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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AIDA-1b
Full Name:
Ankyrin repeat and sterile alpha motif domain-containing protein 1B
Alias:
AIDA-1; Amyloid-beta protein intracellular domain-associated protein 1; ANKS1B; ANKS2; Ankyrin repeat and sterile alpha motif domain containing 1B; Cajalin-2; E2A-PBX1-associated protein; EB-1
Type:
Plasma membrane, Cytoplasm, Nucleus, Postsynaptic membrane, Synapse, Cell projection, Cell junction protein
Mass (Da):
138185
Number AA:
1249
UniProt ID:
Q7Z6G8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015030
GO:0030054
GO:0005737
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T55
R
G
P
N
V
N
C
T
D
S
S
G
Y
T
A
Site 2
S57
P
N
V
N
C
T
D
S
S
G
Y
T
A
L
H
Site 3
Y93
N
V
A
D
N
K
G
Y
F
P
I
H
L
A
A
Site 4
S119
I
H
H
G
P
S
H
S
R
V
N
E
Q
N
N
Site 5
T155
L
E
E
L
T
D
P
T
I
R
N
S
K
L
E
Site 6
S159
T
D
P
T
I
R
N
S
K
L
E
T
P
L
D
Site 7
T163
I
R
N
S
K
L
E
T
P
L
D
L
A
A
L
Site 8
T196
S
C
N
T
R
K
H
T
P
L
H
L
A
A
R
Site 9
S221
L
E
A
G
M
D
V
S
C
Q
T
E
K
G
S
Site 10
S257
I
D
A
N
I
K
D
S
L
G
R
T
V
L
D
Site 11
T261
I
K
D
S
L
G
R
T
V
L
D
I
L
K
E
Site 12
S271
D
I
L
K
E
H
P
S
Q
K
S
L
Q
I
A
Site 13
S274
K
E
H
P
S
Q
K
S
L
Q
I
A
T
L
L
Site 14
T293
E
G
V
G
K
Y
A
T
V
L
E
E
P
V
Q
Site 15
T304
E
P
V
Q
E
D
A
T
Q
E
T
H
I
S
S
Site 16
S310
A
T
Q
E
T
H
I
S
S
P
V
E
S
P
S
Site 17
S311
T
Q
E
T
H
I
S
S
P
V
E
S
P
S
Q
Site 18
S315
H
I
S
S
P
V
E
S
P
S
Q
K
T
K
S
Site 19
S317
S
S
P
V
E
S
P
S
Q
K
T
K
S
E
T
Site 20
S322
S
P
S
Q
K
T
K
S
E
T
V
T
G
E
L
Site 21
T324
S
Q
K
T
K
S
E
T
V
T
G
E
L
S
K
Site 22
T326
K
T
K
S
E
T
V
T
G
E
L
S
K
L
L
Site 23
Y344
K
L
C
Q
E
K
D
Y
S
F
E
D
L
C
H
Site 24
T352
S
F
E
D
L
C
H
T
I
S
D
H
Y
L
D
Site 25
S354
E
D
L
C
H
T
I
S
D
H
Y
L
D
N
L
Site 26
Y357
C
H
T
I
S
D
H
Y
L
D
N
L
S
K
I
Site 27
S362
D
H
Y
L
D
N
L
S
K
I
S
E
E
E
L
Site 28
S365
L
D
N
L
S
K
I
S
E
E
E
L
G
K
N
Site 29
S374
E
E
L
G
K
N
G
S
Q
S
V
R
T
S
S
Site 30
S376
L
G
K
N
G
S
Q
S
V
R
T
S
S
T
I
Site 31
S380
G
S
Q
S
V
R
T
S
S
T
I
N
L
S
P
Site 32
S381
S
Q
S
V
R
T
S
S
T
I
N
L
S
P
G
Site 33
T382
Q
S
V
R
T
S
S
T
I
N
L
S
P
G
E
Site 34
S386
T
S
S
T
I
N
L
S
P
G
E
V
E
E
E
Site 35
T399
E
E
D
D
D
E
N
T
C
G
P
S
G
L
W
Site 36
T410
S
G
L
W
E
A
L
T
P
C
N
G
C
R
N
Site 37
S427
F
P
M
L
A
Q
E
S
Y
P
K
K
R
N
Y
Site 38
Y428
P
M
L
A
Q
E
S
Y
P
K
K
R
N
Y
T
Site 39
Y434
S
Y
P
K
K
R
N
Y
T
M
E
I
V
P
S
Site 40
T435
Y
P
K
K
R
N
Y
T
M
E
I
V
P
S
A
Site 41
S443
M
E
I
V
P
S
A
S
L
D
T
F
P
S
E
Site 42
T446
V
P
S
A
S
L
D
T
F
P
S
E
N
E
N
Site 43
S469
A
V
T
K
K
P
C
S
L
E
I
A
R
A
P
Site 44
S477
L
E
I
A
R
A
P
S
P
R
T
D
N
A
S
Site 45
T480
A
R
A
P
S
P
R
T
D
N
A
S
E
V
A
Site 46
S484
S
P
R
T
D
N
A
S
E
V
A
V
T
T
P
Site 47
T489
N
A
S
E
V
A
V
T
T
P
G
T
S
N
H
Site 48
T490
A
S
E
V
A
V
T
T
P
G
T
S
N
H
R
Site 49
S494
A
V
T
T
P
G
T
S
N
H
R
N
S
S
T
Site 50
S499
G
T
S
N
H
R
N
S
S
T
G
P
T
P
D
Site 51
S500
T
S
N
H
R
N
S
S
T
G
P
T
P
D
C
Site 52
T504
R
N
S
S
T
G
P
T
P
D
C
S
P
P
S
Site 53
S508
T
G
P
T
P
D
C
S
P
P
S
P
D
T
A
Site 54
S511
T
P
D
C
S
P
P
S
P
D
T
A
L
K
N
Site 55
T514
C
S
P
P
S
P
D
T
A
L
K
N
I
V
K
Site 56
T531
R
P
Q
P
K
Q
R
T
S
I
V
S
S
L
D
Site 57
S532
P
Q
P
K
Q
R
T
S
I
V
S
S
L
D
F
Site 58
S535
K
Q
R
T
S
I
V
S
S
L
D
F
H
R
M
Site 59
S536
Q
R
T
S
I
V
S
S
L
D
F
H
R
M
N
Site 60
Y548
R
M
N
H
N
Q
E
Y
F
E
I
N
T
S
T
Site 61
T555
Y
F
E
I
N
T
S
T
G
C
T
S
F
T
A
Site 62
S559
N
T
S
T
G
C
T
S
F
T
A
S
P
P
A
Site 63
T561
S
T
G
C
T
S
F
T
A
S
P
P
A
S
P
Site 64
S563
G
C
T
S
F
T
A
S
P
P
A
S
P
P
T
Site 65
S567
F
T
A
S
P
P
A
S
P
P
T
S
S
V
G
Site 66
T570
S
P
P
A
S
P
P
T
S
S
V
G
T
T
E
Site 67
S571
P
P
A
S
P
P
T
S
S
V
G
T
T
E
V
Site 68
S572
P
A
S
P
P
T
S
S
V
G
T
T
E
V
K
Site 69
T575
P
P
T
S
S
V
G
T
T
E
V
K
N
E
G
Site 70
T576
P
T
S
S
V
G
T
T
E
V
K
N
E
G
T
Site 71
S590
T
N
H
T
D
D
L
S
R
Q
D
D
N
D
P
Site 72
S614
A
G
L
L
H
G
S
S
P
A
C
E
S
P
E
Site 73
S619
G
S
S
P
A
C
E
S
P
E
N
P
F
H
L
Site 74
Y627
P
E
N
P
F
H
L
Y
G
K
R
E
Q
C
E
Site 75
S641
E
K
G
Q
D
E
V
S
L
A
N
S
P
L
P
Site 76
S645
D
E
V
S
L
A
N
S
P
L
P
F
K
Q
S
Site 77
S652
S
P
L
P
F
K
Q
S
P
I
E
N
N
S
E
Site 78
S692
H
T
I
V
G
T
R
S
T
R
S
G
S
R
N
Site 79
T693
T
I
V
G
T
R
S
T
R
S
G
S
R
N
G
Site 80
S695
V
G
T
R
S
T
R
S
G
S
R
N
G
D
Q
Site 81
S697
T
R
S
T
R
S
G
S
R
N
G
D
Q
W
V
Site 82
S733
A
L
I
D
M
H
L
S
K
S
V
S
K
S
D
Site 83
S735
I
D
M
H
L
S
K
S
V
S
K
S
D
S
D
Site 84
S737
M
H
L
S
K
S
V
S
K
S
D
S
D
L
I
Site 85
S739
L
S
K
S
V
S
K
S
D
S
D
L
I
A
Y
Site 86
S741
K
S
V
S
K
S
D
S
D
L
I
A
Y
P
S
Site 87
Y746
S
D
S
D
L
I
A
Y
P
S
N
E
K
T
S
Site 88
S748
S
D
L
I
A
Y
P
S
N
E
K
T
S
R
V
Site 89
T752
A
Y
P
S
N
E
K
T
S
R
V
N
W
S
E
Site 90
S758
K
T
S
R
V
N
W
S
E
S
S
T
A
E
H
Site 91
S760
S
R
V
N
W
S
E
S
S
T
A
E
H
S
S
Site 92
S761
R
V
N
W
S
E
S
S
T
A
E
H
S
S
K
Site 93
T762
V
N
W
S
E
S
S
T
A
E
H
S
S
K
G
Site 94
S767
S
S
T
A
E
H
S
S
K
G
N
S
E
R
T
Site 95
S771
E
H
S
S
K
G
N
S
E
R
T
P
S
F
T
Site 96
T774
S
K
G
N
S
E
R
T
P
S
F
T
S
E
W
Site 97
S776
G
N
S
E
R
T
P
S
F
T
S
E
W
E
E
Site 98
T778
S
E
R
T
P
S
F
T
S
E
W
E
E
I
D
Site 99
S789
E
E
I
D
K
I
M
S
S
I
D
V
G
I
N
Site 100
S790
E
I
D
K
I
M
S
S
I
D
V
G
I
N
N
Site 101
T806
L
K
E
M
N
G
E
T
T
R
P
R
C
P
V
Site 102
T815
R
P
R
C
P
V
Q
T
V
G
Q
W
L
E
S
Site 103
Y828
E
S
I
G
L
P
Q
Y
E
N
H
L
M
A
N
Site 104
S861
L
E
I
G
I
L
N
S
G
H
R
Q
R
I
L
Site 105
Y885
R
P
I
G
H
D
G
Y
H
P
T
S
V
A
E
Site 106
S889
H
D
G
Y
H
P
T
S
V
A
E
W
L
D
S
Site 107
S896
S
V
A
E
W
L
D
S
I
E
L
G
D
Y
T
Site 108
Y902
D
S
I
E
L
G
D
Y
T
K
A
F
L
I
N
Site 109
S943
H
R
K
R
I
L
A
S
L
G
D
R
L
H
D
Site 110
S959
P
P
Q
K
P
P
R
S
I
T
L
R
E
P
S
Site 111
T961
Q
K
P
P
R
S
I
T
L
R
E
P
S
G
N
Site 112
S966
S
I
T
L
R
E
P
S
G
N
H
T
P
P
Q
Site 113
T970
R
E
P
S
G
N
H
T
P
P
Q
L
S
P
S
Site 114
S975
N
H
T
P
P
Q
L
S
P
S
L
S
Q
S
T
Site 115
S977
T
P
P
Q
L
S
P
S
L
S
Q
S
T
Y
T
Site 116
S979
P
Q
L
S
P
S
L
S
Q
S
T
Y
T
T
G
Site 117
S981
L
S
P
S
L
S
Q
S
T
Y
T
T
G
G
S
Site 118
Y983
P
S
L
S
Q
S
T
Y
T
T
G
G
S
L
D
Site 119
T984
S
L
S
Q
S
T
Y
T
T
G
G
S
L
D
V
Site 120
T985
L
S
Q
S
T
Y
T
T
G
G
S
L
D
V
P
Site 121
S988
S
T
Y
T
T
G
G
S
L
D
V
P
H
I
I
Site 122
Y1008
R
R
R
R
N
E
N
Y
F
D
D
I
P
R
S
Site 123
S1015
Y
F
D
D
I
P
R
S
K
L
E
R
Q
M
A
Site 124
T1024
L
E
R
Q
M
A
Q
T
G
D
W
G
E
P
S
Site 125
S1031
T
G
D
W
G
E
P
S
I
T
L
R
P
P
N
Site 126
T1033
D
W
G
E
P
S
I
T
L
R
P
P
N
E
A
Site 127
S1043
P
P
N
E
A
T
A
S
T
P
V
Q
Y
W
Q
Site 128
T1044
P
N
E
A
T
A
S
T
P
V
Q
Y
W
Q
H
Site 129
Y1048
T
A
S
T
P
V
Q
Y
W
Q
H
H
P
E
K
Site 130
T1079
L
I
K
E
L
R
G
T
E
S
T
Q
D
A
C
Site 131
S1081
K
E
L
R
G
T
E
S
T
Q
D
A
C
A
K
Site 132
T1082
E
L
R
G
T
E
S
T
Q
D
A
C
A
K
M
Site 133
S1135
E
H
E
I
R
N
I
S
C
A
A
Q
D
P
E
Site 134
S1145
A
Q
D
P
E
D
L
S
T
F
A
Y
I
T
K
Site 135
T1146
Q
D
P
E
D
L
S
T
F
A
Y
I
T
K
D
Site 136
Y1149
E
D
L
S
T
F
A
Y
I
T
K
D
L
K
S
Site 137
Y1160
D
L
K
S
N
H
H
Y
C
H
V
F
T
A
F
Site 138
S1199
Q
A
R
K
G
G
H
S
S
T
L
P
E
S
F
Site 139
S1200
A
R
K
G
G
H
S
S
T
L
P
E
S
F
E
Site 140
T1201
R
K
G
G
H
S
S
T
L
P
E
S
F
E
N
Site 141
S1205
H
S
S
T
L
P
E
S
F
E
N
K
P
S
K
Site 142
S1211
E
S
F
E
N
K
P
S
K
P
I
P
K
P
R
Site 143
S1220
P
I
P
K
P
R
V
S
I
R
K
S
V
D
L
Site 144
S1224
P
R
V
S
I
R
K
S
V
D
L
L
H
A
S
Site 145
S1231
S
V
D
L
L
H
A
S
H
T
G
Q
E
P
S
Site 146
S1238
S
H
T
G
Q
E
P
S
E
R
H
T
E
E
A
Site 147
T1242
Q
E
P
S
E
R
H
T
E
E
A
L
R
K
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation