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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AKNA
Full Name:
AT-hook-containing transcription factor
Alias:
AKNA transcript F2; AT-hook transcription factor; AT-hook transcription factor AKNA; KIAA1968
Type:
Transcription, coactivator/corepressor
Mass (Da):
155139
Number AA:
1439
UniProt ID:
Q7Z591
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S36
D
K
R
D
V
D
R
S
S
S
Q
S
W
E
E
Site 2
S37
K
R
D
V
D
R
S
S
S
Q
S
W
E
E
E
Site 3
S38
R
D
V
D
R
S
S
S
Q
S
W
E
E
E
R
Site 4
S40
V
D
R
S
S
S
Q
S
W
E
E
E
R
L
F
Site 5
T51
E
R
L
F
P
N
A
T
S
P
E
L
L
E
D
Site 6
S52
R
L
F
P
N
A
T
S
P
E
L
L
E
D
F
Site 7
S83
Q
P
D
G
H
Q
D
S
E
S
G
E
T
S
G
Site 8
S85
D
G
H
Q
D
S
E
S
G
E
T
S
G
E
E
Site 9
S89
D
S
E
S
G
E
T
S
G
E
E
A
E
A
E
Site 10
S100
A
E
A
E
D
V
D
S
P
A
S
S
H
E
P
Site 11
S103
E
D
V
D
S
P
A
S
S
H
E
P
L
A
W
Site 12
S104
D
V
D
S
P
A
S
S
H
E
P
L
A
W
L
Site 13
T121
Q
G
R
Q
L
D
M
T
E
E
E
P
D
G
T
Site 14
T128
T
E
E
E
P
D
G
T
L
G
S
L
E
V
E
Site 15
S131
E
P
D
G
T
L
G
S
L
E
V
E
E
A
G
Site 16
S140
E
V
E
E
A
G
E
S
S
S
R
L
G
Y
E
Site 17
S141
V
E
E
A
G
E
S
S
S
R
L
G
Y
E
A
Site 18
Y146
E
S
S
S
R
L
G
Y
E
A
G
L
S
L
E
Site 19
S151
L
G
Y
E
A
G
L
S
L
E
G
H
G
N
T
Site 20
S159
L
E
G
H
G
N
T
S
P
M
A
L
G
H
G
Site 21
S174
Q
A
R
G
W
V
A
S
G
E
Q
A
S
G
D
Site 22
S179
V
A
S
G
E
Q
A
S
G
D
K
L
S
E
H
Site 23
S184
Q
A
S
G
D
K
L
S
E
H
S
E
V
N
P
Site 24
S192
E
H
S
E
V
N
P
S
V
E
L
S
P
A
R
Site 25
S196
V
N
P
S
V
E
L
S
P
A
R
S
W
S
S
Site 26
S200
V
E
L
S
P
A
R
S
W
S
S
G
T
V
S
Site 27
S202
L
S
P
A
R
S
W
S
S
G
T
V
S
L
D
Site 28
S203
S
P
A
R
S
W
S
S
G
T
V
S
L
D
H
Site 29
T205
A
R
S
W
S
S
G
T
V
S
L
D
H
P
S
Site 30
S207
S
W
S
S
G
T
V
S
L
D
H
P
S
D
S
Site 31
S212
T
V
S
L
D
H
P
S
D
S
L
D
S
T
W
Site 32
S214
S
L
D
H
P
S
D
S
L
D
S
T
W
E
G
Site 33
S217
H
P
S
D
S
L
D
S
T
W
E
G
E
T
D
Site 34
T218
P
S
D
S
L
D
S
T
W
E
G
E
T
D
G
Site 35
S240
E
T
L
P
E
G
P
S
H
H
L
L
S
P
D
Site 36
S245
G
P
S
H
H
L
L
S
P
D
G
R
T
G
G
Site 37
S253
P
D
G
R
T
G
G
S
V
A
R
A
T
P
M
Site 38
T258
G
G
S
V
A
R
A
T
P
M
E
F
Q
D
S
Site 39
S265
T
P
M
E
F
Q
D
S
S
A
P
P
A
Q
S
Site 40
S266
P
M
E
F
Q
D
S
S
A
P
P
A
Q
S
P
Site 41
S272
S
S
A
P
P
A
Q
S
P
Q
H
A
T
D
R
Site 42
T302
H
I
W
K
Q
T
K
T
S
P
K
P
L
P
S
Site 43
S303
I
W
K
Q
T
K
T
S
P
K
P
L
P
S
R
Site 44
S309
T
S
P
K
P
L
P
S
R
F
I
G
S
I
S
Site 45
S314
L
P
S
R
F
I
G
S
I
S
P
L
N
P
Q
Site 46
S316
S
R
F
I
G
S
I
S
P
L
N
P
Q
P
R
Site 47
T325
L
N
P
Q
P
R
P
T
R
Q
G
R
P
L
P
Site 48
T337
P
L
P
R
Q
G
A
T
L
A
G
R
S
S
S
Site 49
S342
G
A
T
L
A
G
R
S
S
S
N
A
P
K
Y
Site 50
S343
A
T
L
A
G
R
S
S
S
N
A
P
K
Y
G
Site 51
S344
T
L
A
G
R
S
S
S
N
A
P
K
Y
G
R
Site 52
Y349
S
S
S
N
A
P
K
Y
G
R
G
Q
L
N
Y
Site 53
Y356
Y
G
R
G
Q
L
N
Y
P
L
P
D
F
S
K
Site 54
S375
V
R
F
P
K
D
E
S
Y
R
P
P
K
S
R
Site 55
Y376
R
F
P
K
D
E
S
Y
R
P
P
K
S
R
S
Site 56
S381
E
S
Y
R
P
P
K
S
R
S
H
N
R
K
P
Site 57
S383
Y
R
P
P
K
S
R
S
H
N
R
K
P
Q
A
Site 58
S399
A
R
P
L
I
F
K
S
P
A
E
I
V
Q
E
Site 59
T420
E
A
A
L
A
K
D
T
P
P
A
H
P
I
T
Site 60
T427
T
P
P
A
H
P
I
T
R
V
P
Q
E
F
Q
Site 61
T435
R
V
P
Q
E
F
Q
T
P
E
Q
A
T
E
L
Site 62
Y450
V
H
Q
L
Q
E
D
Y
H
R
L
L
T
K
Y
Site 63
T455
E
D
Y
H
R
L
L
T
K
Y
A
E
A
E
N
Site 64
Y457
Y
H
R
L
L
T
K
Y
A
E
A
E
N
T
I
Site 65
T463
K
Y
A
E
A
E
N
T
I
D
Q
L
R
L
G
Site 66
S477
G
A
K
V
N
L
F
S
D
P
P
Q
P
N
H
Site 67
S499
P
Q
G
T
K
V
L
S
F
T
I
P
Q
P
R
Site 68
S521
P
A
E
D
P
Q
A
S
A
A
S
G
W
P
S
Site 69
S524
D
P
Q
A
S
A
A
S
G
W
P
S
A
R
G
Site 70
S528
S
A
A
S
G
W
P
S
A
R
G
D
L
S
P
Site 71
S534
P
S
A
R
G
D
L
S
P
S
S
L
T
S
M
Site 72
S536
A
R
G
D
L
S
P
S
S
L
T
S
M
P
T
Site 73
S537
R
G
D
L
S
P
S
S
L
T
S
M
P
T
L
Site 74
T539
D
L
S
P
S
S
L
T
S
M
P
T
L
G
W
Site 75
T543
S
S
L
T
S
M
P
T
L
G
W
L
P
E
N
Site 76
S554
L
P
E
N
R
D
I
S
E
D
Q
S
S
A
E
Site 77
S558
R
D
I
S
E
D
Q
S
S
A
E
Q
T
Q
A
Site 78
S559
D
I
S
E
D
Q
S
S
A
E
Q
T
Q
A
L
Site 79
T563
D
Q
S
S
A
E
Q
T
Q
A
L
A
S
Q
A
Site 80
S568
E
Q
T
Q
A
L
A
S
Q
A
S
Q
F
L
A
Site 81
T631
P
L
A
G
S
K
G
T
P
G
R
F
D
P
R
Site 82
Y646
R
E
L
E
A
E
I
Y
R
L
G
S
C
L
E
Site 83
S650
A
E
I
Y
R
L
G
S
C
L
E
E
L
K
E
Site 84
T662
L
K
E
H
I
D
Q
T
Q
Q
E
P
E
P
P
Site 85
S671
Q
E
P
E
P
P
G
S
D
S
A
L
D
S
T
Site 86
S673
P
E
P
P
G
S
D
S
A
L
D
S
T
P
A
Site 87
T678
S
D
S
A
L
D
S
T
P
A
L
P
C
L
H
Site 88
T688
L
P
C
L
H
Q
P
T
H
L
P
A
P
S
G
Site 89
T704
A
P
M
P
A
I
K
T
S
C
P
E
P
A
T
Site 90
S705
P
M
P
A
I
K
T
S
C
P
E
P
A
T
T
Site 91
T712
S
C
P
E
P
A
T
T
T
A
A
A
S
T
G
Site 92
S734
V
E
V
S
S
G
N
S
E
V
E
D
R
P
Q
Site 93
Y758
E
L
Q
M
E
Q
V
Y
H
G
L
M
E
R
Y
Site 94
Y765
Y
H
G
L
M
E
R
Y
L
S
V
K
S
L
P
Site 95
S767
G
L
M
E
R
Y
L
S
V
K
S
L
P
E
A
Site 96
S770
E
R
Y
L
S
V
K
S
L
P
E
A
M
R
M
Site 97
S795
E
E
E
G
G
G
D
S
L
E
V
D
G
V
A
Site 98
T804
E
V
D
G
V
A
A
T
P
G
K
A
E
A
T
Site 99
S839
E
A
T
E
K
M
V
S
M
K
P
P
G
F
Q
Site 100
S848
K
P
P
G
F
Q
A
S
L
A
R
D
G
H
M
Site 101
S856
L
A
R
D
G
H
M
S
G
L
G
K
A
E
A
Site 102
T877
V
P
P
H
P
P
G
T
K
S
A
A
S
H
Q
Site 103
S879
P
H
P
P
G
T
K
S
A
A
S
H
Q
S
S
Site 104
S882
P
G
T
K
S
A
A
S
H
Q
S
S
M
T
S
Site 105
S885
K
S
A
A
S
H
Q
S
S
M
T
S
L
E
G
Site 106
S886
S
A
A
S
H
Q
S
S
M
T
S
L
E
G
S
Site 107
S889
S
H
Q
S
S
M
T
S
L
E
G
S
G
I
S
Site 108
S893
S
M
T
S
L
E
G
S
G
I
S
E
R
L
P
Site 109
S896
S
L
E
G
S
G
I
S
E
R
L
P
Q
K
P
Site 110
T915
G
G
P
H
L
E
E
T
W
M
A
S
P
E
T
Site 111
S919
L
E
E
T
W
M
A
S
P
E
T
D
S
G
F
Site 112
T922
T
W
M
A
S
P
E
T
D
S
G
F
V
G
S
Site 113
S924
M
A
S
P
E
T
D
S
G
F
V
G
S
E
T
Site 114
S929
T
D
S
G
F
V
G
S
E
T
S
R
V
S
P
Site 115
T931
S
G
F
V
G
S
E
T
S
R
V
S
P
L
T
Site 116
S932
G
F
V
G
S
E
T
S
R
V
S
P
L
T
Q
Site 117
S935
G
S
E
T
S
R
V
S
P
L
T
Q
T
P
E
Site 118
T938
T
S
R
V
S
P
L
T
Q
T
P
E
H
R
L
Site 119
T940
R
V
S
P
L
T
Q
T
P
E
H
R
L
S
H
Site 120
S946
Q
T
P
E
H
R
L
S
H
I
S
T
A
G
T
Site 121
S949
E
H
R
L
S
H
I
S
T
A
G
T
L
A
Q
Site 122
S961
L
A
Q
P
F
A
A
S
V
P
R
D
G
A
S
Site 123
S968
S
V
P
R
D
G
A
S
Y
P
K
A
R
G
S
Site 124
Y969
V
P
R
D
G
A
S
Y
P
K
A
R
G
S
L
Site 125
S975
S
Y
P
K
A
R
G
S
L
I
P
R
R
A
T
Site 126
T982
S
L
I
P
R
R
A
T
E
P
S
T
P
R
S
Site 127
S985
P
R
R
A
T
E
P
S
T
P
R
S
Q
A
Q
Site 128
T986
R
R
A
T
E
P
S
T
P
R
S
Q
A
Q
R
Site 129
S989
T
E
P
S
T
P
R
S
Q
A
Q
R
Y
L
S
Site 130
Y994
P
R
S
Q
A
Q
R
Y
L
S
S
P
S
G
P
Site 131
S996
S
Q
A
Q
R
Y
L
S
S
P
S
G
P
L
R
Site 132
S997
Q
A
Q
R
Y
L
S
S
P
S
G
P
L
R
Q
Site 133
S1010
R
Q
R
A
P
N
F
S
L
E
R
T
L
A
A
Site 134
S1024
A
E
M
A
V
P
G
S
E
F
E
G
H
K
R
Site 135
S1033
F
E
G
H
K
R
I
S
E
Q
P
L
P
N
K
Site 136
T1041
E
Q
P
L
P
N
K
T
I
S
P
P
P
A
P
Site 137
S1043
P
L
P
N
K
T
I
S
P
P
P
A
P
A
P
Site 138
T1069
T
I
P
S
F
L
L
T
R
A
G
R
D
Q
A
Site 139
S1094
L
R
L
R
L
E
D
S
L
H
Q
P
L
Q
G
Site 140
S1102
L
H
Q
P
L
Q
G
S
P
T
R
P
A
S
A
Site 141
T1104
Q
P
L
Q
G
S
P
T
R
P
A
S
A
F
D
Site 142
S1108
G
S
P
T
R
P
A
S
A
F
D
R
P
A
R
Site 143
S1123
T
R
G
R
P
A
D
S
P
A
T
W
G
S
H
Site 144
S1129
D
S
P
A
T
W
G
S
H
Y
G
S
K
S
T
Site 145
Y1131
P
A
T
W
G
S
H
Y
G
S
K
S
T
E
R
Site 146
S1133
T
W
G
S
H
Y
G
S
K
S
T
E
R
L
P
Site 147
S1135
G
S
H
Y
G
S
K
S
T
E
R
L
P
G
E
Site 148
S1159
P
G
R
Q
R
A
R
S
S
S
V
P
R
E
V
Site 149
S1160
G
R
Q
R
A
R
S
S
S
V
P
R
E
V
L
Site 150
S1161
R
Q
R
A
R
S
S
S
V
P
R
E
V
L
R
Site 151
S1170
P
R
E
V
L
R
L
S
L
S
S
E
S
E
L
Site 152
S1172
E
V
L
R
L
S
L
S
S
E
S
E
L
P
S
Site 153
S1173
V
L
R
L
S
L
S
S
E
S
E
L
P
S
L
Site 154
S1175
R
L
S
L
S
S
E
S
E
L
P
S
L
P
L
Site 155
S1179
S
S
E
S
E
L
P
S
L
P
L
F
S
E
K
Site 156
S1184
L
P
S
L
P
L
F
S
E
K
S
K
T
T
K
Site 157
S1187
L
P
L
F
S
E
K
S
K
T
T
K
D
S
P
Site 158
T1189
L
F
S
E
K
S
K
T
T
K
D
S
P
Q
A
Site 159
S1193
K
S
K
T
T
K
D
S
P
Q
A
A
R
D
G
Site 160
S1206
D
G
K
R
G
V
G
S
A
G
W
P
D
R
V
Site 161
T1214
A
G
W
P
D
R
V
T
F
R
G
Q
Y
T
G
Site 162
Y1219
R
V
T
F
R
G
Q
Y
T
G
H
E
Y
H
V
Site 163
Y1224
G
Q
Y
T
G
H
E
Y
H
V
L
S
P
K
A
Site 164
S1228
G
H
E
Y
H
V
L
S
P
K
A
V
P
K
G
Site 165
T1238
A
V
P
K
G
N
G
T
V
S
C
P
H
C
R
Site 166
S1240
P
K
G
N
G
T
V
S
C
P
H
C
R
P
I
Site 167
S1279
P
L
C
G
Q
V
G
S
P
P
E
A
D
G
P
Site 168
S1288
P
E
A
D
G
P
G
S
A
T
S
G
A
E
K
Site 169
T1297
T
S
G
A
E
K
A
T
T
R
R
K
A
S
S
Site 170
T1298
S
G
A
E
K
A
T
T
R
R
K
A
S
S
T
Site 171
S1303
A
T
T
R
R
K
A
S
S
T
P
S
P
K
Q
Site 172
S1304
T
T
R
R
K
A
S
S
T
P
S
P
K
Q
R
Site 173
T1305
T
R
R
K
A
S
S
T
P
S
P
K
Q
R
S
Site 174
S1307
R
K
A
S
S
T
P
S
P
K
Q
R
S
K
Q
Site 175
S1312
T
P
S
P
K
Q
R
S
K
Q
A
G
S
S
P
Site 176
S1317
Q
R
S
K
Q
A
G
S
S
P
R
P
P
P
G
Site 177
S1318
R
S
K
Q
A
G
S
S
P
R
P
P
P
G
L
Site 178
Y1327
R
P
P
P
G
L
W
Y
L
A
T
A
P
P
A
Site 179
Y1357
P
Y
P
P
A
A
V
Y
Y
A
P
A
G
P
T
Site 180
Y1358
Y
P
P
A
A
V
Y
Y
A
P
A
G
P
T
S
Site 181
S1365
Y
A
P
A
G
P
T
S
A
Q
P
A
A
K
W
Site 182
T1375
P
A
A
K
W
P
P
T
A
S
P
P
P
A
R
Site 183
S1377
A
K
W
P
P
T
A
S
P
P
P
A
R
R
H
Site 184
S1387
P
A
R
R
H
R
H
S
I
Q
L
D
L
G
D
Site 185
S1411
R
A
V
Q
A
A
E
S
V
R
S
T
T
R
Q
Site 186
S1414
Q
A
A
E
S
V
R
S
T
T
R
Q
M
R
S
Site 187
T1415
A
A
E
S
V
R
S
T
T
R
Q
M
R
S
S
Site 188
T1416
A
E
S
V
R
S
T
T
R
Q
M
R
S
S
L
Site 189
S1422
T
T
R
Q
M
R
S
S
L
S
A
D
L
R
Q
Site 190
S1424
R
Q
M
R
S
S
L
S
A
D
L
R
Q
A
H
Site 191
S1432
A
D
L
R
Q
A
H
S
L
R
G
S
C
L
F
Site 192
S1436
Q
A
H
S
L
R
G
S
C
L
F
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation