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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EMSY
Full Name:
Protein EMSY
Alias:
C11orf30; Chromosome 11 open reading frame 30; GL002
Type:
DNA repair
Mass (Da):
141468
Number AA:
1322
UniProt ID:
Q7Z589
International Prot ID:
IPI00152627
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0016568
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
W
P
T
L
L
D
L
S
R
D
E
C
K
R
I
Site 2
Y28
R
K
L
E
L
E
A
Y
A
G
V
I
S
A
L
Site 3
T42
L
R
A
Q
G
D
L
T
K
E
K
K
D
L
L
Site 4
S57
G
E
L
S
K
V
L
S
I
S
T
E
R
H
R
Site 5
T77
A
V
N
D
E
R
L
T
T
I
A
H
N
M
S
Site 6
T78
V
N
D
E
R
L
T
T
I
A
H
N
M
S
G
Site 7
S84
T
T
I
A
H
N
M
S
G
P
N
S
S
S
E
Site 8
S88
H
N
M
S
G
P
N
S
S
S
E
W
S
I
E
Site 9
S89
N
M
S
G
P
N
S
S
S
E
W
S
I
E
G
Site 10
S90
M
S
G
P
N
S
S
S
E
W
S
I
E
G
R
Site 11
S93
P
N
S
S
S
E
W
S
I
E
G
R
R
L
V
Site 12
S138
P
V
P
A
E
T
G
S
K
E
V
V
C
Y
S
Site 13
Y144
G
S
K
E
V
V
C
Y
S
Y
T
S
T
T
S
Site 14
S145
S
K
E
V
V
C
Y
S
Y
T
S
T
T
S
T
Site 15
Y146
K
E
V
V
C
Y
S
Y
T
S
T
T
S
T
P
Site 16
S148
V
V
C
Y
S
Y
T
S
T
T
S
T
P
T
S
Site 17
T149
V
C
Y
S
Y
T
S
T
T
S
T
P
T
S
T
Site 18
S151
Y
S
Y
T
S
T
T
S
T
P
T
S
T
P
V
Site 19
T152
S
Y
T
S
T
T
S
T
P
T
S
T
P
V
P
Site 20
T154
T
S
T
T
S
T
P
T
S
T
P
V
P
S
G
Site 21
S155
S
T
T
S
T
P
T
S
T
P
V
P
S
G
S
Site 22
T156
T
T
S
T
P
T
S
T
P
V
P
S
G
S
I
Site 23
S160
P
T
S
T
P
V
P
S
G
S
I
A
T
V
K
Site 24
S162
S
T
P
V
P
S
G
S
I
A
T
V
K
S
P
Site 25
S168
G
S
I
A
T
V
K
S
P
R
P
A
S
P
A
Site 26
S173
V
K
S
P
R
P
A
S
P
A
S
N
V
V
V
Site 27
S176
P
R
P
A
S
P
A
S
N
V
V
V
L
P
S
Site 28
Y188
L
P
S
G
S
T
V
Y
V
K
S
V
S
C
S
Site 29
S191
G
S
T
V
Y
V
K
S
V
S
C
S
D
E
D
Site 30
S193
T
V
Y
V
K
S
V
S
C
S
D
E
D
E
K
Site 31
S195
Y
V
K
S
V
S
C
S
D
E
D
E
K
P
R
Site 32
T207
K
P
R
K
R
R
R
T
N
S
S
S
S
S
P
Site 33
S209
R
K
R
R
R
T
N
S
S
S
S
S
P
V
V
Site 34
S210
K
R
R
R
T
N
S
S
S
S
S
P
V
V
L
Site 35
S211
R
R
R
T
N
S
S
S
S
S
P
V
V
L
K
Site 36
S212
R
R
T
N
S
S
S
S
S
P
V
V
L
K
E
Site 37
S213
R
T
N
S
S
S
S
S
P
V
V
L
K
E
V
Site 38
S228
P
K
A
V
V
P
V
S
K
T
I
T
V
P
V
Site 39
S236
K
T
I
T
V
P
V
S
G
S
P
K
M
S
N
Site 40
S238
I
T
V
P
V
S
G
S
P
K
M
S
N
I
M
Site 41
S242
V
S
G
S
P
K
M
S
N
I
M
Q
S
I
A
Site 42
S247
K
M
S
N
I
M
Q
S
I
A
N
S
L
P
P
Site 43
S251
I
M
Q
S
I
A
N
S
L
P
P
H
M
S
P
Site 44
S257
N
S
L
P
P
H
M
S
P
V
K
I
T
F
T
Site 45
T262
H
M
S
P
V
K
I
T
F
T
K
P
S
T
Q
Site 46
T271
T
K
P
S
T
Q
T
T
N
T
T
T
Q
K
V
Site 47
S295
T
F
V
P
N
I
L
S
K
S
H
N
Y
A
A
Site 48
S297
V
P
N
I
L
S
K
S
H
N
Y
A
A
V
T
Site 49
S329
V
I
T
A
S
Q
S
S
L
V
S
N
S
S
S
Site 50
S332
A
S
Q
S
S
L
V
S
N
S
S
S
G
S
S
Site 51
S334
Q
S
S
L
V
S
N
S
S
S
G
S
S
S
S
Site 52
S335
S
S
L
V
S
N
S
S
S
G
S
S
S
S
T
Site 53
S336
S
L
V
S
N
S
S
S
G
S
S
S
S
T
P
Site 54
S338
V
S
N
S
S
S
G
S
S
S
S
T
P
S
P
Site 55
S339
S
N
S
S
S
G
S
S
S
S
T
P
S
P
I
Site 56
S340
N
S
S
S
G
S
S
S
S
T
P
S
P
I
P
Site 57
S341
S
S
S
G
S
S
S
S
T
P
S
P
I
P
N
Site 58
T342
S
S
G
S
S
S
S
T
P
S
P
I
P
N
T
Site 59
S344
G
S
S
S
S
T
P
S
P
I
P
N
T
V
A
Site 60
S380
T
S
A
I
K
M
A
S
T
R
L
P
S
P
K
Site 61
T381
S
A
I
K
M
A
S
T
R
L
P
S
P
K
S
Site 62
S385
M
A
S
T
R
L
P
S
P
K
S
L
V
S
A
Site 63
S388
T
R
L
P
S
P
K
S
L
V
S
A
P
T
Q
Site 64
S407
F
P
K
Q
H
Q
Q
S
P
K
Q
Q
L
Y
Q
Site 65
Y413
Q
S
P
K
Q
Q
L
Y
Q
V
Q
Q
Q
T
Q
Site 66
S427
Q
Q
Q
V
A
Q
P
S
P
V
S
H
Q
Q
Q
Site 67
S430
V
A
Q
P
S
P
V
S
H
Q
Q
Q
P
Q
Q
Site 68
S438
H
Q
Q
Q
P
Q
Q
S
P
L
P
P
G
I
K
Site 69
T460
E
S
G
V
K
I
I
T
Q
Q
V
Q
P
S
K
Site 70
T474
K
I
L
P
K
P
V
T
A
T
L
P
T
S
S
Site 71
T476
L
P
K
P
V
T
A
T
L
P
T
S
S
N
S
Site 72
T502
M
T
T
K
L
V
T
T
P
T
G
T
Q
A
T
Site 73
T504
T
K
L
V
T
T
P
T
G
T
Q
A
T
Y
T
Site 74
Y510
P
T
G
T
Q
A
T
Y
T
R
P
T
V
S
P
Site 75
T511
T
G
T
Q
A
T
Y
T
R
P
T
V
S
P
S
Site 76
T514
Q
A
T
Y
T
R
P
T
V
S
P
S
I
G
R
Site 77
S516
T
Y
T
R
P
T
V
S
P
S
I
G
R
M
A
Site 78
Y531
A
T
P
G
A
A
T
Y
V
K
T
T
S
G
S
Site 79
T565
N
I
V
S
G
T
T
T
K
I
T
T
I
P
M
Site 80
T568
S
G
T
T
T
K
I
T
T
I
P
M
T
S
K
Site 81
T569
G
T
T
T
K
I
T
T
I
P
M
T
S
K
P
Site 82
T602
P
G
K
N
V
V
T
T
L
L
N
A
G
G
E
Site 83
T611
L
N
A
G
G
E
K
T
I
Q
T
V
P
T
G
Site 84
T614
G
G
E
K
T
I
Q
T
V
P
T
G
A
K
P
Site 85
T644
Q
P
K
G
I
G
S
T
V
Q
P
A
A
K
I
Site 86
Y658
I
I
P
T
K
I
V
Y
G
Q
Q
G
K
T
Q
Site 87
T678
K
P
V
T
F
Q
A
T
V
V
S
E
Q
T
R
Site 88
S704
R
V
A
E
A
G
N
S
S
I
Q
E
G
K
E
Site 89
Y716
G
K
E
E
P
Q
N
Y
T
D
S
S
S
S
S
Site 90
T717
K
E
E
P
Q
N
Y
T
D
S
S
S
S
S
T
Site 91
S719
E
P
Q
N
Y
T
D
S
S
S
S
S
T
E
S
Site 92
S720
P
Q
N
Y
T
D
S
S
S
S
S
T
E
S
S
Site 93
S721
Q
N
Y
T
D
S
S
S
S
S
T
E
S
S
Q
Site 94
S722
N
Y
T
D
S
S
S
S
S
T
E
S
S
Q
S
Site 95
S723
Y
T
D
S
S
S
S
S
T
E
S
S
Q
S
S
Site 96
T724
T
D
S
S
S
S
S
T
E
S
S
Q
S
S
Q
Site 97
S726
S
S
S
S
S
T
E
S
S
Q
S
S
Q
D
S
Site 98
S727
S
S
S
S
T
E
S
S
Q
S
S
Q
D
S
Q
Site 99
S729
S
S
T
E
S
S
Q
S
S
Q
D
S
Q
P
V
Site 100
S730
S
T
E
S
S
Q
S
S
Q
D
S
Q
P
V
V
Site 101
S733
S
S
Q
S
S
Q
D
S
Q
P
V
V
H
V
I
Site 102
S742
P
V
V
H
V
I
A
S
R
R
Q
D
W
S
E
Site 103
S748
A
S
R
R
Q
D
W
S
E
H
E
I
A
M
E
Site 104
S757
H
E
I
A
M
E
T
S
P
T
I
I
Y
Q
D
Site 105
Y762
E
T
S
P
T
I
I
Y
Q
D
V
S
S
E
S
Site 106
S766
T
I
I
Y
Q
D
V
S
S
E
S
Q
S
A
T
Site 107
S767
I
I
Y
Q
D
V
S
S
E
S
Q
S
A
T
S
Site 108
S769
Y
Q
D
V
S
S
E
S
Q
S
A
T
S
T
I
Site 109
S771
D
V
S
S
E
S
Q
S
A
T
S
T
I
K
A
Site 110
T773
S
S
E
S
Q
S
A
T
S
T
I
K
A
L
L
Site 111
T775
E
S
Q
S
A
T
S
T
I
K
A
L
L
E
L
Site 112
T785
A
L
L
E
L
Q
Q
T
T
V
K
E
K
L
E
Site 113
S793
T
V
K
E
K
L
E
S
K
P
R
Q
P
T
I
Site 114
T799
E
S
K
P
R
Q
P
T
I
D
L
S
Q
M
A
Site 115
S803
R
Q
P
T
I
D
L
S
Q
M
A
V
P
I
Q
Site 116
S818
M
T
Q
E
K
R
H
S
P
E
S
P
S
I
A
Site 117
S821
E
K
R
H
S
P
E
S
P
S
I
A
V
V
E
Site 118
S823
R
H
S
P
E
S
P
S
I
A
V
V
E
S
E
Site 119
T838
L
V
A
E
Y
I
T
T
E
R
T
D
E
G
T
Site 120
T845
T
E
R
T
D
E
G
T
E
V
A
F
P
L
L
Site 121
S854
V
A
F
P
L
L
V
S
H
R
S
Q
P
Q
Q
Site 122
S857
P
L
L
V
S
H
R
S
Q
P
Q
Q
P
S
Q
Site 123
S863
R
S
Q
P
Q
Q
P
S
Q
P
Q
R
T
L
L
Site 124
S876
L
L
Q
H
V
A
Q
S
Q
T
A
T
Q
T
S
Site 125
S883
S
Q
T
A
T
Q
T
S
V
V
V
K
S
I
P
Site 126
S907
I
M
Q
Q
A
L
S
S
H
T
A
F
T
K
H
Site 127
T920
K
H
S
E
E
L
G
T
E
E
G
E
V
E
E
Site 128
T930
G
E
V
E
E
M
D
T
L
D
P
Q
T
G
L
Site 129
S941
Q
T
G
L
F
Y
R
S
A
L
T
Q
S
Q
S
Site 130
T944
L
F
Y
R
S
A
L
T
Q
S
Q
S
A
K
Q
Site 131
S946
Y
R
S
A
L
T
Q
S
Q
S
A
K
Q
Q
K
Site 132
S948
S
A
L
T
Q
S
Q
S
A
K
Q
Q
K
L
S
Site 133
S955
S
A
K
Q
Q
K
L
S
Q
P
P
L
E
Q
T
Site 134
T968
Q
T
Q
L
Q
V
K
T
L
Q
C
F
Q
T
K
Site 135
T974
K
T
L
Q
C
F
Q
T
K
Q
K
Q
T
I
H
Site 136
S998
L
P
Q
M
P
Q
L
S
I
R
H
Q
K
L
T
Site 137
T1005
S
I
R
H
Q
K
L
T
P
L
Q
Q
E
Q
A
Site 138
T1021
P
K
P
D
V
Q
H
T
Q
H
P
M
V
A
K
Site 139
T1034
A
K
D
R
Q
L
P
T
L
M
A
Q
P
P
Q
Site 140
Y1068
A
P
N
Q
P
K
I
Y
V
Q
P
Q
T
P
Q
Site 141
T1073
K
I
Y
V
Q
P
Q
T
P
Q
S
Q
M
S
L
Site 142
S1076
V
Q
P
Q
T
P
Q
S
Q
M
S
L
P
A
S
Site 143
S1079
Q
T
P
Q
S
Q
M
S
L
P
A
S
S
E
K
Site 144
S1083
S
Q
M
S
L
P
A
S
S
E
K
Q
T
A
S
Site 145
T1088
P
A
S
S
E
K
Q
T
A
S
Q
V
E
Q
P
Site 146
S1090
S
S
E
K
Q
T
A
S
Q
V
E
Q
P
I
I
Site 147
T1107
G
S
S
V
T
K
I
T
F
E
G
R
Q
P
P
Site 148
T1115
F
E
G
R
Q
P
P
T
V
T
K
I
T
G
G
Site 149
S1124
T
K
I
T
G
G
S
S
V
P
K
L
T
S
P
Site 150
T1129
G
S
S
V
P
K
L
T
S
P
V
T
S
I
S
Site 151
S1130
S
S
V
P
K
L
T
S
P
V
T
S
I
S
P
Site 152
S1134
K
L
T
S
P
V
T
S
I
S
P
I
Q
A
S
Site 153
S1136
T
S
P
V
T
S
I
S
P
I
Q
A
S
E
K
Site 154
T1201
V
A
G
M
A
N
S
T
P
Q
Q
Q
K
C
R
Site 155
S1210
Q
Q
Q
K
C
R
E
S
C
S
S
P
S
T
V
Site 156
S1212
Q
K
C
R
E
S
C
S
S
P
S
T
V
G
S
Site 157
S1213
K
C
R
E
S
C
S
S
P
S
T
V
G
S
S
Site 158
S1215
R
E
S
C
S
S
P
S
T
V
G
S
S
L
T
Site 159
T1216
E
S
C
S
S
P
S
T
V
G
S
S
L
T
T
Site 160
S1219
S
S
P
S
T
V
G
S
S
L
T
T
R
K
I
Site 161
T1222
S
T
V
G
S
S
L
T
T
R
K
I
D
P
P
Site 162
T1223
T
V
G
S
S
L
T
T
R
K
I
D
P
P
A
Site 163
S1251
G
Q
K
K
A
E
E
S
P
A
E
I
I
I
Q
Site 164
S1288
L
E
L
N
N
F
T
S
Q
Q
L
D
D
E
E
Site 165
S1304
A
M
E
Q
D
I
D
S
S
T
E
D
G
T
E
Site 166
S1305
M
E
Q
D
I
D
S
S
T
E
D
G
T
E
P
Site 167
T1306
E
Q
D
I
D
S
S
T
E
D
G
T
E
P
S
Site 168
T1310
D
S
S
T
E
D
G
T
E
P
S
P
S
Q
S
Site 169
S1313
T
E
D
G
T
E
P
S
P
S
Q
S
S
A
E
Site 170
S1315
D
G
T
E
P
S
P
S
Q
S
S
A
E
R
S
Site 171
S1317
T
E
P
S
P
S
Q
S
S
A
E
R
S
_
_
Site 172
S1318
E
P
S
P
S
Q
S
S
A
E
R
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation