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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HEATR3
Full Name:
HEAT repeat-containing protein 3
Alias:
FLJ20718; HEAT repeat containing 3; HEAT3
Type:
Unknown function
Mass (Da):
74583
Number AA:
680
UniProt ID:
Q7Z4Q2
International Prot ID:
IPI00100984
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
G
K
S
R
T
K
R
F
K
R
P
Q
Site 2
S15
R
F
K
R
P
Q
F
S
P
T
G
D
C
Q
A
Site 3
T17
K
R
P
Q
F
S
P
T
G
D
C
Q
A
E
A
Site 4
T31
A
A
A
A
A
N
G
T
G
G
E
E
D
D
G
Site 5
T98
P
S
L
A
V
R
E
T
A
A
G
A
L
R
N
Site 6
T120
E
V
C
D
D
M
V
T
K
D
I
M
T
P
L
Site 7
S135
V
A
L
L
K
E
C
S
A
G
L
D
S
N
E
Site 8
S140
E
C
S
A
G
L
D
S
N
E
M
S
L
Q
E
Site 9
S144
G
L
D
S
N
E
M
S
L
Q
E
K
K
D
Q
Site 10
S155
K
K
D
Q
N
R
N
S
I
E
N
I
A
N
E
Site 11
S179
E
C
S
S
R
A
V
S
I
F
N
K
E
G
C
Site 12
S195
E
I
V
L
K
Y
L
S
R
F
P
T
N
V
D
Site 13
T199
K
Y
L
S
R
F
P
T
N
V
D
L
A
I
S
Site 14
T213
S
V
A
Y
C
L
Q
T
V
T
E
D
N
P
E
Site 15
S224
D
N
P
E
L
L
K
S
F
S
A
T
A
L
N
Site 16
S268
K
D
I
I
P
C
K
S
Q
A
E
I
I
N
A
Site 17
T300
I
Q
M
K
E
A
E
T
Q
R
L
K
T
A
A
Site 18
T305
A
E
T
Q
R
L
K
T
A
A
E
A
E
E
I
Site 19
S331
D
D
E
M
E
G
I
S
H
K
R
R
V
R
R
Site 20
T340
K
R
R
V
R
R
K
T
F
V
S
D
L
L
P
Site 21
S343
V
R
R
K
T
F
V
S
D
L
L
P
P
T
D
Site 22
T356
T
D
K
E
L
R
E
T
I
A
L
L
T
A
Q
Site 23
S388
D
D
E
W
E
E
L
S
S
S
D
E
S
D
A
Site 24
S389
D
E
W
E
E
L
S
S
S
D
E
S
D
A
F
Site 25
S390
E
W
E
E
L
S
S
S
D
E
S
D
A
F
M
Site 26
S393
E
L
S
S
S
D
E
S
D
A
F
M
E
N
S
Site 27
S400
S
D
A
F
M
E
N
S
F
S
E
C
G
G
Q
Site 28
S402
A
F
M
E
N
S
F
S
E
C
G
G
Q
L
F
Site 29
S410
E
C
G
G
Q
L
F
S
P
L
C
L
S
H
E
Site 30
T435
P
K
K
I
F
E
K
T
A
F
P
N
S
I
A
Site 31
S447
S
I
A
V
D
L
C
S
R
N
P
T
W
K
P
Site 32
T451
D
L
C
S
R
N
P
T
W
K
P
L
I
R
K
Site 33
S496
Q
T
L
A
Q
H
L
S
Q
L
L
F
S
Q
P
Site 34
S501
H
L
S
Q
L
L
F
S
Q
P
D
F
A
K
H
Site 35
S532
T
M
A
S
K
N
I
S
Q
C
M
T
P
D
Q
Site 36
T536
K
N
I
S
Q
C
M
T
P
D
Q
L
M
T
L
Site 37
S551
C
K
A
G
I
H
S
S
N
V
G
V
R
V
N
Site 38
S561
G
V
R
V
N
V
V
S
I
L
G
I
T
G
S
Site 39
S621
G
K
E
A
E
R
A
S
I
Q
I
K
L
L
S
Site 40
Y649
R
K
E
G
R
G
N
Y
S
T
D
Q
L
C
V
Site 41
S650
K
E
G
R
G
N
Y
S
T
D
Q
L
C
V
L
Site 42
T651
E
G
R
G
N
Y
S
T
D
Q
L
C
V
L
D
Site 43
Y670
N
L
R
R
F
I
A
Y
Q
E
T
V
E
K
R
Site 44
T673
R
F
I
A
Y
Q
E
T
V
E
K
R
L
T
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation