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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIF21A
Full Name:
Kinesin-like protein KIF21A
Alias:
CFEOM; CFEOM1; FEOM; FEOM1; Fibrosis of extraocular muscles, congenital, 1, autosomal dominant; Fibrosis of the extraocular muscles, congenital, 1; FLJ20052; KI21A; KIF2; Kinesin family member 21A; Kinesin-like protein KIF2; NY-REN-62; Renal carcinoma antigen NY-REN-62
Type:
Microtubule binding protein; Motor protein
Mass (Da):
187179
Number AA:
1674
UniProt ID:
Q7Z4S6
International Prot ID:
IPI00425404
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003777
PhosphoSite+
KinaseNET
Biological Process:
GO:0007018
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
E
G
C
H
I
C
T
S
V
T
P
G
E
P
Q
Site 2
Y53
D
K
A
F
T
F
D
Y
V
F
D
I
D
S
Q
Site 3
Y65
D
S
Q
Q
E
Q
I
Y
I
Q
C
I
E
K
L
Site 4
Y80
I
E
G
C
F
E
G
Y
N
A
T
V
F
A
Y
Site 5
Y87
Y
N
A
T
V
F
A
Y
G
Q
T
G
A
G
K
Site 6
Y96
Q
T
G
A
G
K
T
Y
T
M
G
T
G
F
D
Site 7
S124
A
V
K
H
L
F
K
S
I
E
E
K
K
H
I
Site 8
Y152
N
A
Q
F
L
E
L
Y
N
E
E
V
L
D
L
Site 9
T162
E
V
L
D
L
F
D
T
T
R
D
I
D
A
K
Site 10
S170
T
R
D
I
D
A
K
S
K
K
S
N
I
R
I
Site 11
S173
I
D
A
K
S
K
K
S
N
I
R
I
H
E
D
Site 12
S181
N
I
R
I
H
E
D
S
T
G
G
I
Y
T
V
Site 13
Y186
E
D
S
T
G
G
I
Y
T
V
G
V
T
T
R
Site 14
T187
D
S
T
G
G
I
Y
T
V
G
V
T
T
R
T
Site 15
T194
T
V
G
V
T
T
R
T
V
N
T
E
S
E
M
Site 16
T214
L
G
A
L
S
R
T
T
A
S
T
Q
M
N
V
Site 17
T217
L
S
R
T
T
A
S
T
Q
M
N
V
Q
S
S
Site 18
S223
S
T
Q
M
N
V
Q
S
S
R
S
H
A
I
F
Site 19
T249
Q
I
D
A
D
N
A
T
D
N
K
I
I
S
E
Site 20
S278
H
F
V
D
L
A
G
S
E
R
L
K
R
T
G
Site 21
S315
I
S
A
L
G
D
K
S
K
R
A
T
H
V
P
Site 22
T319
G
D
K
S
K
R
A
T
H
V
P
Y
R
D
S
Site 23
S326
T
H
V
P
Y
R
D
S
K
L
T
R
L
L
Q
Site 24
T329
P
Y
R
D
S
K
L
T
R
L
L
Q
D
S
L
Site 25
S335
L
T
R
L
L
Q
D
S
L
G
G
N
S
Q
T
Site 26
S340
Q
D
S
L
G
G
N
S
Q
T
I
M
I
A
C
Site 27
S351
M
I
A
C
V
S
P
S
D
R
D
F
M
E
T
Site 28
T358
S
D
R
D
F
M
E
T
L
N
T
L
K
Y
A
Site 29
T361
D
F
M
E
T
L
N
T
L
K
Y
A
N
R
A
Site 30
Y364
E
T
L
N
T
L
K
Y
A
N
R
A
R
N
I
Site 31
S383
M
V
N
Q
D
R
A
S
Q
Q
I
N
A
L
R
Site 32
Y403
L
Q
M
E
L
M
E
Y
K
T
G
K
R
I
I
Site 33
T445
R
I
K
A
M
Q
E
T
V
D
A
L
R
S
R
Site 34
T454
D
A
L
R
S
R
I
T
Q
L
V
S
D
Q
A
Site 35
S496
L
R
A
K
L
L
E
S
E
A
V
N
E
N
L
Site 36
T511
R
K
N
L
T
R
A
T
A
R
A
P
Y
F
S
Site 37
Y516
R
A
T
A
R
A
P
Y
F
S
G
S
S
T
F
Site 38
S518
T
A
R
A
P
Y
F
S
G
S
S
T
F
S
P
Site 39
S520
R
A
P
Y
F
S
G
S
S
T
F
S
P
T
I
Site 40
T522
P
Y
F
S
G
S
S
T
F
S
P
T
I
L
S
Site 41
S524
F
S
G
S
S
T
F
S
P
T
I
L
S
S
D
Site 42
T526
G
S
S
T
F
S
P
T
I
L
S
S
D
K
E
Site 43
S529
T
F
S
P
T
I
L
S
S
D
K
E
T
I
E
Site 44
S530
F
S
P
T
I
L
S
S
D
K
E
T
I
E
I
Site 45
S565
R
L
Q
K
L
E
E
S
N
R
E
E
R
S
V
Site 46
T579
V
A
G
K
E
D
N
T
D
T
D
Q
E
K
K
Site 47
T581
G
K
E
D
N
T
D
T
D
Q
E
K
K
E
E
Site 48
S592
K
K
E
E
K
G
V
S
E
R
E
N
N
E
L
Site 49
S604
N
E
L
E
V
E
E
S
Q
E
V
S
D
H
E
Site 50
S608
V
E
E
S
Q
E
V
S
D
H
E
D
E
E
E
Site 51
S629
D
D
I
D
G
G
E
S
S
D
E
S
D
S
E
Site 52
S630
D
I
D
G
G
E
S
S
D
E
S
D
S
E
S
Site 53
S633
G
G
E
S
S
D
E
S
D
S
E
S
D
E
K
Site 54
S635
E
S
S
D
E
S
D
S
E
S
D
E
K
A
N
Site 55
S637
S
D
E
S
D
S
E
S
D
E
K
A
N
Y
Q
Site 56
Y643
E
S
D
E
K
A
N
Y
Q
A
D
L
A
N
I
Site 57
S667
L
I
D
E
L
E
N
S
Q
K
R
L
Q
T
L
Site 58
T673
N
S
Q
K
R
L
Q
T
L
K
K
Q
Y
E
E
Site 59
T692
L
Q
H
K
I
R
D
T
Q
L
E
R
D
Q
V
Site 60
S705
Q
V
L
Q
N
L
G
S
V
E
S
Y
S
E
E
Site 61
S708
Q
N
L
G
S
V
E
S
Y
S
E
E
K
A
K
Site 62
S710
L
G
S
V
E
S
Y
S
E
E
K
A
K
K
V
Site 63
S719
E
K
A
K
K
V
R
S
E
Y
E
K
K
L
Q
Site 64
Y721
A
K
K
V
R
S
E
Y
E
K
K
L
Q
A
M
Site 65
S750
A
R
L
L
K
N
Q
S
Q
Y
E
K
Q
L
K
Site 66
T769
D
V
M
E
M
K
K
T
K
V
R
L
M
K
Q
Site 67
T787
E
Q
E
K
A
R
L
T
E
S
R
R
N
R
E
Site 68
S789
E
K
A
R
L
T
E
S
R
R
N
R
E
I
A
Site 69
T827
E
V
V
L
R
R
K
T
E
E
V
T
A
L
R
Site 70
S841
R
R
Q
V
R
P
M
S
D
K
V
A
G
K
V
Site 71
T849
D
K
V
A
G
K
V
T
R
K
L
S
S
S
D
Site 72
S853
G
K
V
T
R
K
L
S
S
S
D
A
P
A
Q
Site 73
S854
K
V
T
R
K
L
S
S
S
D
A
P
A
Q
D
Site 74
S855
V
T
R
K
L
S
S
S
D
A
P
A
Q
D
T
Site 75
T862
S
D
A
P
A
Q
D
T
G
S
S
A
A
A
V
Site 76
S864
A
P
A
Q
D
T
G
S
S
A
A
A
V
E
T
Site 77
S865
P
A
Q
D
T
G
S
S
A
A
A
V
E
T
D
Site 78
S874
A
A
V
E
T
D
A
S
R
T
G
A
Q
Q
K
Site 79
T894
A
R
V
Q
A
L
P
T
P
A
T
N
G
N
R
Site 80
T897
Q
A
L
P
T
P
A
T
N
G
N
R
K
K
Y
Site 81
Y904
T
N
G
N
R
K
K
Y
Q
R
K
G
L
T
G
Site 82
T910
K
Y
Q
R
K
G
L
T
G
R
V
F
I
S
K
Site 83
T918
G
R
V
F
I
S
K
T
A
R
M
K
W
Q
L
Site 84
T931
Q
L
L
E
R
R
V
T
D
I
I
M
Q
K
M
Site 85
T958
L
K
Q
R
E
E
L
T
K
R
R
E
K
L
S
Site 86
S965
T
K
R
R
E
K
L
S
K
R
R
E
K
I
V
Site 87
Y998
S
L
T
A
N
I
D
Y
I
N
D
S
I
S
D
Site 88
T1022
E
A
K
E
E
G
E
T
L
D
V
T
A
V
I
Site 89
S1110
H
A
L
Q
D
L
D
S
V
P
L
E
N
V
E
Site 90
S1119
P
L
E
N
V
E
D
S
T
D
E
D
A
P
L
Site 91
T1120
L
E
N
V
E
D
S
T
D
E
D
A
P
L
N
Site 92
S1128
D
E
D
A
P
L
N
S
P
G
S
E
G
S
T
Site 93
S1131
A
P
L
N
S
P
G
S
E
G
S
T
L
S
S
Site 94
S1134
N
S
P
G
S
E
G
S
T
L
S
S
D
L
M
Site 95
T1135
S
P
G
S
E
G
S
T
L
S
S
D
L
M
K
Site 96
S1137
G
S
E
G
S
T
L
S
S
D
L
M
K
L
C
Site 97
S1138
S
E
G
S
T
L
S
S
D
L
M
K
L
C
G
Site 98
T1157
K
N
K
A
R
R
R
T
T
T
Q
M
E
L
L
Site 99
T1158
N
K
A
R
R
R
T
T
T
Q
M
E
L
L
Y
Site 100
T1159
K
A
R
R
R
T
T
T
Q
M
E
L
L
Y
A
Site 101
Y1165
T
T
Q
M
E
L
L
Y
A
D
S
S
E
L
A
Site 102
S1168
M
E
L
L
Y
A
D
S
S
E
L
A
S
D
T
Site 103
S1169
E
L
L
Y
A
D
S
S
E
L
A
S
D
T
S
Site 104
S1173
A
D
S
S
E
L
A
S
D
T
S
T
G
D
A
Site 105
T1175
S
S
E
L
A
S
D
T
S
T
G
D
A
S
L
Site 106
S1176
S
E
L
A
S
D
T
S
T
G
D
A
S
L
P
Site 107
T1177
E
L
A
S
D
T
S
T
G
D
A
S
L
P
G
Site 108
S1181
D
T
S
T
G
D
A
S
L
P
G
P
L
T
P
Site 109
T1187
A
S
L
P
G
P
L
T
P
V
A
E
G
Q
E
Site 110
S1212
S
A
R
E
K
E
L
S
P
P
P
G
L
P
S
Site 111
S1219
S
P
P
P
G
L
P
S
K
I
G
S
I
S
R
Site 112
S1223
G
L
P
S
K
I
G
S
I
S
R
Q
S
S
L
Site 113
S1225
P
S
K
I
G
S
I
S
R
Q
S
S
L
S
E
Site 114
S1228
I
G
S
I
S
R
Q
S
S
L
S
E
K
K
I
Site 115
S1229
G
S
I
S
R
Q
S
S
L
S
E
K
K
I
P
Site 116
S1231
I
S
R
Q
S
S
L
S
E
K
K
I
P
E
P
Site 117
S1239
E
K
K
I
P
E
P
S
P
V
T
R
R
K
A
Site 118
T1242
I
P
E
P
S
P
V
T
R
R
K
A
Y
E
K
Site 119
Y1247
P
V
T
R
R
K
A
Y
E
K
A
E
K
S
K
Site 120
S1253
A
Y
E
K
A
E
K
S
K
A
K
E
Q
K
H
Site 121
S1261
K
A
K
E
Q
K
H
S
D
S
G
T
S
E
A
Site 122
S1263
K
E
Q
K
H
S
D
S
G
T
S
E
A
S
L
Site 123
T1265
Q
K
H
S
D
S
G
T
S
E
A
S
L
S
P
Site 124
S1266
K
H
S
D
S
G
T
S
E
A
S
L
S
P
P
Site 125
S1269
D
S
G
T
S
E
A
S
L
S
P
P
S
S
P
Site 126
S1271
G
T
S
E
A
S
L
S
P
P
S
S
P
P
S
Site 127
S1274
E
A
S
L
S
P
P
S
S
P
P
S
R
P
R
Site 128
S1275
A
S
L
S
P
P
S
S
P
P
S
R
P
R
N
Site 129
S1278
S
P
P
S
S
P
P
S
R
P
R
N
E
L
N
Site 130
T1291
L
N
V
F
N
R
L
T
V
S
Q
G
N
T
S
Site 131
S1293
V
F
N
R
L
T
V
S
Q
G
N
T
S
V
Q
Site 132
S1304
T
S
V
Q
Q
D
K
S
D
E
S
D
S
S
L
Site 133
S1307
Q
Q
D
K
S
D
E
S
D
S
S
L
S
E
V
Site 134
S1309
D
K
S
D
E
S
D
S
S
L
S
E
V
H
R
Site 135
S1310
K
S
D
E
S
D
S
S
L
S
E
V
H
R
S
Site 136
S1312
D
E
S
D
S
S
L
S
E
V
H
R
S
S
R
Site 137
S1317
S
L
S
E
V
H
R
S
S
R
R
G
I
I
N
Site 138
S1318
L
S
E
V
H
R
S
S
R
R
G
I
I
N
P
Site 139
S1364
D
D
L
L
F
T
G
S
K
D
R
T
C
K
V
Site 140
S1382
V
T
G
Q
E
I
M
S
L
G
G
H
P
N
N
Site 141
T1424
D
S
A
K
C
I
R
T
L
T
S
S
G
Q
V
Site 142
S1442
D
A
C
S
A
S
T
S
R
T
V
A
I
P
S
Site 143
T1444
C
S
A
S
T
S
R
T
V
A
I
P
S
G
E
Site 144
S1484
W
D
L
K
R
F
Q
S
T
G
K
L
T
G
H
Site 145
T1512
S
G
Q
D
L
I
I
T
G
S
K
D
H
Y
I
Site 146
Y1518
I
T
G
S
K
D
H
Y
I
K
M
F
D
V
T
Site 147
T1531
V
T
E
G
A
L
G
T
V
S
P
T
H
N
F
Site 148
S1533
E
G
A
L
G
T
V
S
P
T
H
N
F
E
P
Site 149
Y1543
H
N
F
E
P
P
H
Y
D
G
I
E
A
L
T
Site 150
S1560
G
D
N
L
F
S
G
S
R
D
N
G
I
K
K
Site 151
T1571
G
I
K
K
W
D
L
T
Q
K
D
L
L
Q
Q
Site 152
S1627
G
E
M
K
G
H
D
S
P
I
N
A
I
C
V
Site 153
T1647
F
T
A
A
D
D
R
T
V
R
I
W
K
A
R
Site 154
S1662
N
L
Q
D
G
Q
I
S
D
T
G
D
L
G
E
Site 155
T1664
Q
D
G
Q
I
S
D
T
G
D
L
G
E
D
I
Site 156
S1673
D
L
G
E
D
I
A
S
N
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation