KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
FGD2
Full Name:
FYVE, RhoGEF and PH domain-containing protein 2
Alias:
Zinc finger FYVE domain-containing protein 4
Type:
Mass (Da):
74892
Number AA:
655
UniProt ID:
Q7Z6J4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
A
S
V
S
N
L
V
T
V
F
E
N
S
R
T
Site 2
T24
T
V
F
E
N
S
R
T
P
E
A
A
P
R
G
Site 3
S48
P
E
C
R
P
P
E
S
P
G
P
R
E
K
T
Site 4
T55
S
P
G
P
R
E
K
T
N
V
G
E
A
V
G
Site 5
S63
N
V
G
E
A
V
G
S
E
P
R
T
V
S
R
Site 6
T67
A
V
G
S
E
P
R
T
V
S
R
R
Y
L
N
Site 7
S69
G
S
E
P
R
T
V
S
R
R
Y
L
N
S
L
Site 8
Y72
P
R
T
V
S
R
R
Y
L
N
S
L
K
N
K
Site 9
S75
V
S
R
R
Y
L
N
S
L
K
N
K
L
S
S
Site 10
S81
N
S
L
K
N
K
L
S
S
E
A
W
R
K
S
Site 11
S88
S
S
E
A
W
R
K
S
C
Q
P
V
T
L
S
Site 12
T93
R
K
S
C
Q
P
V
T
L
S
G
S
G
T
Q
Site 13
S95
S
C
Q
P
V
T
L
S
G
S
G
T
Q
E
P
Site 14
T99
V
T
L
S
G
S
G
T
Q
E
P
E
K
K
I
Site 15
T113
I
V
Q
E
L
L
E
T
E
Q
A
Y
V
A
R
Site 16
T135
F
F
Q
E
L
L
K
T
A
R
S
S
K
A
F
Site 17
S138
E
L
L
K
T
A
R
S
S
K
A
F
P
E
D
Site 18
S139
L
L
K
T
A
R
S
S
K
A
F
P
E
D
V
Site 19
Y158
F
S
N
I
S
S
I
Y
Q
F
H
S
Q
F
F
Site 20
S162
S
S
I
Y
Q
F
H
S
Q
F
F
L
P
E
L
Site 21
T177
Q
R
R
L
D
D
W
T
A
N
P
R
I
G
D
Site 22
Y199
F
L
K
M
Y
S
E
Y
V
K
N
F
E
R
A
Site 23
T212
R
A
A
E
L
L
A
T
W
T
D
K
S
P
L
Site 24
T214
A
E
L
L
A
T
W
T
D
K
S
P
L
F
Q
Site 25
S217
L
A
T
W
T
D
K
S
P
L
F
Q
E
V
L
Site 26
T225
P
L
F
Q
E
V
L
T
R
I
Q
S
S
E
A
Site 27
S229
E
V
L
T
R
I
Q
S
S
E
A
S
G
S
L
Site 28
S230
V
L
T
R
I
Q
S
S
E
A
S
G
S
L
T
Site 29
S233
R
I
Q
S
S
E
A
S
G
S
L
T
L
Q
H
Site 30
S235
Q
S
S
E
A
S
G
S
L
T
L
Q
H
H
M
Site 31
T237
S
E
A
S
G
S
L
T
L
Q
H
H
M
L
E
Site 32
Y252
P
V
Q
R
I
P
R
Y
E
L
L
L
K
E
Y
Site 33
Y259
Y
E
L
L
L
K
E
Y
I
Q
K
L
P
A
Q
Site 34
S282
K
A
L
D
M
I
F
S
A
A
Q
H
S
N
A
Site 35
Y304
L
Q
D
L
W
E
V
Y
Q
R
L
G
L
E
D
Site 36
S330
E
G
P
V
L
K
I
S
F
R
R
N
D
P
M
Site 37
Y340
R
N
D
P
M
E
R
Y
L
F
L
F
N
N
M
Site 38
S386
M
D
A
E
F
P
H
S
F
L
V
S
G
K
Q
Site 39
S390
F
P
H
S
F
L
V
S
G
K
Q
R
T
L
E
Site 40
T395
L
V
S
G
K
Q
R
T
L
E
L
Q
A
R
S
Site 41
S402
T
L
E
L
Q
A
R
S
Q
E
E
M
I
S
W
Site 42
T426
Q
I
E
K
R
N
E
T
F
K
A
A
A
Q
G
Site 43
Y495
V
C
A
R
C
S
D
Y
R
A
E
L
K
Y
D
Site 44
Y501
D
Y
R
A
E
L
K
Y
D
D
N
R
P
N
R
Site 45
S539
G
I
L
E
K
G
S
S
A
T
P
D
Q
S
L
Site 46
T541
L
E
K
G
S
S
A
T
P
D
Q
S
L
M
C
Site 47
S545
S
S
A
T
P
D
Q
S
L
M
C
S
F
L
Q
Site 48
Y578
R
D
D
P
L
V
L
Y
V
Y
A
A
P
Q
D
Site 49
T590
P
Q
D
M
R
A
H
T
S
I
P
L
L
G
Y
Site 50
S591
Q
D
M
R
A
H
T
S
I
P
L
L
G
Y
Q
Site 51
T600
P
L
L
G
Y
Q
V
T
V
G
P
Q
G
D
P
Site 52
Y619
L
Q
Q
S
G
Q
L
Y
T
F
K
A
E
T
E
Site 53
T620
Q
Q
S
G
Q
L
Y
T
F
K
A
E
T
E
E
Site 54
S641
K
A
M
E
R
A
A
S
G
W
S
P
S
W
P
Site 55
S644
E
R
A
A
S
G
W
S
P
S
W
P
N
D
G
Site 56
S646
A
A
S
G
W
S
P
S
W
P
N
D
G
D
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation