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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PBRM1
Full Name:
Protein polybromo-1
Alias:
BRG1-associated factor 180; HPB1; PB1; PBRM1; PB1; Polybromo-1D
Type:
DNA binding protein
Mass (Da):
192948
Number AA:
1689
UniProt ID:
Q86U86
International Prot ID:
IPI00384176
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000228
GO:0005634
GO:0005694
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003682
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006338
GO:0007067
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
G
S
K
R
R
R
A
T
S
P
S
S
S
V
S
Site 2
S10
S
K
R
R
R
A
T
S
P
S
S
S
V
S
G
Site 3
S12
R
R
R
A
T
S
P
S
S
S
V
S
G
D
F
Site 4
S13
R
R
A
T
S
P
S
S
S
V
S
G
D
F
D
Site 5
S14
R
A
T
S
P
S
S
S
V
S
G
D
F
D
D
Site 6
S16
T
S
P
S
S
S
V
S
G
D
F
D
D
G
H
Site 7
S25
D
F
D
D
G
H
H
S
V
S
T
P
G
P
S
Site 8
S27
D
D
G
H
H
S
V
S
T
P
G
P
S
R
K
Site 9
T28
D
G
H
H
S
V
S
T
P
G
P
S
R
K
R
Site 10
S32
S
V
S
T
P
G
P
S
R
K
R
R
R
L
S
Site 11
S39
S
R
K
R
R
R
L
S
N
L
P
T
V
D
P
Site 12
T43
R
R
L
S
N
L
P
T
V
D
P
I
A
V
C
Site 13
Y54
I
A
V
C
H
E
L
Y
N
T
I
R
D
Y
K
Site 14
T56
V
C
H
E
L
Y
N
T
I
R
D
Y
K
D
E
Site 15
Y60
L
Y
N
T
I
R
D
Y
K
D
E
Q
G
R
L
Site 16
Y84
K
R
R
N
Q
P
D
Y
Y
E
V
V
S
Q
P
Site 17
Y85
R
R
N
Q
P
D
Y
Y
E
V
V
S
Q
P
I
Site 18
S89
P
D
Y
Y
E
V
V
S
Q
P
I
D
L
M
K
Site 19
Y106
Q
K
L
K
M
E
E
Y
D
D
V
N
L
L
T
Site 20
S125
L
L
F
N
N
A
K
S
Y
Y
K
P
D
S
P
Site 21
Y126
L
F
N
N
A
K
S
Y
Y
K
P
D
S
P
E
Site 22
Y127
F
N
N
A
K
S
Y
Y
K
P
D
S
P
E
Y
Site 23
S131
K
S
Y
Y
K
P
D
S
P
E
Y
K
A
A
C
Site 24
Y134
Y
K
P
D
S
P
E
Y
K
A
A
C
K
L
W
Site 25
Y144
A
C
K
L
W
D
L
Y
L
R
T
R
N
E
F
Site 26
T172
D
G
Q
D
N
Q
G
T
V
T
E
G
S
S
P
Site 27
T174
Q
D
N
Q
G
T
V
T
E
G
S
S
P
A
Y
Site 28
S177
Q
G
T
V
T
E
G
S
S
P
A
Y
L
K
E
Site 29
S178
G
T
V
T
E
G
S
S
P
A
Y
L
K
E
I
Site 30
Y181
T
E
G
S
S
P
A
Y
L
K
E
I
L
E
Q
Site 31
S205
N
P
S
G
R
L
I
S
E
L
F
Q
K
L
P
Site 32
S213
E
L
F
Q
K
L
P
S
K
V
Q
Y
P
D
Y
Site 33
Y217
K
L
P
S
K
V
Q
Y
P
D
Y
Y
A
I
I
Site 34
Y220
S
K
V
Q
Y
P
D
Y
Y
A
I
I
K
E
P
Site 35
Y221
K
V
Q
Y
P
D
Y
Y
A
I
I
K
E
P
I
Site 36
T232
K
E
P
I
D
L
K
T
I
A
Q
R
I
Q
N
Site 37
S241
A
Q
R
I
Q
N
G
S
Y
K
S
I
H
A
M
Site 38
Y242
Q
R
I
Q
N
G
S
Y
K
S
I
H
A
M
A
Site 39
Y262
L
A
K
N
A
K
T
Y
N
E
P
G
S
Q
V
Site 40
S267
K
T
Y
N
E
P
G
S
Q
V
F
K
D
A
N
Site 41
S295
E
H
H
E
M
A
K
S
S
L
R
M
R
T
P
Site 42
S296
H
H
E
M
A
K
S
S
L
R
M
R
T
P
S
Site 43
T301
K
S
S
L
R
M
R
T
P
S
N
L
A
A
A
Site 44
S303
S
L
R
M
R
T
P
S
N
L
A
A
A
R
L
Site 45
T311
N
L
A
A
A
R
L
T
G
P
S
H
S
K
G
Site 46
S314
A
A
R
L
T
G
P
S
H
S
K
G
S
L
G
Site 47
S316
R
L
T
G
P
S
H
S
K
G
S
L
G
E
E
Site 48
S319
G
P
S
H
S
K
G
S
L
G
E
E
R
N
P
Site 49
T327
L
G
E
E
R
N
P
T
S
K
Y
Y
R
N
K
Site 50
S328
G
E
E
R
N
P
T
S
K
Y
Y
R
N
K
R
Site 51
Y330
E
R
N
P
T
S
K
Y
Y
R
N
K
R
A
V
Site 52
S343
A
V
Q
G
G
R
L
S
A
I
T
M
A
L
Q
Site 53
T346
G
G
R
L
S
A
I
T
M
A
L
Q
Y
G
S
Site 54
Y351
A
I
T
M
A
L
Q
Y
G
S
E
S
E
E
D
Site 55
S353
T
M
A
L
Q
Y
G
S
E
S
E
E
D
A
A
Site 56
S355
A
L
Q
Y
G
S
E
S
E
E
D
A
A
L
A
Site 57
Y366
A
A
L
A
A
A
R
Y
E
E
G
E
S
E
A
Site 58
S371
A
R
Y
E
E
G
E
S
E
A
E
S
I
T
S
Site 59
S375
E
G
E
S
E
A
E
S
I
T
S
F
M
D
V
Site 60
S378
S
E
A
E
S
I
T
S
F
M
D
V
S
N
P
Site 61
Y387
M
D
V
S
N
P
F
Y
Q
L
Y
D
T
V
R
Site 62
Y390
S
N
P
F
Y
Q
L
Y
D
T
V
R
S
C
R
Site 63
Y409
Q
L
I
A
E
P
F
Y
H
L
P
S
K
K
K
Site 64
S413
E
P
F
Y
H
L
P
S
K
K
K
Y
P
D
Y
Site 65
Y417
H
L
P
S
K
K
K
Y
P
D
Y
Y
Q
Q
I
Site 66
Y420
S
K
K
K
Y
P
D
Y
Y
Q
Q
I
K
M
P
Site 67
Y421
K
K
K
Y
P
D
Y
Y
Q
Q
I
K
M
P
I
Site 68
S429
Q
Q
I
K
M
P
I
S
L
Q
Q
I
R
T
K
Site 69
Y462
M
F
E
N
A
K
R
Y
N
V
P
N
S
A
I
Site 70
S467
K
R
Y
N
V
P
N
S
A
I
Y
K
R
V
L
Site 71
Y470
N
V
P
N
S
A
I
Y
K
R
V
L
K
L
Q
Site 72
S498
D
D
I
E
D
G
D
S
M
I
S
S
A
T
S
Site 73
S501
E
D
G
D
S
M
I
S
S
A
T
S
D
T
G
Site 74
S502
D
G
D
S
M
I
S
S
A
T
S
D
T
G
S
Site 75
T504
D
S
M
I
S
S
A
T
S
D
T
G
S
A
K
Site 76
S505
S
M
I
S
S
A
T
S
D
T
G
S
A
K
R
Site 77
T507
I
S
S
A
T
S
D
T
G
S
A
K
R
K
S
Site 78
S509
S
A
T
S
D
T
G
S
A
K
R
K
S
K
K
Site 79
S514
T
G
S
A
K
R
K
S
K
K
N
I
R
K
Q
Site 80
S538
L
E
A
R
E
P
G
S
G
R
R
L
C
D
L
Site 81
Y555
V
K
P
S
K
K
D
Y
P
D
Y
Y
K
I
I
Site 82
Y558
S
K
K
D
Y
P
D
Y
Y
K
I
I
L
E
P
Site 83
Y559
K
K
D
Y
P
D
Y
Y
K
I
I
L
E
P
M
Site 84
Y580
H
N
I
R
N
D
K
Y
A
G
E
E
G
M
I
Site 85
Y600
M
F
R
N
A
R
H
Y
N
E
E
G
S
Q
V
Site 86
S636
P
D
D
D
D
M
A
S
P
K
L
K
L
S
R
Site 87
S642
A
S
P
K
L
K
L
S
R
K
S
G
I
S
P
Site 88
S645
K
L
K
L
S
R
K
S
G
I
S
P
K
K
S
Site 89
S648
L
S
R
K
S
G
I
S
P
K
K
S
K
Y
M
Site 90
S652
S
G
I
S
P
K
K
S
K
Y
M
T
P
M
Q
Site 91
Y654
I
S
P
K
K
S
K
Y
M
T
P
M
Q
Q
K
Site 92
T656
P
K
K
S
K
Y
M
T
P
M
Q
Q
K
L
N
Site 93
Y666
Q
Q
K
L
N
E
V
Y
E
A
V
K
N
Y
T
Site 94
Y672
V
Y
E
A
V
K
N
Y
T
D
K
R
G
R
R
Site 95
S681
D
K
R
G
R
R
L
S
A
I
F
L
R
L
P
Site 96
S689
A
I
F
L
R
L
P
S
R
S
E
L
P
D
Y
Site 97
S691
F
L
R
L
P
S
R
S
E
L
P
D
Y
Y
L
Site 98
Y696
S
R
S
E
L
P
D
Y
Y
L
T
I
K
K
P
Site 99
Y697
R
S
E
L
P
D
Y
Y
L
T
I
K
K
P
M
Site 100
Y718
S
H
M
M
A
N
K
Y
Q
D
I
D
S
M
V
Site 101
Y738
M
F
N
N
A
C
T
Y
N
E
P
E
S
L
I
Site 102
S743
C
T
Y
N
E
P
E
S
L
I
Y
K
D
A
L
Site 103
Y746
N
E
P
E
S
L
I
Y
K
D
A
L
V
L
H
Site 104
S769
D
L
E
G
D
E
D
S
H
V
P
N
V
T
L
Site 105
Y800
Q
D
D
E
G
R
C
Y
S
D
S
L
A
E
I
Site 106
S801
D
D
E
G
R
C
Y
S
D
S
L
A
E
I
P
Site 107
S803
E
G
R
C
Y
S
D
S
L
A
E
I
P
A
V
Site 108
T821
F
P
N
K
P
P
L
T
F
D
I
I
R
K
N
Site 109
Y834
K
N
V
E
N
N
R
Y
R
R
L
D
L
F
Q
Site 110
T857
R
A
R
R
M
N
R
T
D
S
E
I
Y
E
D
Site 111
S859
R
R
M
N
R
T
D
S
E
I
Y
E
D
A
V
Site 112
S888
K
N
G
E
I
L
L
S
P
A
L
S
Y
T
T
Site 113
S931
E
K
R
E
A
E
K
S
E
D
S
S
G
A
A
Site 114
S935
A
E
K
S
E
D
S
S
G
A
A
G
L
S
G
Site 115
S941
S
S
G
A
A
G
L
S
G
L
H
R
T
Y
S
Site 116
T946
G
L
S
G
L
H
R
T
Y
S
Q
D
C
S
F
Site 117
Y947
L
S
G
L
H
R
T
Y
S
Q
D
C
S
F
K
Site 118
S948
S
G
L
H
R
T
Y
S
Q
D
C
S
F
K
N
Site 119
Y958
C
S
F
K
N
S
M
Y
H
V
G
D
Y
V
Y
Site 120
Y963
S
M
Y
H
V
G
D
Y
V
Y
V
E
P
A
E
Site 121
Y965
Y
H
V
G
D
Y
V
Y
V
E
P
A
E
A
N
Site 122
S987
I
E
R
L
W
E
D
S
A
G
E
K
W
L
Y
Site 123
Y994
S
A
G
E
K
W
L
Y
G
C
W
F
Y
R
P
Site 124
S1020
L
E
K
E
V
F
K
S
D
Y
Y
N
K
V
P
Site 125
Y1022
K
E
V
F
K
S
D
Y
Y
N
K
V
P
V
S
Site 126
Y1023
E
V
F
K
S
D
Y
Y
N
K
V
P
V
S
K
Site 127
S1064
F
V
C
E
S
R
Y
S
A
K
T
K
S
F
K
Site 128
T1067
E
S
R
Y
S
A
K
T
K
S
F
K
K
I
K
Site 129
S1069
R
Y
S
A
K
T
K
S
F
K
K
I
K
L
W
Site 130
T1077
F
K
K
I
K
L
W
T
M
P
I
S
S
V
R
Site 131
S1081
K
L
W
T
M
P
I
S
S
V
R
F
V
P
R
Site 132
T1113
K
G
D
D
E
K
N
T
D
N
S
E
D
S
R
Site 133
S1116
D
E
K
N
T
D
N
S
E
D
S
R
A
E
D
Site 134
S1119
N
T
D
N
S
E
D
S
R
A
E
D
N
F
N
Site 135
S1139
E
D
V
P
V
E
M
S
N
G
E
P
G
C
H
Site 136
Y1147
N
G
E
P
G
C
H
Y
F
E
Q
L
H
Y
N
Site 137
S1168
G
D
C
V
F
I
K
S
H
G
L
V
R
P
R
Site 138
Y1192
R
D
G
A
A
Y
F
Y
G
P
I
F
I
H
P
Site 139
S1218
Y
K
K
E
V
F
L
S
N
L
E
E
T
C
P
Site 140
S1243
L
S
F
K
D
F
L
S
C
R
P
T
E
I
P
Site 141
T1247
D
F
L
S
C
R
P
T
E
I
P
E
N
D
I
Site 142
S1259
N
D
I
L
L
C
E
S
R
Y
N
E
S
D
K
Site 143
S1278
F
K
G
L
K
R
F
S
L
S
A
K
V
V
D
Site 144
S1280
G
L
K
R
F
S
L
S
A
K
V
V
D
D
E
Site 145
Y1289
K
V
V
D
D
E
I
Y
Y
F
R
K
P
I
V
Site 146
Y1290
V
V
D
D
E
I
Y
Y
F
R
K
P
I
V
P
Site 147
S1302
I
V
P
Q
K
E
P
S
P
L
L
E
K
K
I
Site 148
S1334
E
E
M
G
E
E
D
S
E
V
I
E
P
P
S
Site 149
S1341
S
E
V
I
E
P
P
S
L
P
Q
L
Q
T
P
Site 150
T1347
P
S
L
P
Q
L
Q
T
P
L
A
S
E
L
D
Site 151
S1351
Q
L
Q
T
P
L
A
S
E
L
D
L
M
P
Y
Site 152
Y1358
S
E
L
D
L
M
P
Y
T
P
P
Q
S
T
P
Site 153
T1359
E
L
D
L
M
P
Y
T
P
P
Q
S
T
P
K
Site 154
S1363
M
P
Y
T
P
P
Q
S
T
P
K
S
A
K
G
Site 155
T1364
P
Y
T
P
P
Q
S
T
P
K
S
A
K
G
S
Site 156
S1367
P
P
Q
S
T
P
K
S
A
K
G
S
A
K
K
Site 157
S1371
T
P
K
S
A
K
G
S
A
K
K
E
G
S
K
Site 158
S1377
G
S
A
K
K
E
G
S
K
R
K
I
N
M
S
Site 159
S1384
S
K
R
K
I
N
M
S
G
Y
I
L
F
S
S
Site 160
Y1386
R
K
I
N
M
S
G
Y
I
L
F
S
S
E
M
Site 161
Y1404
I
K
A
Q
H
P
D
Y
S
F
G
E
L
S
R
Site 162
S1405
K
A
Q
H
P
D
Y
S
F
G
E
L
S
R
L
Site 163
S1410
D
Y
S
F
G
E
L
S
R
L
V
G
T
E
W
Site 164
S1451
A
A
Q
Q
Q
Q
P
S
A
S
P
R
A
G
T
Site 165
S1453
Q
Q
Q
Q
P
S
A
S
P
R
A
G
T
P
V
Site 166
S1509
D
G
L
V
S
M
G
S
M
Q
P
L
H
P
G
Site 167
S1555
G
T
P
A
P
G
G
S
P
Y
G
Q
Q
V
G
Site 168
Y1557
P
A
P
G
G
S
P
Y
G
Q
Q
V
G
V
L
Site 169
Y1575
G
Q
Q
A
P
P
P
Y
P
G
P
H
P
A
G
Site 170
T1601
F
V
A
P
P
P
K
T
Q
R
L
L
H
S
E
Site 171
S1607
K
T
Q
R
L
L
H
S
E
A
Y
L
K
Y
I
Site 172
Y1610
R
L
L
H
S
E
A
Y
L
K
Y
I
E
G
L
Site 173
Y1613
H
S
E
A
Y
L
K
Y
I
E
G
L
S
A
E
Site 174
S1618
L
K
Y
I
E
G
L
S
A
E
S
N
S
I
S
Site 175
S1621
I
E
G
L
S
A
E
S
N
S
I
S
K
W
D
Site 176
S1623
G
L
S
A
E
S
N
S
I
S
K
W
D
Q
T
Site 177
S1625
S
A
E
S
N
S
I
S
K
W
D
Q
T
L
A
Site 178
T1630
S
I
S
K
W
D
Q
T
L
A
A
R
R
R
D
Site 179
S1641
R
R
R
D
V
H
L
S
K
E
Q
E
S
R
L
Site 180
S1646
H
L
S
K
E
Q
E
S
R
L
P
S
H
W
L
Site 181
S1650
E
Q
E
S
R
L
P
S
H
W
L
K
S
K
G
Site 182
T1677
R
D
L
M
L
R
D
T
L
N
I
R
Q
A
Y
Site 183
Y1684
T
L
N
I
R
Q
A
Y
N
L
E
N
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation