
T800
T
R
H
H
R
I
H
T
G
E
K
P
Y
Q
C
Site 80
Y805
I
H
T
G
E
K
P
Y
Q
C
K
E
C
G
K
Site 81
S817
C
G
K
A
F
I
R
S
D
Q
L
T
L
H
Q
Site 82
T821
F
I
R
S
D
Q
L
T
L
H
Q
R
N
H
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation