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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX53
Full Name:
Probable ATP-dependent RNA helicase DDX53
Alias:
Cancer-associated gene protein;Cancer/testis antigen 26;DEAD box protein 53;DEAD box protein CAGE
Type:
Mass (Da):
71154
Number AA:
631
UniProt ID:
Q86TM3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
N
P
R
D
L
G
A
S
W
D
V
R
G
S
R
Site 2
S27
A
S
W
D
V
R
G
S
R
G
S
G
W
S
G
Site 3
S30
D
V
R
G
S
R
G
S
G
W
S
G
P
F
G
Site 4
S33
G
S
R
G
S
G
W
S
G
P
F
G
H
Q
G
Site 5
S46
Q
G
P
R
A
A
G
S
R
E
P
P
L
C
F
Site 6
S69
V
V
I
G
Y
S
G
S
K
I
K
D
L
Q
H
Site 7
T80
D
L
Q
H
S
T
N
T
K
I
Q
I
I
N
G
Site 8
S118
T
L
I
R
K
Q
E
S
Y
N
S
E
S
S
V
Site 9
Y119
L
I
R
K
Q
E
S
Y
N
S
E
S
S
V
D
Site 10
S121
R
K
Q
E
S
Y
N
S
E
S
S
V
D
N
A
Site 11
S124
E
S
Y
N
S
E
S
S
V
D
N
A
A
S
Q
Site 12
S130
S
S
V
D
N
A
A
S
Q
T
P
I
G
R
N
Site 13
T132
V
D
N
A
A
S
Q
T
P
I
G
R
N
L
G
Site 14
S151
V
G
E
A
E
P
L
S
N
W
D
R
I
R
A
Site 15
Y179
P
P
V
K
K
N
F
Y
I
E
S
K
A
T
S
Site 16
S186
Y
I
E
S
K
A
T
S
C
M
S
E
M
Q
V
Site 17
S210
I
T
C
D
D
L
K
S
G
E
K
R
L
I
P
Site 18
T220
K
R
L
I
P
K
P
T
C
R
F
K
D
A
F
Site 19
Y230
F
K
D
A
F
Q
Q
Y
P
D
L
L
K
S
I
Site 20
T246
R
V
G
I
V
K
P
T
P
I
Q
S
Q
A
W
Site 21
T273
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
Site 22
S286
P
G
F
I
H
L
D
S
Q
P
I
S
R
E
Q
Site 23
S290
H
L
D
S
Q
P
I
S
R
E
Q
R
N
G
P
Site 24
S317
L
H
V
E
A
E
C
S
K
Y
S
Y
K
G
L
Site 25
Y319
V
E
A
E
C
S
K
Y
S
Y
K
G
L
K
S
Site 26
S320
E
A
E
C
S
K
Y
S
Y
K
G
L
K
S
I
Site 27
Y321
A
E
C
S
K
Y
S
Y
K
G
L
K
S
I
C
Site 28
Y330
G
L
K
S
I
C
I
Y
G
G
R
N
R
N
G
Site 29
S364
N
D
L
Q
M
N
N
S
V
N
L
R
S
I
T
Site 30
T403
D
V
R
P
D
R
Q
T
V
M
T
S
A
T
W
Site 31
T406
P
D
R
Q
T
V
M
T
S
A
T
W
P
D
T
Site 32
S407
D
R
Q
T
V
M
T
S
A
T
W
P
D
T
V
Site 33
T409
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
Site 34
T413
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Site 35
T457
E
K
E
K
R
A
L
T
Q
E
F
V
E
N
M
Site 36
S465
Q
E
F
V
E
N
M
S
P
N
D
K
V
I
M
Site 37
S484
K
H
I
A
D
D
L
S
S
D
F
N
I
Q
G
Site 38
S485
H
I
A
D
D
L
S
S
D
F
N
I
Q
G
I
Site 39
S493
D
F
N
I
Q
G
I
S
A
E
S
L
H
G
N
Site 40
S496
I
Q
G
I
S
A
E
S
L
H
G
N
S
E
Q
Site 41
T537
G
L
D
L
N
D
V
T
H
V
Y
N
Y
D
F
Site 42
Y540
L
N
D
V
T
H
V
Y
N
Y
D
F
P
R
N
Site 43
Y542
D
V
T
H
V
Y
N
Y
D
F
P
R
N
I
D
Site 44
Y557
V
Y
V
H
R
V
G
Y
I
G
R
T
G
K
T
Site 45
S567
R
T
G
K
T
G
T
S
V
T
L
I
T
Q
R
Site 46
T572
G
T
S
V
T
L
I
T
Q
R
D
S
K
M
A
Site 47
S576
T
L
I
T
Q
R
D
S
K
M
A
G
E
L
I
Site 48
T615
Q
Q
K
R
H
R
E
T
R
S
R
K
P
G
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation