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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FILIP1
Full Name:
Filamin-A-interacting protein 1
Alias:
DKFZp451B134; Filamin A interacting protein 1; FILIP; FLIP1; KIAA1275
Type:
Mass (Da):
138109
Number AA:
1213
UniProt ID:
Q7Z7B0
International Prot ID:
IPI00745798
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
R
N
Q
G
G
E
S
A
S
D
G
H
I
S
Site 2
S12
N
Q
G
G
E
S
A
S
D
G
H
I
S
C
P
Site 3
S17
S
A
S
D
G
H
I
S
C
P
K
P
S
I
I
Site 4
S31
I
G
N
A
G
E
K
S
L
S
E
D
A
K
K
Site 5
S33
N
A
G
E
K
S
L
S
E
D
A
K
K
K
K
Site 6
S42
D
A
K
K
K
K
K
S
N
R
K
E
D
D
V
Site 7
S62
V
K
R
H
L
K
T
S
G
E
C
E
R
K
T
Site 8
T69
S
G
E
C
E
R
K
T
K
K
S
L
E
L
S
Site 9
S72
C
E
R
K
T
K
K
S
L
E
L
S
K
E
D
Site 10
S76
T
K
K
S
L
E
L
S
K
E
D
L
I
Q
L
Site 11
T103
D
V
I
H
M
L
K
T
E
K
T
K
P
E
V
Site 12
T106
H
M
L
K
T
E
K
T
K
P
E
V
L
E
A
Site 13
Y115
P
E
V
L
E
A
H
Y
G
S
A
E
P
E
K
Site 14
S138
A
I
L
A
Q
E
K
S
I
G
E
D
V
Y
E
Site 15
Y144
K
S
I
G
E
D
V
Y
E
K
P
I
S
E
L
Site 16
S149
D
V
Y
E
K
P
I
S
E
L
D
R
L
E
E
Site 17
T161
L
E
E
K
Q
K
E
T
Y
R
R
M
L
E
Q
Site 18
Y162
E
E
K
Q
K
E
T
Y
R
R
M
L
E
Q
L
Site 19
T179
A
E
K
C
H
R
R
T
V
Y
E
L
E
N
E
Site 20
Y181
K
C
H
R
R
T
V
Y
E
L
E
N
E
K
H
Site 21
Y193
E
K
H
K
H
T
D
Y
M
N
K
S
D
D
F
Site 22
T201
M
N
K
S
D
D
F
T
N
L
L
E
Q
E
R
Site 23
T272
S
Q
K
V
Q
D
L
T
Q
K
L
R
E
E
E
Site 24
S287
E
K
L
K
A
I
T
S
K
S
K
E
D
R
Q
Site 25
S289
L
K
A
I
T
S
K
S
K
E
D
R
Q
K
L
Site 26
S308
V
D
F
E
H
K
A
S
R
F
S
Q
E
H
E
Site 27
S311
E
H
K
A
S
R
F
S
Q
E
H
E
E
M
N
Site 28
S326
A
K
L
A
N
Q
E
S
H
N
R
Q
L
R
L
Site 29
T348
R
I
E
E
L
E
E
T
N
K
N
L
Q
K
A
Site 30
S374
A
K
G
E
C
G
N
S
S
L
M
A
E
V
E
Site 31
S375
K
G
E
C
G
N
S
S
L
M
A
E
V
E
N
Site 32
T398
E
G
K
D
E
E
I
T
K
T
E
S
Q
C
R
Site 33
T400
K
D
E
E
I
T
K
T
E
S
Q
C
R
E
L
Site 34
S402
E
E
I
T
K
T
E
S
Q
C
R
E
L
R
K
Site 35
S418
L
Q
E
E
E
H
H
S
K
E
L
R
L
E
V
Site 36
S433
E
K
L
Q
K
R
M
S
E
L
E
K
L
E
E
Site 37
S443
E
K
L
E
E
A
F
S
K
S
K
S
E
C
T
Site 38
S445
L
E
E
A
F
S
K
S
K
S
E
C
T
Q
L
Site 39
S447
E
A
F
S
K
S
K
S
E
C
T
Q
L
H
L
Site 40
T463
L
E
K
E
K
N
L
T
K
D
L
L
N
E
L
Site 41
S475
N
E
L
E
V
V
K
S
R
V
K
E
L
E
C
Site 42
S483
R
V
K
E
L
E
C
S
E
S
R
L
E
K
A
Site 43
S485
K
E
L
E
C
S
E
S
R
L
E
K
A
E
L
Site 44
S493
R
L
E
K
A
E
L
S
L
K
D
D
L
T
K
Site 45
T499
L
S
L
K
D
D
L
T
K
L
K
S
F
T
V
Site 46
T544
Q
G
K
V
M
D
V
T
E
K
L
I
E
E
S
Site 47
S559
K
K
L
L
K
L
K
S
E
M
E
E
K
V
Y
Site 48
Y566
S
E
M
E
E
K
V
Y
N
L
T
R
E
R
D
Site 49
S581
E
L
I
G
K
L
K
S
E
E
E
K
S
S
E
Site 50
S586
L
K
S
E
E
E
K
S
S
E
L
S
C
S
V
Site 51
S587
K
S
E
E
E
K
S
S
E
L
S
C
S
V
D
Site 52
S590
E
E
K
S
S
E
L
S
C
S
V
D
L
L
K
Site 53
S592
K
S
S
E
L
S
C
S
V
D
L
L
K
K
R
Site 54
T611
E
E
V
E
R
E
I
T
R
G
R
S
R
K
G
Site 55
S615
R
E
I
T
R
G
R
S
R
K
G
S
E
L
T
Site 56
S619
R
G
R
S
R
K
G
S
E
L
T
C
P
E
D
Site 57
T633
D
N
K
I
K
E
L
T
L
E
I
E
R
L
K
Site 58
Y660
L
M
K
T
E
D
E
Y
D
Q
L
E
Q
K
F
Site 59
S678
Q
D
K
A
N
F
L
S
Q
Q
L
E
E
I
K
Site 60
S717
F
R
L
E
E
A
K
S
R
D
L
K
A
E
V
Site 61
S742
M
N
K
E
D
Q
L
S
Q
L
Q
V
D
Y
S
Site 62
Y748
L
S
Q
L
Q
V
D
Y
S
V
L
Q
Q
R
F
Site 63
S749
S
Q
L
Q
V
D
Y
S
V
L
Q
Q
R
F
M
Site 64
T773
G
Q
E
V
L
N
L
T
K
E
L
E
L
S
K
Site 65
S779
L
T
K
E
L
E
L
S
K
R
Y
S
R
A
L
Site 66
S783
L
E
L
S
K
R
Y
S
R
A
L
R
P
S
V
Site 67
S789
Y
S
R
A
L
R
P
S
V
N
G
R
R
M
V
Site 68
T807
V
T
S
T
G
V
Q
T
D
A
V
S
G
E
A
Site 69
S811
G
V
Q
T
D
A
V
S
G
E
A
A
E
E
E
Site 70
T819
G
E
A
A
E
E
E
T
P
A
V
F
I
R
K
Site 71
S827
P
A
V
F
I
R
K
S
F
Q
E
E
N
H
I
Site 72
S836
Q
E
E
N
H
I
M
S
N
L
R
Q
V
G
L
Site 73
S851
K
K
P
V
E
R
S
S
V
L
D
R
Y
P
P
Site 74
Y856
R
S
S
V
L
D
R
Y
P
P
A
A
N
E
L
Site 75
T864
P
P
A
A
N
E
L
T
M
R
K
S
W
I
P
Site 76
S881
R
K
R
E
N
G
P
S
I
T
Q
E
K
G
P
Site 77
T883
R
E
N
G
P
S
I
T
Q
E
K
G
P
R
T
Site 78
T890
T
Q
E
K
G
P
R
T
N
S
S
P
G
H
P
Site 79
S892
E
K
G
P
R
T
N
S
S
P
G
H
P
G
E
Site 80
S893
K
G
P
R
T
N
S
S
P
G
H
P
G
E
V
Site 81
S903
H
P
G
E
V
V
L
S
P
K
Q
G
Q
P
L
Site 82
T915
Q
P
L
H
I
R
V
T
P
D
H
E
N
S
T
Site 83
S929
T
A
T
L
E
I
T
S
P
T
S
E
E
F
F
Site 84
S932
L
E
I
T
S
P
T
S
E
E
F
F
S
S
T
Site 85
S937
P
T
S
E
E
F
F
S
S
T
T
V
I
P
T
Site 86
T940
E
E
F
F
S
S
T
T
V
I
P
T
L
G
N
Site 87
T953
G
N
Q
K
P
R
I
T
I
I
P
S
P
N
V
Site 88
S957
P
R
I
T
I
I
P
S
P
N
V
M
P
Q
K
Site 89
S967
V
M
P
Q
K
Q
K
S
G
D
T
T
L
G
P
Site 90
T971
K
Q
K
S
G
D
T
T
L
G
P
E
R
A
M
Site 91
T982
E
R
A
M
S
P
V
T
I
T
T
F
S
R
E
Site 92
T985
M
S
P
V
T
I
T
T
F
S
R
E
K
T
P
Site 93
S987
P
V
T
I
T
T
F
S
R
E
K
T
P
E
S
Site 94
T991
T
T
F
S
R
E
K
T
P
E
S
G
R
G
A
Site 95
S994
S
R
E
K
T
P
E
S
G
R
G
A
F
A
D
Site 96
T1004
G
A
F
A
D
R
P
T
S
P
I
Q
I
M
T
Site 97
S1024
A
P
A
E
I
A
V
S
P
E
S
Q
E
M
P
Site 98
S1027
E
I
A
V
S
P
E
S
Q
E
M
P
M
G
R
Site 99
T1035
Q
E
M
P
M
G
R
T
I
L
K
V
T
P
E
Site 100
T1040
G
R
T
I
L
K
V
T
P
E
K
Q
T
V
P
Site 101
T1045
K
V
T
P
E
K
Q
T
V
P
T
P
V
R
K
Site 102
T1048
P
E
K
Q
T
V
P
T
P
V
R
K
Y
N
S
Site 103
Y1053
V
P
T
P
V
R
K
Y
N
S
N
A
N
I
I
Site 104
S1073
K
I
H
I
H
L
G
S
Q
F
K
R
S
P
G
Site 105
S1078
L
G
S
Q
F
K
R
S
P
G
T
S
G
E
G
Site 106
S1082
F
K
R
S
P
G
T
S
G
E
G
V
S
P
V
Site 107
S1087
G
T
S
G
E
G
V
S
P
V
I
T
V
R
P
Site 108
T1098
T
V
R
P
V
N
V
T
A
E
K
E
V
S
T
Site 109
S1104
V
T
A
E
K
E
V
S
T
G
T
V
L
R
S
Site 110
T1107
E
K
E
V
S
T
G
T
V
L
R
S
P
R
N
Site 111
S1111
S
T
G
T
V
L
R
S
P
R
N
H
L
S
S
Site 112
S1117
R
S
P
R
N
H
L
S
S
R
P
G
A
S
K
Site 113
S1118
S
P
R
N
H
L
S
S
R
P
G
A
S
K
V
Site 114
S1123
L
S
S
R
P
G
A
S
K
V
T
S
T
I
T
Site 115
S1138
I
T
P
V
T
T
S
S
A
R
G
T
Q
S
V
Site 116
T1142
T
T
S
S
A
R
G
T
Q
S
V
S
G
Q
D
Site 117
S1144
S
S
A
R
G
T
Q
S
V
S
G
Q
D
G
S
Site 118
S1146
A
R
G
T
Q
S
V
S
G
Q
D
G
S
S
Q
Site 119
S1151
S
V
S
G
Q
D
G
S
S
Q
R
P
T
P
T
Site 120
S1152
V
S
G
Q
D
G
S
S
Q
R
P
T
P
T
R
Site 121
T1156
D
G
S
S
Q
R
P
T
P
T
R
I
P
M
S
Site 122
T1158
S
S
Q
R
P
T
P
T
R
I
P
M
S
K
G
Site 123
S1163
T
P
T
R
I
P
M
S
K
G
M
K
A
G
K
Site 124
T1190
K
F
E
P
R
A
E
T
Q
S
M
K
I
E
L
Site 125
S1192
E
P
R
A
E
T
Q
S
M
K
I
E
L
K
K
Site 126
S1200
M
K
I
E
L
K
K
S
A
A
S
S
T
T
S
Site 127
S1203
E
L
K
K
S
A
A
S
S
T
T
S
L
G
G
Site 128
S1204
L
K
K
S
A
A
S
S
T
T
S
L
G
G
G
Site 129
S1207
S
A
A
S
S
T
T
S
L
G
G
G
K
G
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation