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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TTC21B
Full Name:
Tetratricopeptide repeat protein 21B
Alias:
Nbla10696; TT21B
Type:
Uncharacterized
Mass (Da):
150939
Number AA:
1316
UniProt ID:
Q7Z4L5
International Prot ID:
IPI00178386
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0035085
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
D
S
Q
E
L
K
T
L
I
N
Y
Y
C
Q
Site 2
Y12
E
L
K
T
L
I
N
Y
Y
C
Q
E
R
Y
F
Site 3
S35
E
G
I
K
R
Y
G
S
D
P
V
F
R
F
Y
Site 4
Y42
S
D
P
V
F
R
F
Y
H
A
Y
G
T
L
M
Site 5
Y45
V
F
R
F
Y
H
A
Y
G
T
L
M
E
G
K
Site 6
T53
G
T
L
M
E
G
K
T
Q
E
A
L
R
E
F
Site 7
S84
L
I
Y
A
H
K
M
S
P
N
P
D
R
E
A
Site 8
S95
D
R
E
A
I
L
E
S
D
A
R
V
K
E
Q
Site 9
Y130
R
H
D
K
A
R
E
Y
I
D
R
M
I
K
I
Site 10
S138
I
D
R
M
I
K
I
S
D
G
S
K
Q
G
H
Site 11
T154
L
K
A
W
L
D
I
T
R
G
K
E
P
Y
T
Site 12
Y160
I
T
R
G
K
E
P
Y
T
K
K
A
L
K
Y
Site 13
Y167
Y
T
K
K
A
L
K
Y
F
E
E
G
L
Q
D
Site 14
T178
G
L
Q
D
G
N
D
T
F
A
L
L
G
K
A
Site 15
Y194
C
L
E
M
R
Q
N
Y
S
G
A
L
E
T
M
Site 16
T231
A
L
Q
D
W
D
Q
T
V
E
T
A
Q
R
L
Site 17
S243
Q
R
L
L
L
Q
D
S
Q
N
V
E
A
L
R
Site 18
Y255
A
L
R
M
Q
A
L
Y
Y
V
C
R
E
G
D
Site 19
Y256
L
R
M
Q
A
L
Y
Y
V
C
R
E
G
D
I
Site 20
T268
G
D
I
E
K
A
S
T
K
L
E
N
L
G
N
Site 21
S302
F
S
R
T
C
G
R
S
Q
L
I
L
Q
K
I
Site 22
S318
T
L
L
E
R
A
F
S
L
N
P
Q
Q
S
E
Site 23
T328
P
Q
Q
S
E
F
A
T
E
L
G
Y
Q
M
I
Site 24
Y332
E
F
A
T
E
L
G
Y
Q
M
I
L
Q
G
R
Site 25
T349
E
A
L
K
W
Y
K
T
A
M
T
L
D
E
T
Site 26
T352
K
W
Y
K
T
A
M
T
L
D
E
T
S
V
S
Site 27
S390
F
L
N
E
I
Q
Q
S
I
G
K
S
A
E
L
Site 28
S394
I
Q
Q
S
I
G
K
S
A
E
L
I
Y
L
H
Site 29
T425
L
L
N
D
V
L
D
T
H
F
S
Q
L
E
G
Site 30
Y439
G
L
P
L
G
I
Q
Y
F
E
K
L
N
P
D
Site 31
S465
F
C
P
M
Q
P
A
S
P
G
Q
P
L
C
P
Site 32
S524
H
C
L
E
H
N
P
S
Y
A
D
A
H
L
L
Site 33
Y525
C
L
E
H
N
P
S
Y
A
D
A
H
L
L
L
Site 34
S546
Q
E
K
V
K
L
C
S
Q
S
L
E
L
C
L
Site 35
S554
Q
S
L
E
L
C
L
S
Y
D
F
K
V
R
D
Site 36
Y562
Y
D
F
K
V
R
D
Y
P
L
Y
H
L
I
K
Site 37
Y565
K
V
R
D
Y
P
L
Y
H
L
I
K
A
Q
S
Site 38
S572
Y
H
L
I
K
A
Q
S
Q
K
K
M
G
E
I
Site 39
S591
K
T
L
H
M
A
M
S
L
P
G
M
K
R
I
Site 40
T602
M
K
R
I
G
A
S
T
K
S
K
D
R
K
T
Site 41
S604
R
I
G
A
S
T
K
S
K
D
R
K
T
E
V
Site 42
T609
T
K
S
K
D
R
K
T
E
V
D
T
S
H
R
Site 43
T613
D
R
K
T
E
V
D
T
S
H
R
L
S
I
F
Site 44
S614
R
K
T
E
V
D
T
S
H
R
L
S
I
F
L
Site 45
T650
A
I
H
E
F
S
G
T
S
E
E
V
R
V
T
Site 46
Y698
R
E
K
M
A
D
I
Y
L
K
H
R
K
D
K
Site 47
Y708
H
R
K
D
K
M
L
Y
I
T
C
F
R
E
I
Site 48
S724
E
R
M
A
N
P
R
S
F
L
L
L
G
D
A
Site 49
T757
N
Q
N
P
K
D
G
T
L
A
S
K
M
G
K
Site 50
S760
P
K
D
G
T
L
A
S
K
M
G
K
A
L
I
Site 51
Y790
L
K
T
G
Q
K
N
Y
L
C
Y
D
L
A
E
Site 52
Y805
L
L
L
K
L
K
W
Y
D
K
A
E
K
V
L
Site 53
S894
C
A
E
I
A
K
H
S
V
A
Q
R
D
Y
E
Site 54
Y900
H
S
V
A
Q
R
D
Y
E
K
A
I
K
F
Y
Site 55
Y928
M
L
E
L
A
R
L
Y
L
A
Q
D
D
P
D
Site 56
S936
L
A
Q
D
D
P
D
S
C
L
R
Q
C
A
L
Site 57
Y968
L
M
F
R
K
Q
D
Y
E
Q
A
V
F
H
L
Site 58
Y986
L
E
R
K
P
D
N
Y
M
T
L
S
R
L
I
Site 59
T988
R
K
P
D
N
Y
M
T
L
S
R
L
I
D
L
Site 60
S990
P
D
N
Y
M
T
L
S
R
L
I
D
L
L
R
Site 61
S1010
E
D
V
P
R
F
F
S
M
A
E
K
R
N
S
Site 62
S1017
S
M
A
E
K
R
N
S
R
A
K
L
E
P
G
Site 63
Y1027
K
L
E
P
G
F
Q
Y
C
K
G
L
Y
L
W
Site 64
Y1032
F
Q
Y
C
K
G
L
Y
L
W
Y
T
G
E
P
Site 65
T1036
K
G
L
Y
L
W
Y
T
G
E
P
N
D
A
L
Site 66
T1074
C
L
N
P
D
N
E
T
V
G
G
E
V
F
E
Site 67
S1090
L
D
G
D
L
G
N
S
T
E
K
Q
E
S
V
Site 68
T1091
D
G
D
L
G
N
S
T
E
K
Q
E
S
V
Q
Site 69
S1096
N
S
T
E
K
Q
E
S
V
Q
L
A
V
R
T
Site 70
T1115
L
K
E
L
K
P
Q
T
V
Q
G
H
V
Q
L
Site 71
Y1128
Q
L
R
I
M
E
N
Y
C
L
M
A
T
K
Q
Site 72
S1137
L
M
A
T
K
Q
K
S
N
V
E
Q
A
L
N
Site 73
T1145
N
V
E
Q
A
L
N
T
F
T
E
I
A
A
S
Site 74
S1152
T
F
T
E
I
A
A
S
E
K
E
H
I
P
A
Site 75
T1173
A
Y
M
I
L
K
Q
T
P
R
A
R
N
Q
L
Site 76
S1199
D
A
E
E
F
E
K
S
W
L
L
L
A
D
I
Site 77
Y1239
K
A
Y
E
Y
M
G
Y
I
M
E
K
E
Q
A
Site 78
T1248
M
E
K
E
Q
A
Y
T
D
A
A
L
N
Y
E
Site 79
Y1260
N
Y
E
M
A
W
K
Y
S
N
R
T
N
P
A
Site 80
Y1276
G
Y
K
L
A
F
N
Y
L
K
A
K
R
Y
V
Site 81
Y1282
N
Y
L
K
A
K
R
Y
V
D
S
I
D
I
C
Site 82
T1298
Q
V
L
E
A
H
P
T
Y
P
K
I
R
K
D
Site 83
Y1299
V
L
E
A
H
P
T
Y
P
K
I
R
K
D
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation