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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RbBP6
Full Name:
E3 ubiquitin-protein ligase RBBP6
Alias:
My038; P2PR; P53-associated cellular protein of testis; PACT; RBQ1
Type:
Transcription factor, cell cycle protein
Mass (Da):
201564
Number AA:
1792
UniProt ID:
Q7Z6E9
International Prot ID:
IPI00021363
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0000151
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0005515
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0016567
GO:0006366
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
K
F
S
S
K
L
N
Y
D
T
V
T
F
D
G
Site 2
T16
S
S
K
L
N
Y
D
T
V
T
F
D
G
L
H
Site 3
T18
K
L
N
Y
D
T
V
T
F
D
G
L
H
I
S
Site 4
S25
T
F
D
G
L
H
I
S
L
C
D
L
K
K
Q
Site 5
T53
L
Q
I
T
N
A
Q
T
K
E
E
Y
T
D
D
Site 6
T86
G
V
K
S
T
S
K
T
Y
V
I
S
R
T
E
Site 7
Y87
V
K
S
T
S
K
T
Y
V
I
S
R
T
E
P
Site 8
S105
T
T
K
A
I
D
D
S
S
A
S
I
S
L
A
Site 9
S106
T
K
A
I
D
D
S
S
A
S
I
S
L
A
Q
Site 10
S110
D
D
S
S
A
S
I
S
L
A
Q
L
T
K
T
Site 11
S126
N
L
A
E
A
N
A
S
E
E
D
K
I
K
A
Site 12
S136
D
K
I
K
A
M
M
S
Q
S
G
H
E
Y
D
Site 13
S138
I
K
A
M
M
S
Q
S
G
H
E
Y
D
P
I
Site 14
Y142
M
S
Q
S
G
H
E
Y
D
P
I
N
Y
M
K
Site 15
S158
P
L
G
P
P
P
P
S
Y
T
C
F
R
C
G
Site 16
Y159
L
G
P
P
P
P
S
Y
T
C
F
R
C
G
K
Site 17
T160
G
P
P
P
P
S
Y
T
C
F
R
C
G
K
P
Site 18
Y170
R
C
G
K
P
G
H
Y
I
K
N
C
P
T
N
Site 19
S184
N
G
D
K
N
F
E
S
G
P
R
I
K
K
S
Site 20
S191
S
G
P
R
I
K
K
S
T
G
I
P
R
S
F
Site 21
T192
G
P
R
I
K
K
S
T
G
I
P
R
S
F
M
Site 22
S197
K
S
T
G
I
P
R
S
F
M
M
E
V
K
D
Site 23
T213
N
M
K
G
A
M
L
T
N
T
G
K
Y
A
I
Site 24
T215
K
G
A
M
L
T
N
T
G
K
Y
A
I
P
T
Site 25
Y218
M
L
T
N
T
G
K
Y
A
I
P
T
I
D
A
Site 26
T222
T
G
K
Y
A
I
P
T
I
D
A
E
A
Y
A
Site 27
Y228
P
T
I
D
A
E
A
Y
A
I
G
K
K
E
K
Site 28
S244
P
F
L
P
E
E
P
S
S
S
S
E
E
D
D
Site 29
S245
F
L
P
E
E
P
S
S
S
S
E
E
D
D
P
Site 30
S246
L
P
E
E
P
S
S
S
S
E
E
D
D
P
I
Site 31
S247
P
E
E
P
S
S
S
S
E
E
D
D
P
I
P
Site 32
T286
Y
C
D
E
C
I
R
T
A
L
L
E
S
D
E
Site 33
T295
L
L
E
S
D
E
H
T
C
P
T
C
H
Q
N
Site 34
S305
T
C
H
Q
N
D
V
S
P
D
A
L
I
A
N
Site 35
T329
F
K
N
E
T
G
Y
T
K
R
L
R
K
Q
L
Site 36
S360
N
L
Q
P
L
M
R
S
P
I
S
R
Q
Q
D
Site 37
S363
P
L
M
R
S
P
I
S
R
Q
Q
D
P
L
M
Site 38
T374
D
P
L
M
I
P
V
T
S
S
S
T
H
P
A
Site 39
S375
P
L
M
I
P
V
T
S
S
S
T
H
P
A
P
Site 40
S383
S
S
T
H
P
A
P
S
I
S
S
L
T
S
N
Site 41
S385
T
H
P
A
P
S
I
S
S
L
T
S
N
Q
S
Site 42
S386
H
P
A
P
S
I
S
S
L
T
S
N
Q
S
S
Site 43
T388
A
P
S
I
S
S
L
T
S
N
Q
S
S
L
A
Site 44
S389
P
S
I
S
S
L
T
S
N
Q
S
S
L
A
P
Site 45
S392
S
S
L
T
S
N
Q
S
S
L
A
P
P
V
S
Site 46
S393
S
L
T
S
N
Q
S
S
L
A
P
P
V
S
G
Site 47
S399
S
S
L
A
P
P
V
S
G
N
P
S
S
A
P
Site 48
S403
P
P
V
S
G
N
P
S
S
A
P
A
P
V
P
Site 49
S404
P
V
S
G
N
P
S
S
A
P
A
P
V
P
D
Site 50
S417
P
D
I
T
A
T
V
S
I
S
V
H
S
E
K
Site 51
S419
I
T
A
T
V
S
I
S
V
H
S
E
K
S
D
Site 52
S425
I
S
V
H
S
E
K
S
D
G
P
F
R
D
S
Site 53
S432
S
D
G
P
F
R
D
S
D
N
K
I
L
P
A
Site 54
S444
L
P
A
A
A
L
A
S
E
H
S
K
G
T
S
Site 55
S447
A
A
L
A
S
E
H
S
K
G
T
S
S
I
A
Site 56
S451
S
E
H
S
K
G
T
S
S
I
A
I
T
A
L
Site 57
T488
H
G
Q
L
I
P
T
T
G
P
V
R
I
N
T
Site 58
T495
T
G
P
V
R
I
N
T
A
R
P
G
G
G
R
Site 59
S508
G
R
P
G
W
E
H
S
N
K
L
G
Y
L
V
Site 60
Y513
E
H
S
N
K
L
G
Y
L
V
S
P
P
Q
Q
Site 61
S516
N
K
L
G
Y
L
V
S
P
P
Q
Q
I
R
R
Site 62
S527
Q
I
R
R
G
E
R
S
C
Y
R
S
I
N
R
Site 63
Y529
R
R
G
E
R
S
C
Y
R
S
I
N
R
G
R
Site 64
S531
G
E
R
S
C
Y
R
S
I
N
R
G
R
H
H
Site 65
S539
I
N
R
G
R
H
H
S
E
R
S
Q
R
T
Q
Site 66
S542
G
R
H
H
S
E
R
S
Q
R
T
Q
G
P
S
Site 67
T545
H
S
E
R
S
Q
R
T
Q
G
P
S
L
P
A
Site 68
S549
S
Q
R
T
Q
G
P
S
L
P
A
T
P
V
F
Site 69
Y565
P
V
P
P
P
P
L
Y
P
P
P
P
H
T
L
Site 70
T571
L
Y
P
P
P
P
H
T
L
P
L
P
P
G
V
Site 71
S584
G
V
P
P
P
Q
F
S
P
Q
F
P
P
G
Q
Site 72
Y597
G
Q
P
P
P
A
G
Y
S
V
P
P
P
G
F
Site 73
S598
Q
P
P
P
A
G
Y
S
V
P
P
P
G
F
P
Site 74
S612
P
P
A
P
A
N
L
S
T
P
W
V
S
S
G
Site 75
S618
L
S
T
P
W
V
S
S
G
V
Q
T
A
H
S
Site 76
T622
W
V
S
S
G
V
Q
T
A
H
S
N
T
I
P
Site 77
T631
H
S
N
T
I
P
T
T
Q
A
P
P
L
S
R
Site 78
S637
T
T
Q
A
P
P
L
S
R
E
E
F
Y
R
E
Site 79
S656
K
E
E
E
K
K
K
S
K
L
D
E
F
T
N
Site 80
Y672
F
A
K
E
L
M
E
Y
K
K
I
Q
K
E
R
Site 81
S682
I
Q
K
E
R
R
R
S
F
S
R
S
K
S
P
Site 82
S684
K
E
R
R
R
S
F
S
R
S
K
S
P
Y
S
Site 83
S686
R
R
R
S
F
S
R
S
K
S
P
Y
S
G
S
Site 84
S688
R
S
F
S
R
S
K
S
P
Y
S
G
S
S
Y
Site 85
Y690
F
S
R
S
K
S
P
Y
S
G
S
S
Y
S
R
Site 86
S691
S
R
S
K
S
P
Y
S
G
S
S
Y
S
R
S
Site 87
S693
S
K
S
P
Y
S
G
S
S
Y
S
R
S
S
Y
Site 88
S694
K
S
P
Y
S
G
S
S
Y
S
R
S
S
Y
T
Site 89
Y695
S
P
Y
S
G
S
S
Y
S
R
S
S
Y
T
Y
Site 90
S696
P
Y
S
G
S
S
Y
S
R
S
S
Y
T
Y
S
Site 91
S698
S
G
S
S
Y
S
R
S
S
Y
T
Y
S
K
S
Site 92
S699
G
S
S
Y
S
R
S
S
Y
T
Y
S
K
S
R
Site 93
Y700
S
S
Y
S
R
S
S
Y
T
Y
S
K
S
R
S
Site 94
T701
S
Y
S
R
S
S
Y
T
Y
S
K
S
R
S
G
Site 95
Y702
Y
S
R
S
S
Y
T
Y
S
K
S
R
S
G
S
Site 96
S703
S
R
S
S
Y
T
Y
S
K
S
R
S
G
S
T
Site 97
S705
S
S
Y
T
Y
S
K
S
R
S
G
S
T
R
S
Site 98
S707
Y
T
Y
S
K
S
R
S
G
S
T
R
S
R
S
Site 99
S709
Y
S
K
S
R
S
G
S
T
R
S
R
S
Y
S
Site 100
T710
S
K
S
R
S
G
S
T
R
S
R
S
Y
S
R
Site 101
S712
S
R
S
G
S
T
R
S
R
S
Y
S
R
S
F
Site 102
S714
S
G
S
T
R
S
R
S
Y
S
R
S
F
S
R
Site 103
Y715
G
S
T
R
S
R
S
Y
S
R
S
F
S
R
S
Site 104
S716
S
T
R
S
R
S
Y
S
R
S
F
S
R
S
H
Site 105
S718
R
S
R
S
Y
S
R
S
F
S
R
S
H
S
R
Site 106
S720
R
S
Y
S
R
S
F
S
R
S
H
S
R
S
Y
Site 107
S722
Y
S
R
S
F
S
R
S
H
S
R
S
Y
S
R
Site 108
S724
R
S
F
S
R
S
H
S
R
S
Y
S
R
S
P
Site 109
S726
F
S
R
S
H
S
R
S
Y
S
R
S
P
P
Y
Site 110
Y727
S
R
S
H
S
R
S
Y
S
R
S
P
P
Y
P
Site 111
S728
R
S
H
S
R
S
Y
S
R
S
P
P
Y
P
R
Site 112
S730
H
S
R
S
Y
S
R
S
P
P
Y
P
R
R
G
Site 113
Y733
S
Y
S
R
S
P
P
Y
P
R
R
G
R
G
K
Site 114
S741
P
R
R
G
R
G
K
S
R
N
Y
R
S
R
S
Site 115
Y744
G
R
G
K
S
R
N
Y
R
S
R
S
R
S
H
Site 116
S746
G
K
S
R
N
Y
R
S
R
S
R
S
H
G
Y
Site 117
S748
S
R
N
Y
R
S
R
S
R
S
H
G
Y
H
R
Site 118
S750
N
Y
R
S
R
S
R
S
H
G
Y
H
R
S
R
Site 119
Y753
S
R
S
R
S
H
G
Y
H
R
S
R
S
R
S
Site 120
S756
R
S
H
G
Y
H
R
S
R
S
R
S
P
P
Y
Site 121
S758
H
G
Y
H
R
S
R
S
R
S
P
P
Y
R
R
Site 122
S760
Y
H
R
S
R
S
R
S
P
P
Y
R
R
Y
H
Site 123
Y763
S
R
S
R
S
P
P
Y
R
R
Y
H
S
R
S
Site 124
Y766
R
S
P
P
Y
R
R
Y
H
S
R
S
R
S
P
Site 125
S768
P
P
Y
R
R
Y
H
S
R
S
R
S
P
Q
A
Site 126
S770
Y
R
R
Y
H
S
R
S
R
S
P
Q
A
F
R
Site 127
S772
R
Y
H
S
R
S
R
S
P
Q
A
F
R
G
Q
Site 128
S780
P
Q
A
F
R
G
Q
S
P
N
K
R
N
V
P
Site 129
Y795
Q
G
E
T
E
R
E
Y
F
N
R
Y
R
E
V
Site 130
Y799
E
R
E
Y
F
N
R
Y
R
E
V
P
P
P
Y
Site 131
Y806
Y
R
E
V
P
P
P
Y
D
M
K
A
Y
Y
G
Site 132
Y811
P
P
Y
D
M
K
A
Y
Y
G
R
S
V
D
F
Site 133
Y812
P
Y
D
M
K
A
Y
Y
G
R
S
V
D
F
R
Site 134
S815
M
K
A
Y
Y
G
R
S
V
D
F
R
D
P
F
Site 135
Y827
D
P
F
E
K
E
R
Y
R
E
W
E
R
K
Y
Site 136
Y834
Y
R
E
W
E
R
K
Y
R
E
W
Y
E
K
Y
Site 137
Y838
E
R
K
Y
R
E
W
Y
E
K
Y
Y
K
G
Y
Site 138
Y841
Y
R
E
W
Y
E
K
Y
Y
K
G
Y
A
A
G
Site 139
Y845
Y
E
K
Y
Y
K
G
Y
A
A
G
A
Q
P
R
Site 140
S854
A
G
A
Q
P
R
P
S
A
N
R
E
N
F
S
Site 141
S861
S
A
N
R
E
N
F
S
P
E
R
F
L
P
L
Site 142
S873
L
P
L
N
I
R
N
S
P
F
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P
S
R
S
H
S
P
S
G
S
Q
Site 295
S1705
V
S
P
S
R
S
H
S
P
S
G
S
Q
T
R
Site 296
S1707
P
S
R
S
H
S
P
S
G
S
Q
T
R
S
H
Site 297
S1709
R
S
H
S
P
S
G
S
Q
T
R
S
H
S
S
Site 298
T1711
H
S
P
S
G
S
Q
T
R
S
H
S
S
S
A
Site 299
S1713
P
S
G
S
Q
T
R
S
H
S
S
S
A
S
S
Site 300
S1715
G
S
Q
T
R
S
H
S
S
S
A
S
S
A
E
Site 301
S1716
S
Q
T
R
S
H
S
S
S
A
S
S
A
E
S
Site 302
S1717
Q
T
R
S
H
S
S
S
A
S
S
A
E
S
Q
Site 303
S1719
R
S
H
S
S
S
A
S
S
A
E
S
Q
D
S
Site 304
S1720
S
H
S
S
S
A
S
S
A
E
S
Q
D
S
K
Site 305
S1723
S
S
A
S
S
A
E
S
Q
D
S
K
K
K
K
Site 306
S1726
S
S
A
E
S
Q
D
S
K
K
K
K
K
K
K
Site 307
S1760
T
E
V
E
L
E
K
S
Q
K
H
K
H
K
K
Site 308
S1770
H
K
H
K
K
K
K
S
K
K
N
K
D
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation