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Updated November 2019
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Protein Info
Short Name:
PHLDB2
Full Name:
Pleckstrin homology-like domain family B member 2
Alias:
FLJ21791; LL5 beta; LL5b; LL5beta; PHLB2; Pleckstrin homology-like domain, family B, member 2; Pleckstriny-like domain, family B, member 2; Protein LL5-beta
Type:
Vesicle protein
Mass (Da):
142158
Number AA:
1253
UniProt ID:
Q86SQ0
International Prot ID:
IPI00410259
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
E
L
D
L
Q
N
G
S
L
E
E
D
S
V
V
Site 2
S22
N
G
S
L
E
E
D
S
V
V
H
S
V
E
N
Site 3
S26
E
E
D
S
V
V
H
S
V
E
N
D
S
Q
N
Site 4
S31
V
H
S
V
E
N
D
S
Q
N
M
M
E
S
L
Site 5
S37
D
S
Q
N
M
M
E
S
L
S
P
K
K
Y
S
Site 6
S39
Q
N
M
M
E
S
L
S
P
K
K
Y
S
S
S
Site 7
Y43
E
S
L
S
P
K
K
Y
S
S
S
L
R
F
K
Site 8
S45
L
S
P
K
K
Y
S
S
S
L
R
F
K
A
N
Site 9
S46
S
P
K
K
Y
S
S
S
L
R
F
K
A
N
G
Site 10
Y55
R
F
K
A
N
G
D
Y
S
G
S
Y
L
T
L
Site 11
S56
F
K
A
N
G
D
Y
S
G
S
Y
L
T
L
S
Site 12
S58
A
N
G
D
Y
S
G
S
Y
L
T
L
S
Q
P
Site 13
Y59
N
G
D
Y
S
G
S
Y
L
T
L
S
Q
P
V
Site 14
T61
D
Y
S
G
S
Y
L
T
L
S
Q
P
V
P
A
Site 15
S63
S
G
S
Y
L
T
L
S
Q
P
V
P
A
K
R
Site 16
S71
Q
P
V
P
A
K
R
S
P
S
P
L
G
T
S
Site 17
S73
V
P
A
K
R
S
P
S
P
L
G
T
S
V
R
Site 18
T77
R
S
P
S
P
L
G
T
S
V
R
S
S
P
S
Site 19
S78
S
P
S
P
L
G
T
S
V
R
S
S
P
S
L
Site 20
S82
L
G
T
S
V
R
S
S
P
S
L
A
K
I
Q
Site 21
S84
T
S
V
R
S
S
P
S
L
A
K
I
Q
G
S
Site 22
S91
S
L
A
K
I
Q
G
S
K
Q
F
S
Y
D
G
Site 23
S95
I
Q
G
S
K
Q
F
S
Y
D
G
T
D
K
N
Site 24
Y96
Q
G
S
K
Q
F
S
Y
D
G
T
D
K
N
I
Site 25
T99
K
Q
F
S
Y
D
G
T
D
K
N
I
P
M
K
Site 26
T109
N
I
P
M
K
P
P
T
P
L
L
N
T
T
S
Site 27
T114
P
P
T
P
L
L
N
T
T
S
S
L
S
G
Y
Site 28
T115
P
T
P
L
L
N
T
T
S
S
L
S
G
Y
P
Site 29
S116
T
P
L
L
N
T
T
S
S
L
S
G
Y
P
L
Site 30
S117
P
L
L
N
T
T
S
S
L
S
G
Y
P
L
G
Site 31
S119
L
N
T
T
S
S
L
S
G
Y
P
L
G
R
A
Site 32
Y121
T
T
S
S
L
S
G
Y
P
L
G
R
A
D
F
Site 33
Y131
G
R
A
D
F
D
H
Y
T
G
R
D
S
E
R
Site 34
T132
R
A
D
F
D
H
Y
T
G
R
D
S
E
R
A
Site 35
S136
D
H
Y
T
G
R
D
S
E
R
A
L
R
L
S
Site 36
S143
S
E
R
A
L
R
L
S
E
K
P
P
Y
S
K
Site 37
Y148
R
L
S
E
K
P
P
Y
S
K
Y
S
S
R
H
Site 38
S149
L
S
E
K
P
P
Y
S
K
Y
S
S
R
H
K
Site 39
Y151
E
K
P
P
Y
S
K
Y
S
S
R
H
K
S
H
Site 40
S152
K
P
P
Y
S
K
Y
S
S
R
H
K
S
H
D
Site 41
S153
P
P
Y
S
K
Y
S
S
R
H
K
S
H
D
N
Site 42
S157
K
Y
S
S
R
H
K
S
H
D
N
V
Y
S
L
Site 43
Y162
H
K
S
H
D
N
V
Y
S
L
G
G
L
E
G
Site 44
S163
K
S
H
D
N
V
Y
S
L
G
G
L
E
G
R
Site 45
S173
G
L
E
G
R
K
A
S
G
S
L
L
A
M
W
Site 46
S175
E
G
R
K
A
S
G
S
L
L
A
M
W
N
G
Site 47
S184
L
A
M
W
N
G
S
S
L
S
D
A
G
P
P
Site 48
S186
M
W
N
G
S
S
L
S
D
A
G
P
P
P
I
Site 49
S194
D
A
G
P
P
P
I
S
R
S
G
A
A
S
M
Site 50
S196
G
P
P
P
I
S
R
S
G
A
A
S
M
P
S
Site 51
S200
I
S
R
S
G
A
A
S
M
P
S
S
P
K
Q
Site 52
S203
S
G
A
A
S
M
P
S
S
P
K
Q
A
R
K
Site 53
S204
G
A
A
S
M
P
S
S
P
K
Q
A
R
K
M
Site 54
S212
P
K
Q
A
R
K
M
S
I
Q
D
S
L
A
L
Site 55
S216
R
K
M
S
I
Q
D
S
L
A
L
Q
P
K
L
Site 56
T224
L
A
L
Q
P
K
L
T
R
H
K
E
L
A
S
Site 57
T238
S
E
N
I
N
L
R
T
R
K
Y
S
S
S
S
Site 58
Y241
I
N
L
R
T
R
K
Y
S
S
S
S
L
S
H
Site 59
S242
N
L
R
T
R
K
Y
S
S
S
S
L
S
H
M
Site 60
S243
L
R
T
R
K
Y
S
S
S
S
L
S
H
M
G
Site 61
S244
R
T
R
K
Y
S
S
S
S
L
S
H
M
G
A
Site 62
S245
T
R
K
Y
S
S
S
S
L
S
H
M
G
A
Y
Site 63
S247
K
Y
S
S
S
S
L
S
H
M
G
A
Y
S
R
Site 64
Y252
S
L
S
H
M
G
A
Y
S
R
S
L
P
R
L
Site 65
S253
L
S
H
M
G
A
Y
S
R
S
L
P
R
L
Y
Site 66
S255
H
M
G
A
Y
S
R
S
L
P
R
L
Y
R
A
Site 67
Y260
S
R
S
L
P
R
L
Y
R
A
T
E
N
Q
L
Site 68
T263
L
P
R
L
Y
R
A
T
E
N
Q
L
T
P
L
Site 69
T268
R
A
T
E
N
Q
L
T
P
L
S
L
P
P
R
Site 70
S271
E
N
Q
L
T
P
L
S
L
P
P
R
N
S
L
Site 71
S277
L
S
L
P
P
R
N
S
L
G
N
S
K
R
T
Site 72
S281
P
R
N
S
L
G
N
S
K
R
T
K
L
G
E
Site 73
S294
G
E
K
D
L
P
H
S
V
I
D
N
D
N
Y
Site 74
Y301
S
V
I
D
N
D
N
Y
L
N
F
S
S
L
S
Site 75
S305
N
D
N
Y
L
N
F
S
S
L
S
S
G
A
L
Site 76
S306
D
N
Y
L
N
F
S
S
L
S
S
G
A
L
P
Site 77
S308
Y
L
N
F
S
S
L
S
S
G
A
L
P
Y
K
Site 78
S309
L
N
F
S
S
L
S
S
G
A
L
P
Y
K
T
Site 79
T316
S
G
A
L
P
Y
K
T
S
A
S
E
G
N
P
Site 80
S317
G
A
L
P
Y
K
T
S
A
S
E
G
N
P
Y
Site 81
S319
L
P
Y
K
T
S
A
S
E
G
N
P
Y
V
S
Site 82
Y324
S
A
S
E
G
N
P
Y
V
S
S
T
L
S
V
Site 83
S326
S
E
G
N
P
Y
V
S
S
T
L
S
V
P
A
Site 84
S327
E
G
N
P
Y
V
S
S
T
L
S
V
P
A
S
Site 85
T328
G
N
P
Y
V
S
S
T
L
S
V
P
A
S
P
Site 86
S330
P
Y
V
S
S
T
L
S
V
P
A
S
P
R
V
Site 87
S334
S
T
L
S
V
P
A
S
P
R
V
A
R
K
M
Site 88
S345
A
R
K
M
L
L
A
S
T
S
S
C
A
S
D
Site 89
S347
K
M
L
L
A
S
T
S
S
C
A
S
D
D
F
Site 90
S348
M
L
L
A
S
T
S
S
C
A
S
D
D
F
D
Site 91
S351
A
S
T
S
S
C
A
S
D
D
F
D
Q
A
S
Site 92
S358
S
D
D
F
D
Q
A
S
Y
V
G
T
N
P
S
Site 93
Y359
D
D
F
D
Q
A
S
Y
V
G
T
N
P
S
H
Site 94
T362
D
Q
A
S
Y
V
G
T
N
P
S
H
S
L
L
Site 95
S365
S
Y
V
G
T
N
P
S
H
S
L
L
A
G
E
Site 96
S367
V
G
T
N
P
S
H
S
L
L
A
G
E
S
D
Site 97
S373
H
S
L
L
A
G
E
S
D
R
V
F
A
T
R
Site 98
T379
E
S
D
R
V
F
A
T
R
R
N
F
S
C
G
Site 99
S384
F
A
T
R
R
N
F
S
C
G
S
V
E
F
D
Site 100
S387
R
R
N
F
S
C
G
S
V
E
F
D
E
A
D
Site 101
S397
F
D
E
A
D
L
E
S
L
R
Q
A
S
G
T
Site 102
S402
L
E
S
L
R
Q
A
S
G
T
P
Q
P
A
L
Site 103
T404
S
L
R
Q
A
S
G
T
P
Q
P
A
L
R
E
Site 104
S414
P
A
L
R
E
R
K
S
S
I
S
S
I
S
G
Site 105
S415
A
L
R
E
R
K
S
S
I
S
S
I
S
G
R
Site 106
S417
R
E
R
K
S
S
I
S
S
I
S
G
R
D
D
Site 107
S418
E
R
K
S
S
I
S
S
I
S
G
R
D
D
L
Site 108
S420
K
S
S
I
S
S
I
S
G
R
D
D
L
M
D
Site 109
Y428
G
R
D
D
L
M
D
Y
H
R
R
Q
R
E
E
Site 110
T452
L
E
R
Q
R
L
E
T
I
L
S
L
C
A
E
Site 111
S455
Q
R
L
E
T
I
L
S
L
C
A
E
Y
T
K
Site 112
Y460
I
L
S
L
C
A
E
Y
T
K
P
D
S
R
L
Site 113
T461
L
S
L
C
A
E
Y
T
K
P
D
S
R
L
S
Site 114
S465
A
E
Y
T
K
P
D
S
R
L
S
T
G
T
T
Site 115
S468
T
K
P
D
S
R
L
S
T
G
T
T
V
E
D
Site 116
T469
K
P
D
S
R
L
S
T
G
T
T
V
E
D
V
Site 117
T471
D
S
R
L
S
T
G
T
T
V
E
D
V
Q
K
Site 118
T472
S
R
L
S
T
G
T
T
V
E
D
V
Q
K
I
Site 119
S489
E
L
E
K
L
Q
L
S
D
E
E
S
V
F
E
Site 120
S493
L
Q
L
S
D
E
E
S
V
F
E
E
A
L
M
Site 121
S501
V
F
E
E
A
L
M
S
P
D
T
R
Y
R
C
Site 122
T504
E
A
L
M
S
P
D
T
R
Y
R
C
H
R
K
Site 123
Y506
L
M
S
P
D
T
R
Y
R
C
H
R
K
D
S
Site 124
S513
Y
R
C
H
R
K
D
S
L
P
D
A
D
L
A
Site 125
S521
L
P
D
A
D
L
A
S
C
G
S
L
S
Q
S
Site 126
S524
A
D
L
A
S
C
G
S
L
S
Q
S
S
A
S
Site 127
S526
L
A
S
C
G
S
L
S
Q
S
S
A
S
F
F
Site 128
S528
S
C
G
S
L
S
Q
S
S
A
S
F
F
T
P
Site 129
S529
C
G
S
L
S
Q
S
S
A
S
F
F
T
P
R
Site 130
S531
S
L
S
Q
S
S
A
S
F
F
T
P
R
S
T
Site 131
T534
Q
S
S
A
S
F
F
T
P
R
S
T
R
N
D
Site 132
S537
A
S
F
F
T
P
R
S
T
R
N
D
E
L
L
Site 133
T538
S
F
F
T
P
R
S
T
R
N
D
E
L
L
S
Site 134
S545
T
R
N
D
E
L
L
S
D
L
T
R
T
P
P
Site 135
T548
D
E
L
L
S
D
L
T
R
T
P
P
P
P
S
Site 136
T550
L
L
S
D
L
T
R
T
P
P
P
P
S
S
T
Site 137
S555
T
R
T
P
P
P
P
S
S
T
F
P
K
A
S
Site 138
S556
R
T
P
P
P
P
S
S
T
F
P
K
A
S
S
Site 139
T557
T
P
P
P
P
S
S
T
F
P
K
A
S
S
E
Site 140
S562
S
S
T
F
P
K
A
S
S
E
S
S
Y
L
S
Site 141
S563
S
T
F
P
K
A
S
S
E
S
S
Y
L
S
I
Site 142
S565
F
P
K
A
S
S
E
S
S
Y
L
S
I
L
P
Site 143
S566
P
K
A
S
S
E
S
S
Y
L
S
I
L
P
K
Site 144
Y567
K
A
S
S
E
S
S
Y
L
S
I
L
P
K
T
Site 145
S569
S
S
E
S
S
Y
L
S
I
L
P
K
T
P
E
Site 146
T574
Y
L
S
I
L
P
K
T
P
E
G
I
S
E
E
Site 147
S579
P
K
T
P
E
G
I
S
E
E
Q
R
S
Q
E
Site 148
S584
G
I
S
E
E
Q
R
S
Q
E
L
A
A
M
E
Site 149
S618
I
N
D
Q
M
D
E
S
F
R
E
L
D
M
E
Site 150
S635
L
L
D
G
E
Q
K
S
E
T
T
E
L
M
K
Site 151
Y686
L
E
R
L
Q
E
L
Y
S
E
Q
K
T
Q
L
Site 152
S687
E
R
L
Q
E
L
Y
S
E
Q
K
T
Q
L
D
Site 153
T691
E
L
Y
S
E
Q
K
T
Q
L
D
N
C
P
E
Site 154
S699
Q
L
D
N
C
P
E
S
M
R
E
Q
L
Q
Q
Site 155
S719
A
D
L
L
D
V
E
S
K
H
F
E
D
L
E
Site 156
Y754
L
L
R
E
V
A
E
Y
Q
R
N
I
V
S
R
Site 157
S766
V
S
R
K
E
K
I
S
A
L
K
K
Q
A
N
Site 158
Y811
L
C
N
L
E
K
K
Y
S
S
L
S
G
G
K
Site 159
S812
C
N
L
E
K
K
Y
S
S
L
S
G
G
K
G
Site 160
S813
N
L
E
K
K
Y
S
S
L
S
G
G
K
G
F
Site 161
S815
E
K
K
Y
S
S
L
S
G
G
K
G
F
P
V
Site 162
T826
G
F
P
V
N
P
N
T
L
K
E
G
Y
I
S
Site 163
Y831
P
N
T
L
K
E
G
Y
I
S
V
N
E
I
N
Site 164
S833
T
L
K
E
G
Y
I
S
V
N
E
I
N
E
P
Site 165
S844
I
N
E
P
C
G
N
S
T
N
L
S
P
S
T
Site 166
S848
C
G
N
S
T
N
L
S
P
S
T
Q
F
P
A
Site 167
T851
S
T
N
L
S
P
S
T
Q
F
P
A
D
A
D
Site 168
S871
P
A
T
A
V
L
A
S
Q
P
Q
S
K
E
H
Site 169
S875
V
L
A
S
Q
P
Q
S
K
E
H
F
R
S
L
Site 170
S881
Q
S
K
E
H
F
R
S
L
E
E
R
K
K
Q
Site 171
Y894
K
Q
H
K
E
G
L
Y
L
S
D
T
L
P
R
Site 172
S896
H
K
E
G
L
Y
L
S
D
T
L
P
R
K
K
Site 173
T898
E
G
L
Y
L
S
D
T
L
P
R
K
K
T
T
Site 174
T904
D
T
L
P
R
K
K
T
T
S
S
I
S
P
H
Site 175
T905
T
L
P
R
K
K
T
T
S
S
I
S
P
H
F
Site 176
S906
L
P
R
K
K
T
T
S
S
I
S
P
H
F
S
Site 177
S907
P
R
K
K
T
T
S
S
I
S
P
H
F
S
S
Site 178
S909
K
K
T
T
S
S
I
S
P
H
F
S
S
A
T
Site 179
S913
S
S
I
S
P
H
F
S
S
A
T
M
G
R
S
Site 180
S914
S
I
S
P
H
F
S
S
A
T
M
G
R
S
I
Site 181
T916
S
P
H
F
S
S
A
T
M
G
R
S
I
T
P
Site 182
S920
S
S
A
T
M
G
R
S
I
T
P
K
A
H
L
Site 183
T922
A
T
M
G
R
S
I
T
P
K
A
H
L
P
L
Site 184
S932
A
H
L
P
L
G
Q
S
N
S
C
G
S
V
L
Site 185
S934
L
P
L
G
Q
S
N
S
C
G
S
V
L
P
P
Site 186
S937
G
Q
S
N
S
C
G
S
V
L
P
P
S
L
A
Site 187
S950
L
A
A
M
A
K
D
S
E
S
R
R
M
L
R
Site 188
S952
A
M
A
K
D
S
E
S
R
R
M
L
R
G
Y
Site 189
Y959
S
R
R
M
L
R
G
Y
N
H
Q
Q
M
S
E
Site 190
S972
S
E
G
H
R
Q
K
S
E
F
Y
N
R
T
A
Site 191
Y975
H
R
Q
K
S
E
F
Y
N
R
T
A
S
E
S
Site 192
T978
K
S
E
F
Y
N
R
T
A
S
E
S
N
V
Y
Site 193
S980
E
F
Y
N
R
T
A
S
E
S
N
V
Y
L
N
Site 194
S982
Y
N
R
T
A
S
E
S
N
V
Y
L
N
S
F
Site 195
Y985
T
A
S
E
S
N
V
Y
L
N
S
F
H
Y
P
Site 196
S988
E
S
N
V
Y
L
N
S
F
H
Y
P
D
H
S
Site 197
Y991
V
Y
L
N
S
F
H
Y
P
D
H
S
Y
K
D
Site 198
Y996
F
H
Y
P
D
H
S
Y
K
D
Q
A
F
D
T
Site 199
T1003
Y
K
D
Q
A
F
D
T
L
S
L
D
S
S
D
Site 200
S1005
D
Q
A
F
D
T
L
S
L
D
S
S
D
S
M
Site 201
S1009
D
T
L
S
L
D
S
S
D
S
M
E
T
S
I
Site 202
S1011
L
S
L
D
S
S
D
S
M
E
T
S
I
S
A
Site 203
S1015
S
S
D
S
M
E
T
S
I
S
A
C
S
P
D
Site 204
S1017
D
S
M
E
T
S
I
S
A
C
S
P
D
N
I
Site 205
S1020
E
T
S
I
S
A
C
S
P
D
N
I
S
S
A
Site 206
S1025
A
C
S
P
D
N
I
S
S
A
S
T
S
N
I
Site 207
S1026
C
S
P
D
N
I
S
S
A
S
T
S
N
I
A
Site 208
S1030
N
I
S
S
A
S
T
S
N
I
A
R
I
E
E
Site 209
S1055
E
K
T
R
L
L
E
S
R
E
R
E
M
E
A
Site 210
T1085
E
K
R
L
Q
E
E
T
S
Q
R
Q
K
L
I
Site 211
S1086
K
R
L
Q
E
E
T
S
Q
R
Q
K
L
I
E
Site 212
T1110
R
A
Q
A
R
P
L
T
R
Y
L
P
V
R
K
Site 213
Y1112
Q
A
R
P
L
T
R
Y
L
P
V
R
K
E
D
Site 214
S1124
K
E
D
F
D
L
R
S
H
V
E
T
A
G
H
Site 215
T1128
D
L
R
S
H
V
E
T
A
G
H
N
I
D
T
Site 216
Y1137
G
H
N
I
D
T
C
Y
H
V
S
I
T
E
K
Site 217
T1145
H
V
S
I
T
E
K
T
C
R
G
F
L
I
K
Site 218
T1173
V
F
D
R
N
K
R
T
F
S
Y
Y
A
D
K
Site 219
S1175
D
R
N
K
R
T
F
S
Y
Y
A
D
K
H
E
Site 220
Y1176
R
N
K
R
T
F
S
Y
Y
A
D
K
H
E
T
Site 221
Y1177
N
K
R
T
F
S
Y
Y
A
D
K
H
E
T
K
Site 222
Y1199
Q
A
I
E
E
V
Y
Y
D
H
L
K
N
A
N
Site 223
S1208
H
L
K
N
A
N
K
S
P
N
P
L
L
T
F
Site 224
T1214
K
S
P
N
P
L
L
T
F
S
V
K
T
H
D
Site 225
S1216
P
N
P
L
L
T
F
S
V
K
T
H
D
R
I
Site 226
T1219
L
L
T
F
S
V
K
T
H
D
R
I
Y
Y
M
Site 227
Y1224
V
K
T
H
D
R
I
Y
Y
M
V
A
P
S
P
Site 228
Y1225
K
T
H
D
R
I
Y
Y
M
V
A
P
S
P
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation