KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
FLJ40243
Full Name:
HEAT repeat-containing protein 7B2
Alias:
DKFZp781F0822; HEAT repeat family member 7B2
Type:
Unknown function
Mass (Da):
180730
Number AA:
1585
UniProt ID:
Q7Z745
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
T
L
S
T
E
E
S
I
E
M
F
G
D
I
Site 2
S35
V
N
K
E
D
I
Y
S
H
L
T
S
V
I
Q
Site 3
S39
D
I
Y
S
H
L
T
S
V
I
Q
N
T
D
I
Site 4
Y57
A
I
V
Q
R
L
I
Y
Y
A
S
K
D
M
R
Site 5
Y58
I
V
Q
R
L
I
Y
Y
A
S
K
D
M
R
D
Site 6
S90
L
A
A
H
D
F
N
S
V
M
Y
E
V
Q
S
Site 7
Y93
H
D
F
N
S
V
M
Y
E
V
Q
S
N
F
R
Site 8
T150
E
D
E
R
M
K
G
T
F
C
I
A
L
E
K
Site 9
Y163
E
K
F
S
K
A
I
Y
K
Y
V
N
H
W
R
Site 10
Y165
F
S
K
A
I
Y
K
Y
V
N
H
W
R
D
F
Site 11
Y174
N
H
W
R
D
F
P
Y
P
R
L
D
A
N
R
Site 12
S183
R
L
D
A
N
R
L
S
D
K
I
F
M
L
F
Site 13
S202
E
K
W
A
P
L
A
S
P
M
Q
T
L
S
I
Site 14
S208
A
S
P
M
Q
T
L
S
I
V
K
A
H
G
P
Site 15
S218
K
A
H
G
P
T
V
S
L
L
L
H
R
E
D
Site 16
Y229
H
R
E
D
F
R
G
Y
A
L
G
Q
V
P
W
Site 17
S271
Y
D
I
G
L
P
R
S
L
R
R
S
I
F
I
Site 18
S324
F
F
D
E
Q
V
R
S
N
N
E
A
I
R
V
Site 19
T335
A
I
R
V
G
I
L
T
L
L
R
L
A
V
N
Site 20
S354
R
L
R
D
H
I
I
S
I
E
R
T
V
K
I
Site 21
S367
K
I
V
M
G
D
L
S
T
K
V
R
N
S
V
Site 22
Y386
Q
T
M
C
E
K
S
Y
I
E
A
R
E
G
W
Site 23
T405
Y
V
F
S
Q
F
A
T
L
N
R
N
L
E
K
Site 24
S427
E
N
E
K
E
E
E
S
V
R
E
T
S
L
E
Site 25
T431
E
E
E
S
V
R
E
T
S
L
E
V
L
K
T
Site 26
S432
E
E
S
V
R
E
T
S
L
E
V
L
K
T
L
Site 27
S487
A
E
E
K
K
Q
H
S
A
K
E
S
T
A
L
Site 28
S491
K
Q
H
S
A
K
E
S
T
A
L
V
I
S
T
Site 29
T492
Q
H
S
A
K
E
S
T
A
L
V
I
S
T
G
Site 30
S497
E
S
T
A
L
V
I
S
T
G
A
V
K
L
P
Site 31
T498
S
T
A
L
V
I
S
T
G
A
V
K
L
P
S
Site 32
S505
T
G
A
V
K
L
P
S
P
Q
Q
L
L
A
R
Site 33
T551
K
L
V
D
L
W
K
T
R
L
P
E
L
L
Q
Site 34
S566
P
L
E
G
K
N
I
S
T
V
L
W
E
T
M
Site 35
S604
D
F
K
Q
Q
M
G
S
Y
S
N
N
S
T
E
Site 36
S609
M
G
S
Y
S
N
N
S
T
E
K
K
F
L
W
Site 37
T610
G
S
Y
S
N
N
S
T
E
K
K
F
L
W
K
Site 38
S634
Q
D
S
D
F
V
N
S
Q
I
K
E
F
L
T
Site 39
T641
S
Q
I
K
E
F
L
T
A
P
N
Q
L
G
D
Site 40
S655
D
Q
R
Q
G
I
T
S
I
L
G
Y
C
A
E
Site 41
T674
I
V
L
K
V
L
K
T
F
Q
N
Q
E
K
F
Site 42
S688
F
F
M
N
R
C
K
S
L
F
S
G
K
K
S
Site 43
S691
N
R
C
K
S
L
F
S
G
K
K
S
L
T
K
Site 44
S695
S
L
F
S
G
K
K
S
L
T
K
T
D
V
M
Site 45
T697
F
S
G
K
K
S
L
T
K
T
D
V
M
V
I
Site 46
T699
G
K
K
S
L
T
K
T
D
V
M
V
I
Y
G
Site 47
S727
R
L
N
Q
D
I
I
S
Q
V
L
S
L
H
G
Site 48
S754
K
D
M
D
L
Q
M
S
F
T
R
S
I
T
E
Site 49
S777
E
D
Q
G
F
Q
F
S
Y
K
E
M
L
I
G
Site 50
Y778
D
Q
G
F
Q
F
S
Y
K
E
M
L
I
G
Y
Site 51
S797
I
R
D
E
P
L
D
S
L
A
S
P
I
R
W
Site 52
S800
E
P
L
D
S
L
A
S
P
I
R
W
K
A
L
Site 53
Y812
K
A
L
I
A
I
R
Y
L
S
K
L
K
P
Q
Site 54
S821
S
K
L
K
P
Q
L
S
L
Q
D
H
L
N
I
Site 55
S847
P
P
L
E
N
L
K
S
E
G
Q
T
D
K
D
Site 56
T851
N
L
K
S
E
G
Q
T
D
K
D
K
E
H
I
Site 57
Y862
K
E
H
I
Q
F
L
Y
E
R
S
M
D
A
L
Site 58
T912
R
E
R
A
F
Q
I
T
A
K
V
L
T
N
D
Site 59
T942
L
A
P
H
S
C
D
T
L
P
T
I
R
Q
A
Site 60
S979
G
L
Q
E
G
L
E
S
D
D
V
Q
V
Q
I
Site 61
S997
S
K
I
A
K
I
V
S
K
F
I
P
N
E
E
Site 62
S1018
E
M
L
D
G
L
E
S
L
N
P
T
C
T
K
Site 63
S1066
V
L
R
Q
K
E
E
S
F
Q
F
I
L
E
A
Site 64
T1100
P
L
P
F
D
R
D
T
K
T
L
W
K
A
L
Site 65
T1102
P
F
D
R
D
T
K
T
L
W
K
A
L
A
E
Site 66
S1113
A
L
A
E
K
P
A
S
S
G
K
L
L
Q
A
Site 67
S1171
T
L
L
L
K
L
V
S
C
T
L
G
Q
K
M
Site 68
T1173
L
L
K
L
V
S
C
T
L
G
Q
K
M
P
T
Site 69
T1180
T
L
G
Q
K
M
P
T
C
P
W
S
H
R
R
Site 70
T1206
P
D
P
C
R
L
S
T
A
T
L
K
C
L
Q
Site 71
T1208
P
C
R
L
S
T
A
T
L
K
C
L
Q
A
Q
Site 72
S1225
R
E
G
L
A
K
E
S
D
E
G
D
N
L
W
Site 73
T1233
D
E
G
D
N
L
W
T
L
L
S
S
P
S
T
Site 74
S1236
D
N
L
W
T
L
L
S
S
P
S
T
H
H
I
Site 75
S1237
N
L
W
T
L
L
S
S
P
S
T
H
H
I
G
Site 76
S1269
D
I
M
E
Q
L
L
S
S
L
T
S
S
S
E
Site 77
S1270
I
M
E
Q
L
L
S
S
L
T
S
S
S
E
N
Site 78
T1272
E
Q
L
L
S
S
L
T
S
S
S
E
N
Y
R
Site 79
S1273
Q
L
L
S
S
L
T
S
S
S
E
N
Y
R
I
Site 80
S1274
L
L
S
S
L
T
S
S
S
E
N
Y
R
I
T
Site 81
S1275
L
S
S
L
T
S
S
S
E
N
Y
R
I
T
G
Site 82
Y1278
L
T
S
S
S
E
N
Y
R
I
T
G
A
A
F
Site 83
T1281
S
S
E
N
Y
R
I
T
G
A
A
F
F
S
E
Site 84
T1330
A
I
R
G
L
G
N
T
A
S
G
A
P
H
K
Site 85
S1332
R
G
L
G
N
T
A
S
G
A
P
H
K
V
K
Site 86
S1348
H
K
Q
L
M
L
E
S
I
I
R
G
L
Y
H
Site 87
Y1354
E
S
I
I
R
G
L
Y
H
L
A
R
T
E
V
Site 88
T1377
K
K
I
L
E
L
L
T
D
R
D
V
S
F
Y
Site 89
Y1384
T
D
R
D
V
S
F
Y
F
K
E
I
V
L
Q
Site 90
T1394
E
I
V
L
Q
T
R
T
F
F
E
D
E
Q
D
Site 91
T1406
E
Q
D
D
V
R
L
T
A
I
F
L
F
E
D
Site 92
T1418
F
E
D
L
A
P
L
T
G
R
R
W
K
I
F
Site 93
Y1487
L
P
R
A
R
D
F
Y
R
Q
F
C
V
K
L
Site 94
T1511
I
L
H
T
H
S
F
T
F
F
T
S
T
W
E
Site 95
S1522
S
T
W
E
V
I
R
S
A
A
V
K
L
T
D
Site 96
Y1539
V
L
N
L
T
S
Q
Y
V
E
L
L
D
R
E
Site 97
T1549
L
L
D
R
E
Q
L
T
T
R
L
Q
A
L
R
Site 98
T1550
L
D
R
E
Q
L
T
T
R
L
Q
A
L
R
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation