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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SYVN1
Full Name:
E3 ubiquitin-protein ligase synoviolin
Alias:
E3 ubiquitin-protein ligase synoviolin; HRD1; synovial apoptosis inhibitor 1; synovial apoptosis inhibitor 1, synoviolin
Type:
Ligase; Ubiquitin conjugating system; EC 6.3.2.-; Endoplasmic reticulum
Mass (Da):
67680
Number AA:
617
UniProt ID:
Q86TM6
International Prot ID:
IPI00166996
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0016021
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0016881
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030433
GO:0006950
GO:0006515
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y30
Y
Y
L
K
H
Q
F
Y
P
T
V
V
Y
L
T
Site 2
T32
L
K
H
Q
F
Y
P
T
V
V
Y
L
T
K
S
Site 3
Y35
Q
F
Y
P
T
V
V
Y
L
T
K
S
S
P
S
Site 4
T37
Y
P
T
V
V
Y
L
T
K
S
S
P
S
M
A
Site 5
Y83
H
L
L
E
R
S
W
Y
A
V
T
E
T
C
L
Site 6
T93
T
E
T
C
L
A
F
T
V
F
R
D
D
F
S
Site 7
S130
R
V
D
F
M
E
R
S
P
N
I
S
W
L
F
Site 8
S201
L
H
S
V
D
L
Q
S
E
N
P
W
D
N
K
Site 9
Y211
P
W
D
N
K
A
V
Y
M
L
Y
T
E
L
F
Site 10
T260
R
Q
F
K
K
A
V
T
D
A
I
M
S
R
R
Site 11
S265
A
V
T
D
A
I
M
S
R
R
A
I
R
N
M
Site 12
T274
R
A
I
R
N
M
N
T
L
Y
P
D
A
T
P
Site 13
Y276
I
R
N
M
N
T
L
Y
P
D
A
T
P
E
E
Site 14
T280
N
T
L
Y
P
D
A
T
P
E
E
L
Q
A
M
Site 15
T300
I
C
R
E
E
M
V
T
G
A
K
R
L
P
C
Site 16
S337
R
M
D
V
L
R
A
S
L
P
A
Q
S
P
P
Site 17
S342
R
A
S
L
P
A
Q
S
P
P
P
P
E
P
A
Site 18
S399
P
P
V
P
P
P
P
S
S
G
E
A
V
A
P
Site 19
S400
P
V
P
P
P
P
S
S
G
E
A
V
A
P
P
Site 20
S415
S
T
S
A
A
A
L
S
R
P
S
G
A
A
T
Site 21
T422
S
R
P
S
G
A
A
T
T
T
A
A
G
T
S
Site 22
S434
G
T
S
A
T
A
A
S
A
T
A
S
G
P
G
Site 23
T436
S
A
T
A
A
S
A
T
A
S
G
P
G
S
G
Site 24
S438
T
A
A
S
A
T
A
S
G
P
G
S
G
S
A
Site 25
S442
A
T
A
S
G
P
G
S
G
S
A
P
E
A
G
Site 26
S444
A
S
G
P
G
S
G
S
A
P
E
A
G
P
A
Site 27
S506
H
L
E
A
R
L
Q
S
L
R
N
I
H
T
L
Site 28
T538
L
G
P
P
R
P
A
T
S
V
N
S
T
E
E
Site 29
S539
G
P
P
R
P
A
T
S
V
N
S
T
E
E
T
Site 30
T543
P
A
T
S
V
N
S
T
E
E
T
A
T
T
V
Site 31
T548
N
S
T
E
E
T
A
T
T
V
V
A
A
A
S
Site 32
S562
S
S
T
S
I
P
S
S
E
A
T
T
P
T
P
Site 33
T565
S
I
P
S
S
E
A
T
T
P
T
P
G
A
S
Site 34
T566
I
P
S
S
E
A
T
T
P
T
P
G
A
S
P
Site 35
T568
S
S
E
A
T
T
P
T
P
G
A
S
P
P
A
Site 36
S572
T
T
P
T
P
G
A
S
P
P
A
P
E
M
E
Site 37
S586
E
R
P
P
A
P
E
S
V
G
T
E
E
M
P
Site 38
T589
P
A
P
E
S
V
G
T
E
E
M
P
E
D
G
Site 39
S613
R
R
L
Q
K
L
E
S
P
V
A
H
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation