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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CEP110
Full Name:
Centriolin
Alias:
110 kDa centrosomal protein
Type:
Microtubule binding protein
Mass (Da):
268886
Number AA:
2325
UniProt ID:
Q7Z7A1
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
G
S
Q
Q
K
I
F
S
K
A
K
I
P
S
S
Site 2
S17
F
S
K
A
K
I
P
S
S
S
H
S
P
I
P
Site 3
S18
S
K
A
K
I
P
S
S
S
H
S
P
I
P
S
Site 4
S19
K
A
K
I
P
S
S
S
H
S
P
I
P
S
S
Site 5
S21
K
I
P
S
S
S
H
S
P
I
P
S
S
M
S
Site 6
S25
S
S
H
S
P
I
P
S
S
M
S
N
M
R
S
Site 7
S26
S
H
S
P
I
P
S
S
M
S
N
M
R
S
R
Site 8
S28
S
P
I
P
S
S
M
S
N
M
R
S
R
S
L
Site 9
S32
S
S
M
S
N
M
R
S
R
S
L
S
P
L
I
Site 10
S34
M
S
N
M
R
S
R
S
L
S
P
L
I
G
S
Site 11
S36
N
M
R
S
R
S
L
S
P
L
I
G
S
E
T
Site 12
T43
S
P
L
I
G
S
E
T
L
P
F
H
S
G
G
Site 13
Y68
E
N
N
M
L
L
D
Y
Q
D
H
K
G
A
D
Site 14
S76
Q
D
H
K
G
A
D
S
H
A
G
V
R
Y
I
Site 15
T92
E
A
L
I
K
K
L
T
K
Q
D
N
L
A
L
Site 16
S106
L
I
K
S
L
N
L
S
L
S
K
D
G
G
K
Site 17
S108
K
S
L
N
L
S
L
S
K
D
G
G
K
K
F
Site 18
Y117
D
G
G
K
K
F
K
Y
I
E
N
L
E
K
C
Site 19
S155
K
L
R
E
L
N
L
S
Y
N
K
I
S
K
I
Site 20
S194
W
L
G
K
K
L
K
S
L
R
V
L
N
L
K
Site 21
S207
L
K
G
N
K
I
S
S
L
Q
D
I
S
K
L
Site 22
S212
I
S
S
L
Q
D
I
S
K
L
K
P
L
Q
D
Site 23
S246
F
T
I
F
H
L
R
S
L
E
S
L
E
G
Q
Site 24
S249
F
H
L
R
S
L
E
S
L
E
G
Q
P
V
T
Site 25
S268
Q
E
A
F
E
R
F
S
L
E
E
V
E
R
L
Site 26
S291
I
E
T
E
E
L
K
S
K
Q
T
R
F
L
E
Site 27
S309
N
Q
D
K
L
N
K
S
L
K
E
E
A
M
L
Site 28
S320
E
A
M
L
Q
K
Q
S
C
E
E
L
K
S
D
Site 29
S326
Q
S
C
E
E
L
K
S
D
L
N
T
K
N
E
Site 30
T330
E
L
K
S
D
L
N
T
K
N
E
L
L
K
Q
Site 31
T339
N
E
L
L
K
Q
K
T
I
E
L
T
R
A
C
Site 32
Y359
L
E
Q
E
L
A
F
Y
K
I
D
A
K
F
E
Site 33
Y370
A
K
F
E
P
L
N
Y
Y
P
S
E
Y
A
E
Site 34
Y371
K
F
E
P
L
N
Y
Y
P
S
E
Y
A
E
I
Site 35
S373
E
P
L
N
Y
Y
P
S
E
Y
A
E
I
D
K
Site 36
Y375
L
N
Y
Y
P
S
E
Y
A
E
I
D
K
A
P
Site 37
S385
I
D
K
A
P
D
E
S
P
Y
I
G
K
S
R
Site 38
Y387
K
A
P
D
E
S
P
Y
I
G
K
S
R
Y
K
Site 39
Y393
P
Y
I
G
K
S
R
Y
K
R
N
M
F
A
T
Site 40
T400
Y
K
R
N
M
F
A
T
E
S
Y
I
I
D
S
Site 41
S402
R
N
M
F
A
T
E
S
Y
I
I
D
S
A
Q
Site 42
T433
H
M
N
L
R
G
H
T
P
L
D
T
Q
L
E
Site 43
T437
R
G
H
T
P
L
D
T
Q
L
E
D
K
E
K
Site 44
S447
E
D
K
E
K
K
I
S
A
A
Q
T
R
L
S
Site 45
T451
K
K
I
S
A
A
Q
T
R
L
S
E
L
H
D
Site 46
S454
S
A
A
Q
T
R
L
S
E
L
H
D
E
I
E
Site 47
T471
E
Q
Q
I
L
R
A
T
E
E
F
K
Q
L
E
Site 48
S487
A
I
Q
L
K
K
I
S
E
A
G
K
D
L
L
Site 49
Y495
E
A
G
K
D
L
L
Y
K
Q
L
S
G
R
L
Site 50
S499
D
L
L
Y
K
Q
L
S
G
R
L
Q
L
V
N
Site 51
S542
D
L
Q
I
A
I
D
S
L
D
S
K
D
P
K
Site 52
S545
I
A
I
D
S
L
D
S
K
D
P
K
H
S
H
Site 53
S551
D
S
K
D
P
K
H
S
H
M
K
A
Q
K
S
Site 54
S558
S
H
M
K
A
Q
K
S
G
K
E
Q
Q
L
D
Site 55
Y571
L
D
I
M
N
K
Q
Y
Q
Q
L
E
S
R
L
Site 56
S583
S
R
L
D
E
I
L
S
R
I
A
K
E
T
E
Site 57
T589
L
S
R
I
A
K
E
T
E
E
I
K
D
L
E
Site 58
T600
K
D
L
E
E
Q
L
T
E
G
Q
I
A
A
N
Site 59
S619
K
D
L
E
G
V
I
S
G
L
Q
E
Y
L
G
Site 60
Y624
V
I
S
G
L
Q
E
Y
L
G
T
I
K
G
Q
Site 61
T627
G
L
Q
E
Y
L
G
T
I
K
G
Q
A
T
Q
Site 62
T648
K
L
R
D
E
K
E
T
L
L
Q
R
L
T
E
Site 63
T654
E
T
L
L
Q
R
L
T
E
V
E
Q
E
R
D
Site 64
S682
K
E
L
A
E
L
E
S
A
L
Q
E
Q
H
E
Site 65
S693
E
Q
H
E
V
N
A
S
L
Q
Q
T
Q
G
D
Site 66
T697
V
N
A
S
L
Q
Q
T
Q
G
D
L
S
A
Y
Site 67
S702
Q
Q
T
Q
G
D
L
S
A
Y
E
A
E
L
E
Site 68
Y704
T
Q
G
D
L
S
A
Y
E
A
E
L
E
A
R
Site 69
T733
L
E
K
V
T
R
L
T
Q
L
E
Q
S
A
L
Site 70
S761
A
L
G
K
A
Q
F
S
E
E
K
E
Q
E
N
Site 71
S769
E
E
K
E
Q
E
N
S
E
L
H
A
K
L
K
Site 72
S831
T
G
E
M
N
I
H
S
P
S
D
V
L
G
K
Site 73
S833
E
M
N
I
H
S
P
S
D
V
L
G
K
S
L
Site 74
S839
P
S
D
V
L
G
K
S
L
A
D
L
Q
K
Q
Site 75
S854
F
S
E
I
L
A
R
S
K
W
E
R
D
E
A
Site 76
Y918
Q
M
E
N
E
I
H
Y
L
Q
E
N
L
K
S
Site 77
S925
Y
L
Q
E
N
L
K
S
M
E
E
I
Q
G
L
Site 78
S965
K
K
L
E
D
A
K
S
Q
E
Q
V
F
G
L
Site 79
S1003
I
A
K
D
Q
L
K
S
L
H
G
T
V
M
K
Site 80
T1007
Q
L
K
S
L
H
G
T
V
M
K
I
N
Q
E
Site 81
S1026
L
Q
E
A
E
R
F
S
R
K
A
A
Q
A
A
Site 82
T1037
A
Q
A
A
R
D
L
T
R
A
E
A
E
I
E
Site 83
T1064
F
R
L
E
M
E
K
T
G
V
G
T
G
A
N
Site 84
S1072
G
V
G
T
G
A
N
S
Q
V
L
E
I
E
K
Site 85
T1089
E
T
M
E
R
Q
R
T
E
I
A
R
L
Q
N
Site 86
T1101
L
Q
N
V
L
D
L
T
G
S
D
N
K
G
G
Site 87
S1103
N
V
L
D
L
T
G
S
D
N
K
G
G
F
E
Site 88
S1124
A
E
L
R
R
E
V
S
Y
Q
N
D
Y
I
S
Site 89
Y1125
E
L
R
R
E
V
S
Y
Q
N
D
Y
I
S
S
Site 90
Y1129
E
V
S
Y
Q
N
D
Y
I
S
S
M
A
D
P
Site 91
S1131
S
Y
Q
N
D
Y
I
S
S
M
A
D
P
F
K
Site 92
Y1142
D
P
F
K
R
R
G
Y
W
Y
F
M
P
P
P
Site 93
Y1144
F
K
R
R
G
Y
W
Y
F
M
P
P
P
P
S
Site 94
S1151
Y
F
M
P
P
P
P
S
S
K
V
S
S
H
S
Site 95
S1152
F
M
P
P
P
P
S
S
K
V
S
S
H
S
S
Site 96
S1155
P
P
P
S
S
K
V
S
S
H
S
S
Q
A
T
Site 97
S1156
P
P
S
S
K
V
S
S
H
S
S
Q
A
T
K
Site 98
S1159
S
K
V
S
S
H
S
S
Q
A
T
K
D
S
G
Site 99
T1162
S
S
H
S
S
Q
A
T
K
D
S
G
V
G
L
Site 100
S1165
S
S
Q
A
T
K
D
S
G
V
G
L
K
Y
S
Site 101
Y1171
D
S
G
V
G
L
K
Y
S
A
S
T
P
V
R
Site 102
S1172
S
G
V
G
L
K
Y
S
A
S
T
P
V
R
K
Site 103
S1174
V
G
L
K
Y
S
A
S
T
P
V
R
K
P
R
Site 104
T1175
G
L
K
Y
S
A
S
T
P
V
R
K
P
R
P
Site 105
S1191
Q
Q
D
G
K
E
G
S
Q
P
P
P
A
S
G
Site 106
S1197
G
S
Q
P
P
P
A
S
G
Y
W
V
Y
S
P
Site 107
Y1199
Q
P
P
P
A
S
G
Y
W
V
Y
S
P
I
R
Site 108
Y1202
P
A
S
G
Y
W
V
Y
S
P
I
R
S
G
L
Site 109
S1203
A
S
G
Y
W
V
Y
S
P
I
R
S
G
L
H
Site 110
S1207
W
V
Y
S
P
I
R
S
G
L
H
K
L
F
P
Site 111
S1215
G
L
H
K
L
F
P
S
R
D
A
D
S
G
G
Site 112
S1220
F
P
S
R
D
A
D
S
G
G
D
S
Q
E
E
Site 113
S1224
D
A
D
S
G
G
D
S
Q
E
E
S
E
L
D
Site 114
S1228
G
G
D
S
Q
E
E
S
E
L
D
D
Q
E
E
Site 115
Y1247
P
P
P
G
Y
M
M
Y
T
V
L
P
D
G
S
Site 116
T1248
P
P
G
Y
M
M
Y
T
V
L
P
D
G
S
P
Site 117
S1254
Y
T
V
L
P
D
G
S
P
V
P
Q
G
M
A
Site 118
S1273
P
P
P
L
P
N
N
S
R
P
L
T
P
G
T
Site 119
T1277
P
N
N
S
R
P
L
T
P
G
T
V
V
Y
G
Site 120
T1280
S
R
P
L
T
P
G
T
V
V
Y
G
P
P
P
Site 121
Y1294
P
A
G
A
P
M
V
Y
G
P
P
P
P
N
F
Site 122
S1326
H
N
L
E
N
E
V
S
R
L
E
D
I
M
Q
Site 123
S1337
D
I
M
Q
H
L
K
S
K
K
R
E
E
R
W
Site 124
S1348
E
E
R
W
M
R
A
S
K
R
Q
S
E
K
E
Site 125
S1352
M
R
A
S
K
R
Q
S
E
K
E
M
E
E
L
Site 126
S1372
D
L
L
Q
E
K
K
S
L
E
C
E
V
E
E
Site 127
T1383
E
V
E
E
L
H
R
T
V
Q
K
R
Q
Q
Q
Site 128
T1403
G
N
V
E
S
L
M
T
E
L
E
I
E
K
S
Site 129
S1410
T
E
L
E
I
E
K
S
L
K
H
H
E
D
I
Site 130
T1427
E
I
E
C
I
E
K
T
L
L
K
R
R
S
E
Site 131
S1433
K
T
L
L
K
R
R
S
E
L
R
E
A
D
R
Site 132
S1450
A
E
A
E
S
E
L
S
C
T
K
E
K
T
K
Site 133
T1452
A
E
S
E
L
S
C
T
K
E
K
T
K
N
A
Site 134
S1469
K
F
T
D
A
K
R
S
L
L
Q
T
E
S
D
Site 135
T1473
A
K
R
S
L
L
Q
T
E
S
D
A
E
E
L
Site 136
S1475
R
S
L
L
Q
T
E
S
D
A
E
E
L
E
R
Site 137
T1487
L
E
R
R
A
Q
E
T
A
V
N
L
V
K
A
Site 138
S1500
K
A
D
Q
Q
L
R
S
L
Q
A
D
A
K
D
Site 139
S1531
K
I
V
A
A
K
D
S
D
F
Q
C
L
S
K
Site 140
S1537
D
S
D
F
Q
C
L
S
K
K
K
E
K
L
T
Site 141
S1587
A
E
L
E
K
L
K
S
Q
V
T
S
Q
Q
Q
Site 142
S1591
K
L
K
S
Q
V
T
S
Q
Q
Q
E
M
A
V
Site 143
T1636
R
L
G
E
T
E
V
T
E
K
C
N
H
I
R
Site 144
S1647
N
H
I
R
E
V
K
S
L
L
E
E
L
S
F
Site 145
S1653
K
S
L
L
E
E
L
S
F
Q
K
G
E
L
N
Site 146
S1664
G
E
L
N
V
Q
I
S
E
R
K
T
Q
L
T
Site 147
T1668
V
Q
I
S
E
R
K
T
Q
L
T
L
I
K
Q
Site 148
T1671
S
E
R
K
T
Q
L
T
L
I
K
Q
E
I
E
Site 149
S1692
Q
V
V
L
R
Q
M
S
K
H
K
T
E
L
K
Site 150
T1696
R
Q
M
S
K
H
K
T
E
L
K
N
I
L
D
Site 151
S1724
L
Q
H
D
Q
R
V
S
E
L
E
K
T
Q
V
Site 152
T1729
R
V
S
E
L
E
K
T
Q
V
A
V
L
E
E
Site 153
S1747
L
E
N
L
Q
Q
I
S
Q
Q
Q
K
G
E
I
Site 154
T1772
K
R
E
I
E
R
M
T
A
E
S
R
A
L
Q
Site 155
S1775
I
E
R
M
T
A
E
S
R
A
L
Q
S
C
V
Site 156
S1780
A
E
S
R
A
L
Q
S
C
V
E
C
L
S
K
Site 157
S1786
Q
S
C
V
E
C
L
S
K
E
K
E
D
L
Q
Site 158
S1822
E
N
S
K
M
E
Q
S
N
L
E
K
L
E
L
Site 159
S1847
Q
L
N
R
D
K
L
S
L
H
N
D
I
S
A
Site 160
S1853
L
S
L
H
N
D
I
S
A
M
Q
Q
Q
L
Q
Site 161
S1868
E
K
R
E
A
V
N
S
L
Q
E
E
L
A
N
Site 162
S1909
T
R
L
Q
K
D
I
S
E
W
A
N
R
F
E
Site 163
S1959
R
L
Q
K
E
R
E
S
E
E
S
K
L
E
T
Site 164
S1962
K
E
R
E
S
E
E
S
K
L
E
T
S
K
V
Site 165
T1966
S
E
E
S
K
L
E
T
S
K
V
T
L
K
E
Site 166
T1983
H
Q
L
E
K
E
L
T
D
Q
K
S
K
L
D
Site 167
S1987
K
E
L
T
D
Q
K
S
K
L
D
Q
V
L
S
Site 168
S1994
S
K
L
D
Q
V
L
S
K
V
L
A
A
E
E
Site 169
T2005
A
A
E
E
R
V
R
T
L
Q
E
E
E
R
W
Site 170
S2015
E
E
E
R
W
C
E
S
L
E
K
T
L
S
Q
Site 171
T2019
W
C
E
S
L
E
K
T
L
S
Q
T
K
R
Q
Site 172
S2021
E
S
L
E
K
T
L
S
Q
T
K
R
Q
L
S
Site 173
T2023
L
E
K
T
L
S
Q
T
K
R
Q
L
S
E
R
Site 174
S2028
S
Q
T
K
R
Q
L
S
E
R
E
Q
Q
L
V
Site 175
S2038
E
Q
Q
L
V
E
K
S
G
E
L
L
A
L
Q
Site 176
S2050
A
L
Q
K
E
A
D
S
M
R
A
D
F
S
L
Site 177
S2056
D
S
M
R
A
D
F
S
L
L
R
N
Q
F
L
Site 178
T2064
L
L
R
N
Q
F
L
T
E
R
K
K
A
E
K
Site 179
S2085
E
A
L
K
I
Q
R
S
Q
L
E
K
N
L
L
Site 180
Y2131
K
E
L
N
Q
M
Q
Y
E
Y
T
E
L
K
K
Site 181
S2154
E
R
R
Q
M
E
I
S
D
A
M
R
T
L
K
Site 182
S2162
D
A
M
R
T
L
K
S
E
V
K
D
E
I
R
Site 183
S2171
V
K
D
E
I
R
T
S
L
K
N
L
N
Q
F
Site 184
S2202
N
L
E
G
E
L
E
S
L
K
E
N
L
P
F
Site 185
T2210
L
K
E
N
L
P
F
T
M
N
E
G
P
F
E
Site 186
S2223
F
E
E
K
L
N
F
S
Q
V
H
I
M
D
E
Site 187
T2270
L
I
K
G
K
R
Q
T
E
G
T
L
H
S
L
Site 188
T2273
G
K
R
Q
T
E
G
T
L
H
S
L
R
R
Q
Site 189
S2276
Q
T
E
G
T
L
H
S
L
R
R
Q
V
D
A
Site 190
S2290
A
L
G
E
L
V
T
S
T
S
A
D
S
A
S
Site 191
T2291
L
G
E
L
V
T
S
T
S
A
D
S
A
S
S
Site 192
S2292
G
E
L
V
T
S
T
S
A
D
S
A
S
S
P
Site 193
S2295
V
T
S
T
S
A
D
S
A
S
S
P
S
L
S
Site 194
S2297
S
T
S
A
D
S
A
S
S
P
S
L
S
Q
L
Site 195
S2298
T
S
A
D
S
A
S
S
P
S
L
S
Q
L
E
Site 196
S2300
A
D
S
A
S
S
P
S
L
S
Q
L
E
S
S
Site 197
S2302
S
A
S
S
P
S
L
S
Q
L
E
S
S
L
T
Site 198
S2306
P
S
L
S
Q
L
E
S
S
L
T
E
D
S
Q
Site 199
S2307
S
L
S
Q
L
E
S
S
L
T
E
D
S
Q
L
Site 200
T2309
S
Q
L
E
S
S
L
T
E
D
S
Q
L
G
Q
Site 201
S2312
E
S
S
L
T
E
D
S
Q
L
G
Q
N
Q
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation