PhosphoNET

           
Protein Info 
   
Short Name:  SPRED2
Full Name:  Sprouty-related, EVH1 domain-containing protein 2
Alias:  FLJ21897; FLJ31917; SPRE2; spred-2; sprouty protein with EVH-1 domain 2, related sequence; sprouty-related protein with EVH-1 domain 2; sprouty-related, EVH1 domain containing 2; sprouty-related, EVH1 domain containing protein 2
Type:  Vesicle protein
Mass (Da):  47558
Number AA:  418
UniProt ID:  Q7Z698
International Prot ID:  IPI00375554
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0031410  GO:0016020   Uniprot OncoNet
Molecular Function:  GO:0005173     PhosphoSite+ KinaseNET
Biological Process:  GO:0000188  GO:0007275   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S11ETHPDDDSYIVRVKA
Site 2Y12THPDDDSYIVRVKAV
Site 3T22RVKAVVMTRDDSSGG
Site 4S26VVMTRDDSSGGWFPQ
Site 5S27VMTRDDSSGGWFPQE
Site 6S39PQEGGGISRVGVCKV
Site 7Y81YVRKDLVYTKANPTF
Site 8T101DNRKFGLTFQSPADA
Site 9S104KFGLTFQSPADARAF
Site 10S126IEDLIEGSTTSSSTI
Site 11T127EDLIEGSTTSSSTIH
Site 12T128DLIEGSTTSSSTIHN
Site 13S130IEGSTTSSSTIHNEA
Site 14S131EGSTTSSSTIHNEAE
Site 15T146LGDDDVFTTATDSSS
Site 16T147GDDDVFTTATDSSSN
Site 17T149DDVFTTATDSSSNSS
Site 18S151VFTTATDSSSNSSQK
Site 19S152FTTATDSSSNSSQKR
Site 20S153TTATDSSSNSSQKRE
Site 21S155ATDSSSNSSQKREQP
Site 22S156TDSSSNSSQKREQPT
Site 23T163SQKREQPTRTISSPT
Site 24T165KREQPTRTISSPTSC
Site 25S167EQPTRTISSPTSCEH
Site 26S168QPTRTISSPTSCEHR
Site 27S171RTISSPTSCEHRRIY
Site 28Y178SCEHRRIYTLGHLHD
Site 29T179CEHRRIYTLGHLHDS
Site 30Y187LGHLHDSYPTDHYHL
Site 31Y192DSYPTDHYHLDQPMP
Site 32Y202DQPMPRPYRQVSFPD
Site 33S206PRPYRQVSFPDDDEE
Site 34Y228 EKIWMTGYEDYRHAP
Site 35Y231WMTGYEDYRHAPVRG
Site 36Y240HAPVRGKYPDPSEDA
Site 37S244RGKYPDPSEDADSSY
Site 38S249DPSEDADSSYVRFAK
Site 39S250PSEDADSSYVRFAKG
Site 40Y251SEDADSSYVRFAKGE
Site 41Y264GEVPKHDYNYPYVDS
Site 42Y266VPKHDYNYPYVDSSD
Site 43Y268KHDYNYPYVDSSDFG
Site 44S271YNYPYVDSSDFGLGE
Site 45S272NYPYVDSSDFGLGED
Site 46S286DPKGRGGSVIKTQPS
Site 47T290RGGSVIKTQPSRGKS
Site 48S293SVIKTQPSRGKSRRR
Site 49S297TQPSRGKSRRRKEDG
Site 50Y361MSDPEGDYTDPCSCD
Site 51T362SDPEGDYTDPCSCDT
Site 52S366GDYTDPCSCDTSDEK
Site 53S370DPCSCDTSDEKFCLR
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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