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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRUNE
Full Name:
Protein prune homolog
Alias:
DRES-17; EC 3.6.1.1; HTCD37; TcD37
Type:
Uncharacterized protein
Mass (Da):
50228
Number AA:
453
UniProt ID:
Q86TP1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005925
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004427
GO:0030145
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S61
P
V
L
N
I
K
R
S
E
L
P
L
R
G
D
Site 2
S81
Q
K
V
H
I
P
E
S
I
L
I
F
R
D
E
Site 3
S111
L
V
D
H
H
I
L
S
K
S
D
T
A
L
E
Site 4
S113
D
H
H
I
L
S
K
S
D
T
A
L
E
E
A
Site 5
T115
H
I
L
S
K
S
D
T
A
L
E
E
A
V
A
Site 6
T168
P
E
I
L
D
R
Q
T
A
A
L
L
H
G
T
Site 7
T191
D
L
K
I
G
K
A
T
P
K
D
S
K
Y
V
Site 8
S195
G
K
A
T
P
K
D
S
K
Y
V
E
K
L
E
Site 9
Y197
A
T
P
K
D
S
K
Y
V
E
K
L
E
A
L
Site 10
S217
K
R
N
D
I
F
D
S
L
Q
K
A
K
F
D
Site 11
T230
F
D
V
S
G
L
T
T
E
Q
M
L
R
K
D
Site 12
T240
M
L
R
K
D
Q
K
T
I
Y
R
Q
G
V
K
Site 13
Y242
R
K
D
Q
K
T
I
Y
R
Q
G
V
K
V
A
Site 14
S319
I
C
E
V
L
E
R
S
H
S
P
P
L
K
L
Site 15
S321
E
V
L
E
R
S
H
S
P
P
L
K
L
T
P
Site 16
T327
H
S
P
P
L
K
L
T
P
A
S
S
T
H
P
Site 17
S330
P
L
K
L
T
P
A
S
S
T
H
P
N
L
H
Site 18
S331
L
K
L
T
P
A
S
S
T
H
P
N
L
H
A
Site 19
Y339
T
H
P
N
L
H
A
Y
L
Q
G
N
T
Q
V
Site 20
S360
P
L
L
Q
E
A
L
S
A
Y
F
D
S
M
K
Site 21
Y362
L
Q
E
A
L
S
A
Y
F
D
S
M
K
I
P
Site 22
S365
A
L
S
A
Y
F
D
S
M
K
I
P
S
G
Q
Site 23
T375
I
P
S
G
Q
P
E
T
A
D
V
S
R
E
Q
Site 24
S391
D
K
E
L
D
R
A
S
N
S
L
I
S
G
L
Site 25
S393
E
L
D
R
A
S
N
S
L
I
S
G
L
S
Q
Site 26
S399
N
S
L
I
S
G
L
S
Q
D
E
E
D
P
P
Site 27
T410
E
D
P
P
L
P
P
T
P
M
N
S
L
V
D
Site 28
S414
L
P
P
T
P
M
N
S
L
V
D
E
C
P
L
Site 29
S438
E
A
V
F
E
K
C
S
Q
I
S
L
S
Q
S
Site 30
S441
F
E
K
C
S
Q
I
S
L
S
Q
S
T
T
A
Site 31
S443
K
C
S
Q
I
S
L
S
Q
S
T
T
A
S
L
Site 32
S445
S
Q
I
S
L
S
Q
S
T
T
A
S
L
S
K
Site 33
T447
I
S
L
S
Q
S
T
T
A
S
L
S
K
K
_
Site 34
S449
L
S
Q
S
T
T
A
S
L
S
K
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation