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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP37
Full Name:
Ubiquitin carboxyl-terminal hydrolase 37
Alias:
Deubiquitinating enzyme 37; KIAA1594; Tmp_locus_50; Ubiquitin specific peptidase 37; Ubiquitin specific protease 37; Ubiquitin thioesterase 37; Ubiquitin-specific-processing protease 37; UBP37
Type:
Protease; EC 3.1.2.15; Ubiquitin conjugating system
Mass (Da):
110101
Number AA:
979
UniProt ID:
Q86T82
International Prot ID:
IPI00472977
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
H
G
P
I
R
I
R
S
M
Q
T
G
I
T
K
Site 2
T17
I
R
I
R
S
M
Q
T
G
I
T
K
W
K
E
Site 3
S26
I
T
K
W
K
E
G
S
F
E
I
V
E
K
E
Site 4
S37
V
E
K
E
N
K
V
S
L
V
V
H
Y
N
T
Site 5
S65
K
N
V
V
L
R
P
S
G
A
K
Q
S
R
L
Site 6
T75
K
Q
S
R
L
M
L
T
L
Q
D
N
S
F
L
Site 7
S83
L
Q
D
N
S
F
L
S
I
D
K
V
P
S
K
Site 8
S89
L
S
I
D
K
V
P
S
K
D
A
E
E
M
R
Site 9
S114
L
P
A
A
M
K
P
S
Q
G
S
G
S
F
G
Site 10
S119
K
P
S
Q
G
S
G
S
F
G
A
I
L
G
S
Site 11
S129
A
I
L
G
S
R
T
S
Q
K
E
T
S
R
Q
Site 12
T133
S
R
T
S
Q
K
E
T
S
R
Q
L
S
Y
S
Site 13
S134
R
T
S
Q
K
E
T
S
R
Q
L
S
Y
S
D
Site 14
S138
K
E
T
S
R
Q
L
S
Y
S
D
N
Q
A
S
Site 15
S140
T
S
R
Q
L
S
Y
S
D
N
Q
A
S
A
K
Site 16
S145
S
Y
S
D
N
Q
A
S
A
K
R
G
S
L
E
Site 17
S150
Q
A
S
A
K
R
G
S
L
E
T
K
D
D
I
Site 18
T153
A
K
R
G
S
L
E
T
K
D
D
I
P
F
R
Site 19
S170
L
G
N
P
G
R
G
S
I
K
T
V
A
G
S
Site 20
S185
G
I
A
R
T
I
P
S
L
T
S
T
S
T
P
Site 21
T187
A
R
T
I
P
S
L
T
S
T
S
T
P
L
R
Site 22
S188
R
T
I
P
S
L
T
S
T
S
T
P
L
R
S
Site 23
T189
T
I
P
S
L
T
S
T
S
T
P
L
R
S
G
Site 24
S190
I
P
S
L
T
S
T
S
T
P
L
R
S
G
L
Site 25
T191
P
S
L
T
S
T
S
T
P
L
R
S
G
L
L
Site 26
T202
S
G
L
L
E
N
R
T
E
K
R
K
R
M
I
Site 27
S210
E
K
R
K
R
M
I
S
T
G
S
E
L
N
E
Site 28
T211
K
R
K
R
M
I
S
T
G
S
E
L
N
E
D
Site 29
S213
K
R
M
I
S
T
G
S
E
L
N
E
D
Y
P
Site 30
Y219
G
S
E
L
N
E
D
Y
P
K
E
D
G
S
S
Site 31
S226
Y
P
K
E
D
G
S
S
S
N
N
K
A
M
T
Site 32
S227
P
K
E
D
G
S
S
S
N
N
K
A
M
T
D
Site 33
S236
N
K
A
M
T
D
P
S
R
K
Y
L
T
S
S
Site 34
Y239
M
T
D
P
S
R
K
Y
L
T
S
S
R
E
K
Site 35
T241
D
P
S
R
K
Y
L
T
S
S
R
E
K
Q
L
Site 36
S242
P
S
R
K
Y
L
T
S
S
R
E
K
Q
L
S
Site 37
S243
S
R
K
Y
L
T
S
S
R
E
K
Q
L
S
L
Site 38
S249
S
S
R
E
K
Q
L
S
L
K
Q
S
E
E
N
Site 39
S253
K
Q
L
S
L
K
Q
S
E
E
N
R
T
S
G
Site 40
T258
K
Q
S
E
E
N
R
T
S
G
L
L
P
L
Q
Site 41
S259
Q
S
E
E
N
R
T
S
G
L
L
P
L
Q
S
Site 42
S266
S
G
L
L
P
L
Q
S
S
S
F
Y
G
S
R
Site 43
S267
G
L
L
P
L
Q
S
S
S
F
Y
G
S
R
A
Site 44
S268
L
L
P
L
Q
S
S
S
F
Y
G
S
R
A
G
Site 45
Y270
P
L
Q
S
S
S
F
Y
G
S
R
A
G
S
K
Site 46
S272
Q
S
S
S
F
Y
G
S
R
A
G
S
K
E
H
Site 47
S276
F
Y
G
S
R
A
G
S
K
E
H
S
S
G
G
Site 48
S280
R
A
G
S
K
E
H
S
S
G
G
T
N
L
D
Site 49
S281
A
G
S
K
E
H
S
S
G
G
T
N
L
D
R
Site 50
T289
G
G
T
N
L
D
R
T
N
V
S
S
Q
T
P
Site 51
S293
L
D
R
T
N
V
S
S
Q
T
P
S
A
K
R
Site 52
T295
R
T
N
V
S
S
Q
T
P
S
A
K
R
S
L
Site 53
S297
N
V
S
S
Q
T
P
S
A
K
R
S
L
G
F
Site 54
S301
Q
T
P
S
A
K
R
S
L
G
F
L
P
Q
P
Site 55
S312
L
P
Q
P
V
P
L
S
V
K
K
L
R
C
N
Site 56
Y322
K
L
R
C
N
Q
D
Y
T
G
W
N
K
P
R
Site 57
S333
N
K
P
R
V
P
L
S
S
H
Q
Q
Q
Q
L
Site 58
S334
K
P
R
V
P
L
S
S
H
Q
Q
Q
Q
L
Q
Site 59
Y351
S
N
L
G
N
T
C
Y
M
N
A
I
L
Q
S
Site 60
S364
Q
S
L
F
S
L
Q
S
F
A
N
D
L
L
K
Site 61
S400
V
K
K
D
I
C
N
S
E
T
K
K
D
L
L
Site 62
S415
K
K
V
K
N
A
I
S
A
T
A
E
R
F
S
Site 63
T417
V
K
N
A
I
S
A
T
A
E
R
F
S
G
Y
Site 64
S422
S
A
T
A
E
R
F
S
G
Y
M
Q
N
D
A
Site 65
S434
N
D
A
H
E
F
L
S
Q
C
L
D
Q
L
K
Site 66
T450
D
M
E
K
L
N
K
T
W
K
T
E
P
I
S
Site 67
T453
K
L
N
K
T
W
K
T
E
P
I
S
G
E
E
Site 68
S457
T
W
K
T
E
P
I
S
G
E
E
N
S
P
D
Site 69
S462
P
I
S
G
E
E
N
S
P
D
I
S
A
T
R
Site 70
S466
E
E
N
S
P
D
I
S
A
T
R
A
Y
T
C
Site 71
S506
R
E
Q
F
N
D
L
S
I
D
L
P
R
R
K
Site 72
S520
K
K
P
L
P
P
R
S
I
Q
D
S
L
D
L
Site 73
S524
P
P
R
S
I
Q
D
S
L
D
L
F
F
R
A
Site 74
Y536
F
R
A
E
E
L
E
Y
S
C
E
K
C
G
G
Site 75
S537
R
A
E
E
L
E
Y
S
C
E
K
C
G
G
K
Site 76
S573
Y
S
F
N
V
A
L
S
L
N
N
K
I
G
Q
Site 77
S591
I
P
R
Y
L
T
L
S
S
H
C
T
E
N
T
Site 78
S592
P
R
Y
L
T
L
S
S
H
C
T
E
N
T
K
Site 79
T595
L
T
L
S
S
H
C
T
E
N
T
K
P
P
F
Site 80
T598
S
S
H
C
T
E
N
T
K
P
P
F
T
L
G
Site 81
T603
E
N
T
K
P
P
F
T
L
G
W
S
A
H
M
Site 82
S613
W
S
A
H
M
A
I
S
R
P
L
K
A
S
Q
Site 83
S624
K
A
S
Q
M
V
N
S
C
I
T
S
P
S
T
Site 84
T627
Q
M
V
N
S
C
I
T
S
P
S
T
P
S
K
Site 85
S628
M
V
N
S
C
I
T
S
P
S
T
P
S
K
K
Site 86
S630
N
S
C
I
T
S
P
S
T
P
S
K
K
F
T
Site 87
T631
S
C
I
T
S
P
S
T
P
S
K
K
F
T
F
Site 88
T637
S
T
P
S
K
K
F
T
F
K
S
K
S
S
L
Site 89
S640
S
K
K
F
T
F
K
S
K
S
S
L
A
L
C
Site 90
S650
S
L
A
L
C
L
D
S
D
S
E
D
E
L
K
Site 91
S652
A
L
C
L
D
S
D
S
E
D
E
L
K
R
S
Site 92
S659
S
E
D
E
L
K
R
S
V
A
L
S
Q
R
L
Site 93
S693
C
P
I
E
P
D
K
S
E
L
E
N
S
G
F
Site 94
S698
D
K
S
E
L
E
N
S
G
F
D
R
M
S
E
Site 95
S704
N
S
G
F
D
R
M
S
E
E
E
L
L
A
A
Site 96
S716
L
A
A
V
L
E
I
S
K
R
D
A
S
P
S
Site 97
S721
E
I
S
K
R
D
A
S
P
S
L
S
H
E
D
Site 98
S723
S
K
R
D
A
S
P
S
L
S
H
E
D
D
D
Site 99
S725
R
D
A
S
P
S
L
S
H
E
D
D
D
K
P
Site 100
T733
H
E
D
D
D
K
P
T
S
S
P
D
T
G
F
Site 101
S734
E
D
D
D
K
P
T
S
S
P
D
T
G
F
A
Site 102
S735
D
D
D
K
P
T
S
S
P
D
T
G
F
A
E
Site 103
T738
K
P
T
S
S
P
D
T
G
F
A
E
D
D
I
Site 104
T754
E
M
P
E
N
P
D
T
M
E
T
E
K
P
K
Site 105
T757
E
N
P
D
T
M
E
T
E
K
P
K
T
I
T
Site 106
T762
M
E
T
E
K
P
K
T
I
T
E
L
D
P
A
Site 107
S770
I
T
E
L
D
P
A
S
F
T
E
I
T
K
D
Site 108
T786
D
E
N
K
E
N
K
T
P
E
G
S
Q
G
E
Site 109
Y800
E
V
D
W
L
Q
Q
Y
D
M
E
R
E
R
E
Site 110
T837
D
D
D
L
K
R
A
T
E
L
S
L
Q
E
F
Site 111
S840
L
K
R
A
T
E
L
S
L
Q
E
F
N
N
S
Site 112
S847
S
L
Q
E
F
N
N
S
F
V
D
A
L
G
S
Site 113
S854
S
F
V
D
A
L
G
S
D
E
D
S
G
N
E
Site 114
S858
A
L
G
S
D
E
D
S
G
N
E
D
V
F
D
Site 115
Y868
E
D
V
F
D
M
E
Y
T
E
A
E
A
E
E
Site 116
S888
E
T
G
N
L
P
H
S
Y
R
L
I
S
V
V
Site 117
Y889
T
G
N
L
P
H
S
Y
R
L
I
S
V
V
S
Site 118
S900
S
V
V
S
H
I
G
S
T
S
S
S
G
H
Y
Site 119
S902
V
S
H
I
G
S
T
S
S
S
G
H
Y
I
S
Site 120
S903
S
H
I
G
S
T
S
S
S
G
H
Y
I
S
D
Site 121
S904
H
I
G
S
T
S
S
S
G
H
Y
I
S
D
V
Site 122
Y907
S
T
S
S
S
G
H
Y
I
S
D
V
Y
D
I
Site 123
S909
S
S
S
G
H
Y
I
S
D
V
Y
D
I
K
K
Site 124
Y912
G
H
Y
I
S
D
V
Y
D
I
K
K
Q
A
W
Site 125
S937
I
Q
E
A
A
V
Q
S
D
R
D
R
S
G
Y
Site 126
Y944
S
D
R
D
R
S
G
Y
I
F
F
Y
M
H
K
Site 127
Y948
R
S
G
Y
I
F
F
Y
M
H
K
E
I
F
D
Site 128
T960
I
F
D
E
L
L
E
T
E
K
N
S
Q
S
L
Site 129
S964
L
L
E
T
E
K
N
S
Q
S
L
S
T
E
V
Site 130
S966
E
T
E
K
N
S
Q
S
L
S
T
E
V
G
K
Site 131
S968
E
K
N
S
Q
S
L
S
T
E
V
G
K
T
T
Site 132
T974
L
S
T
E
V
G
K
T
T
R
Q
A
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation