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Updated November 2019
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Protein Info
Short Name:
SDK1
Full Name:
Protein sidekick-1
Alias:
FLJ31425; Sidekick 1, cell adhesion molecule; Sidekick-1
Type:
Membrane, Integral membrane protein
Mass (Da):
242076
Number AA:
2213
UniProt ID:
Q7Z5N4
International Prot ID:
IPI00784490
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
R
G
A
R
P
S
A
A
G
G
G
G
G
Site 2
S31
G
P
G
R
P
R
G
S
P
P
G
R
A
R
P
Site 3
S39
P
P
G
R
A
R
P
S
L
A
P
R
P
G
P
Site 4
S49
P
R
P
G
P
E
P
S
R
P
R
A
A
P
E
Site 5
T57
R
P
R
A
A
P
E
T
P
G
G
D
T
A
G
Site 6
Y105
A
Q
D
D
V
A
P
Y
F
K
T
E
P
G
L
Site 7
T108
D
V
A
P
Y
F
K
T
E
P
G
L
P
Q
I
Site 8
S143
F
K
W
M
R
D
D
S
E
L
T
T
Y
S
S
Site 9
T146
M
R
D
D
S
E
L
T
T
Y
S
S
E
Y
K
Site 10
T147
R
D
D
S
E
L
T
T
Y
S
S
E
Y
K
Y
Site 11
Y148
D
D
S
E
L
T
T
Y
S
S
E
Y
K
Y
I
Site 12
Y154
T
Y
S
S
E
Y
K
Y
I
I
P
S
L
Q
K
Site 13
S158
E
Y
K
Y
I
I
P
S
L
Q
K
L
D
A
G
Site 14
Y167
Q
K
L
D
A
G
F
Y
R
C
V
V
R
N
R
Site 15
S183
G
A
L
L
Q
R
K
S
E
V
Q
V
A
Y
M
Site 16
Y189
K
S
E
V
Q
V
A
Y
M
G
S
F
M
D
T
Site 17
T196
Y
M
G
S
F
M
D
T
D
Q
R
K
T
V
S
Site 18
T201
M
D
T
D
Q
R
K
T
V
S
Q
G
R
A
A
Site 19
S203
T
D
Q
R
K
T
V
S
Q
G
R
A
A
I
L
Site 20
S217
L
N
L
L
P
I
T
S
Y
P
R
P
Q
V
T
Site 21
Y218
N
L
L
P
I
T
S
Y
P
R
P
Q
V
T
W
Site 22
T224
S
Y
P
R
P
Q
V
T
W
F
R
E
G
H
K
Site 23
Y260
T
S
D
A
G
A
Y
Y
V
Q
A
V
N
E
K
Site 24
S274
K
N
G
E
N
K
T
S
P
F
I
H
L
S
I
Site 25
T287
S
I
A
R
D
V
G
T
P
E
T
M
A
P
T
Site 26
S303
V
V
P
P
G
N
R
S
V
V
A
G
S
S
E
Site 27
S326
A
R
P
V
E
D
L
S
V
T
W
K
R
N
G
Site 28
T337
K
R
N
G
V
R
I
T
S
G
L
H
S
F
G
Site 29
S338
R
N
G
V
R
I
T
S
G
L
H
S
F
G
R
Site 30
S342
R
I
T
S
G
L
H
S
F
G
R
H
L
T
I
Site 31
T348
H
S
F
G
R
H
L
T
I
S
N
P
T
S
A
Site 32
S350
F
G
R
H
L
T
I
S
N
P
T
S
A
D
T
Site 33
S354
L
T
I
S
N
P
T
S
A
D
T
G
P
Y
V
Site 34
S397
A
E
P
E
S
R
I
S
A
E
V
E
E
T
V
Site 35
Y421
P
L
P
T
L
Q
W
Y
K
D
A
I
S
I
S
Site 36
S426
Q
W
Y
K
D
A
I
S
I
S
R
L
Q
N
P
Site 37
S428
Y
K
D
A
I
S
I
S
R
L
Q
N
P
R
Y
Site 38
Y435
S
R
L
Q
N
P
R
Y
K
V
L
A
S
G
G
Site 39
S453
Q
K
L
R
P
E
D
S
G
I
F
Q
C
F
A
Site 40
Y472
G
E
I
Q
T
H
T
Y
L
D
V
T
N
I
A
Site 41
T483
T
N
I
A
P
V
F
T
Q
R
P
V
D
T
T
Site 42
T490
T
Q
R
P
V
D
T
T
V
T
D
G
M
T
A
Site 43
T512
G
A
P
K
P
A
I
T
W
K
R
E
N
H
I
Site 44
Y554
D
A
G
N
Y
T
C
Y
A
A
N
T
E
G
S
Site 45
S561
Y
A
A
N
T
E
G
S
L
N
A
S
A
T
L
Site 46
S565
T
E
G
S
L
N
A
S
A
T
L
T
V
W
N
Site 47
T567
G
S
L
N
A
S
A
T
L
T
V
W
N
R
T
Site 48
S575
L
T
V
W
N
R
T
S
I
V
H
P
P
E
D
Site 49
S604
A
T
H
D
P
R
V
S
L
R
Y
V
W
K
K
Site 50
Y607
D
P
R
V
S
L
R
Y
V
W
K
K
D
N
V
Site 51
T617
K
K
D
N
V
A
L
T
P
S
S
T
S
R
I
Site 52
S635
K
D
G
S
L
L
I
S
Q
T
W
S
G
D
I
Site 53
T637
G
S
L
L
I
S
Q
T
W
S
G
D
I
G
D
Site 54
S639
L
L
I
S
Q
T
W
S
G
D
I
G
D
Y
S
Site 55
Y645
W
S
G
D
I
G
D
Y
S
C
E
I
V
S
E
Site 56
S646
S
G
D
I
G
D
Y
S
C
E
I
V
S
E
G
Site 57
S657
V
S
E
G
G
N
D
S
R
M
A
R
L
E
V
Site 58
S677
S
P
Q
N
L
L
V
S
P
N
S
S
H
S
H
Site 59
S683
V
S
P
N
S
S
H
S
H
A
V
V
L
S
W
Site 60
S689
H
S
H
A
V
V
L
S
W
V
R
P
F
D
G
Site 61
Y702
D
G
N
S
P
I
L
Y
Y
I
V
E
L
S
E
Site 62
Y703
G
N
S
P
I
L
Y
Y
I
V
E
L
S
E
N
Site 63
S708
L
Y
Y
I
V
E
L
S
E
N
S
S
P
W
K
Site 64
S712
V
E
L
S
E
N
S
S
P
W
K
V
H
L
S
Site 65
S719
S
P
W
K
V
H
L
S
N
V
G
P
E
M
T
Site 66
T738
S
G
L
T
P
A
R
T
Y
Q
F
R
V
C
A
Site 67
Y754
N
E
V
G
R
G
Q
Y
S
A
E
T
S
R
L
Site 68
S755
E
V
G
R
G
Q
Y
S
A
E
T
S
R
L
M
Site 69
S759
G
Q
Y
S
A
E
T
S
R
L
M
L
P
E
E
Site 70
S769
M
L
P
E
E
P
P
S
A
P
P
K
N
I
V
Site 71
S778
P
P
K
N
I
V
A
S
G
R
T
N
Q
S
I
Site 72
Y804
H
N
G
V
L
R
G
Y
I
L
R
Y
R
L
A
Site 73
T823
E
Y
Q
Q
R
N
I
T
S
P
E
V
N
Y
C
Site 74
Y863
F
S
R
A
V
T
E
Y
T
L
Q
G
V
P
T
Site 75
T864
S
R
A
V
T
E
Y
T
L
Q
G
V
P
T
A
Site 76
T870
Y
T
L
Q
G
V
P
T
A
P
P
Q
N
V
Q
Site 77
T953
T
S
V
L
C
F
T
T
P
G
D
G
P
P
S
Site 78
S960
T
P
G
D
G
P
P
S
T
P
Q
L
V
W
T
Site 79
T961
P
G
D
G
P
P
S
T
P
Q
L
V
W
T
Q
Site 80
T967
S
T
P
Q
L
V
W
T
Q
E
D
K
P
G
A
Site 81
T986
S
F
T
E
I
L
D
T
S
L
K
V
S
W
Q
Site 82
S987
F
T
E
I
L
D
T
S
L
K
V
S
W
Q
E
Site 83
S991
L
D
T
S
L
K
V
S
W
Q
E
P
L
E
K
Site 84
Y1005
K
N
G
I
I
T
G
Y
Q
I
S
W
E
V
Y
Site 85
Y1012
Y
Q
I
S
W
E
V
Y
G
R
N
D
S
R
L
Site 86
S1017
E
V
Y
G
R
N
D
S
R
L
T
H
T
L
N
Site 87
T1020
G
R
N
D
S
R
L
T
H
T
L
N
S
T
T
Site 88
T1022
N
D
S
R
L
T
H
T
L
N
S
T
T
H
E
Site 89
Y1030
L
N
S
T
T
H
E
Y
K
I
Q
G
L
S
S
Site 90
S1037
Y
K
I
Q
G
L
S
S
L
T
T
Y
T
I
D
Site 91
S1063
V
T
S
S
T
I
S
S
G
V
P
P
D
L
P
Site 92
S1079
A
P
S
N
L
V
I
S
N
I
S
P
R
S
A
Site 93
S1082
N
L
V
I
S
N
I
S
P
R
S
A
T
L
Q
Site 94
S1085
I
S
N
I
S
P
R
S
A
T
L
Q
F
R
P
Site 95
T1087
N
I
S
P
R
S
A
T
L
Q
F
R
P
G
Y
Site 96
Y1094
T
L
Q
F
R
P
G
Y
D
G
K
T
S
I
S
Site 97
T1098
R
P
G
Y
D
G
K
T
S
I
S
R
W
I
V
Site 98
S1099
P
G
Y
D
G
K
T
S
I
S
R
W
I
V
E
Site 99
T1120
G
D
E
E
E
W
V
T
L
Y
E
E
E
N
E
Site 100
Y1122
E
E
E
W
V
T
L
Y
E
E
E
N
E
P
D
Site 101
T1139
M
L
E
I
P
N
L
T
P
Y
T
H
Y
R
F
Site 102
Y1141
E
I
P
N
L
T
P
Y
T
H
Y
R
F
R
M
Site 103
S1157
Q
V
N
I
V
G
P
S
P
Y
S
P
S
S
R
Site 104
S1160
I
V
G
P
S
P
Y
S
P
S
S
R
V
I
Q
Site 105
S1162
G
P
S
P
Y
S
P
S
S
R
V
I
Q
T
L
Site 106
S1163
P
S
P
Y
S
P
S
S
R
V
I
Q
T
L
Q
Site 107
S1179
P
P
D
V
A
P
T
S
V
T
V
R
T
A
S
Site 108
T1181
D
V
A
P
T
S
V
T
V
R
T
A
S
E
T
Site 109
S1186
S
V
T
V
R
T
A
S
E
T
S
L
R
L
R
Site 110
T1188
T
V
R
T
A
S
E
T
S
L
R
L
R
W
V
Site 111
S1189
V
R
T
A
S
E
T
S
L
R
L
R
W
V
P
Site 112
S1200
R
W
V
P
L
P
D
S
Q
Y
N
G
N
P
E
Site 113
Y1202
V
P
L
P
D
S
Q
Y
N
G
N
P
E
S
V
Site 114
Y1211
G
N
P
E
S
V
G
Y
R
I
K
Y
W
R
S
Site 115
Y1215
S
V
G
Y
R
I
K
Y
W
R
S
D
L
Q
S
Site 116
S1218
Y
R
I
K
Y
W
R
S
D
L
Q
S
S
A
V
Site 117
S1222
Y
W
R
S
D
L
Q
S
S
A
V
A
Q
V
V
Site 118
S1230
S
A
V
A
Q
V
V
S
D
R
L
E
R
E
F
Site 119
T1238
D
R
L
E
R
E
F
T
I
E
E
L
E
E
W
Site 120
Y1248
E
L
E
E
W
M
E
Y
E
L
Q
M
Q
A
F
Site 121
S1264
A
V
G
A
G
P
W
S
E
V
V
R
G
R
T
Site 122
T1271
S
E
V
V
R
G
R
T
R
E
S
V
P
S
A
Site 123
S1274
V
R
G
R
T
R
E
S
V
P
S
A
A
P
E
Site 124
S1277
R
T
R
E
S
V
P
S
A
A
P
E
N
V
S
Site 125
T1296
S
S
T
Q
I
L
L
T
W
T
S
V
P
E
Q
Site 126
S1299
Q
I
L
L
T
W
T
S
V
P
E
Q
D
Q
N
Site 127
Y1312
Q
N
G
L
I
L
G
Y
K
I
L
F
R
A
K
Site 128
S1327
D
L
D
P
E
P
R
S
H
I
V
R
G
N
H
Site 129
S1365
R
I
G
N
G
V
P
S
T
P
L
I
L
E
R
Site 130
S1419
Q
I
A
Y
R
L
A
S
S
S
P
H
T
F
T
Site 131
S1421
A
Y
R
L
A
S
S
S
P
H
T
F
T
T
V
Site 132
T1438
G
A
T
V
R
Q
F
T
A
T
D
L
A
P
E
Site 133
T1440
T
V
R
Q
F
T
A
T
D
L
A
P
E
S
A
Site 134
Y1448
D
L
A
P
E
S
A
Y
I
F
R
L
S
A
K
Site 135
S1453
S
A
Y
I
F
R
L
S
A
K
T
R
Q
G
W
Site 136
T1456
I
F
R
L
S
A
K
T
R
Q
G
W
G
E
P
Site 137
T1467
W
G
E
P
L
E
A
T
V
I
T
T
E
K
R
Site 138
S1494
Q
A
E
V
T
A
R
S
L
R
L
Q
W
V
P
Site 139
S1503
R
L
Q
W
V
P
G
S
D
G
A
S
P
I
R
Site 140
S1507
V
P
G
S
D
G
A
S
P
I
R
Y
F
T
M
Site 141
Y1511
D
G
A
S
P
I
R
Y
F
T
M
Q
V
R
E
Site 142
T1513
A
S
P
I
R
Y
F
T
M
Q
V
R
E
L
P
Site 143
T1526
L
P
R
G
E
W
Q
T
Y
S
S
S
I
S
H
Site 144
Y1527
P
R
G
E
W
Q
T
Y
S
S
S
I
S
H
E
Site 145
S1528
R
G
E
W
Q
T
Y
S
S
S
I
S
H
E
A
Site 146
S1530
E
W
Q
T
Y
S
S
S
I
S
H
E
A
T
A
Site 147
S1532
Q
T
Y
S
S
S
I
S
H
E
A
T
A
C
V
Site 148
T1547
V
D
R
L
R
P
F
T
S
Y
K
L
R
L
K
Site 149
S1548
D
R
L
R
P
F
T
S
Y
K
L
R
L
K
A
Site 150
Y1549
R
L
R
P
F
T
S
Y
K
L
R
L
K
A
T
Site 151
S1562
A
T
N
D
I
G
D
S
D
F
S
S
E
T
E
Site 152
S1566
I
G
D
S
D
F
S
S
E
T
E
A
V
T
T
Site 153
T1573
S
E
T
E
A
V
T
T
L
Q
D
V
P
G
E
Site 154
S1584
V
P
G
E
P
P
G
S
V
S
A
T
P
H
T
Site 155
S1586
G
E
P
P
G
S
V
S
A
T
P
H
T
T
S
Site 156
T1588
P
P
G
S
V
S
A
T
P
H
T
T
S
S
V
Site 157
S1606
W
Q
P
P
R
D
E
S
L
N
G
L
L
Q
G
Site 158
Y1617
L
L
Q
G
Y
R
I
Y
Y
R
E
L
E
Y
E
Site 159
Y1618
L
Q
G
Y
R
I
Y
Y
R
E
L
E
Y
E
A
Site 160
Y1623
I
Y
Y
R
E
L
E
Y
E
A
G
S
G
T
E
Site 161
T1633
G
S
G
T
E
A
K
T
L
K
N
P
I
A
L
Site 162
Y1670
E
L
T
H
L
K
K
Y
R
R
Y
E
V
I
M
Site 163
Y1673
H
L
K
K
Y
R
R
Y
E
V
I
M
T
A
Y
Site 164
T1678
R
R
Y
E
V
I
M
T
A
Y
N
I
I
G
E
Site 165
S1686
A
Y
N
I
I
G
E
S
P
A
S
A
P
V
E
Site 166
T1711
A
P
Q
N
V
Q
V
T
P
L
T
A
S
Q
L
Site 167
S1716
Q
V
T
P
L
T
A
S
Q
L
E
V
T
W
D
Site 168
T1721
T
A
S
Q
L
E
V
T
W
D
P
P
P
P
E
Site 169
S1729
W
D
P
P
P
P
E
S
Q
N
G
N
I
Q
G
Site 170
Y1741
I
Q
G
Y
K
I
Y
Y
W
E
A
D
S
Q
N
Site 171
T1750
E
A
D
S
Q
N
E
T
E
K
M
K
V
L
F
Site 172
S1770
V
R
L
K
N
L
T
S
H
T
K
Y
L
V
S
Site 173
S1790
A
A
G
D
G
P
K
S
D
P
Q
Q
G
R
T
Site 174
T1817
F
S
E
I
T
S
T
T
L
N
V
S
W
G
E
Site 175
T1853
Q
G
V
S
K
V
V
T
V
E
V
R
G
N
W
Site 176
Y1875
D
L
T
K
G
V
T
Y
F
F
R
V
Q
A
R
Site 177
T1883
F
F
R
V
Q
A
R
T
I
T
Y
G
P
E
L
Site 178
T1885
R
V
Q
A
R
T
I
T
Y
G
P
E
L
Q
A
Site 179
T1895
P
E
L
Q
A
N
I
T
A
G
P
A
E
G
S
Site 180
S1902
T
A
G
P
A
E
G
S
P
G
S
P
R
D
V
Site 181
S1905
P
A
E
G
S
P
G
S
P
R
D
V
L
V
T
Site 182
T1912
S
P
R
D
V
L
V
T
K
S
A
S
E
L
T
Site 183
S1914
R
D
V
L
V
T
K
S
A
S
E
L
T
L
Q
Site 184
T1923
S
E
L
T
L
Q
W
T
E
G
H
S
G
D
T
Site 185
T1930
T
E
G
H
S
G
D
T
P
T
T
G
Y
V
I
Site 186
Y1935
G
D
T
P
T
T
G
Y
V
I
E
A
R
P
S
Site 187
S1942
Y
V
I
E
A
R
P
S
D
E
G
L
W
D
M
Site 188
S1957
F
V
K
D
I
P
R
S
A
T
S
Y
T
L
S
Site 189
T1959
K
D
I
P
R
S
A
T
S
Y
T
L
S
L
D
Site 190
S1960
D
I
P
R
S
A
T
S
Y
T
L
S
L
D
K
Site 191
Y1961
I
P
R
S
A
T
S
Y
T
L
S
L
D
K
L
Site 192
T1962
P
R
S
A
T
S
Y
T
L
S
L
D
K
L
R
Site 193
S1964
S
A
T
S
Y
T
L
S
L
D
K
L
R
Q
G
Site 194
Y1986
V
A
V
N
E
A
G
Y
G
E
P
S
N
P
S
Site 195
S1990
E
A
G
Y
G
E
P
S
N
P
S
T
A
V
S
Site 196
S1993
Y
G
E
P
S
N
P
S
T
A
V
S
A
Q
V
Site 197
T1994
G
E
P
S
N
P
S
T
A
V
S
A
Q
V
E
Site 198
S1997
S
N
P
S
T
A
V
S
A
Q
V
E
A
P
F
Site 199
Y2038
L
H
G
Q
N
K
K
Y
K
N
C
S
T
G
K
Site 200
T2043
K
K
Y
K
N
C
S
T
G
K
G
I
S
T
M
Site 201
T2049
S
T
G
K
G
I
S
T
M
E
E
S
V
T
L
Site 202
S2053
G
I
S
T
M
E
E
S
V
T
L
D
N
G
G
Site 203
T2055
S
T
M
E
E
S
V
T
L
D
N
G
G
F
A
Site 204
S2067
G
F
A
A
L
E
L
S
S
R
H
L
N
V
K
Site 205
S2075
S
R
H
L
N
V
K
S
T
F
S
K
K
N
G
Site 206
T2076
R
H
L
N
V
K
S
T
F
S
K
K
N
G
T
Site 207
S2085
S
K
K
N
G
T
R
S
P
P
R
P
S
P
G
Site 208
S2090
T
R
S
P
P
R
P
S
P
G
G
L
H
Y
S
Site 209
S2097
S
P
G
G
L
H
Y
S
D
E
D
I
C
N
K
Site 210
Y2105
D
E
D
I
C
N
K
Y
N
G
A
V
L
T
E
Site 211
T2111
K
Y
N
G
A
V
L
T
E
S
V
S
L
K
E
Site 212
S2113
N
G
A
V
L
T
E
S
V
S
L
K
E
K
S
Site 213
S2115
A
V
L
T
E
S
V
S
L
K
E
K
S
A
D
Site 214
S2120
S
V
S
L
K
E
K
S
A
D
A
S
E
S
E
Site 215
S2124
K
E
K
S
A
D
A
S
E
S
E
A
T
D
S
Site 216
S2126
K
S
A
D
A
S
E
S
E
A
T
D
S
D
Y
Site 217
T2129
D
A
S
E
S
E
A
T
D
S
D
Y
E
D
A
Site 218
S2131
S
E
S
E
A
T
D
S
D
Y
E
D
A
L
P
Site 219
Y2133
S
E
A
T
D
S
D
Y
E
D
A
L
P
K
H
Site 220
S2141
E
D
A
L
P
K
H
S
F
V
N
H
Y
M
S
Site 221
Y2146
K
H
S
F
V
N
H
Y
M
S
D
P
T
Y
Y
Site 222
Y2152
H
Y
M
S
D
P
T
Y
Y
N
S
W
K
R
R
Site 223
Y2153
Y
M
S
D
P
T
Y
Y
N
S
W
K
R
R
A
Site 224
S2155
S
D
P
T
Y
Y
N
S
W
K
R
R
A
Q
G
Site 225
Y2170
R
A
P
A
P
H
R
Y
E
A
V
A
G
S
E
Site 226
Y2195
T
Q
S
A
G
G
V
Y
T
P
A
G
P
G
A
Site 227
T2196
Q
S
A
G
G
V
Y
T
P
A
G
P
G
A
R
Site 228
T2204
P
A
G
P
G
A
R
T
P
L
T
G
F
S
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation